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Michael Benjamin Stout

TitleScientist,Research Sr
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentNutritional Sciences
Address1200 N Stonewall Ave
Oklahoma City OK 73117-1215
Phone405/271-8001
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    Collapse research activities and funding
    K99AG051661     (STOUT, MICHAEL B)Sep 1, 2016 - Apr 30, 2018
    NIH/NIA
    Mechanisms of metabolic, inflammatory and healthspan enhancement by 17a-estradiol
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Du M, Mangold CA, Bixler GV, Brucklacher RM, Masser DR, Stout MB, Elliott MH, Freeman WM. Retinal gene expression responses to aging are sexually divergent. Mol Vis. 2017; 23:707-717. PMID: 29062222.
      View in: PubMed
    2. Gesing A, Wiesenborn D, Do A, Menon V, Schneider A, Victoria B, Stout MB, Kopchick JJ, Bartke A, Masternak MM. A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies. J Gerontol A Biol Sci Med Sci. 2017 Aug 01; 72(8):1054-1061. PMID: 27688483.
      View in: PubMed
    3. Stout MB, Justice JN, Nicklas BJ, Kirkland JL. Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda). 2017 Jan; 32(1):9-19. PMID: 27927801.
      View in: PubMed
    4. Li R, Steyn FJ, Stout MB, Lee K, Cully TR, Calderón JC, Ngo ST. Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles. J Physiol. 2016 Dec 15; 594(24):7197-7213. PMID: 27619319.
      View in: PubMed
    5. Kirkland JL, Stout MB, Sierra F. Resilience in Aging Mice. J Gerontol A Biol Sci Med Sci. 2016 Nov; 71(11):1407-1414. PMID: 27535963.
      View in: PubMed
    6. Huffman DM, Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN. Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience. J Gerontol A Biol Sci Med Sci. 2016 Nov; 71(11):1395-1406. PMID: 27535967.
      View in: PubMed
    7. Chen VP, Gao Y, Geng L, Stout MB, Jensen MD, Brimijoin S. Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet. Endocrinology. 2016 Aug; 157(8):3086-95. PMID: 27300766; PMCID: PMC4967128 [Available on 08/01/17].
    8. Zhu Y, Tchkonia T, Fuhrmann-Stroissnigg H, Dai HM, Ling YY, Stout MB, Pirtskhalava T, Giorgadze N, Johnson KO, Giles CB, Wren JD, Niedernhofer LJ, Robbins PD, Kirkland JL. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors. Aging Cell. 2016 Jun; 15(3):428-35. PMID: 26711051; PMCID: PMC4854923.
    9. Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue. Diabetes. 2016 Jun; 65(6):1606-15. PMID: 26983960; PMCID: PMC4878429 [Available on 06/01/17].
    10. Stout MB, Steyn FJ, Jurczak MJ, Camporez JG, Zhu Y, Hawse JR, Jurk D, Palmer AK, Xu M, Pirtskhalava T, Evans GL, de Souza Santos R, Frank AP, White TA, Monroe DG, Singh RJ, Casaclang-Verzosa G, Miller JD, Clegg DJ, LeBrasseur NK, von Zglinicki T, Shulman GI, Tchkonia T, Kirkland JL. 17a-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. J Gerontol A Biol Sci Med Sci. 2017 Jan; 72(1):3-15. PMID: 26809497.
      View in: PubMed
    11. Xu M, Palmer AK, Ding H, Weivoda MM, Pirtskhalava T, White TA, Sepe A, Johnson KO, Stout MB, Giorgadze N, Jensen MD, LeBrasseur NK, Tchkonia T, Kirkland JL. Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife. 2015 Dec 19; 4:e12997. PMID: 26687007; PMCID: PMC4758946.
    12. Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6301-10. PMID: 26578790; PMCID: PMC4655580.
    13. Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM. Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice. Oncotarget. 2015 Sep 29; 6(29):26702-15. PMID: 26436954; PMCID: PMC4694946.
    14. List EO, Berryman DE, Ikeno Y, Hubbard GB, Funk K, Comisford R, Young JA, Stout MB, Tchkonia T, Masternak MM, Bartke A, Kirkland JL, Miller RA, Kopchick JJ. Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice. Aging (Albany NY). 2015 Jul; 7(7):500-12. PMID: 26233957; PMCID: PMC4543039.
    15. Stout MB, Tchkonia T, Kirkland JL. Growth hormone in adipose dysfunction and senescence. Oncotarget. 2015 May 10; 6(13):10667-8. PMID: 25951493; PMCID: PMC4484409.
    16. Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O'Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14(4):644-58. PMID: 25754370; PMCID: PMC4531078.
    17. Zhu Y, Tchkonia T, Stout MB, Giorgadze N, Wang L, Li PW, Heppelmann CJ, Bouloumié A, Jensen MD, Bergen HR, Kirkland JL. Inflammation and the depot-specific secretome of human preadipocytes. Obesity (Silver Spring). 2015 May; 23(5):989-99. PMID: 25864718; PMCID: PMC4414793.
    18. Kliewer KL, Ke JY, Lee HY, Stout MB, Cole RM, Samuel VT, Shulman GI, Belury MA. Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice. J Nutr Biochem. 2015 Jul; 26(7):721-8. PMID: 25913018; PMCID: PMC4461460.
    19. Zawada I, Masternak MM, List EO, Stout MB, Berryman DE, Lewinski A, Kopchick JJ, Bartke A, Karbownik-Lewinska M, Gesing A. Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver. Aging (Albany NY). 2015 Mar; 7(3):195-204. PMID: 25855408; PMCID: PMC4394730.
    20. Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. J Hepatol. 2015 May; 62(5):1156-63. PMID: 25445398; PMCID: PMC4404200.
    21. Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging (Albany NY). 2014 Jul; 6(7):575-86. PMID: 25063774; PMCID: PMC4153624.
    22. List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles. Endocrinology. 2014 May; 155(5):1793-805. PMID: 24517230; PMCID: PMC3990850.
    23. Stout MB, Liu LF, Belury MA. Hepatic steatosis by dietary-conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C e in mice. Mol Nutr Food Res. 2011 Jul; 55(7):1010-7. PMID: 21480517.
      View in: PubMed
    24. Asp ML, Collene AL, Norris LE, Cole RM, Stout MB, Tang SY, Hsu JC, Belury MA. Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, crossover study. Clin Nutr. 2011 Aug; 30(4):443-9. PMID: 21295383; PMCID: PMC3115398.
    25. Tian M, Kliewer KL, Asp ML, Stout MB, Belury MA. c9t11-Conjugated linoleic acid-rich oil fails to attenuate wasting in colon-26 tumor-induced late-stage cancer cachexia in male CD2F1 mice. Mol Nutr Food Res. 2011 Feb; 55(2):268-77. PMID: 20827675.
      View in: PubMed
    26. Tian M, Nishijima Y, Asp ML, Stout MB, Reiser PJ, Belury MA. Cardiac alterations in cancer-induced cachexia in mice. Int J Oncol. 2010 Aug; 37(2):347-53. PMID: 20596662.
      View in: PubMed
    27. Campbell JA, Martin JE, Melendez K, Stout MB, Lyvers-Peffer PA. Postnatal hepatic fatty acid oxidative capacity of preterm pigs receiving TPN does not differ from that of term pigs and is not affected by supplemental arachidonic and docosahexaenoic acids. J Nutr. 2010 Apr; 140(4):752-9. PMID: 20164367.
      View in: PubMed
    28. Winnick JJ, Sherman WM, Habash DL, Stout MB, Failla ML, Belury MA, Schuster DP. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab. 2008 Mar; 93(3):771-8. PMID: 18073312; PMCID: PMC2266960.
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