Loading...
Header Logo
Keywords
Last Name
Institution

Leonidas Tsiokas

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-8001
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    F32DK009625     (TSIOKAS, LEONIDAS)Oct 5, 1997
    NIH/NIDDK
    STRUCTURE/FUNCTION ANALYSIS OF K CADHERIN
    Role: Principal Investigator

    R01DK059599     (TSIOKAS, LEONIDAS)Apr 1, 2001 - Apr 30, 2021
    NIH/NIDDK
    Regulation of calcium signaling by the PKD2 gene product
    Role: Principal Investigator

    R56DK059599     (TSIOKAS, LEONIDAS)Sep 1, 2010 - Aug 31, 2011
    NIH/NIDDK
    Regulation of calcium signaling by the PKD2 gene product
    Role: Principal Investigator

    R01AR064211     (TSIOKAS, LEONIDAS)Sep 17, 2013 - Aug 31, 2018
    NIH/NIAMS
    Calcium Regulation in Osteoclasts
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L, Ong ACM. The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex. J Am Soc Nephrol. 2017 Oct; 28(10):2973-2984. PMID: 28620080.
      View in: PubMed
    2. Chakraborty PK, Mustafi SB, Xiong X, Dwivedi SKD, Nesin V, Saha S, Zhang M, Dhanasekaran D, Jayaraman M, Mannel R, Moore K, McMeekin S, Yang D, Zuna R, Ding K, Tsiokas L, Bhattacharya R, Mukherjee P. MICU1 drives glycolysis and chemoresistance in ovarian cancer. Nat Commun. 2017 May 22; 8:14634. PMID: 28530221.
      View in: PubMed
    3. Keeling J, Tsiokas L, Maskey D. Cellular Mechanisms of Ciliary Length Control. Cells. 2016 Jan 29; 5(1). PMID: 26840332; PMCID: PMC4810091.
    4. Maskey D, Marlin MC, Kim S, Kim S, Ong EC, Li G, Tsiokas L. Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. EMBO J. 2015 Oct 01; 34(19):2424-40. PMID: 26206584; PMCID: PMC4601663 [Available on 10/01/16].
    5. Nesin V, Wiley G, Kousi M, Ong EC, Lehmann T, Nicholl DJ, Suri M, Shahrizaila N, Katsanis N, Gaffney PM, Wierenga KJ, Tsiokas L. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4197-202. PMID: 24591628; PMCID: PMC3964084.
    6. Nesin V, Tsiokas L. TRPC1. Handb Exp Pharmacol. 2014; 222:15-51. PMID: 24756701.
      View in: PubMed
    7. Ong EC, Nesin V, Long CL, Bai CX, Guz JL, Ivanov IP, Abramowitz J, Birnbaumer L, Humphrey MB, Tsiokas L. A TRPC1 protein-dependent pathway regulates osteoclast formation and function. J Biol Chem. 2013 Aug 02; 288(31):22219-32. PMID: 23770672; PMCID: PMC3829314.
    8. Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21(26):5456-71. PMID: 23001567; PMCID: PMC3516131.
    9. Kim S, Tsiokas L. Cilia and cell cycle re-entry: more than a coincidence. Cell Cycle. 2011 Aug 15; 10(16):2683-90. PMID: 21814045; PMCID: PMC3219538.
    10. Kim S, Zaghloul NA, Bubenshchikova E, Oh EC, Rankin S, Katsanis N, Obara T, Tsiokas L. Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol. 2011 Apr; 13(4):351-60. PMID: 21394081; PMCID: PMC3077088.
    11. Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn M, Abramowitz J, Rockman HA, Birnbaumer L, Rosenberg P. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res. 2009 Nov 06; 105(10):1023-30. PMID: 19797170; PMCID: PMC2881555.
    12. Tsiokas L. Function and regulation of TRPP2 at the plasma membrane. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F1-9. PMID: 19244406; PMCID: PMC2711710.
    13. Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C. Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2. BMC Nephrol. 2008 Aug 25; 9:10. PMID: 18721488; PMCID: PMC2533650.
    14. Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T, Ong AC. Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J Biol Chem. 2008 Oct 17; 283(42):28471-9. PMID: 18701462; PMCID: PMC2568912.
    15. Bai CX, Kim S, Li WP, Streets AJ, Ong AC, Tsiokas L. Activation of TRPP2 through mDia1-dependent voltage gating. EMBO J. 2008 May 07; 27(9):1345-56. PMID: 18388856; PMCID: PMC2374846.
    16. Bai CX, Giamarchi A, Rodat-Despoix L, Padilla F, Downs T, Tsiokas L, Delmas P. Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 2008 May; 9(5):472-9. PMID: 18323855; PMCID: PMC2373364.
    17. Kaznacheyeva E, Glushankova L, Bugaj V, Zimina O, Skopin A, Alexeenko V, Tsiokas L, Bezprozvanny I, Mozhayeva GN. Suppression of TRPC3 leads to disappearance of store-operated channels and formation of a new type of store-independent channels in A431 cells. J Biol Chem. 2007 Aug 10; 282(32):23655-62. PMID: 17569672.
      View in: PubMed
    18. Tsiokas L, Kim S, Ong EC. Cell biology of polycystin-2. Cell Signal. 2007 Mar; 19(3):444-53. PMID: 17084592; PMCID: PMC1817723.
    19. Pan W, Jia Y, Wang J, Tao D, Gan X, Tsiokas L, Jing N, Wu D, Li L. Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17378-83. PMID: 16301527; PMCID: PMC1297664.
    20. Ma R, Li WP, Rundle D, Kong J, Akbarali HI, Tsiokas L. PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol Cell Biol. 2005 Sep; 25(18):8285-98. PMID: 16135816; PMCID: PMC1234340.
    21. Rajala RV, McClellan ME, Chan MD, Tsiokas L, Anderson RE. Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase. Biochemistry. 2004 May 18; 43(19):5637-50. PMID: 15134438.
      View in: PubMed
    22. Rundle DR, Gorbsky G, Tsiokas L. PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. J Biol Chem. 2004 Jul 09; 279(28):29728-39. PMID: 15123714.
      View in: PubMed
    23. Li WP, Tsiokas L, Sansom SC, Ma R. Epidermal growth factor activates store-operated Ca2+ channels through an inositol 1,4,5-trisphosphate-independent pathway in human glomerular mesangial cells. J Biol Chem. 2004 Feb 06; 279(6):4570-7. PMID: 14612458.
      View in: PubMed
    24. Ma R, Rundle D, Jacks J, Koch M, Downs T, Tsiokas L. Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1. J Biol Chem. 2003 Dec 26; 278(52):52763-72. PMID: 14530267.
      View in: PubMed
    25. Ong HL, Chen J, Chataway T, Brereton H, Zhang L, Downs T, Tsiokas L, Barritt G. Specific detection of the endogenous transient receptor potential (TRP)-1 protein in liver and airway smooth muscle cells using immunoprecipitation and Western-blot analysis. Biochem J. 2002 Jun 15; 364(Pt 3):641-8. PMID: 12049627; PMCID: PMC1222612.
    26. Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP. Cell surface glypicans are low-affinity endostatin receptors. Mol Cell. 2001 Apr; 7(4):811-22. PMID: 11336704.
      View in: PubMed
    27. Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature. 2000 Dec 21-28; 408(6815):990-4. PMID: 11140688.
      View in: PubMed
    28. Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G. Interaction between RGS7 and polycystin. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6371-6. PMID: 10339594; PMCID: PMC26888.
    29. Arnould T, Sellin L, Benzing T, Tsiokas L, Cohen HT, Kim E, Walz G. Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol. 1999 May; 19(5):3423-34. PMID: 10207066; PMCID: PMC84135.
    30. Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3934-9. PMID: 10097141; PMCID: PMC22398.
    31. Arnould T, Kim E, Tsiokas L, Jochimsen F, Grüning W, Chang JD, Walz G. The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1. J Biol Chem. 1998 Mar 13; 273(11):6013-8. PMID: 9497315.
      View in: PubMed
    32. Tsiokas L, Kim E, Arnould T, Sukhatme VP, Walz G. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6965-70. PMID: 9192675; PMCID: PMC21268.
    33. Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995 Jun 15; 375(6532):577-81. PMID: 7540725.
      View in: PubMed
    Tsiokas's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _