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Zain Ul Abideen Asad

TitleResident
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept. of Medicine, Residency
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    Collapse Biography 
    Collapse education and training
    University of Oklahoma Health Sciences Center, Oklahoma City6/30/20Cardiovascular Disease Fellowship
    University of Oklahoma Health Sciences Center, Oklahoma City6/30/17Internal Medicine Residency
    Collapse awards and honors
    2019Best Original Research Oral Presentation, American College of Physicians Oklahoma Chapter Meeting
    2019Best Original Research Poster, American College of Cardiology Oklahoma Chapter Meeting
    2018Best Original Research Poster, American College of Cardiology Oklahoma Chapter Meeting
    2014 - 2017Outstanding Resident Research Award , Internal Medicine Residency Program University of Oklahoma Health Sciences Center
    2016Best Original Research Oral Presentation, American College of Physicians Oklahoma Chapter Meeting
    2016Best Original Research Poster, American College of Physicians Oklahoma Chapter Meeting
    2016Best Clinical Case Poster, American College of Physicians Oklahoma Chapter Meeting
    2016Trainee Travel Grant, Central Society for Clinical & Translational Research
    2007 - 2012Gold Medal, Medical School Valedictorian/Best Graduate Class of 2007-2012, Nishtar Medical College, Multan, Pakistan
    2012Gold Medal, 1st Position University of Health Sciences in Final Professional MBBS, University of Health Sciences, Lahore, Pakistan

    Collapse Overview 
    Collapse overview
    My areas of interest in research include:
    • Non-invasive neuromodulation in different cardiovascular diseases.
    • Systematic reviews and meta-analyses.
    • Outcomes research related to atrial fibrillation, heart failure and septic shock.

    Collapse Research 
    Collapse research activities and funding
    ATS 2020     (Zain Ul Abideen Asad)Jun 1, 2020
    Academy of Teaching Scholars Education Grant
    A Systematic Review and Meta-Analysis Curriculum for Internal Medicine Residents
    Role Description: The goal of this project is to enhance resident skills in conducting systematic reviews and meta-analysis through a 1-month structured curriculum with input from Bird library and College of Public Health.
    Role: Principal Investigator

    Grant No A002     (Zain Ul Abideen Asad)Apr 1, 2019 - Jun 30, 2021
    Veterans Affairs Pilot Research Grant Award $50,000
    Neuromodulation to Regulate Inflammation and Autonomic Balance in Sepsis (NERINA-Sepsis)
    Role Description: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. It is the most expensive healthcare condition to treat in United States and has a mortality rate of nearly 30%. It is widely known that exaggerated inflammation and imbalance between sympathetic and parasympathetic arms of the autonomic nervous system (ANS) contribute to progression and adverse outcomes in sepsis. The role of unchecked inflammation and unregulated ANS as a potential treatment target is an important gap in our knowledge that should be explored. Cholinergic anti-inflammatory pathway (CAP) is an intricate network where the ANS senses inflammation by vagus nerve afferents and tries to regulate it by vagus nerve efferents to the reticuloendothelial system. The central hypothesis of this pilot clinical trial is that transcutaneous vagus nerve stimulation (TVNS) at tragus of the external ear can activate the CAP to suppress inflammation and improve autonomic imbalance as measured by inflammatory cytokine levels and heart rate variability (HRV) analysis. The investigators plan to randomize patients with septic shock into active and sham stimulation groups and study the effects of vagal stimulation on inflammatory cytokines, HRV and a clinical severity score of sepsis. Both groups will continue to receive the standard of care treatment for sepsis irrespective of group assignments. The investigators hypothesize that 4 hours of TVNS will suppress inflammatory markers and improve the balance between sympathetic and parasympathetic arms of ANS as measured by HRV, resulting in improved Sequential Organ Failure Assessment Score (SOFA). The preliminary data generated from this pilot study will lay the foundation for a larger clinical trial.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Asad ZUA, Khan SU, Amritphale A, Shroff A, Lata K, Seto AH, Khan MS, Rao SV, Abu-Fadel M. Early vs late discharge in low-risk ST-elevation myocardial infarction patients treated with percutaneous coronary intervention: A systematic review and meta-analysis. Cardiovasc Revasc Med. 2020 May 01. PMID: 32473910.
      View in: PubMed
    2. Khan MS, Khan MS, Ansari ZN, Siddiqi TJ, Khan SU, Riaz IB, Asad ZUA, Mandrola J, Wason J, Warraich HJ, Stone GW, Bhatt DL, Kapadia SR, Kalra A . Prevalence of Multiplicity and Appropriate Adjustments Among Cardiovascular Randomized Clinical Trials Published in Major Medical Journals. JAMA Network Open American Medical Association. 2020.
    3. Khan SU, Khan MZ, Asad ZUA, Valavoor S, Khan MU, Khan MS, Krupica T, Alkhouli M, Kaluski E. Efficacy and safety of low dose rivaroxaban in patients with coronary heart disease: a systematic review and meta-analysis. J Thromb Thrombolysis. 2020 Apr 13. PMID: 32281069.
      View in: PubMed
    4. Khan MS, Khan MS, Ansari ZN, Siddiqi TJ, Khan SU, Riaz IB, Asad ZUA, Mandrola J, Wason J, Warraich HJ, Stone GW, Bhatt DL, Kapadia SR, Kalra A. Prevalence of Multiplicity and Appropriate Adjustments Among Cardiovascular Randomized Clinical Trials Published in Major Medical Journals. JAMA Netw Open. 2020 Apr 01; 3(4):e203082. PMID: 32301992.
      View in: PubMed
    5. Hayat M, Syed TA, Disbrow M, Tran NTB, Asad ZUA, Tierney WM. Recurrent Pancreatitis Secondary to Diffuse Large B Cell Lymphoma. J Gastrointest Cancer. 2019 Dec; 50(4):1009-1013. PMID: 30393828.
      View in: PubMed
    6. Asad ZUA, Yousif A, Khan MS, Al-Khatib SM, Stavrakis S. Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Circ Arrhythm Electrophysiol. 2019 09; 12(9):e007414. PMID: 31431051.
      View in: PubMed
    7. Asad ZUA, Huard D, Dasari TW. An Unusual Case of Left Sinus of Valsalva Rupture Into Right Atrium. J Am Coll Cardiol Case Rep JACC: Case Reports An Unusual Case of Left Sinus of Valsalva Rupture Into Right Atrium. 2019; 1(2).
    8. Asad ZUA, Stavrakis S. Vagus nerve stimulation for the treatment of heart failure. Bioelectronics in Medicine Future Medicine. 2019; 2(1):43-54.
    9. Asad ZUA, Ijaz SH, Chaudhary AMD, Khan SU, Pakala A. Hemorrhagic Cardiac Tamponade Associated with Apixaban: A Case Report and Systematic Review of Literature. Cardiovasc Revasc Med. 2019 Nov; 20(11S):15-20. PMID: 31088720.
      View in: PubMed
    10. Khan SU, Lone AN, Asad ZUA, Rahman H, Khan MS, Saleem MA, Arshad A, Nawaz N, Sattur S, Kaluski E. Meta-Analysis of Efficacy and Safety of Proton Pump Inhibitors with Dual Antiplatelet Therapy for Coronary Artery Disease. Cardiovasc Revasc Med. 2019 Dec; 20(12):1125-1133. PMID: 30773427.
      View in: PubMed
    11. Khan SU, Ul Abideen Asad Z, Khan MU, Talluri S, Ali F, Shahzeb Khan M, Lone AN, Mookadam F, Krasuski RA, Kaluski E. Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis. Eur J Prev Cardiol. 2019 Jan 30; 2047487319825510. PMID: 30700151.
      View in: PubMed
    12. Tran N, Asad Z, Elkholey K, Scherlag BJ, Po SS, Stavrakis S. Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans. J Cardiovasc Transl Res. 2019 06; 12(3):221-230. PMID: 30560316.
      View in: PubMed
    13. Bockus LB, Asad ZUA, Chaudhary AMD, Awab A. Reversible Blindness as Presenting Manifestation of Severe Diabetic Ketoacidosis. Am J Med Sci. 2019 02; 357(2):164-167. PMID: 30454845.
      View in: PubMed
    14. Asad ZUA, Tunnell C. ABIM/ACC Competency-Based Education Pilot in Internal Medicine-Cardiology: A Fellow's Perspective. J Am Coll Cardiol. 2018 09 18; 72(12):1422-1426. PMID: 30213335.
      View in: PubMed
    15. Asad ZUA, Maiwand M, Farah F, Dasari TW. Peripartum cardiomyopathy: A systematic review of the literature. Clin Cardiol. 2018 May; 41(5):693-697. PMID: 29749620.
      View in: PubMed
    16. Asad Z, Abbas M, Javed I, Korantzopoulos P, Stavrakis S. Obesity is associated with incident atrial fibrillation independent of gender: A meta-analysis. J Cardiovasc Electrophysiol. 2018 05; 29(5):725-732. PMID: 29443438.
      View in: PubMed
    17. Syed TA, Ul Abideen Asad Z, Salem G, Garg K, Rubin E, Agudelo N. Dissecting Cellulitis of the Scalp: A Rare Dermatological Manifestation of Crohn's Disease. ACG Case Rep J. 2018; 5:e8. PMID: 29430467.
      View in: PubMed
    18. Stavrakis S, Asad Z, Reynolds D. Implantable Cardioverter Defibrillators for Primary Prevention of Mortality in Patients With Nonischemic Cardiomyopathy: A Meta-Analysis of Randomized Controlled Trials. J Cardiovasc Electrophysiol. 2017 Jun; 28(6):659-665. PMID: 28316104.
      View in: PubMed
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