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Simon Stepan Terzyan

TitleScientist,Staff
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Phone405/271-8313
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Terzyan SS, Shen T, Liu X, Huang Q, Teng P, Zhou M, Hilberg F, Cai J, Mooers BHM, Wu J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 Jul 05; 294(27):10428-10437. PMID: 31118272.
      View in: PubMed
    2. Terzyan SS, Cook PF, Heroux A, Hanigan MH. Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation. Protein Sci. 2017 06; 26(6):1196-1205. PMID: 28378915.
      View in: PubMed
    3. Mehta-D'souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017 02 10; 292(6):2510-2518. PMID: 28011641.
      View in: PubMed
    4. Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86. PMID: 26013825.
      View in: PubMed
    5. Wickham S, Regan N, West MB, Thai J, Cook PF, Terzyan SS, Li PK, Hanigan MH. Inhibition of human ?-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors. Biochem J. 2013 Mar 15; 450(3):547-57. PMID: 23301618.
      View in: PubMed
    6. Ghosh AK, Venkateswara Rao K, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Structure-based design of highly selective ß-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. J Med Chem. 2012 Nov 08; 55(21):9195-207. PMID: 22954357.
      View in: PubMed
    7. Kurien BT, D'Souza A, Terzyan S, Scofield RH. Putative sequences on Ro60 three-dimensional structure accessible for 4-hydroxy-2-nonenal (HNE) modification compared to in vitro HNE modification of Ro60 sequences. Mol Immunol. 2012 Apr; 50(4):185-92. PMID: 22336572.
      View in: PubMed
    8. Li F, Chvyrkova I, Terzyan S, Wakeham N, Turner R, Ghosh AK, Zhang XC, Tang J. Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. Appl Microbiol Biotechnol. 2012 May; 94(4):1041-9. PMID: 22270239.
      View in: PubMed
    9. Parthasarathy S, Altuve A, Terzyan S, Zhang X, Kuczera K, Rivera M, Benson DR. Accommodating a nonconservative internal mutation by water-mediated hydrogen bonding between ß-sheet strands: a comparison of human and rat type B (mitochondrial) cytochrome b5. Biochemistry. 2011 Jun 21; 50(24):5544-54. PMID: 21574570.
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    10. Li F, Terzyan S, Tang J. Subsite specificity of anthrax lethal factor and its implications for inhibitor development. Biochem Biophys Res Commun. 2011 Apr 08; 407(2):400-5. PMID: 21396916.
      View in: PubMed
    11. Nguyen ML, Terzyan S, Ballard JD, James JA, Farris AD. The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes. Infect Immun. 2009 Nov; 77(11):4714-23. PMID: 19720758.
      View in: PubMed
    12. Lee KN, Jackson KW, Terzyan S, Christiansen VJ, McKee PA. Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design. Biochemistry. 2009 Jun 16; 48(23):5149-58. PMID: 19402713.
      View in: PubMed
    13. Chvyrkova I, Zhang XC, Terzyan S. Lethal factor of anthrax toxin binds monomeric form of protective antigen. Biochem Biophys Res Commun. 2007 Aug 31; 360(3):690-5. PMID: 17617379.
      View in: PubMed
    14. Zhu G, Chen J, Liu J, Brunzelle JS, Huang B, Wakeham N, Terzyan S, Li X, Rao Z, Li G, Zhang XC. Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J. 2007 Jul 25; 26(14):3484-93. PMID: 17581628.
      View in: PubMed
    15. Wang L, Cowley AB, Terzyan S, Zhang X, Benson DR. Comparison of cytochromes b5 from insects and vertebrates. Proteins. 2007 May 01; 67(2):293-304. PMID: 17299762.
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    16. Wang L, Sun N, Terzyan S, Zhang X, Benson DR. A histidine/tryptophan pi-stacking interaction stabilizes the heme-independent folding core of microsomal apocytochrome b5 relative to that of mitochondrial apocytochrome b5. Biochemistry. 2006 Nov 21; 45(46):13750-9. PMID: 17105194.
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    17. Ramsland PA, Terzyan SS, Cloud G, Bourne CR, Farrugia W, Tribbick G, Geysen HM, Moomaw CR, Slaughter CA, Edmundson AB. Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody. Biochem J. 2006 May 01; 395(3):473-81. PMID: 16422668.
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    18. Bourne PC, Terzyan SS, Cloud G, Landolfi NF, Vásquez M, Edmundson AB. Three-dimensional structures of a humanized anti-IFN-gamma Fab (HuZAF) in two crystal forms. Acta Crystallogr D Biol Crystallogr. 2004 Oct; 60(Pt 10):1761-9. PMID: 15388922.
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    19. Zhu G, Zhai P, Liu J, Terzyan S, Li G, Zhang XC. Structural basis of Rab5-Rabaptin5 interaction in endocytosis. Nat Struct Mol Biol. 2004 Oct; 11(10):975-83. PMID: 15378032.
      View in: PubMed
    20. Terzyan S, Wakeham N, Zhai P, Rodgers K, Zhang XC. Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain. Proteins. 2004 Aug 01; 56(2):277-84. PMID: 15211511.
      View in: PubMed
    21. Terzyan S, Ramsland PA, Voss EW, Herron JN, Edmundson AB. Three-dimensional structures of idiotypically related Fabs with intermediate and high affinity for fluorescein. J Mol Biol. 2004 Jun 18; 339(5):1141-51. PMID: 15178254.
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    22. Terzyan S, Zhu G, Li G, Zhang XC. Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution. Acta Crystallogr D Biol Crystallogr. 2004 Jan; 60(Pt 1):54-60. PMID: 14684892.
      View in: PubMed
    23. Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. Crystal structure of the human GGA1 GAT domain. Biochemistry. 2003 Jun 03; 42(21):6392-9. PMID: 12767220.
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    24. Terzyan SS, Bourne CR, Ramsland PA, Bourne PC, Edmundson AB. Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95. J Mol Recognit. 2003 Mar-Apr; 16(2):83-90. PMID: 12720277.
      View in: PubMed
    25. Zhu G, He X, Zhai P, Terzyan S, Tang J, Zhang XC. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. FEBS Lett. 2003 Feb 27; 537(1-3):171-6. PMID: 12606052.
      View in: PubMed
    26. Zhu G, Liu J, Terzyan S, Zhai P, Li G, Zhang XC. High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. J Biol Chem. 2003 Jan 24; 278(4):2452-60. PMID: 12433916.
      View in: PubMed
    27. Cowley AB, Altuve A, Kuchment O, Terzyan S, Zhang X, Rivera M, Benson DR. Toward engineering the stability and hemin-binding properties of microsomal cytochromes b5 into rat outer mitochondrial membrane cytochrome b5: examining the influence of residues 25 and 71. Biochemistry. 2002 Oct 01; 41(39):11566-81. PMID: 12269800.
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    28. Wakeham N, Terzyan S, Zhai P, Loy JA, Tang J, Zhang XC. Effects of deletion of streptokinase residues 48-59 on plasminogen activation. Protein Eng. 2002 Sep; 15(9):753-61. PMID: 12456874.
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    29. Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL, Esmon CT. The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem. 2002 Jul 12; 277(28):24851-4. PMID: 12034704.
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    30. Bourne PC, Ramsland PA, Shan L, Fan ZC, DeWitt CR, Shultz BB, Terzyan SS, Moomaw CR, Slaughter CA, Guddat LW, Edmundson AB. Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallogr D Biol Crystallogr. 2002 May; 58(Pt 5):815-23. PMID: 11976493.
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    31. Altuve A, Silchenko S, Lee KH, Kuczera K, Terzyan S, Zhang X, Benson DR, Rivera M. Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5. Biochemistry. 2001 Aug 14; 40(32):9469-83. PMID: 11583146.
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    32. Pous J, Mallorquí-Fernández G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Rüth FX, Coll M. Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution. Acta Crystallogr D Biol Crystallogr. 2001 Apr; 57(Pt 4):498-505. PMID: 11264578.
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    33. Pous J, Canals A, Terzyan SS, Guasch A, Benito A, Ribó M, Vilanova M, Coll M. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. J Mol Biol. 2000 Oct 13; 303(1):49-60. PMID: 11021969.
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    34. Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science. 2000 Oct 06; 290(5489):150-3. PMID: 11021803.
      View in: PubMed
    35. Terzyan S, Wang CS, Downs D, Hunter B, Zhang XC. Crystal structure of the catalytic domain of human bile salt activated lipase. Protein Sci. 2000 Sep; 9(9):1783-90. PMID: 11045623.
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    36. Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC. Human plasminogen catalytic domain undergoes an unusual conformational change upon activation. J Mol Biol. 2000 Jan 28; 295(4):903-14. PMID: 10656799.
      View in: PubMed
    37. Terzyan SS, Peracaula R, de Llorens R, Tsushima Y, Yamada H, Seno M, Gomis-Rüth FX, Coll M. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. J Mol Biol. 1999 Jan 08; 285(1):205-14. PMID: 9878400.
      View in: PubMed
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