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Ammaji Rajala

TitleAsst,Research II
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentOphthalmology
Phone405/271-8001
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rajala A, Wang Y, Soni K, Rajala RVS. Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration. Cell Death Dis. 2018 Jul 03; 9(7):737. PMID: 29970877.
      View in: PubMed
    2. Rajala A, Wang Y, Brush RS, Tsantilas K, Jankowski CSR, Lindsay KJ, Linton JD, Hurley JB, Anderson RE, Rajala RVS. Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death Dis. 2018 02 14; 9(2):240. PMID: 29445082.
      View in: PubMed
    3. Rajala RVS, Rajala A. Redundant and Nonredundant Functions of Akt Isoforms in the Retina. Adv Exp Med Biol. 2018; 1074:585-591. PMID: 29721991.
      View in: PubMed
    4. Wang Y, Rajala A, Rajala RVS. Nanoparticles as Delivery Vehicles for the Treatment of Retinal Degenerative Diseases. Adv Exp Med Biol. 2018; 1074:117-123. PMID: 29721935.
      View in: PubMed
    5. Rajala A, Wang Y, Rajala RVS. Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice. Adv Exp Med Biol. 2018; 1074:491-497. PMID: 29721981.
      View in: PubMed
    6. Rajala A, Wang Y, Abcouwer SF, Gardner TW, Rajala RVS. Developmental and light regulation of tumor suppressor protein PP2A in the retina. Oncotarget. 2018 Jan 05; 9(2):1505-1523. PMID: 29416710.
      View in: PubMed
    7. Rajala RV, Rajala A, Kooker C, Wang Y, Anderson RE. The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina. Sci Rep. 2016 11 24; 6:37727. PMID: 27883057.
      View in: PubMed
    8. Rajala A, Wang Y, Rajala RV. Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival. Oncotarget. 2016 Jul 26; 7(30):46924-46942. PMID: 27391439.
      View in: PubMed
    9. Wang Y, Rajala A, Cao B, Ranjo-Bishop M, Agbaga MP, Mao C, Rajala RV. Cell-Specific Promoters Enable Lipid-Based Nanoparticles to Deliver Genes to Specific Cells of the Retina In Vivo. Theranostics. 2016; 6(10):1514-27. PMID: 27446487.
      View in: PubMed
    10. Wang Y, Rajala A, Rajala RV. Lipid Nanoparticles for Ocular Gene Delivery. J Funct Biomater. 2015 Jun 08; 6(2):379-94. PMID: 26062170.
      View in: PubMed
    11. Rajala RV, Ranjo-Bishop M, Wang Y, Rajala A, Anderson RE. The p110a isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival. Biochimie. 2015 May; 112:35-40. PMID: 25742742.
      View in: PubMed
    12. Gupta VK, Rajala A, Rajala RV. Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells. Cell Commun Signal. 2015 Feb 03; 13:7. PMID: 25644171.
      View in: PubMed
    13. Woodruff ML, Rajala A, Fain GL, Rajala RV. Effect of knocking down the insulin receptor on mouse rod responses. Sci Rep. 2015 Jan 19; 5:7858. PMID: 25598343.
      View in: PubMed
    14. Rajala A, Wang Y, Zhu Y, Ranjo-Bishop M, Ma JX, Mao C, Rajala RV. Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano Lett. 2014 Sep 10; 14(9):5257-63. PMID: 25115433.
      View in: PubMed
    15. Rajala RV, Rajala A, Morris AJ, Anderson RE. Phosphoinositides: minor lipids make a major impact on photoreceptor cell functions. Sci Rep. 2014 Jun 26; 4:5463. PMID: 24964953.
      View in: PubMed
    16. Rajala RV, Basavarajappa DK, Dighe R, Rajala A. Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Commun Signal. 2013 Dec 18; 11:96. PMID: 24350791.
      View in: PubMed
    17. Rajala RV, Rajala A. Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons. Protein Cell. 2013 Dec; 4(12):890-2. PMID: 24203758.
      View in: PubMed
    18. Woodruff ML, Rajala A, Fain GL, Rajala RV. Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem. 2014 Jan 03; 289(1):358-64. PMID: 24273167.
      View in: PubMed
    19. Rajala A, Gupta VK, Anderson RE, Rajala RV. Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion. 2013 Nov; 13(6):566-76. PMID: 23993956.
      View in: PubMed
    20. Rajala A, Dighe R, Agbaga MP, Anderson RE, Rajala RV. Insulin receptor signaling in cones. J Biol Chem. 2013 Jul 05; 288(27):19503-15. PMID: 23673657.
      View in: PubMed
    21. Rajala A, Dilly AK, Rajala RV. Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Commun Signal. 2013 Mar 22; 11(1):20. PMID: 23521888.
      View in: PubMed
    22. Gupta VK, Rajala A, Rajala RV. Insulin receptor regulates photoreceptor CNG channel activity. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1363-72. PMID: 23032687.
      View in: PubMed
    23. Rajala RV, Rajala A, Gupta VK. Conservation and divergence of Grb7 family of Ras-binding domains. Protein Cell. 2012 Jan; 3(1):60-70. PMID: 22271596.
      View in: PubMed
    24. Gupta VK, Rajala A, Rajala RV. Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators. Adv Exp Med Biol. 2012; 723:777-82. PMID: 22183406.
      View in: PubMed
    25. Gupta VK, Rajala A, Rodgers KK, Rajala RV. Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell. 2011 Nov; 2(11):906-17. PMID: 22180090.
      View in: PubMed
    26. Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV. Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14. Mol Cell Biol. 2011 Oct; 31(19):3975-87. PMID: 21791607.
      View in: PubMed
    27. Gupta VK, Rajala A, Daly RJ, Rajala RV. Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel. EMBO Rep. 2010 Nov; 11(11):861-7. PMID: 20890309.
      View in: PubMed
    28. Rajala RV, Tanito M, Neel BG, Rajala A. Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. J Biol Chem. 2010 Mar 19; 285(12):8894-904. PMID: 20061388.
      View in: PubMed
    29. Rajala RV, Rajala A, Brush RS, Rotstein NP, Politi LE. Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. J Neurochem. 2009 Sep; 110(5):1648-60. PMID: 19575708.
      View in: PubMed
    30. Rajala A, Daly RJ, Tanito M, Allen DT, Holt LJ, Lobanova ES, Arshavsky VY, Rajala RV. Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry. 2009 Jun 23; 48(24):5563-72. PMID: 19438210.
      View in: PubMed
    31. Rajala RV, Rajala A. Cytoskeletal components enhance the autophosphorylation of retinal insulin receptor. Chem Biol Interact. 2009 Jul 15; 180(2):245-53. PMID: 19497423.
      View in: PubMed
    32. Rajala RV, Wiskur B, Tanito M, Callegan M, Rajala A. Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1033-40. PMID: 19029027.
      View in: PubMed
    33. Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV. Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides. J Neurochem. 2008 Dec; 107(5):1382-97. PMID: 18823366.
      View in: PubMed
    34. Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem. 2008 Jul 11; 283(28):19781-92. PMID: 18480052.
      View in: PubMed
    35. Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J Biol Chem. 2007 Mar 30; 282(13):9865-73. PMID: 17272282.
      View in: PubMed
    36. Rajala RV, Chan MD, Rajala A. Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling. Biochemistry. 2005 Nov 29; 44(47):15461-71. PMID: 16300394.
      View in: PubMed
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