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Padmaja Dhanasekaran

TitleMgr,Laboratory Shared Resource
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
Phone405/271-6857
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mizuguchi C, Hata M, Dhanasekaran P, Nickel M, Okuhira K, Phillips MC, Lund-Katz S, Saito H. Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4. Biochim Biophys Acta. 2014 Dec; 1841(12):1716-24. PMID: 25281910.
      View in: PubMed
    2. Nguyen D, Dhanasekaran P, Nickel M, Mizuguchi C, Watanabe M, Saito H, Phillips MC, Lund-Katz S. Influence of domain stability on the properties of human apolipoprotein E3 and E4 and mouse apolipoprotein E. Biochemistry. 2014 Jun 24; 53(24):4025-33. PMID: 24871385.
      View in: PubMed
    3. Nagao K, Hata M, Tanaka K, Takechi Y, Nguyen D, Dhanasekaran P, Lund-Katz S, Phillips MC, Saito H. The roles of C-terminal helices of human apolipoprotein A-I in formation of high-density lipoprotein particles. Biochim Biophys Acta. 2014 Jan; 1841(1):80-7. PMID: 24120703.
      View in: PubMed
    4. Li H, Dhanasekaran P, Alexander ET, Rader DJ, Phillips MC, Lund-Katz S. Molecular mechanisms responsible for the differential effects of apoE3 and apoE4 on plasma lipoprotein-cholesterol levels. Arterioscler Thromb Vasc Biol. 2013 Apr; 33(4):687-93. PMID: 23413428.
      View in: PubMed
    5. Adachi E, Nakajima H, Mizuguchi C, Dhanasekaran P, Kawashima H, Nagao K, Akaji K, Lund-Katz S, Phillips MC, Saito H. Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation. J Biol Chem. 2013 Jan 25; 288(4):2848-56. PMID: 23233678.
      View in: PubMed
    6. Chetty PS, Ohshiro M, Saito H, Dhanasekaran P, Lund-Katz S, Mayne L, Englander W, Phillips MC. Effects of the Iowa and Milano mutations on apolipoprotein A-I structure and dynamics determined by hydrogen exchange and mass spectrometry. Biochemistry. 2012 Nov 06; 51(44):8993-9001. PMID: 23066790.
      View in: PubMed
    7. Mizuguchi C, Hata M, Dhanasekaran P, Nickel M, Phillips MC, Lund-Katz S, Saito H. Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4. Biochemistry. 2012 Jul 17; 51(28):5580-8. PMID: 22730894.
      View in: PubMed
    8. Lyssenko NN, Hata M, Dhanasekaran P, Nickel M, Nguyen D, Chetty PS, Saito H, Lund-Katz S, Phillips MC. Influence of C-terminal a-helix hydrophobicity and aromatic amino acid content on apolipoprotein A-I functionality. Biochim Biophys Acta. 2012 Mar; 1821(3):456-63. PMID: 21840419.
      View in: PubMed
    9. Nguyen D, Dhanasekaran P, Nickel M, Nakatani R, Saito H, Phillips MC, Lund-Katz S. Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4. Biochemistry. 2010 Dec 28; 49(51):10881-9. PMID: 21114327.
      View in: PubMed
    10. Tanaka M, Dhanasekaran P, Nguyen D, Nickel M, Takechi Y, Lund-Katz S, Phillips MC, Saito H. Influence of N-terminal helix bundle stability on the lipid-binding properties of human apolipoprotein A-I. Biochim Biophys Acta. 2011 Jan; 1811(1):25-30. PMID: 21040803.
      View in: PubMed
    11. Vedhachalam C, Chetty PS, Nickel M, Dhanasekaran P, Lund-Katz S, Rothblat GH, Phillips MC. Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution. J Biol Chem. 2010 Oct 15; 285(42):31965-73. PMID: 20679346.
      View in: PubMed
    12. Kono M, Tanaka T, Tanaka M, Vedhachalam C, Chetty PS, Nguyen D, Dhanasekaran P, Lund-Katz S, Phillips MC, Saito H. Disruption of the C-terminal helix by single amino acid deletion is directly responsible for impaired cholesterol efflux ability of apolipoprotein A-I Nichinan. J Lipid Res. 2010 Apr; 51(4):809-18. PMID: 19805625.
      View in: PubMed
    13. Lund-Katz S, Nguyen D, Dhanasekaran P, Kono M, Nickel M, Saito H, Phillips MC. Surface plasmon resonance analysis of the mechanism of binding of apoA-I to high density lipoprotein particles. J Lipid Res. 2010 Mar; 51(3):606-17. PMID: 19786567.
      View in: PubMed
    14. Nguyen DV, Drover VA, Knopfel M, Dhanasekaran P, Hauser H, Phillips MC. Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. J Lipid Res. 2009 Nov; 50(11):2235-44. PMID: 19454765.
      View in: PubMed
    15. Nguyen D, Dhanasekaran P, Phillips MC, Lund-Katz S. Molecular mechanism of apolipoprotein E binding to lipoprotein particles. Biochemistry. 2009 Apr 07; 48(13):3025-32. PMID: 19209940.
      View in: PubMed
    16. Koyama M, Tanaka M, Dhanasekaran P, Lund-Katz S, Phillips MC, Saito H. Interaction between the N- and C-terminal domains modulates the stability and lipid binding of apolipoprotein A-I. Biochemistry. 2009 Mar 24; 48(11):2529-37. PMID: 19239199.
      View in: PubMed
    17. Kono M, Okumura Y, Tanaka M, Nguyen D, Dhanasekaran P, Lund-Katz S, Phillips MC, Saito H. Conformational flexibility of the N-terminal domain of apolipoprotein a-I bound to spherical lipid particles. Biochemistry. 2008 Oct 28; 47(43):11340-7. PMID: 18831538.
      View in: PubMed
    18. Yamauchi Y, Deguchi N, Takagi C, Tanaka M, Dhanasekaran P, Nakano M, Handa T, Phillips MC, Lund-Katz S, Saito H. Role of the N- and C-terminal domains in binding of apolipoprotein E isoforms to heparan sulfate and dermatan sulfate: a surface plasmon resonance study. Biochemistry. 2008 Jun 24; 47(25):6702-10. PMID: 18507396.
      View in: PubMed
    19. Tanaka M, Koyama M, Dhanasekaran P, Nguyen D, Nickel M, Lund-Katz S, Saito H, Phillips MC. Influence of tertiary structure domain properties on the functionality of apolipoprotein A-I. Biochemistry. 2008 Feb 19; 47(7):2172-80. PMID: 18205410.
      View in: PubMed
    20. Sakamoto T, Tanaka M, Vedhachalam C, Nickel M, Nguyen D, Dhanasekaran P, Phillips MC, Lund-Katz S, Saito H. Contributions of the carboxyl-terminal helical segment to the self-association and lipoprotein preferences of human apolipoprotein E3 and E4 isoforms. Biochemistry. 2008 Mar 04; 47(9):2968-77. PMID: 18201068.
      View in: PubMed
    21. Vedhachalam C, Duong PT, Nickel M, Nguyen D, Dhanasekaran P, Saito H, Rothblat GH, Lund-Katz S, Phillips MC. Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles. J Biol Chem. 2007 Aug 24; 282(34):25123-30. PMID: 17604270.
      View in: PubMed
    22. Tanaka M, Dhanasekaran P, Nguyen D, Ohta S, Lund-Katz S, Phillips MC, Saito H. Contributions of the N- and C-terminal helical segments to the lipid-free structure and lipid interaction of apolipoprotein A-I. Biochemistry. 2006 Aug 29; 45(34):10351-8. PMID: 16922511.
      View in: PubMed
    23. Tanaka M, Vedhachalam C, Sakamoto T, Dhanasekaran P, Phillips MC, Lund-Katz S, Saito H. Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4. Biochemistry. 2006 Apr 04; 45(13):4240-7. PMID: 16566598.
      View in: PubMed
    24. Tanaka M, Saito H, Dhanasekaran P, Wehrli S, Handa T, Lund-Katz S, Phillips MC. Effects of the core lipid on the energetics of binding of ApoA-I to model lipoprotein particles of different sizes. Biochemistry. 2005 Aug 09; 44(31):10689-95. PMID: 16060677.
      View in: PubMed
    25. Futamura M, Dhanasekaran P, Handa T, Phillips MC, Lund-Katz S, Saito H. Two-step mechanism of binding of apolipoprotein E to heparin: implications for the kinetics of apolipoprotein E-heparan sulfate proteoglycan complex formation on cell surfaces. J Biol Chem. 2005 Feb 18; 280(7):5414-22. PMID: 15583000.
      View in: PubMed
    26. Vedhachalam C, Liu L, Nickel M, Dhanasekaran P, Anantharamaiah GM, Lund-Katz S, Rothblat GH, Phillips MC. Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids. J Biol Chem. 2004 Nov 26; 279(48):49931-9. PMID: 15383537.
      View in: PubMed
    27. Saito H, Dhanasekaran P, Nguyen D, Deridder E, Holvoet P, Lund-Katz S, Phillips MC. Alpha-helix formation is required for high affinity binding of human apolipoprotein A-I to lipids. J Biol Chem. 2004 May 14; 279(20):20974-81. PMID: 15020600.
      View in: PubMed
    28. Narayanaswami V, Maiorano JN, Dhanasekaran P, Ryan RO, Phillips MC, Lund-Katz S, Davidson WS. Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles. J Biol Chem. 2004 Apr 02; 279(14):14273-9. PMID: 14739281.
      View in: PubMed
    29. Thuahnai ST, Lund-Katz S, Dhanasekaran P, de la Llera-Moya M, Connelly MA, Williams DL, Rothblat GH, Phillips MC. Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure. J Biol Chem. 2004 Mar 26; 279(13):12448-55. PMID: 14718538.
      View in: PubMed
    30. Liu L, Bortnick AE, Nickel M, Dhanasekaran P, Subbaiah PV, Lund-Katz S, Rothblat GH, Phillips MC. Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem. 2003 Oct 31; 278(44):42976-84. PMID: 12928428.
      View in: PubMed
    31. Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC, Lund-Katz S. Effects of polymorphism on the lipid interaction of human apolipoprotein E. J Biol Chem. 2003 Oct 17; 278(42):40723-9. PMID: 12917433.
      View in: PubMed
    32. Saito H, Dhanasekaran P, Nguyen D, Holvoet P, Lund-Katz S, Phillips MC. Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model. J Biol Chem. 2003 Jun 27; 278(26):23227-32. PMID: 12709430.
      View in: PubMed
    33. Saito H, Dhanasekaran P, Nguyen D, Baldwin F, Weisgraber KH, Wehrli S, Phillips MC, Lund-Katz S. Characterization of the heparin binding sites in human apolipoprotein E. J Biol Chem. 2003 Apr 25; 278(17):14782-7. PMID: 12588864.
      View in: PubMed
    34. Segall ML, Dhanasekaran P, Baldwin F, Anantharamaiah GM, Weisgraber KH, Phillips MC, Lund-Katz S. Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization. J Lipid Res. 2002 Oct; 43(10):1688-700. PMID: 12364553.
      View in: PubMed
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