 Osteocalcin
"Osteocalcin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
| Descriptor ID |
D015675
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| MeSH Number(s) |
D12.776.157.125.700
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| Concept/Terms |
Osteocalcin- Osteocalcin
- Bone gamma-Carboxyglutamic Acid Protein
- Bone gamma Carboxyglutamic Acid Protein
- Vitamin K-Dependent Bone Protein
- Vitamin K Dependent Bone Protein
- Calcium-Binding Protein, Vitamin K-Dependent
- Calcium Binding Protein, Vitamin K Dependent
- Gla Protein, Bone
- 4-Carboxyglutamic Protein, Bone
- 4 Carboxyglutamic Protein, Bone
- Bone 4-Carboxyglutamic Protein
- Protein, Bone 4-Carboxyglutamic
- Bone Gla Protein
- Protein, Bone Gla
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Below are MeSH descriptors whose meaning is more general than "Osteocalcin".
Below are MeSH descriptors whose meaning is more specific than "Osteocalcin".
This graph shows the total number of publications written about "Osteocalcin" by people in this website by year, and whether "Osteocalcin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 2 | 2 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 2 | 2 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Osteocalcin" by people in Profiles.
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Simmons AD, Sikavitsas VI. Monitoring Bone Tissue Engineered (BTE) Constructs Based on the Shifting Metabolism of Differentiating Stem Cells. Ann Biomed Eng. 2018 Jan; 46(1):37-47.
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Wang J, Yang Q, Mao C, Zhang S. Osteogenic differentiation of bone marrow mesenchymal stem cells on the collagen/silk fibroin bi-template-induced biomimetic bone substitutes. J Biomed Mater Res A. 2012 Nov; 100(11):2929-38.
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Takedachi M, Oohara H, Smith BJ, Iyama M, Kobashi M, Maeda K, Long CL, Humphrey MB, Stoecker BJ, Toyosawa S, Thompson LF, Murakami S. CD73-generated adenosine promotes osteoblast differentiation. J Cell Physiol. 2012 Jun; 227(6):2622-31.
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Payne JB, Stoner JA, Lee HM, Nummikoski PV, Reinhardt RA, Golub LM. Serum bone biomarkers and oral/systemic bone loss in humans. J Dent Res. 2011 Jun; 90(6):747-51.
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Wang L, Dormer NH, Bonewald LF, Detamore MS. Osteogenic differentiation of human umbilical cord mesenchymal stromal cells in polyglycolic acid scaffolds. Tissue Eng Part A. 2010 Jun; 16(6):1937-48.
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Golub LM, Lee HM, Stoner JA, Reinhardt RA, Sorsa T, Goren AD, Payne JB. Doxycycline effects on serum bone biomarkers in post-menopausal women. J Dent Res. 2010 Jun; 89(6):644-9.
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van den Dolder J, Bancroft GN, Sikavitsas VI, Spauwen PH, Mikos AG, Jansen JA. Effect of fibronectin- and collagen I-coated titanium fiber mesh on proliferation and differentiation of osteogenic cells. Tissue Eng. 2003 Jun; 9(3):505-15.
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Zhang M, Faugere MC, Malluche H, Rosen CJ, Chernausek SD, Clemens TL. Paracrine overexpression of IGFBP-4 in osteoblasts of transgenic mice decreases bone turnover and causes global growth retardation. J Bone Miner Res. 2003 May; 18(5):836-43.
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Bancroft GN, Sikavitsas VI, van den Dolder J, Sheffield TL, Ambrose CG, Jansen JA, Mikos AG. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12600-5.
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Bemben DA, Langdon DB. Relationship between estrogen use and musculoskeletal function in postmenopausal women. Maturitas. 2002 Jun 25; 42(2):119-27.
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