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Courtney T Griffin

TitleProf, Asst
InstitutionOklahoma Medical Research Foundation
DepartmentCardiovascular Biology Research Program
Address825 NE 13th St
Oklahoma City OK
Phone405/271-7073
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    Collapse Research 
    Collapse research activities and funding
    R01HL134778     (GRIFFIN, COURTNEY T)Dec 9, 2016 - Nov 30, 2020
    NIH/NHLBI
    Epigenetic regulation of endothelial cell necroptosis impacts vascular integrity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A. Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Nat Rev Cardiol. 2018 May 24. PMID: 29795441.
      View in: PubMed
    2. Gao S, Silasi-Mansat R, Behar M, Lupu F, Griffin CT. Excessive plasmin compromises hepatic sinusoidal vascular integrity after acetaminophen overdose. Hepatology. 2018 May 05. PMID: 29729197.
      View in: PubMed
    3. Menendez MT, Ong EC, Shepherd BT, Muthukumar V, Silasi-Mansat R, Lupu F, Griffin CT. BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1674-1682. PMID: 28729363.
      View in: PubMed
    4. Griffin CT, Gao S. Building discontinuous liver sinusoidal vessels. J Clin Invest. 2017 Mar 01; 127(3):790-792. PMID: 28218626.
      View in: PubMed
    5. Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 Jun 01; 126(6):2254-66. PMID: 27140400; PMCID: PMC4887170.
    6. Wiley MM, Muthukumar V, Griffin TM, Griffin CT. SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice. J Am Heart Assoc. 2015 Apr 22; 4(4). PMID: 25904594; PMCID: PMC4579958.
    7. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734. PMID: 24463424; PMCID: PMC4065799.
    8. Ingram KG, Curtis CD, Silasi-Mansat R, Lupu F, Griffin CT. The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis. PLoS Genet. 2013; 9(12):e1004031. PMID: 24348274; PMCID: PMC3861115.
    9. Davis RB, Curtis CD, Griffin CT. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development. 2013 Mar; 140(6):1272-81. PMID: 23406903; PMCID: PMC3585661.
    10. Curtis CD, Davis RB, Ingram KG, Griffin CT. Chromatin-remodeling complex specificity and embryonic vascular development. Cell Mol Life Sci. 2012 Dec; 69(23):3921-31. PMID: 22618247; PMCID: PMC3661716.
    11. Curtis CD, Griffin CT. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol. 2012 Apr; 32(7):1312-20. PMID: 22290435; PMCID: PMC3302445.
    12. Griffin CT, Curtis CD, Davis RB, Muthukumar V, Magnuson T. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2282-7. PMID: 21262838; PMCID: PMC3038709.
    13. Griffin CT, Brennan J, Magnuson T. The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development. 2008 Feb; 135(3):493-500. PMID: 18094026; PMCID: PMC2459551.
    14. Gullapalli A, Wolfe BL, Griffin CT, Magnuson T, Trejo J. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins. Mol Biol Cell. 2006 Mar; 17(3):1228-38. PMID: 16407403; PMCID: PMC1382312.
    15. Griffin CT, Trejo J, Magnuson T. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15173-7. PMID: 16214895; PMCID: PMC1257690.
    16. Kikuchi S, Griffin CT, Wang SS, Bissell DM. Role of CD44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6. J Biol Chem. 2005 Apr 15; 280(15):15398-404. PMID: 15691832.
      View in: PubMed
    17. Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Mol Biol Cell. 2004 May; 15(5):2143-55. PMID: 14978220; PMCID: PMC404011.
    18. Schwarz DG, Griffin CT, Schneider EA, Yee D, Magnuson T. Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Mol Biol Cell. 2002 Oct; 13(10):3588-600. PMID: 12388759; PMCID: PMC129968.
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