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Gary J Gorbsky

TitleProfessor
InstitutionOklahoma Medical Research Foundation
DepartmentCell Cyle and Cancer Biology Research
Phone405/271-8168
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    Collapse Biography 
    Collapse education and training
    Princeton University, Princeton, NJMA1978
    Princeton University, Princeton, NJPhD1982

    Collapse Research 
    Collapse research activities and funding
    R35GM126980     (GORBSKY, GARY J.)Jul 1, 2018 - Jun 30, 2023
    NIH/NIGMS
    Understanding Cell Division
    Role: Principal Investigator

    R01GM111731     (GORBSKY, GARY J.)Sep 15, 2014 - Aug 31, 2018
    NIH/NIGMS
    The role of cohesion fatigue in chromosome instability
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML. CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol. 2019 Feb 14. PMID: 30765437.
      View in: PubMed
    2. Sapkota H, Wasiak E, Daum JR, Gorbsky GJ. Multiple determinants and consequences of cohesion fatigue in mammalian cells. Mol Biol Cell. 2018 08 01; 29(15):1811-1824. PMID: 29846129.
      View in: PubMed
    3. Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ. Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model. Stem Cell Res. 2018 01; 26:1-7. PMID: 29179130.
      View in: PubMed
    4. Sivakumar S, Gorbsky GJ. Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores. Biol Open. 2017 Nov 15; 6(11):1672-1679. PMID: 28982702.
      View in: PubMed
    5. Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ. GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol. 2017 10 02; 216(10):3117-3132. PMID: 28821562.
      View in: PubMed
    6. Potapova T, Gorbsky GJ. The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis. Biology (Basel). 2017 Feb 08; 6(1). PMID: 28208750.
      View in: PubMed
    7. Sivakumar S, Janczyk PL, Qu Q, Brautigam CA, Stukenberg PT, Yu H, Gorbsky GJ. The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores. Elife. 2016 Mar 16; 5. PMID: 26981768; PMCID: PMC4821802.
    8. Sivakumar S, Gorbsky GJ. Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol. 2015 Feb; 16(2):82-94. PMID: 25604195; PMCID: PMC4386896.
    9. Gorbsky GJ. The spindle checkpoint and chromosome segregation in meiosis. FEBS J. 2015 Jul; 282(13):2471-87. PMID: 25470754; PMCID: PMC4454629.
    10. Sivakumar S, Daum JR, Tipton AR, Rankin S, Gorbsky GJ. The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell. 2014 Mar; 25(5):594-605. PMID: 24403607; PMCID: PMC3937086.
    11. Sivakumar S, Daum JR, Gorbsky GJ. Live-cell fluorescence imaging for phenotypic analysis of mitosis. Methods Mol Biol. 2014; 1170:549-62. PMID: 24906336; PMCID: PMC4435798.
    12. Gorbsky GJ. Cohesion fatigue. Curr Biol. 2013 Nov 18; 23(22):R986-R988. PMID: 24262830.
      View in: PubMed
    13. Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol. 2012 10 15; 199(2):251-68. PMID: 23071152; PMCID: PMC3471242.
    14. Daum JR, Potapova TA, Sivakumar S, Daniel JJ, Flynn JN, Rankin S, Gorbsky GJ. Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr Biol. 2011 Jun 21; 21(12):1018-24. PMID: 21658943; PMCID: PMC3119564.
    15. Potapova TA, Sivakumar S, Flynn JN, Li R, Gorbsky GJ. Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited. Mol Biol Cell. 2011 Apr 15; 22(8):1191-206. PMID: 21325631; PMCID: PMC3078080.
    16. Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science. 2010 10 08; 330(6001):231-5. PMID: 20705812; PMCID: PMC2967368.
    17. Hu L, Potapova TA, Li S, Rankin S, Gorbsky GJ, Angeletti PC, Ceresa BP. Expression of HPV16 E5 produces enlarged nuclei and polyploidy through endoreplication. Virology. 2010 Sep 30; 405(2):342-51. PMID: 20605566; PMCID: PMC2923234.
    18. Gorbsky GJ. Duct tape for broken chromosomes. Cell. 2010 Jan 22; 140(2):178-80. PMID: 20141831.
      View in: PubMed
    19. Daum JR, Wren JD, Daniel JJ, Sivakumar S, McAvoy JN, Potapova TA, Gorbsky GJ. Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis. Curr Biol. 2009 Sep 15; 19(17):1467-72. PMID: 19646878; PMCID: PMC2783354.
    20. Salmela AL, Pouwels J, Varis A, Kukkonen AM, Toivonen P, Halonen PK, Perälä M, Kallioniemi O, Gorbsky GJ, Kallio MJ. Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint. Carcinogenesis. 2009 Jun; 30(6):1032-40. PMID: 19395653; PMCID: PMC2691139.
    21. Knowlton AL, Vorozhko VV, Lan W, Gorbsky GJ, Stukenberg PT. ICIS and Aurora B coregulate the microtubule depolymerase Kif2a. Curr Biol. 2009 May 12; 19(9):758-63. PMID: 19327998; PMCID: PMC2775053.
    22. DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ. A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor. Cancer Res. 2009 Feb 15; 69(4):1509-16. PMID: 19190331; PMCID: PMC2655231.
    23. Potapova TA, Daum JR, Byrd KS, Gorbsky GJ. Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit. Mol Biol Cell. 2009 Mar; 20(6):1737-48. PMID: 19158392.
      View in: PubMed
    24. Daum JR, Mo YY, Gorbsky GJ. The dynamics of DNA topoisomerase IIalpha in living cells. Methods Mol Biol. 2009; 582:233-44. PMID: 19763954; PMCID: PMC2950002.
    25. Hu L, Plafker K, Vorozhko V, Zuna RE, Hanigan MH, Gorbsky GJ, Plafker SM, Angeletti PC, Ceresa BP. Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology. 2009 Feb 05; 384(1):125-34. PMID: 19041112; PMCID: PMC2658674.
    26. Vorozhko VV, Emanuele MJ, Kallio MJ, Stukenberg PT, Gorbsky GJ. Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma. 2008 Apr; 117(2):169-79. PMID: 18057949; PMCID: PMC2522317.
    27. Pouwels J, Kukkonen AM, Lan W, Daum JR, Gorbsky GJ, Stukenberg T, Kallio MJ. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle. 2007 Jul 01; 6(13):1579-85. PMID: 17617734.
      View in: PubMed
    28. Yamada HY, Gorbsky GJ. Spindle checkpoint function and cellular sensitivity to antimitotic drugs. Mol Cancer Ther. 2006 Dec; 5(12):2963-9. PMID: 17172401; PMCID: PMC2596631.
    29. Eyster CA, Duggins QS, Gorbsky GJ, Olson AL. Microtubule network is required for insulin signaling through activation of Akt/protein kinase B: evidence that insulin stimulates vesicle docking/fusion but not intracellular mobility. J Biol Chem. 2006 Dec 22; 281(51):39719-27. PMID: 17068336.
      View in: PubMed
    30. Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL, Stukenberg PT, Gorbsky GJ. The reversibility of mitotic exit in vertebrate cells. Nature. 2006 Apr 13; 440(7086):954-8. PMID: 16612388; PMCID: PMC1513549.
    31. Yamada HY, Gorbsky GJ. Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest. Biol Proced Online. 2006; 8:36-43. PMID: 16799695; PMCID: PMC1455480.
    32. Daum JR, Gorbsky GJ. Lysed cell models and isolated chromosomes for the study of kinetochore/centromere biochemistry in vitro. Methods. 2006 Jan; 38(1):52-9. PMID: 16343931; PMCID: PMC2582160.
    33. Yamada HY, Gorbsky GJ. Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons. Mol Cancer Ther. 2006 Jan; 5(1):29-38. PMID: 16432160; PMCID: PMC1630635.
    34. Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol. 2005 Jun 21; 15(12):1078-89. PMID: 15964272.
      View in: PubMed
    35. Beardmore VA, Ahonen LJ, Gorbsky GJ, Kallio MJ. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci. 2004 Aug 15; 117(Pt 18):4033-42. PMID: 15280424.
      View in: PubMed
    36. Gorbsky GJ. Mitosis: MCAK under the aura of Aurora B. Curr Biol. 2004 May 04; 14(9):R346-8. PMID: 15120087.
      View in: PubMed
    37. Rundle DR, Gorbsky G, Tsiokas L. PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. J Biol Chem. 2004 Jul 09; 279(28):29728-39. PMID: 15123714.
      View in: PubMed
    38. McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol. 2004 Jan 20; 14(2):131-7. PMID: 14738735.
      View in: PubMed
    39. McCleland ML, Gardner RD, Kallio MJ, Daum JR, Gorbsky GJ, Burke DJ, Stukenberg PT. The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev. 2003 Jan 01; 17(1):101-14. PMID: 12514103; PMCID: PMC195965.
    40. Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol. 2002 Sep 02; 158(5):841-7. PMID: 12196507; PMCID: PMC2173153.
    41. Tavormina PA, Côme MG, Hudson JR, Mo YY, Beck WT, Gorbsky GJ. Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosis. J Cell Biol. 2002 Jul 08; 158(1):23-9. PMID: 12105179; PMCID: PMC2173008.
    42. Null AP, Hudson J, Gorbsky GJ. Both alpha and beta isoforms of mammalian DNA topoisomerase II associate with chromosomes in mitosis. Cell Growth Differ. 2002 Jul; 13(7):325-33. PMID: 12133901.
      View in: PubMed
    43. Topper LM, Campbell MS, Tugendreich S, Daum JR, Burke DJ, Hieter P, Gorbsky GJ. The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis. Cell Cycle. 2002 Jul-Aug; 1(4):282-92. PMID: 12429948.
      View in: PubMed
    44. Kallio MJ, McCleland ML, Stukenberg PT, Gorbsky GJ. Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis. Curr Biol. 2002 Jun 04; 12(11):900-5. PMID: 12062053.
      View in: PubMed
    45. Giodini A, Kallio MJ, Wall NR, Gorbsky GJ, Tognin S, Marchisio PC, Symons M, Altieri DC. Regulation of microtubule stability and mitotic progression by survivin. Cancer Res. 2002 May 01; 62(9):2462-7. PMID: 11980633.
      View in: PubMed
    46. Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW. Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions. J Biol Chem. 2002 Jun 21; 277(25):23054-64. PMID: 11940573.
      View in: PubMed
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