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Last Name

Adam S Asch

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Hematology/Oncology
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    Collapse Biography 
    Collapse education and training
    Thomas Jefferson University School of Medicine, Philadelphia, PAMD1979Medicine
    Swarthmore College, Swarthmore, PAAB1974
    Long Island Jewish Medical Center, Long Island, NYResident1982Medicine
    Cornell University Medical College, New YorkFellow1985Hematology/Oncology

    Collapse Research 
    Collapse research activities and funding
    1P30CA225520-01     (MANNEL, ROBERT S)May 1, 2018 - Apr 30, 2023
    Stephenson Cancer Center - Cancer Center Support Grant
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rao CV, Farooqui M, Asch AS, Yamada HY. Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model. Cell Cycle. 2018; 17(19-20):2321-2334. PMID: 30231670.
      View in: PubMed
    2. Rao CV, Farooqui M, Zhang Y, Asch AS, Yamada HY. Spontaneous development of Alzheimer's disease-associated brain pathology in a Shugoshin-1 mouse cohesinopathy model. Aging Cell. 2018 Jun 25; e12797. PMID: 29943428.
      View in: PubMed
    3. Mohammed A, Janakiram NB, Madka V, Li M, Asch AS, Rao CV. Current Challenges and Opportunities for Chemoprevention of Pancreatic Cancer. Curr Med Chem. 2018; 25(22):2535-2544. PMID: 28183260.
      View in: PubMed
    4. Rao CV, Mohammed A, Asch AS, Janakiram NB. Immunoprevention of Pancreatic Cancer. Curr Med Chem. 2018; 25(22):2576-2584. PMID: 28240168.
      View in: PubMed
    5. Janakiram NB, Mohammed A, Bryant T, Ritchie R, Stratton N, Jackson L, Lightfoot S, Benbrook DM, Asch AS, Lang ML, Rao CV. Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice. Immunology. 2017 09; 152(1):36-51. PMID: 28419443.
      View in: PubMed
    6. Rao CV, Pal S, Mohammed A, Farooqui M, Doescher MP, Asch AS, Yamada HY. Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damage in vivo. Oncotarget. 2017 Aug 22; 8(34):57605-57621. PMID: 28915699.
      View in: PubMed
    7. Rao CV, Asch AS, Yamada HY. Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer. Carcinogenesis. 2017 01; 38(1):2-11. PMID: 27838634.
      View in: PubMed
    8. Rao CV, Asch AS, Yamada HY. Emerging links among Chromosome Instability (CIN), cancer, and aging. Mol Carcinog. 2017 03; 56(3):791-803. PMID: 27533343.
      View in: PubMed
    9. Park SI, Grover NS, Olajide O, Asch AS, Wall JG, Richards KL, Sobol AL, Deal AM, Ivanova A, Foster MC, Muss HB, Shea TC. A phase II trial of bendamustine in combination with rituximab in older patients with previously untreated diffuse large B-cell lymphoma. Br J Haematol. 2016 Oct; 175(2):281-289. PMID: 27448091.
      View in: PubMed
    10. Datla US, Scovill NC, Brokamp AJ, Kim E, Asch AS, Lee MH. Role of PUF-8/PUF protein in stem cell control, sperm-oocyte decision and cell fate reprogramming. J Cell Physiol. 2014 Oct; 229(10):1306-11. PMID: 24638209.
      View in: PubMed
    11. Kobet RA, Pan X, Zhang B, Pak SC, Asch AS, Lee MH. Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification. Biomol Ther (Seoul). 2014 Sep; 22(5):371-83. PMID: 25414766; PMCID: PMC4201220.
    12. Chen X, Corbin JM, Tipton GJ, Yang LV, Asch AS, Ruiz-Echevarría MJ. The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells. Biochim Biophys Acta. 2014 Jun; 1843(6):1216-24. PMID: 24632071; PMCID: PMC4021708.
    13. Green T, Chen X, Ryan S, Asch AS, Ruiz-Echevarría MJ. TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. Prostate. 2013 Oct; 73(14):1561-75. PMID: 23824605; PMCID: PMC3878307.
    14. Dong L, Li Z, Leffler NR, Asch AS, Chi JT, Yang LV. Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. PLoS One. 2013; 8(4):e61991. PMID: 23613998; PMCID: PMC3628782.
    15. Overcash RF, Chappell VA, Green T, Geyer CB, Asch AS, Ruiz-Echevarría MJ. Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the a subunit of the translation initiation factor 2. PLoS One. 2013; 8(2):e55257. PMID: 23405127; PMCID: PMC3566213.
    16. Whelan JT, Hollis SE, Cha DS, Asch AS, Lee MH. Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway. J Cell Physiol. 2012 Mar; 227(3):1235-41. PMID: 21688267.
      View in: PubMed
    17. Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang LV. Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. PLoS One. 2011; 6(11):e27586. PMID: 22110680; PMCID: PMC3217975.
    18. Chen X, Overcash R, Green T, Hoffman D, Asch AS, Ruiz-Echevarría MJ. The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels. J Biol Chem. 2011 May 06; 286(18):16091-100. PMID: 21393249; PMCID: PMC3091218.
    19. Sigounas G, Hairr JW, Cooke CD, Owen JR, Asch AS, Weidner DA, Wiley JE. Role of benzo[alpha]pyrene in generation of clustered DNA damage in human breast tissue. Free Radic Biol Med. 2010 Jul 01; 49(1):77-87. PMID: 20347033.
      View in: PubMed
    20. Wiestner A, Cho HJ, Asch AS, Michelis MA, Zeller JA, Peerschke EI, Weksler BB, Schechter GP. Rituximab in the treatment of acquired factor VIII inhibitors. Blood. 2002 Nov 01; 100(9):3426-8. PMID: 12384448.
      View in: PubMed
    21. Griffin E, Re A, Hamel N, Fu C, Bush H, McCaffrey T, Asch AS. A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation. Nat Med. 2001 Jul; 7(7):840-6. PMID: 11433350.
      View in: PubMed
    22. Simantov R, Febbraio M, Crombie R, Asch AS, Nachman RL, Silverstein RL. Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. J Clin Invest. 2001 Jan; 107(1):45-52. PMID: 11134179; PMCID: PMC198540.
    23. Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind JS, Asch AS, Cesarman E, Gershengorn MC, Mesri EA, Gerhengorn MC. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 1998 Jan 01; 391(6662):86-9. PMID: 9422510.
      View in: PubMed
    24. Arvanitakis L, Mesri EA, Nador RG, Said JW, Asch AS, Knowles DM, Cesarman E. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood. 1996 Oct 01; 88(7):2648-54. PMID: 8839859.
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    25. Mesri EA, Cesarman E, Arvanitakis L, Rafii S, Moore MA, Posnett DN, Knowles DM, Asch AS. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J Exp Med. 1996 May 01; 183(5):2385-90. PMID: 8642350; PMCID: PMC2192551.
    26. Asch A. To tell the truth: will the real CD36 please stand up? J Lab Clin Med. 1996 Apr; 127(4):321-5. PMID: 8656032.
      View in: PubMed
    27. Rafii S, Oz MC, Seldomridge JA, Ferris B, Asch AS, Nachman RL, Shapiro F, Rose EA, Levin HR. Characterization of hematopoietic cells arising on the textured surface of left ventricular assist devices. Ann Thorac Surg. 1995 Dec; 60(6):1627-32. PMID: 8787455.
      View in: PubMed
    28. Rafii S, Shapiro F, Pettengell R, Ferris B, Nachman RL, Moore MA, Asch AS. Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors. Blood. 1995 Nov 01; 86(9):3353-63. PMID: 7579438.
      View in: PubMed
    29. Dobrescu D, Ursea B, Pope M, Asch AS, Posnett DN. Enhanced HIV-1 replication in V beta 12 T cells due to human cytomegalovirus in monocytes: evidence for a putative herpesvirus superantigen. Cell. 1995 Sep 08; 82(5):753-63. PMID: 7671303.
      View in: PubMed
    30. Dobrescu D, Kabak S, Mehta K, Suh CH, Asch A, Cameron PU, Hodtsev AS, Posnett DN. Human immunodeficiency virus 1 reservoir in CD4+ T cells is restricted to certain V beta subsets. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5563-7. PMID: 7777548; PMCID: PMC41736.
    31. Rafii S, Shapiro F, Rimarachin J, Nachman RL, Ferris B, Weksler B, Moore MA, Asch AS. Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion. Blood. 1994 Jul 01; 84(1):10-9. PMID: 7517203.
      View in: PubMed
    32. Asch AS, Liu I, Briccetti FM, Barnwell JW, Kwakye-Berko F, Dokun A, Goldberger J, Pernambuco M. Analysis of CD36 binding domains: ligand specificity controlled by dephosphorylation of an ectodomain. Science. 1993 Nov 26; 262(5138):1436-40. PMID: 7504322.
      View in: PubMed
    33. Posnett DN, Kabak S, Hodtsev AS, Goldberg EA, Asch A. T-cell antigen receptor V beta subsets are not preferentially deleted in AIDS. AIDS. 1993 May; 7(5):625-31. PMID: 8318171.
      View in: PubMed
    34. Asch AS, Silbiger S, Heimer E, Nachman RL. Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding. Biochem Biophys Res Commun. 1992 Feb 14; 182(3):1208-17. PMID: 1371676.
      View in: PubMed
    35. Asch AS, Tepler J, Silbiger S, Nachman RL. Cellular attachment to thrombospondin. Cooperative interactions between receptor systems. J Biol Chem. 1991 Jan 25; 266(3):1740-5. PMID: 1703153.
      View in: PubMed
    36. Konkle BA, Shapiro SS, Asch AS, Nachman RL. Cytokine-enhanced expression of glycoprotein Ib alpha in human endothelium. J Biol Chem. 1990 Nov 15; 265(32):19833-8. PMID: 2123191.
      View in: PubMed
    37. Barnwell JW, Asch AS, Nachman RL, Yamaya M, Aikawa M, Ingravallo P. A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes. J Clin Invest. 1989 Sep; 84(3):765-72. PMID: 2474574; PMCID: PMC329717.
    38. Nathan C, Srimal S, Farber C, Sanchez E, Kabbash L, Asch A, Gailit J, Wright SD. Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J Cell Biol. 1989 Sep; 109(3):1341-9. PMID: 2475511; PMCID: PMC2115779.
    39. Silverstein RL, Asch AS, Nachman RL. Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. J Clin Invest. 1989 Aug; 84(2):546-52. PMID: 2474571; PMCID: PMC548914.
    40. Asch AS, Nachman RL. Thrombospondin: phenomenology to function. Prog Hemost Thromb. 1989; 9:157-76. PMID: 2464182.
      View in: PubMed
    41. Asch AS, Adelman B, Fujimoto M, Nachman RL. Identification and isolation of a platelet GPIb-like protein in human umbilical vein endothelial cells and bovine aortic smooth muscle cells. J Clin Invest. 1988 May; 81(5):1600-7. PMID: 3284916; PMCID: PMC442595.
    42. Asch AS, Barnwell J, Silverstein RL, Nachman RL. Isolation of the thrombospondin membrane receptor. J Clin Invest. 1987 Apr; 79(4):1054-61. PMID: 2435757; PMCID: PMC424283.
    43. Asch AS, Leung LL, Shapiro J, Nachman RL. Human brain glial cells synthesize thrombospondin. Proc Natl Acad Sci U S A. 1986 May; 83(9):2904-8. PMID: 2939460; PMCID: PMC323415.
    44. Asch AS, Kinoshita T, Jaffe EA, Nussenzweig V. Decay-accelerating factor is present on cultured human umbilical vein endothelial cells. J Exp Med. 1986 Jan 01; 163(1):221-6. PMID: 2416869; PMCID: PMC2188008.
    45. Asch AS, Leung LL, Polley MJ, Nachman RL. Platelet membrane topography: colocalization of thrombospondin and fibrinogen with the glycoprotein IIb-IIIa complex. Blood. 1985 Oct; 66(4):926-34. PMID: 2994782.
      View in: PubMed
    46. Nachmias VT, Sullender J, Fallon J, Asch A. Observations on the "cytoskeleton" of human platelets. Thromb Haemost. 1980 Feb 29; 42(5):1661-6. PMID: 6154324.
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    47. Nachmias V, Sullender J, Asch A. Shape and cytoplasmic filaments in control and lidocaine-treated human platelets. Blood. 1977 Jul; 50(1):39-53. PMID: 871525.
      View in: PubMed
    48. Nachmias VT, Asch A. A calcium-sensitive preparation from Physarum polycephalum. Biochemistry. 1976 Sep 21; 15(19):4273-8. PMID: 134744.
      View in: PubMed
    49. Nachmias V, Asch A. Actin mediated calcium dependency of actomyosin in a myxomycete. Biochem Biophys Res Commun. 1974 Sep 23; 60(2):656-64. PMID: 4278827.
      View in: PubMed
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