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Marie H Hanigan

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-3832
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    Collapse Research 
    Collapse research activities and funding
    R01CA057530     (HANIGAN, MARIE H)Aug 1, 1992 - Aug 31, 2009
    NIH/NCI
    Significance of GGT Expression in Tumors
    Role: Principal Investigator

    R56CA057530     (HANIGAN, MARIE H)Aug 1, 1992 - Aug 31, 2011
    NIH/NCI
    Significance of GGT Expression in Tumors
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Terzyan SS, Cook PF, Heroux A, Hanigan MH. Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation. Protein Sci. 2017 Jun; 26(6):1196-1205. PMID: 28378915.
      View in: PubMed
    2. Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86. PMID: 26013825; PMCID: PMC4498091.
    3. West MB, Partyka K, Feasley CL, Maupin KA, Goppallawa I, West CM, Haab BB, Hanigan MH. Detection of distinct glycosylation patterns on human ?-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology. BMC Biotechnol. 2014 Dec 06; 14:101. PMID: 25479762; PMCID: PMC4297448.
    4. Hanigan MH, Gillies EM, Wickham S, Wakeham N, Wirsig-Wiechmann CR. Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1. Histochem Cell Biol. 2015 May; 143(5):505-15. PMID: 25377544; PMCID: PMC4393757.
    5. Hanigan MH. Gamma-glutamyl transpeptidase: redox regulation and drug resistance. Adv Cancer Res. 2014; 122:103-41. PMID: 24974180; PMCID: PMC4388159.
    6. West MB, Chen Y, Wickham S, Heroux A, Cahill K, Hanigan MH, Mooers BH. Novel insights into eukaryotic ?-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem. 2013 Nov 01; 288(44):31902-13. PMID: 24047895; PMCID: PMC3814782.
    7. West MB, Wickham S, Parks EE, Sherry DM, Hanigan MH. Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling. Antioxid Redox Signal. 2013 Dec 01; 19(16):1877-88. PMID: 23682772; PMCID: PMC3852618.
    8. Wickham S, Regan N, West MB, Thai J, Cook PF, Terzyan SS, Li PK, Hanigan MH. Inhibition of human ?-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors. Biochem J. 2013 Mar 15; 450(3):547-57. PMID: 23301618; PMCID: PMC3836663.
    9. Cooper AJ, Hanigan MH. Food and Chemical Toxicology, 2011, 'Possible role of cysteine-S-conjugate ß-lyase in species differences in cisplatin nephrotoxicity', R. Katayama, S. Nagata, H. Iida, N. Yamagishi, T. Yamashita, K. Furuhama. Food Chem Toxicol. 2011 Dec; 49(12):3279-80. PMID: 21925563.
      View in: PubMed
    10. Wickham S, Regan N, West MB, Kumar VP, Thai J, Li PK, Cook PF, Hanigan MH. Divergent effects of compounds on the hydrolysis and transpeptidation reactions of ?-glutamyl transpeptidase. J Enzyme Inhib Med Chem. 2012 Aug; 27(4):476-89. PMID: 21864033; PMCID: PMC3407035.
    11. West MB, Wickham S, Quinalty LM, Pavlovicz RE, Li C, Hanigan MH. Autocatalytic cleavage of human gamma-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95. J Biol Chem. 2011 Aug 19; 286(33):28876-88. PMID: 21712391; PMCID: PMC3190695.
    12. Wickham S, West MB, Cook PF, Hanigan MH. Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15; 414(2):208-14. PMID: 21447318; PMCID: PMC3099546.
    13. Hanigan MH, Dela Cruz BL, Shord SS, Medina PJ, Fazili J, Thompson DM. Optimizing chemotherapy: concomitant medication lists. Clin Pharmacol Ther. 2011 Jan; 89(1):114-9. PMID: 21124312; PMCID: PMC3826435.
    14. West MB, Hanigan MH. ?-Glutamyl transpeptidase is a heavily N-glycosylated heterodimer in HepG2 cells. Arch Biochem Biophys. 2010 Dec 15; 504(2):177-81. PMID: 20831856; PMCID: PMC2965302.
    15. Zheng J, Lou JR, Zhang XX, Benbrook DM, Hanigan MH, Lind SE, Ding WQ. N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death. Cancer Lett. 2010 Dec 08; 298(2):186-94. PMID: 20667650; PMCID: PMC3881362.
    16. West MB, Segu ZM, Feasley CL, Kang P, Klouckova I, Li C, Novotny MV, West CM, Mechref Y, Hanigan MH. Analysis of site-specific glycosylation of renal and hepatic ?-glutamyl transpeptidase from normal human tissue. J Biol Chem. 2010 Sep 17; 285(38):29511-24. PMID: 20622017; PMCID: PMC2937983.
    17. Hanigan MH. Possible role of mammography in increased incidence of breast cancer not considered. Arch Intern Med. 2009 May 25; 169(10):998-9. PMID: 19468098.
      View in: PubMed
    18. King JB, West MB, Cook PF, Hanigan MH. A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase. J Biol Chem. 2009 Apr 03; 284(14):9059-65. PMID: 19203993; PMCID: PMC2666554.
    19. Hanigan MH. Over-the-counter medications and cancer patients: growing awareness of drug-drug interactions. Expert Opin Drug Metab Toxicol. 2009 Feb; 5(2):105-7. PMID: 19199376.
      View in: PubMed
    20. Hanigan MH, Townsend DM, Cooper AJ. Metabolism of cisplatin to a nephrotoxin. Toxicology. 2009 Mar 29; 257(3):174-5; author reply 176-7. PMID: 19135119; PMCID: PMC2708784.
    21. Hu L, Plafker K, Vorozhko V, Zuna RE, Hanigan MH, Gorbsky GJ, Plafker SM, Angeletti PC, Ceresa BP. Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology. 2009 Feb 05; 384(1):125-34. PMID: 19041112; PMCID: PMC2658674.
    22. Townsend DM, Tew KD, He L, King JB, Hanigan MH. Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity. Biomed Pharmacother. 2009 Feb; 63(2):79-85. PMID: 18819770; PMCID: PMC2667699.
    23. Hanigan MH, Dela Cruz BL, Thompson DM, Farmer KC, Medina PJ. Use of prescription and nonprescription medications and supplements by cancer patients during chemotherapy: questionnaire validation. J Oncol Pharm Pract. 2008 Sep; 14(3):123-30. PMID: 18719067; PMCID: PMC2656681.
    24. Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD. Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc. Cancer Res. 2008 Mar 15; 68(6):1636-46. PMID: 18339842.
      View in: PubMed
    25. Zhang L, Cooper AJ, Krasnikov BF, Xu H, Bubber P, Pinto JT, Gibson GE, Hanigan MH. Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells. Biochemistry. 2006 Jul 25; 45(29):8959-71. PMID: 16846239; PMCID: PMC4133109.
    26. Shord SS, Thompson DM, Krempl GA, Hanigan MH. Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer. Anticancer Drugs. 2006 Feb; 17(2):207-15. PMID: 16428940.
      View in: PubMed
    27. Zaman K, Hanigan MH, Smith A, Vaughan J, Macdonald T, Jones DR, Hunt JF, Gaston B. Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. Am J Respir Cell Mol Biol. 2006 Apr; 34(4):387-93. PMID: 16415251; PMCID: PMC2644202.
    28. Min J, Van Veldhoven PP, Zhang L, Hanigan MH, Alexander H, Alexander S. Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner. Mol Cancer Res. 2005 May; 3(5):287-96. PMID: 15886300.
      View in: PubMed
    29. Min J, Traynor D, Stegner AL, Zhang L, Hanigan MH, Alexander H, Alexander S. Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. Eukaryot Cell. 2005 Jan; 4(1):178-89. PMID: 15643073; PMCID: PMC544159.
    30. Hanigan MH, Deng M, Zhang L, Taylor PT, Lapus MG. Stress response inhibits the nephrotoxicity of cisplatin. Am J Physiol Renal Physiol. 2005 Jan; 288(1):F125-32. PMID: 15353400.
      View in: PubMed
    31. Townsend DM, Marto JA, Deng M, Macdonald TJ, Hanigan MH. High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin. Drug Metab Dispos. 2003 Jun; 31(6):705-13. PMID: 12756201.
      View in: PubMed
    32. Zhang L, Hanigan MH. Role of cysteine S-conjugate beta-lyase in the metabolism of cisplatin. J Pharmacol Exp Ther. 2003 Sep; 306(3):988-94. PMID: 12750429.
      View in: PubMed
    33. Townsend DM, Deng M, Zhang L, Lapus MG, Hanigan MH. Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells. J Am Soc Nephrol. 2003 Jan; 14(1):1-10. PMID: 12506132.
      View in: PubMed
    34. Hanigan MH, Devarajan P. Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther. 2003; 1:47-61. PMID: 18185852.
      View in: PubMed
    35. Townsend DM, Hanigan MH. Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice. J Pharmacol Exp Ther. 2002 Jan; 300(1):142-8. PMID: 11752109.
      View in: PubMed
    36. Hanigan MH, Lykissa ED, Townsend DM, Ou CN, Barrios R, Lieberman MW. Gamma-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin. Am J Pathol. 2001 Nov; 159(5):1889-94. PMID: 11696449; PMCID: PMC1867073.
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