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Robert Matts

TitleProfessor
InstitutionOklahoma State University
DepartmentBiochemistry and Microbiology
Phone405/744-6200
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    Collapse Biography 
    Collapse education and training
    University of Wisconsin, Madison, WIPhD1980Physiological Chemistry

    Collapse Research 
    Collapse research activities and funding
    R15CA219907     (MATTS, ROBERT L.)Jul 1, 2017 - Jun 30, 2020
    NIH
    Structure/Function Studies of Anti-cancer Hsp90 Inhibitors that Target the C-terminal Domain
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Deng Z, Wang J, Lyu W, Wieneke X, Matts R, Ma X, Zhang G. Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds. J Immunol Res. 2018; 2018:5492941. PMID: 30581875.
      View in: PubMed
    2. Lyu W, Deng Z, Sunkara LT, Becker S, Robinson K, Matts R, Zhang G. High Throughput Screening for Natural Host Defense Peptide-Inducing Compounds as Novel Alternatives to Antibiotics. Front Cell Infect Microbiol. 2018; 8:191. PMID: 29942796.
      View in: PubMed
    3. Khandelwal A, Kent CN, Balch M, Peng S, Mishra SJ, Deng J, Day VW, Liu W, Subramanian C, Cohen M, Holzbeierlein JM, Matts R, Blagg BSJ. Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor. Nat Commun. 2018 01 30; 9(1):425. PMID: 29382832.
      View in: PubMed
    4. Voruganti S, Kline JT, Balch MJ, Rogers J, Matts RL, Hartson SD. Proteomic Profiling of Hsp90 Inhibitors. Methods Mol Biol. 2018; 1709:139-162. PMID: 29177657.
      View in: PubMed
    5. Davenport J, Galam L, Matts RL. A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine. Methods Mol Biol. 2018; 1709:87-96. PMID: 29177653.
      View in: PubMed
    6. Sun L, Hartson SD, Matts RL. Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics. Biochim Biophys Acta. 2015 May; 1854(5):365-80. PMID: 25614414.
      View in: PubMed
    7. Manjarrez JR, Sun L, Prince T, Matts RL. Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. PLoS One. 2014; 9(3):e90054. PMID: 24608665; PMCID: PMC3946479.
    8. Davenport J, Balch M, Galam L, Girgis A, Hall J, Blagg BS, Matts RL. High-throughput screen of natural product libraries for hsp90 inhibitors. Biology (Basel). 2014 Feb 10; 3(1):101-38. PMID: 24833337; PMCID: PMC4009755.
    9. Sadikot T, Swink M, Eskew JD, Brown D, Zhao H, Kusuma BR, Rajewski RA, Blagg BS, Matts RL, Holzbeierlein JM, Vielhauer GA. Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors. Assay Drug Dev Technol. 2013 Oct; 11(8):478-88. PMID: 24127661; PMCID: PMC3931435.
    10. Voruganti S, Lacroix JC, Rogers CN, Rogers J, Matts RL, Hartson SD. The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors. J Proteome Res. 2013 Aug 02; 12(8):3697-706. PMID: 23763277; PMCID: PMC3784992.
    11. Xu W, Mollapour M, Prodromou C, Wang S, Scroggins BT, Palchick Z, Beebe K, Siderius M, Lee MJ, Couvillon A, Trepel JB, Miyata Y, Matts R, Neckers L. Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine. Mol Cell. 2012 Aug 10; 47(3):434-43. PMID: 22727666.
      View in: PubMed
    12. Sun L, Prince T, Manjarrez JR, Scroggins BT, Matts RL. Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. Biochim Biophys Acta. 2012 Jun; 1823(6):1092-101. PMID: 22504172.
      View in: PubMed
    13. Eskew JD, Sadikot T, Morales P, Duren A, Dunwiddie I, Swink M, Zhang X, Hembruff S, Donnelly A, Rajewski RA, Blagg BS, Manjarrez JR, Matts RL, Holzbeierlein JM, Vielhauer GA. Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells. BMC Cancer. 2011 Oct 31; 11:468. PMID: 22039910; PMCID: PMC3240935.
    14. Hartson SD, Matts RL. Approaches for defining the Hsp90-dependent proteome. Biochim Biophys Acta. 2012 Mar; 1823(3):656-67. PMID: 21906632; PMCID: PMC3276727.
    15. Matts RL, Dixit A, Peterson LB, Sun L, Voruganti S, Kalyanaraman P, Hartson SD, Verkhivker GM, Blagg BS. Elucidation of the Hsp90 C-terminal inhibitor binding site. ACS Chem Biol. 2011 Aug 19; 6(8):800-7. PMID: 21548602; PMCID: PMC3164513.
    16. Davenport J, Manjarrez JR, Peterson L, Krumm B, Blagg BS, Matts RL. Gambogic acid, a natural product inhibitor of Hsp90. J Nat Prod. 2011 May 27; 74(5):1085-92. PMID: 21486005; PMCID: PMC3103600.
    17. Zhao H, Brandt GE, Galam L, Matts RL, Blagg BS. Identification and initial SAR of silybin: an Hsp90 inhibitor. Bioorg Med Chem Lett. 2011 May 01; 21(9):2659-64. PMID: 21273068.
      View in: PubMed
    18. Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS. A systematic protocol for the characterization of Hsp90 modulators. Bioorg Med Chem. 2011 Jan 01; 19(1):684-92. PMID: 21129982; PMCID: PMC4618652.
    19. Matthews SB, Vielhauer GA, Manthe CA, Chaguturu VK, Szabla K, Matts RL, Donnelly AC, Blagg BS, Holzbeierlein JM. Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells. Prostate. 2010 Jan 01; 70(1):27-36. PMID: 19739131; PMCID: PMC2787716.
    20. Shelton SN, Shawgo ME, Matthews SB, Lu Y, Donnelly AC, Szabla K, Tanol M, Vielhauer GA, Rajewski RA, Matts RL, Blagg BS, Robertson JD. KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol. 2009 Dec; 76(6):1314-22. PMID: 19741006; PMCID: PMC2784729.
    21. Matts RL, Manjarrez JR. Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action. Curr Top Med Chem. 2009; 9(15):1462-78. PMID: 19860729.
      View in: PubMed
    22. Hadden MK, Hill SA, Davenport J, Matts RL, Blagg BS. Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold. Bioorg Med Chem. 2009 Jan 15; 17(2):634-40. PMID: 19101151; PMCID: PMC2669315.
    23. Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS. Derrubone, an inhibitor of the Hsp90 protein folding machinery. J Nat Prod. 2007 Dec; 70(12):2014-8. PMID: 18020309.
      View in: PubMed
    24. Galam L, Hadden MK, Ma Z, Ye QZ, Yun BG, Blagg BS, Matts RL. High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase. Bioorg Med Chem. 2007 Mar 01; 15(5):1939-46. PMID: 17223347; PMCID: PMC1906718.
    25. Colón-Ramos DA, Shenvi CL, Weitzel DH, Gan EC, Matts R, Cate J, Kornbluth S. Direct ribosomal binding by a cellular inhibitor of translation. Nat Struct Mol Biol. 2006 Feb; 13(2):103-11. PMID: 16429152; PMCID: PMC2741086.
    26. Harris MB, Bartoli M, Sood SG, Matts RL, Venema RC. Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity. Circ Res. 2006 Feb 17; 98(3):335-41. PMID: 16410463.
      View in: PubMed
    27. Yun BG, Matts RL. Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation. Cell Signal. 2005 Dec; 17(12):1477-85. PMID: 15935620.
      View in: PubMed
    28. Prince T, Sun L, Matts RL. Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. Biochemistry. 2005 Nov 22; 44(46):15287-95. PMID: 16285732.
      View in: PubMed
    29. Prince T, Matts RL. Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37. Biochem Biophys Res Commun. 2005 Dec 23; 338(3):1447-54. PMID: 16269130.
      View in: PubMed
    30. Yun BG, Matts JA, Matts RL. Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase. Biochim Biophys Acta. 2005 Sep 15; 1725(2):174-81. PMID: 16109458.
      View in: PubMed
    31. Prince T, Shao J, Matts RL, Hartson SD. Evidence for chaperone heterocomplexes containing both Hsp90 and VCP. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1331-7. PMID: 15883021.
      View in: PubMed
    32. Yun BG, Matts RL. Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. Exp Cell Res. 2005 Jul 01; 307(1):212-23. PMID: 15922741.
      View in: PubMed
    33. Prince T, Matts RL. Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37. J Biol Chem. 2004 Sep 17; 279(38):39975-81. PMID: 15258137.
      View in: PubMed
    34. Yun BG, Huang W, Leach N, Hartson SD, Matts RL. Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions. Biochemistry. 2004 Jun 29; 43(25):8217-29. PMID: 15209518.
      View in: PubMed
    35. Inuzuka T, Yun BG, Ishikawa H, Takahashi S, Hori H, Matts RL, Ishimori K, Morishima I. Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase. J Biol Chem. 2004 Feb 20; 279(8):6778-82. PMID: 14672943.
      View in: PubMed
    36. Scroggins BT, Prince T, Shao J, Uma S, Huang W, Guo Y, Yun BG, Hedman K, Matts RL, Hartson SD. High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients. Biochemistry. 2003 Nov 04; 42(43):12550-61. PMID: 14580201.
      View in: PubMed
    37. Shao J, Irwin A, Hartson SD, Matts RL. Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding. Biochemistry. 2003 Nov 04; 42(43):12577-88. PMID: 14580204.
      View in: PubMed
    38. Shao J, Prince T, Hartson SD, Matts RL. Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37. J Biol Chem. 2003 Oct 03; 278(40):38117-20. PMID: 12930845.
      View in: PubMed
    39. Ishikawa H, Yun BG, Takahashi S, Hori H, Matts RL, Ishimori K, Morishima I. NO-induced activation mechanism of the heme-regulated eIF2alpha kinase. J Am Chem Soc. 2002 Nov 20; 124(46):13696-7. PMID: 12431098.
      View in: PubMed
    40. Shao J, Hartson SD, Matts RL. Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase. Biochemistry. 2002 May 28; 41(21):6770-9. PMID: 12022881.
      View in: PubMed
    41. Thulasiraman V, Yun BG, Uma S, Gu Y, Scroggins BT, Matts RL. Differential inhibition of Hsc70 activities by two Hsc70-binding peptides. Biochemistry. 2002 Mar 19; 41(11):3742-53. PMID: 11888292.
      View in: PubMed
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