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Lucila Garcia-Contreras

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
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    Collapse Biography 
    Collapse education and training
    University of Georgia, Athens, GAMSc1995Pharmaceutics
    University of Georgia, Athens, GADrPH1999Pharmaceutical and Biomedical Sciences
    University of North Carolina, Chapel Hill, NCPostdoc2003Postdoc Fellowship

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ibrahim M, Hatipoglu MK, Garcia-Contreras L. Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration. AAPS PharmSciTech. 2019 Jan 02; 20(1):20. PMID: 30604109.
      View in: PubMed
    2. Mahjabeen S, Hatipoglu MK, Benbrook DM, Garcia-Contreras L. Pharmacokinetics and Pharmacodynamics of Escalating Doses of SHetA2 After Vaginal Administration to Mice. J Pharm Sci. 2018 Dec; 107(12):3179-3186. PMID: 30196041.
      View in: PubMed
    3. Kukut Hatipoglu M, Hickey AJ, Garcia-Contreras L. Pharmacokinetics and pharmacodynamics of high doses of inhaled dry powder drugs. Int J Pharm. 2018 Oct 05; 549(1-2):306-316. PMID: 30077761.
      View in: PubMed
    4. Mahjabeen S, Hatipoglu MK, Benbrook DM, Kosanke SD, Garcia-Contreras D, Garcia-Contreras L. Influence of the estrus cycle of the mouse on the disposition of SHetA2 after vaginal administration. Eur J Pharm Biopharm. 2018 Sep; 130:272-280. PMID: 30064701.
      View in: PubMed
    5. Benbrook DM, Janakiram NB, Chandra V, Pathuri G, Madka V, Stratton NC, Masamha CP, Farnsworth CN, Garcia-Contreras L, Hatipoglu MK, Lighfoot S, Rao CV. Development of a dietary formulation of the SHetA2 chemoprevention drug for mice. Invest New Drugs. 2018 08; 36(4):561-570. PMID: 29273857.
      View in: PubMed
    6. Ibrahim M, Hatipoglu MK, Garcia-Contreras L. SHetA2 Dry Powder Aerosols for Tuberculosis: Formulation, Design, and Optimization Using Quality by Design. Mol Pharm. 2018 01 02; 15(1):300-313. PMID: 29219321.
      View in: PubMed
    7. Mahjabeen S, Hatipoglu MK, Chandra V, Benbrook DM, Garcia-Contreras L. Optimization of a Vaginal Suppository Formulation to Deliver SHetA2 as a Novel Treatment for Cervical Dysplasia. J Pharm Sci. 2018 02; 107(2):638-646. PMID: 28989018.
      View in: PubMed
    8. Garcia-Contreras L, Padilla-Carlin DJ, Sung J, VerBerkmoes J, Muttil P, Elbert K, Peloquin C, Edwards D, Hickey A. Pharmacokinetics of Ethionamide Delivered in Spray-Dried Microparticles to the Lungs of Guinea Pigs. J Pharm Sci. 2017 01; 106(1):331-337. PMID: 27842973.
      View in: PubMed
    9. Ibrahim M, Verma R, Garcia-Contreras L. Inhalation drug delivery devices: technology update. Med Devices (Auckl). 2015; 8:131-9. PMID: 25709510; PMCID: PMC4334339.
    10. Garcia-Contreras L, Yadav KS. Inhaled Formulation Design for the Treatment of Lung Infections. Curr Pharm Des. 2015; 21(27):3875-901. PMID: 26290199.
      View in: PubMed
    11. Hanif SN, Hickey AJ, Garcia-Contreras L. Liquid chromatographic determination of CPZEN-45, a novel anti-tubercular drug, in biological samples. J Pharm Biomed Anal. 2014 Jan; 88:370-6. PMID: 24176740; PMCID: PMC4026256.
    12. Ibrahim M, Garcia-Contreras L. Mechanisms of absorption and elimination of drugs administered by inhalation. Ther Deliv. 2013 Aug; 4(8):1027-45. PMID: 23919477.
      View in: PubMed
    13. Garcia-Contreras L, Ibrahim M. Implications of increased nanoparticle absorption by infant lungs: future prospects. Ther Deliv. 2013 Apr; 4(4):417-20. PMID: 23557280.
      View in: PubMed
    14. Hanif SN, Garcia-Contreras L. Pharmaceutical aerosols for the treatment and prevention of tuberculosis. Front Cell Infect Microbiol. 2012; 2:118. PMID: 22973562; PMCID: PMC3435512.
    15. Garcia-Contreras L, Muttil P, Fallon JK, Kabadi M, Gerety R, Hickey AJ. Pharmacokinetics of sequential doses of capreomycin powder for inhalation in guinea pigs. Antimicrob Agents Chemother. 2012 May; 56(5):2612-8. PMID: 22330920; PMCID: PMC3346614.
    16. Wang C, Garcia-Contreras L, Muttil P, Hickey AJ. Isoxyl assays in plasma. J Pharm Biomed Anal. 2012 Feb 23; 60:1-6. PMID: 22119164.
      View in: PubMed
    17. Muttil P, Pulliam B, Garcia-Contreras L, Fallon JK, Wang C, Hickey AJ, Edwards DA. Pulmonary immunization of guinea pigs with diphtheria CRM-197 antigen as nanoparticle aggregate dry powders enhance local and systemic immune responses. AAPS J. 2010 Dec; 12(4):699-707. PMID: 20878294; PMCID: PMC2976983.
    18. Lu D, Garcia-Contreras L, Muttil P, Padilla D, Xu D, Liu J, Braunstein M, McMurray DN, Hickey AJ. Pulmonary immunization using antigen 85-B polymeric microparticles to boost tuberculosis immunity. AAPS J. 2010 Sep; 12(3):338-47. PMID: 20422340; PMCID: PMC2895436.
    19. Muttil P, Prego C, Garcia-Contreras L, Pulliam B, Fallon JK, Wang C, Hickey AJ, Edwards D. Immunization of guinea pigs with novel hepatitis B antigen as nanoparticle aggregate powders administered by the pulmonary route. AAPS J. 2010 Sep; 12(3):330-7. PMID: 20419360; PMCID: PMC2895445.
    20. Garcia-Contreras L, Sung JC, Muttil P, Padilla D, Telko M, Verberkmoes JL, Elbert KJ, Hickey AJ, Edwards DA. Dry powder PA-824 aerosols for treatment of tuberculosis in guinea pigs. Antimicrob Agents Chemother. 2010 Apr; 54(4):1436-42. PMID: 20086154; PMCID: PMC2849359.
    21. Sung JC, Padilla DJ, Garcia-Contreras L, Verberkmoes JL, Durbin D, Peloquin CA, Elbert KJ, Hickey AJ, Edwards DA. Formulation and pharmacokinetics of self-assembled rifampicin nanoparticle systems for pulmonary delivery. Pharm Res. 2009 Aug; 26(8):1847-55. PMID: 19407933.
      View in: PubMed
    22. Wang C, Muttil P, Lu D, Beltran-Torres AA, Garcia-Contreras L, Hickey AJ. Screening for potential adjuvants administered by the pulmonary route for tuberculosis vaccines. AAPS J. 2009 Mar; 11(1):139-47. PMID: 19277872; PMCID: PMC2664889.
    23. Sung JC, Garcia-Contreras L, Verberkmoes JL, Peloquin CA, Elbert KJ, Hickey AJ, Edwards DA. Dry powder nitroimidazopyran antibiotic PA-824 aerosol for inhalation. Antimicrob Agents Chemother. 2009 Apr; 53(4):1338-43. PMID: 19139288; PMCID: PMC2663128.
    24. Garcia-Contreras L, Wong YL, Muttil P, Padilla D, Sadoff J, Derousse J, Germishuizen WA, Goonesekera S, Elbert K, Bloom BR, Miller R, Fourie PB, Hickey A, Edwards D. Immunization by a bacterial aerosol. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4656-60. PMID: 18344320; PMCID: PMC2290758.
    25. Cryan SA, Sivadas N, Garcia-Contreras L. In vivo animal models for drug delivery across the lung mucosal barrier. Adv Drug Deliv Rev. 2007 Sep 30; 59(11):1133-51. PMID: 17900750.
      View in: PubMed
    26. Fiegel J, Garcia-Contreras L, Thomas M, VerBerkmoes J, Elbert K, Hickey A, Edwards D. Preparation and in vivo evaluation of a dry powder for inhalation of capreomycin. Pharm Res. 2008 Apr; 25(4):805-11. PMID: 17657592.
      View in: PubMed
    27. Lu D, Garcia-Contreras L, Xu D, Kurtz SL, Liu J, Braunstein M, McMurray DN, Hickey AJ. Poly (lactide-co-glycolide) microspheres in respirable sizes enhance an in vitro T cell response to recombinant Mycobacterium tuberculosis antigen 85B. Pharm Res. 2007 Oct; 24(10):1834-43. PMID: 17657598.
      View in: PubMed
    28. Garcia-Contreras L, Fiegel J, Telko MJ, Elbert K, Hawi A, Thomas M, VerBerkmoes J, Germishuizen WA, Fourie PB, Hickey AJ, Edwards D. Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother. 2007 Aug; 51(8):2830-6. PMID: 17517845; PMCID: PMC1932523.
    29. Garcia-Contreras L, Sethuraman V, Kazantseva M, Godfrey V, Hickey AJ. Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig. J Antimicrob Chemother. 2006 Nov; 58(5):980-6. PMID: 16971416.
      View in: PubMed
    30. Garcia-Contreras L, Morçöl T, Bell SJ, Hickey AJ. Evaluation of novel particles as pulmonary delivery systems for insulin in rats. AAPS PharmSci. 2003; 5(2):E9. PMID: 12866936; PMCID: PMC2751517.
    31. Garcia-Contreras L, Hickey AJ. Aerosol treatment of cystic fibrosis. Crit Rev Ther Drug Carrier Syst. 2003; 20(5):317-56. PMID: 14959788.
      View in: PubMed
    32. Garcia-Contreras L, Hickey AJ. Pharmaceutical and biotechnological aerosols for cystic fibrosis therapy. Adv Drug Deliv Rev. 2002 Dec 05; 54(11):1491-504. PMID: 12458157.
      View in: PubMed
    33. Suarez S, Garcia-Contreras L, Sarubbi D, Flanders E, O'Toole D, Smart J, Hickey AJ. Facilitation of pulmonary insulin absorption by H-MAP: pharmacokinetics and pharmacodynamics in rats. Pharm Res. 2001 Dec; 18(12):1677-84. PMID: 11785686.
      View in: PubMed
    34. Garcia-Contreras L, Sarubbi D, Flanders E, O'Toole D, Smart J, Newcomer C, Hicke AJ. Immediate and short-term cellular and biochemical responses to pulmonary single-dose studies of insulin and H-MAP. Pharm Res. 2001 Dec; 18(12):1685-93. PMID: 11785687.
      View in: PubMed
    35. Hickey AJ, Garcia-Contreras L. Immunological and toxicological implications of short-term studies in animals of pharmaceutical aerosol delivery to the lungs: relevance to humans. Crit Rev Ther Drug Carrier Syst. 2001; 18(4):387-431. PMID: 11605897.
      View in: PubMed
    36. Abu-Izza K, Garcia-Contreras L, Lu DR. Preparation and evaluation of zidovudine-loaded sustained-release microspheres. 2. Optimization of multiple response variables. J Pharm Sci. 1996 Jun; 85(6):572-6. PMID: 8773951.
      View in: PubMed
    37. Abu-Izza KA, Garcia-Contreras L, Lu DR. Preparation and evaluation of sustained release AZT-loaded microspheres: optimization of the release characteristics using response surface methodology. J Pharm Sci. 1996 Feb; 85(2):144-9. PMID: 8683438.
      View in: PubMed
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