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Mature B cells class switched to IgD are autoreactive in healthy individuals.

Koelsch K, Zheng NY, Zhang Q, Duty A, Helms C, Mathias MD, Jared M, Smith K, Capra JD, Wilson PC. Mature B cells class switched to IgD are autoreactive in healthy individuals. J Clin Invest. 2007 Jun; 117(6):1558-65.

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