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Hong Liu

TitleAcademic Director
InstitutionUniversity of Oklahoma, Norman
DepartmentElectrical and Computer Engineering
Phone405/325-4286
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    Collapse Biography 
    Collapse education and training
    Beijing Institute of Posts & Telecommunications, Beijing, CHINAMS1982Applied Physics
    Worcester Polytechnic Institute, Worcester, MAPhD1992Biomedical Engineering

    Collapse Research 
    Collapse research activities and funding
    R01CA197150     (ZHENG, BIN)Jul 7, 2015 - Jun 30, 2020
    NIH
    Increasing Cancer Detection Yield Using Breast MRI Screening Modality
    Role: Co-Investigator
    R01CA193378     (LIU, HONG)Apr 1, 2015 - Mar 31, 2020
    NIH
    Clinical Translation of High Energy Phase-Sensitive X-ray Breast Tomosynthesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zargari A, Du Y, Heidari M, Thai TC, Gunderson CC, Moore K, Mannel RS, Liu H, Zheng B, Qiu Y. Prediction of chemotherapy response in ovarian cancer patients using a new clustered quantitative image marker. Phys Med Biol. 2018 Aug 06; 63(15):155020. PMID: 30010611.
      View in: PubMed
    2. Du Y, Zhang R, Zargari A, Thai TC, Gunderson CC, Moxley KM, Liu H, Zheng B, Qiu Y. Classification of Tumor Epithelium and Stroma by Exploiting Image Features Learned by Deep Convolutional Neural Networks. Ann Biomed Eng. 2018 Dec; 46(12):1988-1999. PMID: 30051247.
      View in: PubMed
    3. Mirniaharikandehei S, Hollingsworth AB, Patel B, Heidari M, Liu H, Zheng B. Applying a new computer-aided detection scheme generated imaging marker to predict short-term breast cancer risk. Phys Med Biol. 2018 05 15; 63(10):105005. PMID: 29667606.
      View in: PubMed
    4. Ghani MU, Wong MD, Omoumi FH, Zheng B, Fajardo LL, Yan A, Wu X, Liu H. Detectability comparison of simulated tumors in digital breast tomosynthesis using high-energy X-ray inline phase sensitive and commercial imaging systems. Phys Med. 2018 Mar; 47:34-41. PMID: 29609816.
      View in: PubMed
    5. Heidari M, Khuzani AZ, Hollingsworth AB, Danala G, Mirniaharikandehei S, Qiu Y, Liu H, Zheng B. Prediction of breast cancer risk using a machine learning approach embedded with a locality preserving projection algorithm. Phys Med Biol. 2018 01 30; 63(3):035020. PMID: 29239858.
      View in: PubMed
    6. Ren L, Zheng B, Liu H. Tutorial on X-ray photon counting detector characterization. J Xray Sci Technol. 2018; 26(1):1-28. PMID: 29154310.
      View in: PubMed
    7. Wu D, Wong MD, Li Y, Fajardo L, Zheng B, Wu X, Liu H. Quantitative investigation of the edge enhancement in in-line phase contrast projections and tomosynthesis provided by distributing microbubbles on the interface between two tissues: a phantom study. Phys Med Biol. 2017 Nov 21; 62(24):9357-9376. PMID: 29161236.
      View in: PubMed
    8. Danala G, Thai T, Gunderson CC, Moxley KM, Moore K, Mannel RS, Liu H, Zheng B, Qiu Y. Applying Quantitative CT Image Feature Analysis to Predict Response of Ovarian Cancer Patients to Chemotherapy. Acad Radiol. 2017 10; 24(10):1233-1239. PMID: 28554551.
      View in: PubMed
    9. Ghani MU, Wong MD, Wu D, Zheng B, Fajardo LL, Yan A, Fuh J, Wu X, Liu H. Detectability comparison between a high energy x-ray phase sensitive and mammography systems in imaging phantoms with varying glandular-adipose ratios. Phys Med Biol. 2017 05 07; 62(9):3523-3538. PMID: 28379851.
      View in: PubMed
    10. Wang Y, Qiu Y, Thai T, Moore K, Liu H, Zheng B. A two-step convolutional neural network based computer-aided detection scheme for automatically segmenting adipose tissue volume depicting on CT images. Comput Methods Programs Biomed. 2017 Jun; 144:97-104. PMID: 28495009.
      View in: PubMed
    11. Ghani MU, Wong MD, Ren L, Wu D, Zheng B, Rong JX, Wu X, Liu H. Characterization of Continuous and Pulsed Emission modes of a Hybrid Micro Focus X-ray Source for Medical Imaging Applications. Nucl Instrum Methods Phys Res A. 2017 May 01; 853:70-77. PMID: 28959083.
      View in: PubMed
    12. Qiu Y, Yan S, Gundreddy RR, Wang Y, Cheng S, Liu H, Zheng B. A new approach to develop computer-aided diagnosis scheme of breast mass classification using deep learning technology. J Xray Sci Technol. 2017; 25(5):751-763. PMID: 28436410.
      View in: PubMed
    13. Ghani MU, Ren L, Wong M, Li Y, Zheng B, Rong XJ, Yang K, Liu H. Noise Power Characteristics of a Micro-Computed Tomography System. J Comput Assist Tomogr. 2017 Jan; 41(1):82-89. PMID: 27680419.
      View in: PubMed
    14. Wang Y, Qiu Y, Thai T, Moore K, Liu H, Zheng B. Applying a computer-aided scheme to detect a new radiographic image marker for prediction of chemotherapy outcome. BMC Med Imaging. 2016 08 31; 16(1):52. PMID: 27581075.
      View in: PubMed
    15. Ren L, Wu D, Li Y, Zheng B, Chen Y, Yang K, Liu H. Practical alignment method for X-ray spectral measurement in micro-CT system based on 3D printing technology. Biomed Phys Eng Express. 2016 Jun; 2(3). PMID: 27777787.
      View in: PubMed
    16. Wang Y, Thai T, Moore K, Ding K, McMeekin S, Liu H, Zheng B. Quantitative measurement of adiposity using CT images to predict the benefit of bevacizumab-based chemotherapy in epithelial ovarian cancer patients. Oncol Lett. 2016 Jul; 12(1):680-686. PMID: 27347200.
      View in: PubMed
    17. Ghani MU, Zhou Z, Ren L, Li Y, Zheng B, Yang K, Liu H. Investigation of spatial resolution characteristics of an in vivo micro computed tomography system. Nucl Instrum Methods Phys Res A. 2016 Jan 21; 807:129-136. PMID: 26640309.
      View in: PubMed
    18. Ren L, Ghani MU, Wu D, Zheng B, Chen Y, Yang K, Wu X, Liu H. The impact of spectral filtration on image quality in micro-CT system. J Appl Clin Med Phys. 2016 01 08; 17(1):301-315. PMID: 26894340.
      View in: PubMed
    19. Qiu Y, Tan M, McMeekin S, Thai T, Ding K, Moore K, Liu H, Zheng B. Early prediction of clinical benefit of treating ovarian cancer using quantitative CT image feature analysis. Acta Radiol. 2016 Sep; 57(9):1149-55. PMID: 26663390.
      View in: PubMed
    20. Fu Q, Liu HL, Wu Z, Liu A, Yao C, Li X, Xiao W, Yu S, Luo Z, Tang Y. Rough surface Au@Ag core-shell nanoparticles to fabricating high sensitivity SERS immunochromatographic sensors. J Nanobiotechnology. 2015 Nov 14; 13:81. PMID: 26577252.
      View in: PubMed
    21. Aghaei F, Tan M, Hollingsworth AB, Qian W, Liu H, Zheng B. Computer-aided breast MR image feature analysis for prediction of tumor response to chemotherapy. Med Phys. 2015 Nov; 42(11):6520-8. PMID: 26520742.
      View in: PubMed
    22. Gundreddy RR, Tan M, Qiu Y, Cheng S, Liu H, Zheng B. Assessment of performance and reproducibility of applying a content-based image retrieval scheme for classification of breast lesions. Med Phys. 2015 Jul; 42(7):4241-9. PMID: 26133622.
      View in: PubMed
    23. Yan A, Wu X, Liu H. A general theory of interference fringes in x-ray phase grating imaging. Med Phys. 2015 Jun; 42(6):3036-47. PMID: 26127056.
      View in: PubMed
    24. Tan M, Qian W, Pu J, Liu H, Zheng B. A new approach to develop computer-aided detection schemes of digital mammograms. Phys Med Biol. 2015 Jun 07; 60(11):4413-27. PMID: 25984710.
      View in: PubMed
    25. Wu D, Yan A, Li Y, Wong MD, Zheng B, Wu X, Liu H. Characterization of a high-energy in-line phase contrast tomosynthesis prototype. Med Phys. 2015 May; 42(5):2404-20. PMID: 25979035.
      View in: PubMed
    26. Tan M, Pu J, Cheng S, Liu H, Zheng B. Assessment of a Four-View Mammographic Image Feature Based Fusion Model to Predict Near-Term Breast Cancer Risk. Ann Biomed Eng. 2015 Oct; 43(10):2416-28. PMID: 25851469.
      View in: PubMed
    27. Hou C, Liu H, Zhang J, Zhang S, Yang F, Zeng X, Thacker PA, Zhang G, Qiao S. Intestinal microbiota succession and immunomodulatory consequences after introduction of Lactobacillus reuteri I5007 in neonatal piglets. PLoS One. 2015; 10(3):e0119505. PMID: 25775260.
      View in: PubMed
    28. Zhou Z, Gao F, Zhao H, Zhang L, Ren L, Li Z, Ghani MU, Hao T, Liu H. Improving the accuracy of MTF measurement at low frequencies based on oversampled edge spread function deconvolution. J Xray Sci Technol. 2015; 23(4):517-29. PMID: 26410662.
      View in: PubMed
    29. Ghani MU, Yan A, Wong MD, Li Y, Ren L, Wu X, Liu H. Low dose high energy x-ray in-line phase sensitive imaging prototype: Investigation of optimal geometric conditions and design parameters. J Xray Sci Technol. 2015; 23(6):667-82. PMID: 26756405.
      View in: PubMed
    30. Qiu Y, Song J, Lu X, Li Y, Zheng B, Li S, Liu H. Feature selection for the automated detection of metaphase chromosomes: performance comparison using a receiver operating characteristic method. Anal Cell Pathol (Amst). 2014; 2014:565392. PMID: 25763334.
      View in: PubMed
    31. Wong MD, Yan A, Ghani M, Li Y, Fajardo L, Wu X, Liu H. Dose and detectability improvements with high energy phase sensitive x-ray imaging in comparison to low energy conventional imaging. Phys Med Biol. 2014 May 07; 59(9):N37-48. PMID: 24732108.
      View in: PubMed
    32. Ren L, Wu D, Li Y, Wang G, Wu X, Liu H. Three-dimensional x-ray fluorescence mapping of a gold nanoparticle-loaded phantom. Med Phys. 2014 Mar; 41(3):031902. PMID: 24593720.
      View in: PubMed
    33. Ren L, Wu D, Fajardo LL, Li Y, Zheng B, Liu H. Detection of posteriorly located breast tumors using gold nanoparticles: a breast-mimicking phantom study. J Xray Sci Technol. 2014; 22(6):785-96. PMID: 25408395.
      View in: PubMed
    34. Wong MD, Wu X, Liu H. Image quality and dose efficiency of high energy phase sensitive x-ray imaging: phantom studies. J Xray Sci Technol. 2014; 22(3):321-34. PMID: 24865208.
      View in: PubMed
    35. Wu D, Li Y, Wong MD, Liu H. A method of measuring gold nanoparticle concentrations by X-ray fluorescence for biomedical applications. Med Phys. 2013 May; 40(5):051901. PMID: 23635271.
      View in: PubMed
    36. Qiu Y, Chen X, Li Y, Chen WR, Zheng B, Li S, Liu H. Evaluations of auto-focusing methods under a microscopic imaging modality for metaphase chromosome image analysis. Anal Cell Pathol (Amst). 2013; 36(1-2):37-44. PMID: 23629477.
      View in: PubMed
    37. Li Z, Chen X, Ren L, Song J, Li Y, Zheng B, Liu H. Simultaneous dual-color fluorescence microscope: a characterization study. Anal Cell Pathol (Amst). 2013; 36(5-6):163-72. PMID: 24844533.
      View in: PubMed
    38. Ren L, Li Z, Li Y, Zheng B, Li S, Chen X, Liu H. The impact of the condenser on cytogenetic image quality in digital microscope system. Anal Cell Pathol (Amst). 2013; 36(1-2):45-59. PMID: 23676284.
      View in: PubMed
    39. Qiu Y, Chen X, Li Y, Zheng B, Li S, Chen WR, Liu H. Impact of the optical depth of field on cytogenetic image quality. J Biomed Opt. 2012 Sep; 17(9):96017-1. PMID: 23085918.
      View in: PubMed
    40. Le K, Li X, Figueroa D, Towner RA, Garteiser P, Saunders D, Smith N, Liu H, Hode T, Nordquist RE, Chen WR. Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method. J Biomed Opt. 2011 Dec; 16(12):128001. PMID: 22191937.
      View in: PubMed
    41. Wong MD, Wu X, Liu H. The effects of x-ray beam hardening on detective quantum efficiency and radiation dose. J Xray Sci Technol. 2011; 19(4):509-19. PMID: 25214383.
      View in: PubMed
    42. Meng F, Zhang D, Wu X, Liu H. A comparison of iterative algorithms and a mixed approach for in-line x-ray phase retrieval. Opt Commun. 2009 Aug 15; 282(16):3392-3396. PMID: 20161234.
      View in: PubMed
    43. Wang X, Zheng B, Li S, Zhang R, Mulvihill JJ, Chen WR, Liu H. Automated detection and analysis of fluorescent in situ hybridization spots depicted in digital microscopic images of Pap-smear specimens. J Biomed Opt. 2009 Mar-Apr; 14(2):021002. PMID: 19405715.
      View in: PubMed
    44. Meng F, Liu H, Wu X. Feasibility study of the iterative x-ray phase retrieval algorithm. Appl Opt. 2009 Jan 01; 48(1):91-8. PMID: 19107177.
      View in: PubMed
    45. Donovan M, Zhang D, Liu H. Step by step analysis toward optimal MTF algorithm using an edge test device. J Xray Sci Technol. 2009; 17(1):1-15. PMID: 19644210.
      View in: PubMed
    46. Da Z, Donovan M, Wu X, Liu H. A convenient alignment approach for x-ray imaging experiments based on laser positioning devices. Med Phys. 2008 Nov; 35(11):4907-10. PMID: 19070224.
      View in: PubMed
    47. Wang X, Zheng B, Li S, Mulvihill JJ, Liu H. Development and Assessment of an Integrated Computer-Aided Detection Scheme for Digital Microscopic Images of Metaphase Chromosomes. J Electron Imaging. 2008 Oct 01; 17(4). PMID: 23087585.
      View in: PubMed
    48. Zhang D, Donovan M, Fajardo LL, Archer A, Wu X, Liu H. Preliminary feasibility study of an in-line phase contrast X-ray imaging prototype. IEEE Trans Biomed Eng. 2008 Sep; 55(9):2249-57. PMID: 18713694.
      View in: PubMed
    49. Zhang D, Liu H, Wu X. DQE analysis on a dual detector phase x-ray imaging system. Phys Med Biol. 2008 Sep 21; 53(18):5165-76. PMID: 18723931.
      View in: PubMed
    50. Chen Y, Gnyawali SC, Wu F, Liu H, Tesiram YA, Abbott A, Towner RA, Chen WR. Magnetic resonance imaging guidance for laser photothermal therapy. J Biomed Opt. 2008 Jul-Aug; 13(4):044033. PMID: 19021360.
      View in: PubMed
    51. Wang X, Zheng B, Li S, Mulvihill JJ, Wood MC, Liu H. Automated classification of metaphase chromosomes: optimization of an adaptive computerized scheme. J Biomed Inform. 2009 Feb; 42(1):22-31. PMID: 18585097.
      View in: PubMed
    52. Wang X, Zheng B, Li S, Mulvihill JJ, Liu H. A rule-based computer scheme for centromere identification and polarity assignment of metaphase chromosomes. Comput Methods Programs Biomed. 2008 Jan; 89(1):33-42. PMID: 18082909.
      View in: PubMed
    53. Gnyawali SC, Chen Y, Wu F, Bartels KE, Wicksted JP, Liu H, Sen CK, Chen WR. Temperature measurement on tissue surface during laser irradiation. Med Biol Eng Comput. 2008 Feb; 46(2):159-68. PMID: 17891430.
      View in: PubMed
    54. Wang X, Li S, Liu H, Wood M, Chen WR, Zheng B. Automated identification of analyzable metaphase chromosomes depicted on microscopic digital images. J Biomed Inform. 2008 Apr; 41(2):264-71. PMID: 17681496.
      View in: PubMed
    55. Zhang D, Rong J, Chen WR, Gao F, Xu K, Wu X, Liu H. Impact of additive noise on system performance of a digital X-ray imaging system. IEEE Trans Biomed Eng. 2007 Jan; 54(1):69-73. PMID: 17260857.
      View in: PubMed
    56. Wang X, Li S, Liu H, Mulvihill JJ, Chen W, Zheng B. A computer-aided method to expedite the evaluation of prognosis for childhood acute lymphoblastic leukemia. Technol Cancer Res Treat. 2006 Aug; 5(4):429-36. PMID: 16866573.
      View in: PubMed
    57. Zhang Q, Rong J, Wu X, Li Y, Chen WR, Liu H. Impacts of Filtration on Contrast-Detail Detectability of an X-ray Imaging System. Int J Biomed Imaging. 2006; 2006:95754. PMID: 23165063.
      View in: PubMed
    58. Patterson E, Lazzara R, Szabo B, Liu H, Tang D, Li YH, Scherlag BJ, Po SS. Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins. J Am Coll Cardiol. 2006 Mar 21; 47(6):1196-206. PMID: 16545652.
      View in: PubMed
    59. Chen WR, Huang Z, Korbelik M, Nordquist RE, Liu H. Photoimmunotherapy for cancer treatment. J Environ Pathol Toxicol Oncol. 2006; 25(1-2):281-91. PMID: 16566724.
      View in: PubMed
    60. Po SS, Li Y, Tang D, Liu H, Geng N, Jackman WM, Scherlag B, Lazzara R, Patterson E. Rapid and stable re-entry within the pulmonary vein as a mechanism initiating paroxysmal atrial fibrillation. J Am Coll Cardiol. 2005 Jun 07; 45(11):1871-7. PMID: 15936621.
      View in: PubMed
    61. Tang D, Li Y, Wong J, Po S, Patterson E, Chen WR, Jackman W, Liu H. Characteristics of a charged-coupled-device-based optical mapping system for the study of cardiac arrhythmias. J Biomed Opt. 2005 Mar-Apr; 10(2):024009. PMID: 15910083.
      View in: PubMed
    62. Chen WR, Korbelik M, Bartels KE, Liu H, Sun J, Nordquist RE. Enhancement of laser cancer treatment by a chitosan-derived immunoadjuvant. Photochem Photobiol. 2005 Jan-Feb; 81(1):190-5. PMID: 15535737.
      View in: PubMed
    63. Chen WR, Jeong SW, Lucroy MD, Wolf RF, Howard EW, Liu H, Nordquist RE. Induced antitumor immunity against DMBA-4 metastatic mammary tumors in rats using laser immunotherapy. Int J Cancer. 2003 Dec 20; 107(6):1053-7. PMID: 14601069.
      View in: PubMed
    64. Chen WR, Carubelli R, Liu H, Nordquist RE. Detection of anti-tumor immunity induced by laser immunotherapy. Mol Biotechnol. 2003 Sep; 25(1):45-52. PMID: 13679634.
      View in: PubMed
    65. Chen WR, Carubelli R, Liu H, Nordquist RE. Laser immunotherapy: a novel treatment modality for metastatic tumors. Mol Biotechnol. 2003 Sep; 25(1):37-44. PMID: 13679633.
      View in: PubMed
    66. Ishmael DR, Chen WR, Nordquist JA, Liu H, Nordquist RE. Synergistic effect of sequential administration of mitoguazone (MGBG) and gemcitabine in treating tissue cultured human breast cancer cells and mammary rat tumors. Cancer Invest. 2003 Apr; 21(2):217-26. PMID: 12743987.
      View in: PubMed
    67. Ishmael DR, Chen WR, Hamilton SA, Liu H, Nordquist RE. A phase I human trial of mitoguazone and gemcitabine sequential bi-weekly treatment of cancer patients. Cancer Invest. 2003; 21(4):542-9. PMID: 14533444.
      View in: PubMed
    68. Jiang H, Chen WR, Liu H. Techniques to improve the accuracy and to reduce the variance in noise power spectrum measurement. IEEE Trans Biomed Eng. 2002 Nov; 49(11):1270-8. PMID: 12450357.
      View in: PubMed
    69. Chen WR, Liu H, Ritchey JW, Bartels KE, Lucroy MD, Nordquist RE. Effect of different components of laser immunotherapy in treatment of metastatic tumors in rats. Cancer Res. 2002 Aug 01; 62(15):4295-9. PMID: 12154032.
      View in: PubMed
    70. Ouandji F, Potter E, Chen WR, Li Y, Tang D, Liu H. Characterization of a CCD-based digital x-ray imaging system for small-animal studies: properties of spatial resolution. Appl Opt. 2002 May 01; 41(13):2420-7. PMID: 12009151.
      View in: PubMed
    71. Li Y, Chen WR, Zhang Y, Qian W, Liu H. Comparison of analog and digital Fourier transforms in medical image analysis. J Biomed Opt. 2002 Apr; 7(2):255-61. PMID: 11966312.
      View in: PubMed
    72. Chen WR, Liu H, Carubelli R, Nordquist RE. Synergistic effect of photothermal and photoimmunological reactions in treatment of metastatic tumors. J Xray Sci Technol. 2002 Jan 01; 10(3):225-35. PMID: 22388051.
      View in: PubMed
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