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Mark M Huycke

TitleProf,Clin
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Infectious Diseases
Address921 NE 13th St
Oklahoma City OK 73104-5007
Phone405/923-1471
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    Collapse Research 
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    R01CA127893     (HUYCKE, MARK M)Jul 1, 2008 - May 31, 2014
    NIH/NCI
    Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chandrakesan P, May R, Weygant N, Qu D, Berry WL, Sureban SM, Ali N, Rao C, Huycke M, Bronze MS, Houchen CW. Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury. Sci Rep. 2016 Nov 23; 6:37667. PMID: 27876863.
      View in: PubMed
    2. Wang X, Yang Y, Huycke MM. Microbiome-driven carcinogenesis in colorectal cancer: Models and mechanisms. Free Radic Biol Med. 2017 Apr; 105:3-15. PMID: 27810411.
      View in: PubMed
    3. Yang Y, Huycke MM, Herman TS, Wang X. Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer. Oncogene. 2016 Nov 03; 35(44):5795-5806. PMID: 27065323.
      View in: PubMed
    4. Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, Cui Y, Li Y, McDaniel JM, McGee S, Chen W, Huycke MM, Houchen CW, Zenewicz LA, West CM, Chen H, Braun J, Fu J, Xia L. Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology. 2016 Jul; 151(1):152-164.e11. PMID: 27059389.
      View in: PubMed
    5. Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW. Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases. Oncotarget. 2015 Aug 21; 6(24):20327-44. PMID: 25948779; PMCID: PMC4653008.
    6. Wang X, Huycke MM. Colorectal cancer: role of commensal bacteria and bystander effects. Gut Microbes. 2015; 6(6):370-6. PMID: 26727419; PMCID: PMC4826092 [Available on 01/04/17].
    7. Wang X, Yang Y, Huycke MM. Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect. Gut. 2015 Mar; 64(3):459-68. PMID: 24906974; PMCID: PMC4345889.
    8. Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism. PLoS One. 2013; 8(11):e80304. PMID: 24260365; PMCID: PMC3833963.
    9. Yang Y, Wang X, Huycke T, Moore DR, Lightfoot SA, Huycke MM. Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect. Transl Oncol. 2013; 6(5):596-606. PMID: 24151540; PMCID: PMC3799201.
    10. Kurdgelashvili G, Dores GM, Srour SA, Chaturvedi AK, Huycke MM, Devesa SS. Incidence of potentially human papillomavirus-related neoplasms in the United States, 1978 to 2007. Cancer. 2013 Jun 15; 119(12):2291-9. PMID: 23580435; PMCID: PMC4567689.
    11. Wang X, Allen TD, Yang Y, Moore DR, Huycke MM. Cyclooxygenase-2 generates the endogenous mutagen trans-4-hydroxy-2-nonenal in Enterococcus faecalis-infected macrophages. Cancer Prev Res (Phila). 2013 Mar; 6(3):206-16. PMID: 23321929; PMCID: PMC3594346.
    12. Yang Y, Wang X, Moore DR, Lightfoot SA, Huycke MM. TNF-a mediates macrophage-induced bystander effects through Netrin-1. Cancer Res. 2012 Oct 15; 72(20):5219-29. PMID: 22915753; PMCID: PMC3473172.
    13. Benefield RJ, Drevets DA, Huycke MM, Gentry CA. A multicenter evaluation of the safety of drotrecogin alfa (activated) in patients with baseline bleeding precautions. Curr Drug Saf. 2012 Feb; 7(1):3-7. PMID: 22663949.
      View in: PubMed
    14. Wang X, Yang Y, Moore DR, Nimmo SL, Lightfoot SA, Huycke MM. 4-hydroxy-2-nonenal mediates genotoxicity and bystander effects caused by Enterococcus faecalis-infected macrophages. Gastroenterology. 2012 Mar; 142(3):543-551.e7. PMID: 22108198; PMCID: PMC3371374.
    15. Thompson JN, Huycke MM, Greenfield RA, Kurdgelashvili G, Gentry CA. Case-control study of statin prevention of mould infections. Mycoses. 2011 Sep; 54(5):e481-5. PMID: 21554419.
      View in: PubMed
    16. Dores GM, Huycke MM, Devesa SS. Melanoma of the skin and laterality. J Am Acad Dermatol. 2011 Jan; 64(1):193-5; author reply 195-6. PMID: 21167412; PMCID: PMC3011927.
    17. Ghabach B, Anderson WF, Curtis RE, Huycke MM, Lavigne JA, Dores GM. Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study. Breast Cancer Res. 2010; 12(4):R54. PMID: 20653964; PMCID: PMC2949643.
    18. Qubaiah O, Devesa SS, Platz CE, Huycke MM, Dores GM. Small intestinal cancer: a population-based study of incidence and survival patterns in the United States, 1992 to 2006. Cancer Epidemiol Biomarkers Prev. 2010 Aug; 19(8):1908-18. PMID: 20647399; PMCID: PMC2919612.
    19. Dores GM, Huycke MM, Devesa SS, Garcia CA. Primary cutaneous adenoid cystic carcinoma in the United States: incidence, survival, and associated cancers, 1976 to 2005. J Am Acad Dermatol. 2010 Jul; 63(1):71-8. PMID: 20447723; PMCID: PMC2885489.
    20. Floyd RA, Towner RA, Wu D, Abbott A, Cranford R, Branch D, Guo WX, Foster SB, Jones I, Alam R, Moore D, Allen T, Huycke M. Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer. Free Radic Res. 2010 Jan; 44(1):108-17. PMID: 19886748; PMCID: PMC2884269.
    21. Maggio-Price L, Treuting P, Bielefeldt-Ohmann H, Seamons A, Drivdahl R, Zeng W, Lai L, Huycke M, Phelps S, Brabb T, Iritani BM. Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. Am J Pathol. 2009 Jan; 174(1):317-29. PMID: 19119184; PMCID: PMC2631344.
    22. Wang X, Allen TD, May RJ, Lightfoot S, Houchen CW, Huycke MM. Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect. Cancer Res. 2008 Dec 01; 68(23):9909-17. PMID: 19047172; PMCID: PMC2596646.
    23. Allen TD, Moore DR, Wang X, Casu V, May R, Lerner MR, Houchen C, Brackett DJ, Huycke MM. Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression. J Med Microbiol. 2008 Oct; 57(Pt 10):1193-204. PMID: 18809545; PMCID: PMC2692828.
    24. Wang X, Huycke MM. Extracellular superoxide production by Enterococcus faecalis promotes chromosomal instability in mammalian cells. Gastroenterology. 2007 Feb; 132(2):551-61. PMID: 17258726.
      View in: PubMed
    25. Kim SC, Tonkonogy SL, Albright CA, Tsang J, Balish EJ, Braun J, Huycke MM, Sartor RB. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology. 2005 Apr; 128(4):891-906. PMID: 15825073.
      View in: PubMed
    26. Moore DR, Kotake Y, Huycke MM. Effects of iron and phytic acid on production of extracellular radicals by Enterococcus faecalis. Exp Biol Med (Maywood). 2004 Dec; 229(11):1186-95. PMID: 15564446.
      View in: PubMed
    27. Huycke MM, Gaskins HR. Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models. Exp Biol Med (Maywood). 2004 Jul; 229(7):586-97. PMID: 15229352.
      View in: PubMed
    28. Chu FF, Esworthy RS, Chu PG, Longmate JA, Huycke MM, Wilczynski S, Doroshow JH. Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res. 2004 Feb 01; 64(3):962-8. PMID: 14871826.
      View in: PubMed
    29. Bronze MS, Huycke MM, Greenfield RA. Terrorism symposium update and conclusion. J Okla State Med Assoc. 2003 Dec; 96(12):575-8. PMID: 14965028.
      View in: PubMed
    30. Lutz BD, Jin J, Rinaldi MG, Wickes BL, Huycke MM. Outbreak of invasive Aspergillus infection in surgical patients, associated with a contaminated air-handling system. Clin Infect Dis. 2003 Sep 15; 37(6):786-93. PMID: 12955639.
      View in: PubMed
    31. Huycke MM. Smallpox in the post-eradication era. J Okla State Med Assoc. 2002 Nov; 95(11):725-8. PMID: 12471737.
      View in: PubMed
    32. Huycke MM, Moore DR. In vivo production of hydroxyl radical by Enterococcus faecalis colonizing the intestinal tract using aromatic hydroxylation. Free Radic Biol Med. 2002 Sep 15; 33(6):818-26. PMID: 12208369.
      View in: PubMed
    33. Bronze MS, Huycke MM, Machado LJ, Voskuhl GW, Greenfield RA. Viral agents as biological weapons and agents of bioterrorism. Am J Med Sci. 2002 Jun; 323(6):316-25. PMID: 12074486.
      View in: PubMed
    34. Greenfield RA, Lutz BD, Huycke MM, Gilmore MS. Unconventional biological threats and the molecular biological response to biological threats. Am J Med Sci. 2002 Jun; 323(6):350-7. PMID: 12074489.
      View in: PubMed
    35. Huycke MM, Abrams V, Moore DR. Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA. Carcinogenesis. 2002 Mar; 23(3):529-36. PMID: 11895869.
      View in: PubMed
    36. Gusa AA, Buller RS, Storch GA, Huycke MM, Machado LJ, Slater LN, Stockham SL, Massung RF. Identification of a p28 gene in Ehrlichia ewingii: evaluation of gene for use as a target for a species-specific PCR diagnostic assay. J Clin Microbiol. 2001 Nov; 39(11):3871-6. PMID: 11682500; PMCID: PMC88457.
    37. Huycke MM, Moore D, Joyce W, Wise P, Shepard L, Kotake Y, Gilmore MS. Extracellular superoxide production by Enterococcus faecalis requires demethylmenaquinone and is attenuated by functional terminal quinol oxidases. Mol Microbiol. 2001 Nov; 42(3):729-40. PMID: 11722738.
      View in: PubMed
    38. Paddock CD, Folk SM, Shore GM, Machado LJ, Huycke MM, Slater LN, Liddell AM, Buller RS, Storch GA, Monson TP, Rimland D, Sumner JW, Singleton J, Bloch KC, Tang YW, Standaert SM, Childs JE. Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus. Clin Infect Dis. 2001 Nov 01; 33(9):1586-94. PMID: 11568857.
      View in: PubMed
    39. Huycke MM, Naguib MT, Stroemmel MM, Blick K, Monti K, Martin-Munley S, Kaufman C. A double-blind placebo-controlled crossover trial of intravenous magnesium sulfate for foscarnet-induced ionized hypocalcemia and hypomagnesemia in patients with AIDS and cytomegalovirus infection. Antimicrob Agents Chemother. 2000 Aug; 44(8):2143-8. PMID: 10898688; PMCID: PMC90026.
    40. Gentry CA, Greenfield RA, Slater LN, Wack M, Huycke MM. Outcomes of an antimicrobial control program in a teaching hospital. Am J Health Syst Pharm. 2000 Feb 01; 57(3):268-74. PMID: 10674779.
      View in: PubMed
    41. Shankar V, Baghdayan AS, Huycke MM, Lindahl G, Gilmore MS. Infection-derived Enterococcus faecalis strains are enriched in esp, a gene encoding a novel surface protein. Infect Immun. 1999 Jan; 67(1):193-200. PMID: 9864215; PMCID: PMC96296.
    42. Winters MD, Schlinke TL, Joyce WA, Glore SR, Huycke MM. Prospective case-cohort study of intestinal colonization with enterococci that produce extracellular superoxide and the risk for colorectal adenomas or cancer. Am J Gastroenterol. 1998 Dec; 93(12):2491-500. PMID: 9860414.
      View in: PubMed
    43. Huycke MM, Sahm DF, Gilmore MS. Multiple-drug resistant enterococci: the nature of the problem and an agenda for the future. Emerg Infect Dis. 1998 Apr-Jun; 4(2):239-49. PMID: 9621194; PMCID: PMC2640141.
    44. Jett BD, Hatter KL, Huycke MM, Gilmore MS. Simplified agar plate method for quantifying viable bacteria. Biotechniques. 1997 Oct; 23(4):648-50. PMID: 9343684.
      View in: PubMed
    45. Huycke MM, Gilmore MS. In vivo survival of Enterococcus faecalis is enhanced by extracellular superoxide production. Adv Exp Med Biol. 1997; 418:781-4. PMID: 9331768.
      View in: PubMed
    46. Huycke MM, Joyce W, Wack MF. Augmented production of extracellular superoxide by blood isolates of Enterococcus faecalis. J Infect Dis. 1996 Mar; 173(3):743-6. PMID: 8627044.
      View in: PubMed
    47. Huycke MM, Gilmore MS. Frequency of aggregation substance and cytolysin genes among enterococcal endocarditis isolates. Plasmid. 1995 Sep; 34(2):152-6. PMID: 8559804.
      View in: PubMed
    48. Naguib MT, Huycke MM, Pederson JA, Pennington LR, Burton ME, Greenfield RA. Apophysomyces elegans infection in a renal transplant recipient. Am J Kidney Dis. 1995 Aug; 26(2):381-4. PMID: 7645546.
      View in: PubMed
    49. Huycke MM, Joyce WA, Gilmore MS. Enterococcus faecalis cytolysin without effect on the intestinal growth of susceptible enterococci in mice. J Infect Dis. 1995 Jul; 172(1):273-6. PMID: 7797930.
      View in: PubMed
    50. Huycke MM, Gilmore MS. Frequency of aggregation substance and cytolysin genes among enterococcal endocarditis isolates. Dev Biol Stand. 1995; 85:47-50. PMID: 8586219.
      View in: PubMed
    51. Jett BD, Huycke MM, Gilmore MS. Virulence of enterococci. Clin Microbiol Rev. 1994 Oct; 7(4):462-78. PMID: 7834601; PMCID: PMC358337.
    52. Verville TD, Huycke MM, Greenfield RA, Fine DP, Kuhls TL, Slater LN. Rhodococcus equi infections of humans. 12 cases and a review of the literature. Medicine (Baltimore). 1994 May; 73(3):119-32. PMID: 8190035.
      View in: PubMed
    53. Rohlman VC, Haglund LA, Swartz MA, Dahl E, Greenfield RA, Slater LN, Huycke MM, Muchmore HG, Fine DP. Clinical experience with HIV-infected patients at the University of Oklahoma Health Sciences Center: an update. J Okla State Med Assoc. 1993 Apr; 86(4):161-5. PMID: 8483026.
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    54. Huycke MM, Gilmore MS, Jett BD, Booth JL. Transfer of pheromone-inducible plasmids between Enterococcus faecalis in the Syrian hamster gastrointestinal tract. J Infect Dis. 1992 Nov; 166(5):1188-91. PMID: 1402034.
      View in: PubMed
    55. Reiner KL, Huycke MM, McNabb SJ. The descriptive epidemiology of Lyme disease in Oklahoma. J Okla State Med Assoc. 1991 Oct; 84(10):503-9. PMID: 1744781.
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    56. Huycke MM, Spiegel CA, Gilmore MS. Bacteremia caused by hemolytic, high-level gentamicin-resistant Enterococcus faecalis. Antimicrob Agents Chemother. 1991 Aug; 35(8):1626-34. PMID: 1929336; PMCID: PMC245231.
    57. Haglund LA, Flournoy DJ, Gilmore MS, Huycke MM. Enterococcus: an old pathogen with new tricks. J Okla State Med Assoc. 1991 Jul; 84(7):305-9. PMID: 1941300.
      View in: PubMed
    58. Segarra RA, Booth MC, Morales DA, Huycke MM, Gilmore MS. Molecular characterization of the Enterococcus faecalis cytolysin activator. Infect Immun. 1991 Apr; 59(4):1239-46. PMID: 1900808; PMCID: PMC257833.
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