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Lawrence Ian Rothblum

TitleProfessor & Chair
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-2377
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    Collapse Research 
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    R01GM037252     (ROTHBLUM, LAWRENCE I)Jul 1, 1986 - Jun 30, 1990
    NIH/NIGMS
    CHARACTERIZATION OF ENHANCER IN RIBOSOMAL DNA
    Role: Principal Investigator

    R01HL047638     (ROTHBLUM, LAWRENCE I)Feb 1, 1992 - Jan 31, 1997
    NIH/NHLBI
    REGULATION OF RRNA SYNTHESIS DURING CARDIAC HYPERTROPHY
    Role: Principal Investigator

    R01GM046991     (ROTHBLUM, LAWRENCE I)Feb 1, 1992 - Jun 30, 2001
    NIH/NIGMS
    TRANSCRIPTION OF RAT RIBOSOMAL DNA
    Role: Principal Investigator

    R01GM069841     (ROTHBLUM, LAWRENCE I)Sep 1, 2005 - Aug 31, 2010
    NIH/NIGMS
    Protein interactions and initiation by RNA polymerase I
    Role: Principal Investigator

    R01HL077814     (ROTHBLUM, LAWRENCE I)Apr 1, 2006 - Mar 31, 2011
    NIH/NHLBI
    Ribosome Biogenesis: A Molecular Checkpoint for Cardiac Hypertrophy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rothblum LI, Rothblum K, Chang E. PAF53 is essential in mammalian cells: CRISPR/Cas9 fails to eliminate PAF53 expression. Gene. 2017 May 15; 612:55-60. PMID: 28042089.
      View in: PubMed
    2. Hung SS, Lesmana A, Peck A, Lee R, Tchoubrieva E, Hannan KM, Lin J, Sheppard KE, Jastrzebski K, Quinn LM, Rothblum LI, Pearson RB, Hannan RD, Sanij E. Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription. Gene. 2017 May 15; 612:36-48. PMID: 27989772.
      View in: PubMed
    3. Sanij E, Diesch J, Lesmana A, Poortinga G, Hein N, Lidgerwood G, Cameron DP, Ellul J, Goodall GJ, Wong LH, Dhillon AS, Hamdane N, Rothblum LI, Pearson RB, Haviv I, Moss T, Hannan RD. A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes. Genome Res. 2015 Feb; 25(2):201-12. PMID: 25452314; PMCID: PMC4315294.
    4. Penrod Y, Rothblum K, Cavanaugh A, Rothblum LI. Regulation of the association of the PAF53/PAF49 heterodimer with RNA polymerase I. Gene. 2015 Feb 01; 556(1):61-7. PMID: 25225125; PMCID: PMC4272621.
    5. Rothblum K, Hu Q, Penrod Y, Rothblum LI. Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3. Mol Cancer Res. 2014 Nov; 12(11):1586-96. PMID: 25033839; PMCID: PMC4233170.
    6. Stepanchick A, Zhi H, Cavanaugh AH, Rothblum K, Schneider DA, Rothblum LI. DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription. J Biol Chem. 2013 Mar 29; 288(13):9135-44. PMID: 23393135; PMCID: PMC3610986.
    7. Penrod Y, Rothblum K, Rothblum LI. Characterization of the interactions of mammalian RNA polymerase I associated proteins PAF53 and PAF49. Biochemistry. 2012 Aug 21; 51(33):6519-26. PMID: 22849406; PMCID: PMC3426042.
    8. DuRose JB, Scheuner D, Kaufman RJ, Rothblum LI, Niwa M. Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Mol Cell Biol. 2009 Aug; 29(15):4295-307. PMID: 19470760; PMCID: PMC2715810.
    9. Sanij E, Poortinga G, Sharkey K, Hung S, Holloway TP, Quin J, Robb E, Wong LH, Thomas WG, Stefanovsky V, Moss T, Rothblum L, Hannan KM, McArthur GA, Pearson RB, Hannan RD. UBF levels determine the number of active ribosomal RNA genes in mammals. J Cell Biol. 2008 Dec 29; 183(7):1259-74. PMID: 19103806; PMCID: PMC2606969.
    10. Cavanaugh AH, Evans A, Rothblum LI. Mammalian Rrn3 is required for the formation of a transcription competent preinitiation complex containing RNA polymerase I. Gene Expr. 2008; 14(3):131-47. PMID: 18590050; PMCID: PMC2526047.
    11. Cheung JY, Rothblum LI, Moorman JR, Tucker AL, Song J, Ahlers BA, Carl LL, Wang J, Zhang XQ. Regulation of cardiac Na+/Ca2+ exchanger by phospholemman. Ann N Y Acad Sci. 2007 Mar; 1099:119-34. PMID: 17446450.
      View in: PubMed
    12. Wang J, Zhang XQ, Ahlers BA, Carl LL, Song J, Rothblum LI, Stahl RC, Carey DJ, Cheung JY. Cytoplasmic tail of phospholemman interacts with the intracellular loop of the cardiac Na+/Ca2+ exchanger. J Biol Chem. 2006 Oct 20; 281(42):32004-14. PMID: 16921169; PMCID: PMC1613256.
    13. Huang S, Rothblum LI, Chen D. Ribosomal chromatin organization. Biochem Cell Biol. 2006 Aug; 84(4):444-9. PMID: 16936818.
      View in: PubMed
    14. Tucker AL, Song J, Zhang XQ, Wang J, Ahlers BA, Carl LL, Mounsey JP, Moorman JR, Rothblum LI, Cheung JY. Altered contractility and [Ca2+]i homeostasis in phospholemman-deficient murine myocytes: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2199-209. PMID: 16751288; PMCID: PMC1593220.
    15. Zhang XQ, Ahlers BA, Tucker AL, Song J, Wang J, Moorman JR, Mounsey JP, Carl LL, Rothblum LI, Cheung JY. Phospholemman inhibition of the cardiac Na+/Ca2+ exchanger. Role of phosphorylation. J Biol Chem. 2006 Mar 24; 281(12):7784-92. PMID: 16434394; PMCID: PMC1405234.
    16. Vecchio L, Soldani C, Bottone MG, Malatesta M, Martin TE, Rothblum LI, Pellicciari C, Biggiogera M. DADLE induces a reversible hibernation-like state in HeLa cells. Histochem Cell Biol. 2006 Jan; 125(1-2):193-201. PMID: 16235044.
      View in: PubMed
    17. Zhang XQ, Moorman JR, Ahlers BA, Carl LL, Lake DE, Song J, Mounsey JP, Tucker AL, Chan YM, Rothblum LI, Stahl RC, Carey DJ, Cheung JY. Phospholemman overexpression inhibits Na+-K+-ATPase in adult rat cardiac myocytes: relevance to decreased Na+ pump activity in postinfarction myocytes. J Appl Physiol (1985). 2006 Jan; 100(1):212-20. PMID: 16195392; PMCID: PMC1351072.
    18. Ahlers BA, Zhang XQ, Moorman JR, Rothblum LI, Carl LL, Song J, Wang J, Geddis LM, Tucker AL, Mounsey JP, Cheung JY. Identification of an endogenous inhibitor of the cardiac Na+/Ca2+ exchanger, phospholemman. J Biol Chem. 2005 May 20; 280(20):19875-82. PMID: 15774479.
      View in: PubMed
    19. Ahlers BA, Song J, Wang J, Zhang XQ, Carl LL, Tadros GM, Rothblum LI, Cheung JY. Effects of sarcoplasmic reticulum Ca2+-ATPase overexpression in postinfarction rat myocytes. J Appl Physiol (1985). 2005 Jun; 98(6):2169-76. PMID: 15677742.
      View in: PubMed
    20. Song J, Zhang XQ, Ahlers BA, Carl LL, Wang J, Rothblum LI, Stahl RC, Mounsey JP, Tucker AL, Moorman JR, Cheung JY. Serine 68 of phospholemman is critical in modulation of contractility, [Ca2+]i transients, and Na+/Ca2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2342-54. PMID: 15653756.
      View in: PubMed
    21. Cheung JY, Song J, Rothblum LI, Zhang XQ. Exercise training improves cardiac function postinfarction: special emphasis on recent controversies on na+/ca2+ exchanger. Exerc Sport Sci Rev. 2004 Jul; 32(3):83-9. PMID: 15243202.
      View in: PubMed
    22. Song J, Zhang XQ, Wang J, Carl LL, Ahlers BA, Rothblum LI, Cheung JY. Sprint training improves contractility in postinfarction rat myocytes: role of Na+/Ca2+ exchange. J Appl Physiol (1985). 2004 Aug; 97(2):484-90. PMID: 15075297.
      View in: PubMed
    23. Mirza MA, Zhang XQ, Ahlers BA, Qureshi A, Carl LL, Song J, Tucker AL, Mounsey JP, Moorman JR, Rothblum LI, Zhang TS, Cheung JY. Effects of phospholemman downregulation on contractility and [Ca(2+)]i transients in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol. 2004 Apr; 286(4):H1322-30. PMID: 14684371.
      View in: PubMed
    24. Hannan KM, Brandenburger Y, Jenkins A, Sharkey K, Cavanaugh A, Rothblum L, Moss T, Poortinga G, McArthur GA, Pearson RB, Hannan RD. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol. 2003 Dec; 23(23):8862-77. PMID: 14612424; PMCID: PMC262650.
    25. Brandenburger Y, Arthur JF, Woodcock EA, Du XJ, Gao XM, Autelitano DJ, Rothblum LI, Hannan RD. Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF. FEBS Lett. 2003 Jul 31; 548(1-3):79-84. PMID: 12885411.
      View in: PubMed
    26. Hirschler-Laszkiewicz I, Cavanaugh AH, Mirza A, Lun M, Hu Q, Smink T, Rothblum LI. Rrn3 becomes inactivated in the process of ribosomal DNA transcription. J Biol Chem. 2003 May 23; 278(21):18953-9. PMID: 12646563.
      View in: PubMed
    27. Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T. A kinetic framework for a mammalian RNA polymerase in vivo. Science. 2002 Nov 22; 298(5598):1623-6. PMID: 12446911.
      View in: PubMed
    28. Zhang XQ, Qureshi A, Song J, Carl LL, Tian Q, Stahl RC, Carey DJ, Rothblum LI, Cheung JY. Phospholemman modulates Na+/Ca2+ exchange in adult rat cardiac myocytes. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H225-33. PMID: 12388273.
      View in: PubMed
    29. Zhang XQ, Song J, Qureshi A, Rothblum LI, Carl LL, Tian Q, Cheung JY. Rescue of contractile abnormalities by Na+/Ca2+ exchanger overexpression in postinfarction rat myocytes. J Appl Physiol (1985). 2002 Dec; 93(6):1925-31. PMID: 12391043.
      View in: PubMed
    30. Song J, Zhang XQ, Carl LL, Qureshi A, Rothblum LI, Cheung JY. Overexpression of phospholemman alters contractility and [Ca(2+)](i) transients in adult rat myocytes. Am J Physiol Heart Circ Physiol. 2002 Aug; 283(2):H576-83. PMID: 12124204.
      View in: PubMed
    31. Chu X, Cheung JY, Barber DL, Birnbaumer L, Rothblum LI, Conrad K, Abrasonis V, Chan YM, Stahl R, Carey DJ, Miller BA. Erythropoietin modulates calcium influx through TRPC2. J Biol Chem. 2002 Sep 13; 277(37):34375-82. PMID: 12167663.
      View in: PubMed
    32. Hu Q, Suzuki K, Hirschler-Laszkiewicz I, Rothblum LI. Paradoxical effect of eukaryotic expression vectors on reporters. Biotechniques. 2002 Jul; 33(1):74, 76, 78 passim. PMID: 12139260.
      View in: PubMed
    33. Tadros GM, Zhang XQ, Song J, Carl LL, Rothblum LI, Tian Q, Dunn J, Lytton J, Cheung JY. Effects of Na(+)/Ca(2+) exchanger downregulation on contractility and [Ca(2+)](i) transients in adult rat myocytes. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1616-26. PMID: 12234816.
      View in: PubMed
    34. Flynn BJ, Mian HS, Cera PJ, Kabler RL, Mowad JJ, Cavanaugh AH, Rothblum LI. Early molecular changes in bladder hypertrophy due to bladder outlet obstruction. Urology. 2002 Jun; 59(6):978-82. PMID: 12031398.
      View in: PubMed
    35. Cavanaugh AH, Hirschler-Laszkiewicz I, Hu Q, Dundr M, Smink T, Misteli T, Rothblum LI. Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis. J Biol Chem. 2002 Jul 26; 277(30):27423-32. PMID: 12015311.
      View in: PubMed
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