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Last Name

Lauren A Zenewicz

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
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    Collapse Biography 
    Collapse education and training
    University of Pennsylvania, Philadelphia, PAPhD2004Microbiology
    Yale University, New Haven, CTPostdoc2012Immunobiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Seshadri S, Pope RL, Zenewicz LA. Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production. J Immunol. 2018 Aug 15; 201(4):1267-1274. PMID: 29980608.
      View in: PubMed
    2. Budda SA, Zenewicz LA. IL-22 deficiency increases CD4 T cell responses to mucosal immunization. Vaccine. 2018 06 14; 36(25):3694-3700. PMID: 29739717.
      View in: PubMed
    3. Seshadri S, Allan DSJ, Carlyle JR, Zenewicz LA. Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. PLoS Pathog. 2017 Oct; 13(10):e1006690. PMID: 29059238.
      View in: PubMed
    4. Zenewicz LA. Oxygen Levels and Immunological Studies. Front Immunol. 2017; 8:324. PMID: 28377771.
      View in: PubMed
    5. Budda SA, Bhattarai K, Alexander JL, Zenewicz LA. Hypoxic modulation of hepatocyte responses to the cytokine interleukin-22. Immunol Cell Biol. 2017 04; 95(4):380-387. PMID: 27796296.
      View in: PubMed
    6. Budda SA, Girton A, Henderson JG, Zenewicz LA. Transcription Factor HIF-1a Controls Expression of the Cytokine IL-22 in CD4 T Cells. J Immunol. 2016 10 01; 197(7):2646-52. PMID: 27534553.
      View in: PubMed
    7. Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L. Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology. 2016 07; 151(1):152-164.e11. PMID: 27059389.
      View in: PubMed
    8. Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2016 Feb 25; 530(7591):504. PMID: 26605525.
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    9. Zenewicz LA, Yin X, Wang G, Elinav E, Hao L, Zhao L, Flavell RA. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. J Immunol. 2013 May 15; 190(10):5306-12. PMID: 23585682; PMCID: PMC3646987.
    10. Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA. Excessive Th1 responses due to the absence of TGF-ß signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6961-6. PMID: 23569233; PMCID: PMC3637710.
    11. Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 08; 491(7423):259-63. PMID: 23075849; PMCID: PMC3493690.
    12. Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. PLoS One. 2012; 7(8):e44153. PMID: 22952908; PMCID: PMC3429482.
    13. Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25; 484(7395):510-3. PMID: 22538615; PMCID: PMC3340615.
    14. Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012 Feb 24; 36(2):276-87. PMID: 22306017; PMCID: PMC3288454.
    15. Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. J Exp Med. 2011 May 09; 208(5):1027-40. PMID: 21518800; PMCID: PMC3092344.
    16. Zenewicz LA, Flavell RA. Recent advances in IL-22 biology. Int Immunol. 2011 Mar; 23(3):159-63. PMID: 21393631.
      View in: PubMed
    17. O'Connor W, Zenewicz LA, Flavell RA. The dual nature of T(H)17 cells: shifting the focus to function. Nat Immunol. 2010 Jun; 11(6):471-6. PMID: 20485275.
      View in: PubMed
    18. Zenewicz LA, Abraham C, Flavell RA, Cho JH. Unraveling the genetics of autoimmunity. Cell. 2010 Mar 19; 140(6):791-7. PMID: 20303870.
      View in: PubMed
    19. Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG. Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J Infect Dis. 2010 Feb 15; 201(4):534-43. PMID: 20064069; PMCID: PMC2811237.
    20. Priatel JJ, Chen X, Huang YH, Chow MT, Zenewicz LA, Coughlin JJ, Shen H, Stone JC, Tan R, Teh HS. RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells. J Immunol. 2010 Jan 15; 184(2):666-76. PMID: 20007535.
      View in: PubMed
    21. Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA. Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol. 2009 Aug; 9(4):447-53. PMID: 19481975; PMCID: PMC2755239.
    22. Zenewicz LA, Antov A, Flavell RA. CD4 T-cell differentiation and inflammatory bowel disease. Trends Mol Med. 2009 May; 15(5):199-207. PMID: 19362058.
      View in: PubMed
    23. Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity. 2008 Dec 19; 29(6):947-57. PMID: 19100701; PMCID: PMC3269819.
    24. Zenewicz LA, Flavell RA. IL-22 and inflammation: leukin' through a glass onion. Eur J Immunol. 2008 Dec; 38(12):3265-8. PMID: 19016525.
      View in: PubMed
    25. Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity. 2007 Oct; 27(4):647-59. PMID: 17919941; PMCID: PMC2149911.
    26. Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MS, Teh HS. Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion. J Immunol. 2007 Aug 15; 179(4):2143-52. PMID: 17675473.
      View in: PubMed
    27. Zenewicz LA, Shen H. Innate and adaptive immune responses to Listeria monocytogenes: a short overview. Microbes Infect. 2007 Aug; 9(10):1208-15. PMID: 17719259; PMCID: PMC2042024.
    28. Wei Z, Schnupf P, Poussin MA, Zenewicz LA, Shen H, Goldfine H. Characterization of Listeria monocytogenes expressing anthrolysin O and phosphatidylinositol-specific phospholipase C from Bacillus anthracis. Infect Immun. 2005 Oct; 73(10):6639-46. PMID: 16177340.
      View in: PubMed
    29. Wei Z, Zenewicz LA, Goldfine H. Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors. Proc Natl Acad Sci U S A. 2005 Sep 06; 102(36):12927-31. PMID: 16118276; PMCID: PMC1200258.
    30. Eynon EE, Zenewicz LA, Flavell RA. Sugar-coated regulation of T cells. Cell. 2005 Jul 15; 122(1):2-4. PMID: 16009124.
      View in: PubMed
    31. Zenewicz LA, Wei Z, Goldfine H, Shen H. Phosphatidylinositol-specific phospholipase C of Bacillus anthracis down-modulates the immune response. J Immunol. 2005 Jun 15; 174(12):8011-6. PMID: 15944308.
      View in: PubMed
    32. Zenewicz LA, Skinner JA, Goldfine H, Shen H. Listeria monocytogenes virulence proteins induce surface expression of Fas ligand on T lymphocytes. Mol Microbiol. 2004 Mar; 51(5):1483-92. PMID: 14982640.
      View in: PubMed
    33. Jiang J, Zenewicz LA, San Mateo LR, Lau LL, Shen H. Activation of antigen-specific CD8 T cells results in minimal killing of bystander bacteria. J Immunol. 2003 Dec 01; 171(11):6032-8. PMID: 14634115.
      View in: PubMed
    34. Zenewicz LA, Foulds KE, Jiang J, Fan X, Shen H. Nonsecreted bacterial proteins induce recall CD8 T cell responses but do not serve as protective antigens. J Immunol. 2002 Nov 15; 169(10):5805-12. PMID: 12421961.
      View in: PubMed
    35. Foulds KE, Zenewicz LA, Shedlock DJ, Jiang J, Troy AE, Shen H. Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J Immunol. 2002 Feb 15; 168(4):1528-32. PMID: 11823476.
      View in: PubMed
    36. Weiser JN, Bae D, Epino H, Gordon SB, Kapoor M, Zenewicz LA, Shchepetov M. Changes in availability of oxygen accentuate differences in capsular polysaccharide expression by phenotypic variants and clinical isolates of Streptococcus pneumoniae. Infect Immun. 2001 Sep; 69(9):5430-9. PMID: 11500414; PMCID: PMC98654.
    37. Stermitz FR, Tawara-Matsuda J, Lorenz P, Mueller P, Zenewicz L, Lewis K. 5'-Methoxyhydnocarpin-D and pheophorbide A: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus. J Nat Prod. 2000 Aug; 63(8):1146-9. PMID: 10978214.
      View in: PubMed
    38. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1433-7. PMID: 10677479; PMCID: PMC26451.
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