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Jasimuddin Ahamed

TitleProf,Asoc
InstitutionOklahoma Medical Research Foundation
DepartmentCardiovascular Biology Research Program
Address825 NE 13th St
Oklahoma City OK
Phone405/274-2560
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    Collapse Biography 
    Collapse education and training
    Bose Institute/University of Calcutta, Kolkata, IndaPh.D2000Physiology/Biochemistry
    University of Calcutta, Kolkata, IndiaM.S.1993Human Physiology

    Collapse Research 
    Collapse research activities and funding
    R01HL123605     (AHAMED, JASIMUDDIN)Nov 7, 2014 - Oct 31, 2018
    NIH
    The Mechanism of Shear-Induced Release and Activation of TGF-beta1
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ghafoory S, Varshney R, Robison T, Kouzbari K, Woolington S, Murphy B, Xia L, Ahamed J. Platelet TGF-ß1 deficiency decreases liver fibrosis in a mouse model of liver injury. Blood Adv. 2018 Mar 13; 2(5):470-480. PMID: 29490978.
      View in: PubMed
    2. Mancini D, Monteagudo J, Suárez-Fariñas M, Bander J, Varshney R, Gonzalez J, Coller BS, Ahamed J. New methodologies to accurately assess circulating active transforming growth factor-ß1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices. Transl Res. 2018 Feb; 192:15-29. PMID: 29175264.
      View in: PubMed
    3. Laurence J, Elhadad S, Robison T, Terry H, Varshney R, Woolington S, Ghafoory S, Choi ME, Ahamed J. HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-ß1 and can be suppressed by exogenous carbon monoxide. PLoS One. 2017; 12(10):e0187185. PMID: 29088262.
      View in: PubMed
    4. Ahamed J, Laurence J. Role of Platelet-Derived Transforming Growth Factor-ß1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis. Antioxid Redox Signal. 2017 Nov 01; 27(13):977-988. PMID: 28562065.
      View in: PubMed
    5. Ahamed J, Terry H, Choi ME, Laurence J. Transforming growth factor-ß1-mediated cardiac fibrosis: potential role in HIV and HIV/antiretroviral therapy-linked cardiovascular disease. AIDS. 2016 Feb 20; 30(4):535-42. PMID: 26605511; PMCID: PMC4738098 [Available on 02/20/17].
    6. Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med. 2014 Nov; 20(11):1321-6. PMID: 25326798.
      View in: PubMed
    7. Yang F, Dong A, Ahamed J, Sunkara M, Smyth SS. Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2014 Nov 15; 307(10):H1529-38. PMID: 25239803; PMCID: PMC4233303.
    8. Wang W, Vootukuri S, Meyer A, Ahamed J, Coller BS. Association between shear stress and platelet-derived transforming growth factor-ß1 release and activation in animal models of aortic valve stenosis. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1924-32. PMID: 24903096; PMCID: PMC4141006.
    9. Palmerini T, Tomasi L, Barozzi C, Della Riva D, Mariani A, Taglieri N, Leone O, Ceccarelli C, De Servi S, Branzi A, Genereux P, Stone GW, Ahamed J. Detection of tissue factor antigen and coagulation activity in coronary artery thrombi isolated from patients with ST-segment elevation acute myocardial infarction. PLoS One. 2013; 8(12):e81501. PMID: 24349079; PMCID: PMC3859482.
    10. Brophy TM, Coller BS, Ahamed J. Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor ß1 (TGF-ß1) activation. J Biol Chem. 2013 Apr 12; 288(15):10628-39. PMID: 23463512; PMCID: PMC3624443.
    11. Meyer A, Wang W, Qu J, Croft L, Degen JL, Coller BS, Ahamed J. Platelet TGF-ß1 contributions to plasma TGF-ß1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood. 2012 Jan 26; 119(4):1064-74. PMID: 22134166; PMCID: PMC3271718.
    12. Ahamed J, Janczak CA, Wittkowski KM, Coller BS. In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1. PLoS One. 2009 Aug 12; 4(8):e6608. PMID: 19672301; PMCID: PMC2719874.
    13. Ahamed J, Burg N, Yoshinaga K, Janczak CA, Rifkin DB, Coller BS. In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood. 2008 Nov 01; 112(9):3650-60. PMID: 18544680; PMCID: PMC2572792.
    14. Bhattacharjee G, Ahamed J, Pawlinski R, Liu C, Mackman N, Ruf W, Edgington TS. Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. Circ Res. 2008 Feb 29; 102(4):457-64. PMID: 18174463; PMCID: PMC2838720.
    15. Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, Felding-Habermann B, Takada Y, Mueller BM, Ruf W. Inhibition of tissue factor signaling suppresses tumor growth. Blood. 2008 Jan 01; 111(1):190-9. PMID: 17901245; PMCID: PMC2200804.
    16. Lawson BR, Manenkova Y, Ahamed J, Chen X, Zou JP, Baccala R, Theofilopoulos AN, Yuan C. Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system. J Immunol. 2007 Apr 15; 178(8):5366-74. PMID: 17404322.
      View in: PubMed
    17. Ahamed J, Niessen F, Kurokawa T, Lee YK, Bhattacharjee G, Morrissey JH, Ruf W. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia. Blood. 2007 Jun 15; 109(12):5251-9. PMID: 17332247; PMCID: PMC1890821.
    18. Chen VM, Ahamed J, Versteeg HH, Berndt MC, Ruf W, Hogg PJ. Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry. 2006 Oct 03; 45(39):12020-8. PMID: 17002301.
      View in: PubMed
    19. Ahamed J, Versteeg HH, Kerver M, Chen VM, Mueller BM, Hogg PJ, Ruf W. Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):13932-7. PMID: 16959886; PMCID: PMC1599891.
    20. Bhattacharjee G, Ahamed J, Pedersen B, El-Sheikh A, Mackman N, Ruf W, Liu C, Edgington TS. Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78. Arterioscler Thromb Vasc Biol. 2005 Aug; 25(8):1737-43. PMID: 15947236.
      View in: PubMed
    21. Belting M, Ahamed J, Ruf W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler Thromb Vasc Biol. 2005 Aug; 25(8):1545-50. PMID: 15905465.
      View in: PubMed
    22. Ahamed J. Choice of drugs to manage anthrax. Med Hypotheses. 2005; 64(4):883-4. PMID: 15694716.
      View in: PubMed
    23. Ahamed J, Belting M, Ruf W. Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1. Blood. 2005 Mar 15; 105(6):2384-91. PMID: 15550483.
      View in: PubMed
    24. Venkatesha RT, Ahamed J, Nuesch C, Zaidi AK, Ali H. Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. J Biol Chem. 2004 Oct 22; 279(43):44606-12. PMID: 15308653.
      View in: PubMed
    25. Ahamed J, Venkatesha RT, Thangam EB, Ali H. C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1. J Immunol. 2004 Jun 01; 172(11):6961-8. PMID: 15153516.
      View in: PubMed
    26. Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, Ruf W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med. 2004 May; 10(5):502-9. PMID: 15098027.
      View in: PubMed
    27. Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem. 2004 May 28; 279(22):23038-44. PMID: 15039423.
      View in: PubMed
    28. Subbarao K, Jala VR, Mathis S, Suttles J, Zacharias W, Ahamed J, Ali H, Tseng MT, Haribabu B. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):369-75. PMID: 14656734.
      View in: PubMed
    29. Ahamed J, Ali H. Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. J Biol Chem. 2002 Jun 21; 277(25):22685-91. PMID: 11934880.
      View in: PubMed
    30. Krug A, Ahamed J, Ali H. Regulation of inflammatory responses. Penn Dent J (Phila). 2002; 102:8-9. PMID: 15487551.
      View in: PubMed
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