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Robert Matts

TitleProfessor
InstitutionOklahoma State University
DepartmentBiochemistry and Microbiology
Address246C Noble Research Center
Stillwater OK
Phone405/744-6200
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    Collapse Biography 
    Collapse education and training
    University of Wisconsin, Madison, WIPhD1980Physiological Chemistry

    Collapse Research 
    Collapse research activities and funding
    R15CA219907     (MATTS, ROBERT L.)Jul 1, 2017 - Jun 30, 2020
    NIH
    Structure/Function Studies of Anti-cancer Hsp90 Inhibitors that Target the C-terminal Domain
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Khandelwal A, Kent CN, Balch M, Peng S, Mishra SJ, Deng J, Day VW, Liu W, Subramanian C, Cohen M, Holzbeierlein JM, Matts R, Blagg BSJ. Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor. Nat Commun. 2018 Jan 30; 9(1):425. PMID: 29382832.
      View in: PubMed
    2. Voruganti S, Kline JT, Balch MJ, Rogers J, Matts RL, Hartson SD. Proteomic Profiling of Hsp90 Inhibitors. Methods Mol Biol. 2018; 1709:139-162. PMID: 29177657.
      View in: PubMed
    3. Davenport J, Galam L, Matts RL. A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine. Methods Mol Biol. 2018; 1709:87-96. PMID: 29177653.
      View in: PubMed
    4. Sun L, Hartson SD, Matts RL. Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics. Biochim Biophys Acta. 2015 May; 1854(5):365-80. PMID: 25614414.
      View in: PubMed
    5. Manjarrez JR, Sun L, Prince T, Matts RL. Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. PLoS One. 2014; 9(3):e90054. PMID: 24608665; PMCID: PMC3946479.
    6. Davenport J, Balch M, Galam L, Girgis A, Hall J, Blagg BS, Matts RL. High-throughput screen of natural product libraries for hsp90 inhibitors. Biology (Basel). 2014 Feb 10; 3(1):101-38. PMID: 24833337; PMCID: PMC4009755.
    7. Sadikot T, Swink M, Eskew JD, Brown D, Zhao H, Kusuma BR, Rajewski RA, Blagg BS, Matts RL, Holzbeierlein JM, Vielhauer GA. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct; 11(8):478-88. PMID: 24127661; PMCID: PMC3931435.
    8. Voruganti S, Lacroix JC, Rogers CN, Rogers J, Matts RL, Hartson SD. The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors. J Proteome Res. 2013 Aug 02; 12(8):3697-706. PMID: 23763277; PMCID: PMC3784992.
    9. Xu W, Mollapour M, Prodromou C, Wang S, Scroggins BT, Palchick Z, Beebe K, Siderius M, Lee MJ, Couvillon A, Trepel JB, Miyata Y, Matts R, Neckers L. Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Mol Cell. 2012 Aug 10; 47(3):434-43. PMID: 22727666.
      View in: PubMed
    10. Sun L, Prince T, Manjarrez JR, Scroggins BT, Matts RL. Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012 Jun; 1823(6):1092-101. PMID: 22504172.
      View in: PubMed
    11. Eskew JD, Sadikot T, Morales P, Duren A, Dunwiddie I, Swink M, Zhang X, Hembruff S, Donnelly A, Rajewski RA, Blagg BS, Manjarrez JR, Matts RL, Holzbeierlein JM, Vielhauer GA. Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells. BMC Cancer. 2011 Oct 31; 11:468. PMID: 22039910; PMCID: PMC3240935.
    12. Hartson SD, Matts RL. Approaches for defining the Hsp90-dependent proteome. Biochim Biophys Acta. 2012 Mar; 1823(3):656-67. PMID: 21906632; PMCID: PMC3276727.
    13. Matts RL, Dixit A, Peterson LB, Sun L, Voruganti S, Kalyanaraman P, Hartson SD, Verkhivker GM, Blagg BS. Elucidation of the Hsp90 C-terminal inhibitor binding site. ACS Chem Biol. 2011 Aug 19; 6(8):800-7. PMID: 21548602; PMCID: PMC3164513.
    14. Davenport J, Manjarrez JR, Peterson L, Krumm B, Blagg BS, Matts RL. Gambogic acid, a natural product inhibitor of Hsp90. J Nat Prod. 2011 May 27; 74(5):1085-92. PMID: 21486005; PMCID: PMC3103600.
    15. Zhao H, Brandt GE, Galam L, Matts RL, Blagg BS. Identification and initial SAR of silybin: an Hsp90 inhibitor. Bioorg Med Chem Lett. 2011 May 01; 21(9):2659-64. PMID: 21273068.
      View in: PubMed
    16. Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS. A systematic protocol for the characterization of Hsp90 modulators. Bioorg Med Chem. 2011 Jan 01; 19(1):684-92. PMID: 21129982; PMCID: PMC4618652.
    17. Matthews SB, Vielhauer GA, Manthe CA, Chaguturu VK, Szabla K, Matts RL, Donnelly AC, Blagg BS, Holzbeierlein JM. Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells. Prostate. 2010 Jan 01; 70(1):27-36. PMID: 19739131; PMCID: PMC2787716.
    18. Shelton SN, Shawgo ME, Matthews SB, Lu Y, Donnelly AC, Szabla K, Tanol M, Vielhauer GA, Rajewski RA, Matts RL, Blagg BS, Robertson JD. KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol. 2009 Dec; 76(6):1314-22. PMID: 19741006; PMCID: PMC2784729.
    19. Matts RL, Manjarrez JR. Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action. Curr Top Med Chem. 2009; 9(15):1462-78. PMID: 19860729.
      View in: PubMed
    20. Hadden MK, Hill SA, Davenport J, Matts RL, Blagg BS. Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorg Med Chem. 2009 Jan 15; 17(2):634-40. PMID: 19101151; PMCID: PMC2669315.
    21. Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS. Derrubone, an inhibitor of the Hsp90 protein folding machinery. J Nat Prod. 2007 Dec; 70(12):2014-8. PMID: 18020309.
      View in: PubMed
    22. Galam L, Hadden MK, Ma Z, Ye QZ, Yun BG, Blagg BS, Matts RL. High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase. Bioorg Med Chem. 2007 Mar 01; 15(5):1939-46. PMID: 17223347; PMCID: PMC1906718.
    23. Colón-Ramos DA, Shenvi CL, Weitzel DH, Gan EC, Matts R, Cate J, Kornbluth S. Direct ribosomal binding by a cellular inhibitor of translation. Nat Struct Mol Biol. 2006 Feb; 13(2):103-11. PMID: 16429152; PMCID: PMC2741086.
    24. Harris MB, Bartoli M, Sood SG, Matts RL, Venema RC. Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity. Circ Res. 2006 Feb 17; 98(3):335-41. PMID: 16410463.
      View in: PubMed
    25. Yun BG, Matts RL. Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation. Cell Signal. 2005 Dec; 17(12):1477-85. PMID: 15935620.
      View in: PubMed
    26. Prince T, Sun L, Matts RL. Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. Biochemistry. 2005 Nov 22; 44(46):15287-95. PMID: 16285732.
      View in: PubMed
    27. Prince T, Matts RL. Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37. Biochem Biophys Res Commun. 2005 Dec 23; 338(3):1447-54. PMID: 16269130.
      View in: PubMed
    28. Yun BG, Matts JA, Matts RL. Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase. Biochim Biophys Acta. 2005 Sep 15; 1725(2):174-81. PMID: 16109458.
      View in: PubMed
    29. Prince T, Shao J, Matts RL, Hartson SD. Evidence for chaperone heterocomplexes containing both Hsp90 and VCP. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1331-7. PMID: 15883021.
      View in: PubMed
    30. Yun BG, Matts RL. Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. Exp Cell Res. 2005 Jul 01; 307(1):212-23. PMID: 15922741.
      View in: PubMed
    31. Prince T, Matts RL. Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37. J Biol Chem. 2004 Sep 17; 279(38):39975-81. PMID: 15258137.
      View in: PubMed
    32. Yun BG, Huang W, Leach N, Hartson SD, Matts RL. Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions. Biochemistry. 2004 Jun 29; 43(25):8217-29. PMID: 15209518.
      View in: PubMed
    33. Inuzuka T, Yun BG, Ishikawa H, Takahashi S, Hori H, Matts RL, Ishimori K, Morishima I. Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase. J Biol Chem. 2004 Feb 20; 279(8):6778-82. PMID: 14672943.
      View in: PubMed
    34. Scroggins BT, Prince T, Shao J, Uma S, Huang W, Guo Y, Yun BG, Hedman K, Matts RL, Hartson SD. High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients. Biochemistry. 2003 Nov 04; 42(43):12550-61. PMID: 14580201.
      View in: PubMed
    35. Shao J, Irwin A, Hartson SD, Matts RL. Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding. Biochemistry. 2003 Nov 04; 42(43):12577-88. PMID: 14580204.
      View in: PubMed
    36. Shao J, Prince T, Hartson SD, Matts RL. Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37. J Biol Chem. 2003 Oct 03; 278(40):38117-20. PMID: 12930845.
      View in: PubMed
    37. Ishikawa H, Yun BG, Takahashi S, Hori H, Matts RL, Ishimori K, Morishima I. NO-induced activation mechanism of the heme-regulated eIF2alpha kinase. J Am Chem Soc. 2002 Nov 20; 124(46):13696-7. PMID: 12431098.
      View in: PubMed
    38. Shao J, Hartson SD, Matts RL. Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase. Biochemistry. 2002 May 28; 41(21):6770-9. PMID: 12022881.
      View in: PubMed
    39. Thulasiraman V, Yun BG, Uma S, Gu Y, Scroggins BT, Matts RL. Differential inhibition of Hsc70 activities by two Hsc70-binding peptides. Biochemistry. 2002 Mar 19; 41(11):3742-53. PMID: 11888292.
      View in: PubMed
    40. Scholz GM, Hartson SD, Cartledge K, Volk L, Matts RL, Dunn AR. The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart. Cell Growth Differ. 2001 Aug; 12(8):409-17. PMID: 11504706.
      View in: PubMed
    41. Uma S, Yun BG, Matts RL. The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases. J Biol Chem. 2001 May 04; 276(18):14875-83. PMID: 11278914.
      View in: PubMed
    42. Shao J, Grammatikakis N, Scroggins BT, Uma S, Huang W, Chen JJ, Hartson SD, Matts RL. Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. J Biol Chem. 2001 Jan 05; 276(1):206-14. PMID: 11036079.
      View in: PubMed
    43. Scholz G, Hartson SD, Cartledge K, Hall N, Shao J, Dunn AR, Matts RL. p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck. Mol Cell Biol. 2000 Sep; 20(18):6984-95. PMID: 10958693; PMCID: PMC88773.
    44. Hartson SD, Irwin AD, Shao J, Scroggins BT, Volk L, Huang W, Matts RL. p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules. Biochemistry. 2000 Jun 27; 39(25):7631-44. PMID: 10858314.
      View in: PubMed
    45. Marissen WE, Guo Y, Thomas AA, Matts RL, Lloyd RE. Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis. J Biol Chem. 2000 Mar 31; 275(13):9314-23. PMID: 10734073.
      View in: PubMed
    46. Yorgin PD, Hartson SD, Fellah AM, Scroggins BT, Huang W, Katsanis E, Couchman JM, Matts RL, Whitesell L. Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases. J Immunol. 2000 Mar 15; 164(6):2915-23. PMID: 10706677.
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    47. Rafie-Kolpin M, Chefalo PJ, Hussain Z, Hahn J, Uma S, Matts RL, Chen JJ. Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion. J Biol Chem. 2000 Feb 18; 275(7):5171-8. PMID: 10671563.
      View in: PubMed
    48. Uma S, Matts RL, Guo Y, White S, Chen JJ. The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain. Eur J Biochem. 2000 Jan; 267(2):498-506. PMID: 10632719.
      View in: PubMed
    49. Uma S, Thulasiraman V, Matts RL. Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol. 1999 Sep; 19(9):5861-71. PMID: 10454533; PMCID: PMC84435.
    50. Lele Z, Hartson SD, Martin CC, Whitesell L, Matts RL, Krone PH. Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90. Dev Biol. 1999 Jun 01; 210(1):56-70. PMID: 10364427.
      View in: PubMed
    51. Hartson SD, Thulasiraman V, Huang W, Whitesell L, Matts RL. Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates. Biochemistry. 1999 Mar 23; 38(12):3837-49. PMID: 10090774.
      View in: PubMed
    52. Thulasiraman V, Xu Z, Uma S, Gu Y, Chen JJ, Matts RL. Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate. Eur J Biochem. 1998 Aug 01; 255(3):552-62. PMID: 9738893.
      View in: PubMed
    53. Hartson SD, Ottinger EA, Huang W, Barany G, Burn P, Matts RL. Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase. J Biol Chem. 1998 Apr 03; 273(14):8475-82. PMID: 9525961.
      View in: PubMed
    54. Uma S, Barret DJ, Matts RL. Changes in the expression of the heme-regulated eIF-2 alpha kinase and heat shock proteins in rabbit reticulocytes maturing during recovery from anemia. Exp Cell Res. 1998 Jan 10; 238(1):273-82. PMID: 9457081.
      View in: PubMed
    55. Thulasiraman V, Matts RL. Luciferase renaturation assays of chaperones and chaperone antagonists. Methods Mol Biol. 1998; 102:129-41. PMID: 9680615.
      View in: PubMed
    56. Heminger KA, Hartson SD, Rogers J, Matts RL. Cisplatin inhibits protein synthesis in rabbit reticulocyte lysate by causing an arrest in elongation. Arch Biochem Biophys. 1997 Aug 01; 344(1):200-7. PMID: 9244398.
      View in: PubMed
    57. Xu Z, Pal JK, Thulasiraman V, Hahn HP, Chen JJ, Matts RL. The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress. Eur J Biochem. 1997 Jun 01; 246(2):461-70. PMID: 9208939.
      View in: PubMed
    58. Uma S, Hartson SD, Chen JJ, Matts RL. Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation. J Biol Chem. 1997 Apr 25; 272(17):11648-56. PMID: 9111082.
      View in: PubMed
    59. Thulasiraman V, Matts RL. Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysate. Biochemistry. 1996 Oct 15; 35(41):13443-50. PMID: 8873613.
      View in: PubMed
    60. Hartson SD, Barrett DJ, Burn P, Matts RL. Hsp90-mediated folding of the lymphoid cell kinase p56lck. Biochemistry. 1996 Oct 15; 35(41):13451-9. PMID: 8873614.
      View in: PubMed
    61. Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS, Matts RL. Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human. Biochim Biophys Acta. 1996 Jul 17; 1307(3):309-17. PMID: 8688466.
      View in: PubMed
    62. Hartson SD, Matts RL. Association of Hsp90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function. Biochemistry. 1994 Aug 02; 33(30):8912-20. PMID: 8043579.
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    63. Matts RL, Hurst R, Xu Z. Denatured proteins inhibit translation in hemin-supplemented rabbit reticulocyte lysate by inducing the activation of the heme-regulated eIF-2 alpha kinase. Biochemistry. 1993 Jul 27; 32(29):7323-8. PMID: 8101730.
      View in: PubMed
    64. Bushman JL, Asuru AI, Matts RL, Hinnebusch AG. Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol. 1993 Mar; 13(3):1920-32. PMID: 8441423; PMCID: PMC359506.
    65. Matts RL, Hurst R. The relationship between protein synthesis and heat shock proteins levels in rabbit reticulocyte lysates. J Biol Chem. 1992 Sep 05; 267(25):18168-74. PMID: 1517246.
      View in: PubMed
    66. Matts RL, Xu Z, Pal JK, Chen JJ. Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates. J Biol Chem. 1992 Sep 05; 267(25):18160-7. PMID: 1355482.
      View in: PubMed
    67. Matts RL, Schatz JR, Hurst R, Kagen R. Toxic heavy metal ions activate the heme-regulated eukaryotic initiation factor-2 alpha kinase by inhibiting the capacity of hemin-supplemented reticulocyte lysates to reduce disulfide bonds. J Biol Chem. 1991 Jul 05; 266(19):12695-702. PMID: 1676400.
      View in: PubMed
    68. Matts RL, Hurst R. Evidence for the association of the heme-regulated eIF-2 alpha kinase with the 90-kDa heat shock protein in rabbit reticulocyte lysate in situ. J Biol Chem. 1989 Sep 15; 264(26):15542-7. PMID: 2768277.
      View in: PubMed
    69. Matts RL, Thomas NS, Hurst R, London IM. Correlation between the distribution of the reversing factor and eukaryotic initiation factor 2 in heme-deficient or double-stranded RNA-inhibited reticulocyte lysates. FEBS Lett. 1988 Aug 15; 236(1):179-84. PMID: 3402612.
      View in: PubMed
    70. Hurst R, Schatz JR, Matts RL. Inhibition of rabbit reticulocyte lysate protein synthesis by heavy metal ions involves the phosphorylation of the alpha-subunit of the eukaryotic initiation factor 2. J Biol Chem. 1987 Nov 25; 262(33):15939-45. PMID: 3680235.
      View in: PubMed
    71. Hurst R, Matts RL. Phosphorothioated binary complex of eukaryotic initiation factor eIF-2 and GDP inhibits protein synthesis in hemin-supplemented reticulocyte lysates. Biochem Biophys Res Commun. 1987 Sep 15; 147(2):772-7. PMID: 3632699.
      View in: PubMed
    72. Thomas NS, Matts RL, London IM. The storage of globin mRNA during the inhibition of protein synthesis by heme deprivation. Biochem Biophys Res Commun. 1986 Feb 13; 134(3):1048-55. PMID: 3947357.
      View in: PubMed
    73. Matts RL, London IM. The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2. J Biol Chem. 1984 Jun 10; 259(11):6708-11. PMID: 6725267.
      View in: PubMed
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