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Last Name

Mark L Lang

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
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    Collapse Biography 
    Collapse education and training
    University of Dundee, ScotlandPhD02/1998Biochemistry/Immunology
    Dartmouth Medical School, Hanover, NHPostdoc02/2002Microbiology/Immunology

    Collapse Research 
    Collapse research activities and funding
    R01AI134719     (LANG, MARK L)Nov 6, 2017 - Oct 31, 2022
    Activation of semi-invariant and diverse NKT cells with an adjuvant combination
    Role: Principal Investigator

    R21AI125708     (LANG, MARK L)Jul 1, 2016 - Jun 30, 2018
    Re-directing B cell responses to carbohydrate antigens
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shah HB, Smith K, Wren JD, Webb CF, Ballard JD, Bourn RL, James JA, Lang ML. Insights From Analysis of Human Antigen-Specific Memory B Cell Repertoires. Front Immunol. 2018; 9:3064. PMID: 30697210.
      View in: PubMed
    2. Zhou F, Yang J, Zhang Y, Liu M, Lang ML, Li M, Chen WR. Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine. Clin Cancer Res. 2018 Nov 01; 24(21):5335-5346. PMID: 30068705.
      View in: PubMed
    3. Lang ML. The Influence of Invariant Natural Killer T Cells on Humoral Immunity to T-Dependent and -Independent Antigens. Front Immunol. 2018; 9:305. PMID: 29520280.
      View in: PubMed
    4. Lang ML, Shrestha B. Adaptive immune constraints on C. difficile vaccination. Expert Rev Vaccines. 2017 11; 16(11):1053-1055. PMID: 28899198.
      View in: PubMed
    5. Lang ML. CD1d-dependent CLL progression? Blood. 2017 06 29; 129(26):3398-3399. PMID: 28663222.
      View in: PubMed
    6. Janakiram NB, Mohammed A, Bryant T, Ritchie R, Stratton N, Jackson L, Lightfoot S, Benbrook DM, Asch AS, Lang ML, Rao CV. Loss of natural killer T cells promotes pancreatic cancer in LSL-KrasG12D/+ mice. Immunology. 2017 09; 152(1):36-51. PMID: 28419443.
      View in: PubMed
    7. Rampuria P, Lang GA, Devera TS, Gilmore C, Ballard JD, Lang ML. Coordination between T helper cells, iNKT cells, and their follicular helper subsets in the humoral immune response against Clostridium difficile toxin B. J Leukoc Biol. 2017 02; 101(2):567-576. PMID: 27566831.
      View in: PubMed
    8. Richer MJ, Lang ML, Butler NS. T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function. J Immunol. 2016 08 15; 197(4):1009-15. PMID: 27496973; PMCID: PMC4978142 [Available on 08/15/17].
    9. Devera TS, Lang GA, Lanis JM, Rampuria P, Gilmore CL, James JA, Ballard JD, Lang ML. Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B. Infect Immun. 2016 01; 84(1):194-204. PMID: 26502913.
      View in: PubMed
    10. Devera TS, Prusator DK, Joshi SK, Ballard JD, Lang ML. Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge. Toxins (Basel). 2015 Jun 25; 7(7):2371-84. PMID: 26120785; PMCID: PMC4516918.
    11. Rampuria P, Lang ML. CD1d-dependent expansion of NKT follicular helper cells in vivo and in vitro is a product of cellular proliferation and differentiation. Int Immunol. 2015 May; 27(5):253-63. PMID: 25710490; PMCID: PMC4406267.
    12. Lang ML. The importance of B cell CD1d expression for humoral immunity. Expert Rev Vaccines. 2014 Nov; 13(11):1275-8. PMID: 24946838; PMCID: PMC4578709.
    13. Janakiram NB, Mohammed A, Bryant T, Brewer M, Biddick L, Lightfoot S, Lang ML, Rao CV. Adoptive transfer of regulatory T cells promotes intestinal tumorigenesis and is associated with decreased NK cells and IL-22 binding protein. Mol Carcinog. 2015 Oct; 54(10):986-98. PMID: 24797894.
      View in: PubMed
    14. Shah HB, Joshi SK, Rampuria P, Devera TS, Lang GA, Stohl W, Lang ML. BAFF- and APRIL-dependent maintenance of antibody titers after immunization with T-dependent antigen and CD1d-binding ligand. J Immunol. 2013 Aug 01; 191(3):1154-63. PMID: 23797666; PMCID: PMC3720783.
    15. Joshi SK, Lang ML. Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function. Int Immunopharmacol. 2013 Oct; 17(2):260-6. PMID: 23800654; PMCID: PMC3759579.
    16. Shah HB, Devera TS, Rampuria P, Lang GA, Lang ML. Type II NKT cells facilitate Alum-sensing and humoral immunity. J Leukoc Biol. 2012 Oct; 92(4):883-93. PMID: 22798686; PMCID: PMC3441316.
    17. Joshi SK, Lang GA, Devera TS, Johnson AM, Kovats S, Lang ML. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol. 2012 May; 91(5):783-90. PMID: 22331103; PMCID: PMC3336769.
    18. Shah HB, Joshi SK, Lang ML. CD40L-null NKT cells provide B cell help for specific antibody responses. Vaccine. 2011 Nov 15; 29(49):9132-6. PMID: 21959330; PMCID: PMC3206193.
    19. Devera TS, Joshi SK, Aye LM, Lang GA, Ballard JD, Lang ML. Regulation of anthrax toxin-specific antibody titers by natural killer T cell-derived IL-4 and IFN?. PLoS One. 2011; 6(8):e23817. PMID: 21858226; PMCID: PMC3157475.
    20. Lang GA, Johnson AM, Devera TS, Joshi SK, Lang ML. Reduction of CD1d expression in vivo minimally affects NKT-enhanced antibody production but boosts B-cell memory. Int Immunol. 2011 Apr; 23(4):251-60. PMID: 21398691; PMCID: PMC3066037.
    21. Charles E, Joshi S, Ash JD, Fox BA, Farris AD, Bzik DJ, Lang ML, Blader IJ. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun. 2010 Aug; 78(8):3484-92. PMID: 20498261; PMCID: PMC2916285.
    22. Devera TS, Aye LM, Lang GA, Joshi SK, Ballard JD, Lang ML. CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies. Infect Immun. 2010 Apr; 78(4):1610-7. PMID: 20123711; PMCID: PMC2849421.
    23. Joshi SK, Lang GA, Larabee JL, Devera TS, Aye LM, Shah HB, Ballard JD, Lang ML. Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. PLoS Pathog. 2009 Sep; 5(9):e1000588. PMID: 19779559; PMCID: PMC2742733.
    24. Lang ML. How do natural killer T cells help B cells? Expert Rev Vaccines. 2009 Aug; 8(8):1109-21. PMID: 19627191; PMCID: PMC2747240.
    25. Devera TS, Shah HB, Lang GA, Lang ML. Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers. Eur J Immunol. 2008 Apr; 38(4):1001-11. PMID: 18350547; PMCID: PMC3500907.
    26. Lang GA, Devera TS, Lang ML. Requirement for CD1d expression by B cells to stimulate NKT cell-enhanced antibody production. Blood. 2008 Feb 15; 111(4):2158-62. PMID: 18077787; PMCID: PMC2234052.
    27. Saban MR, Hellmich HL, Simpson C, Davis CA, Lang ML, Ihnat MA, O'Donnell MA, Wu XR, Saban R. Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer. 2007 Nov 02; 7:204. PMID: 17980030; PMCID: PMC2212656.
    28. Bessette K, Lang ML, Fava RA, Grundy M, Heinen J, Horne L, Spolski R, Al-Shami A, Morse HC, Leonard WJ, Kelly JA. A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood. 2008 Jan 01; 111(1):344-50. PMID: 17890450; PMCID: PMC2200817.
    29. Lang GA, Exley MA, Lang ML. The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner. Immunology. 2006 Sep; 119(1):116-25. PMID: 16792697; PMCID: PMC1782330.
    30. Pleass RJ, Lang ML, Kerr MA, Woof JM. IgA is a more potent inducer of NADPH oxidase activation and degranulation in blood eosinophils than IgE. Mol Immunol. 2007 Feb; 44(6):1401-8. PMID: 16777227.
      View in: PubMed
    31. Lang GA, Lang ML. Protein kinase Balpha is required for vesicle trafficking and class II presentation of IgA Fc receptor (CD89)-targeted antigen. J Immunol. 2006 Apr 01; 176(7):3987-94. PMID: 16547233.
      View in: PubMed
    32. Lang ML, Glatman-Freedman A. Do CD1-restricted T cells contribute to antibody-mediated immunity against Mycobacterium tuberculosis? Infect Immun. 2006 Feb; 74(2):803-9. PMID: 16428722; PMCID: PMC1360325.
    33. Lang GA, Illarionov PA, Glatman-Freedman A, Besra GS, Lang ML. BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments. Int Immunol. 2005 Jul; 17(7):899-908. PMID: 15967785.
      View in: PubMed
    34. Chen YW, Lang ML, Wade WF. Protein kinase C-alpha and -delta are required for FcalphaR (CD89) trafficking to MHC class II compartments and FcalphaR-mediated antigen presentation. Traffic. 2004 Aug; 5(8):577-94. PMID: 15260828.
      View in: PubMed
    35. Lang GA, Maltsev SD, Besra GS, Lang ML. Presentation of alpha-galactosylceramide by murine CD1d to natural killer T cells is facilitated by plasma membrane glycolipid rafts. Immunology. 2004 Jul; 112(3):386-96. PMID: 15196206; PMCID: PMC1782508.
    36. Lang ML, Chen YW, Shen L, Gao H, Lang GA, Wade TK, Wade WF. IgA Fc receptor (FcalphaR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts. Biochem J. 2002 Jun 01; 364(Pt 2):517-25. PMID: 12023895; PMCID: PMC1222597.
    37. Min B, Legge KL, Bell JJ, Gregg RK, Li L, Caprio JC, Zaghouani H. Neonatal exposure to antigen induces a defective CD40 ligand expression that undermines both IL-12 production by APC and IL-2 receptor up-regulation on splenic T cells and perpetuates IFN-gamma-dependent T cell anergy. J Immunol. 2001 May 01; 166(9):5594-603. PMID: 11313399.
      View in: PubMed
    38. Shen L, van Egmond M, Siemasko K, Gao H, Wade T, Lang ML, Clark M, van De Winkel JG, Wade WF. Presentation of ovalbumin internalized via the immunoglobulin-A Fc receptor is enhanced through Fc receptor gamma-chain signaling. Blood. 2001 Jan 01; 97(1):205-13. PMID: 11133762.
      View in: PubMed
    39. Lang ML, Kerr MA. Characterization of FcalphaR-triggered Ca(2+) signals: role in neutrophil NADPH oxidase activation. Biochem Biophys Res Commun. 2000 Sep 24; 276(2):749-55. PMID: 11027542.
      View in: PubMed
    40. Shen L, Lang ML, Wade WF. The ins and outs of getting in: structures and signals that enhance BCR or Fc receptor-mediated antigen presentation. Immunopharmacology. 2000 Sep; 49(3):227-40. PMID: 10996020.
      View in: PubMed
    41. Lang ML, Yadati S, Seeley ES, Nydam T, Wade TK, Gabriel JL, Yeaman G, Barisas BG, Wade WF. Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression. Int Immunol. 2000 Jun; 12(6):777-86. PMID: 10837405.
      View in: PubMed
    42. Lang ML, Kerr MA. Neutrophil NADPH oxidase does not assemble on macropinocytic vacuole membranes. Immunol Lett. 2000 Apr 03; 72(1):1-6. PMID: 10789674.
      View in: PubMed
    43. Lang ML, Shen L, Wade WF. Gamma-chain dependent recruitment of tyrosine kinases to membrane rafts by the human IgA receptor Fc alpha R. J Immunol. 1999 Nov 15; 163(10):5391-8. PMID: 10553064.
      View in: PubMed
    44. Lang ML, Kerr MA. Neutrophil Fc receptors signal through PI 3-kinase to trigger a respiratory burst. Biochem Soc Trans. 1997 Nov; 25(4):S603. PMID: 9450031.
      View in: PubMed
    45. Furrie E, Bonner BC, Hutchings A, Lang ML, Kerr MA. Differential activation of peripheral blood monocytes using various forms of human IgA. Biochem Soc Trans. 1997 May; 25(2):332S. PMID: 9191377.
      View in: PubMed
    46. Lang ML, Glennie MJ, Kerr MA. Human neutrophil Fc alpha R and Fc gamma RIIa but not Fc gamma RIIIb generate intracellular calcium signals which trigger the respiratory burst. Biochem Soc Trans. 1997 May; 25(2):333S. PMID: 9191378.
      View in: PubMed
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