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Matlock Arizona Jeffries

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentRheumatology/Immunology/Allerg
Phone405/271-7438
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    Collapse Research 
    Collapse research activities and funding
    R01AR076440     (JEFFRIES, MATLOCK)Jun 16, 2020 - May 31, 2025
    NIH/NIAMS
    Peripheral blood mononuclear cell epigenetic associations in and biomarkers for knee osteoarthritis development and progression.
    Role: Principal Investigator

    K08AR070891     (JEFFRIES, MATLOCK)Jun 1, 2017 - May 31, 2022
    NIH/NIAMS
    An integrative study of circulating leukocyte composition, epigenetic patterns, and functional consequences in knee osteoarthritis.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dunn CM, Velasco C, Rivas A, Andrews M, Garman C, Jacob PB, Jeffries MA. Identification of Cartilage Microbial DNA Signatures and Associations With Knee and Hip Osteoarthritis. Arthritis Rheumatol. 2020 Jul; 72(7):1111-1122. PMID: 31961065.
      View in: PubMed
    2. Jeffries MA. The Development of Epigenetics in the Study of Disease Pathogenesis. Adv Exp Med Biol. 2020; 1253:57-94. PMID: 32445091.
      View in: PubMed
    3. M Dunn C, Nevitt MC, Lynch JA, Jeffries MA. A pilot study of peripheral blood DNA methylation models as predictors of knee osteoarthritis radiographic progression: data from the Osteoarthritis Initiative (OAI). Sci Rep. 2019 11 14; 9(1):16880. PMID: 31727952.
      View in: PubMed
    4. Jeffries MA. Osteoarthritis year in review 2018: genetics and epigenetics. Osteoarthritis Cartilage. 2019 03; 27(3):371-377. PMID: 30808485.
      View in: PubMed
    5. Jeffries MA. Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy. Clin Immunol. 2018 11; 196:49-58. PMID: 29421443.
      View in: PubMed
    6. Husain A, Jeffries MA. Epigenetics and Bone Remodeling. Curr Osteoporos Rep. 2017 10; 15(5):450-458. PMID: 28808893.
      View in: PubMed
    7. Simon TC, Jeffries MA. The Epigenomic Landscape in Osteoarthritis. Curr Rheumatol Rep. 2017 Jun; 19(6):30. PMID: 28456906.
      View in: PubMed
    8. Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Beth Humphrey M, James JA, Sawalha AH. Genome-Wide DNA Methylation Study Identifies Significant Epigenomic Changes in Osteoarthritic Subchondral Bone and Similarity to Overlying Cartilage. Arthritis Rheumatol. 2016 06; 68(6):1403-14. PMID: 26713865.
      View in: PubMed
    9. Renauer P, Coit P, Jeffries MA, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Sawalha AH. DNA methylation patterns in naïve CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus. Lupus Sci Med. 2015; 2(1):e000101. PMID: 26405558.
      View in: PubMed
    10. Coit P, Renauer P, Jeffries MA, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Sawalha AH. Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells. J Autoimmun. 2015 Jul; 61:29-35. PMID: 26005050.
      View in: PubMed
    11. Jeffries MA, Sawalha AH. Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve? Expert Rev Clin Immunol. 2015 Jan; 11(1):45-58. PMID: 25534978.
      View in: PubMed
    12. Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Humphrey MB, James JA, Sawalha AH. Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatol. 2014 Oct; 66(10):2804-15. PMID: 24980887.
      View in: PubMed
    13. Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients. J Autoimmun. 2013 Jun; 43:78-84. PMID: 23623029.
      View in: PubMed
    14. Koelsch KA, Webb R, Jeffries M, Dozmorov MG, Frank MB, Guthridge JM, James JA, Wren JD, Sawalha AH. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun. 2013 Mar; 41:168-74. PMID: 23428850.
      View in: PubMed
    15. Jeffries MA, Sawalha AH. Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents. Int J Clin Rheumtol. 2011 Aug; 6(4):423-439. PMID: 22184503.
      View in: PubMed
    16. Jeffries MA, Dozmorov M, Tang Y, Merrill JT, Wren JD, Sawalha AH. Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics. 2011 May; 6(5):593-601. PMID: 21436623.
      View in: PubMed
    17. Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Alarcón-Riquelme ME, James JA, Vyse TJ, Moser KL, Gaffney PM, Gilkeson GS, Harley JB, Sawalha AH. Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum. 2009 Apr; 60(4):1076-84. PMID: 19333917.
      View in: PubMed
    18. Webb R, Jeffries M, Sawalha AH. Uric acid directly promotes human T-cell activation. Am J Med Sci. 2009 Jan; 337(1):23-7. PMID: 19057377.
      View in: PubMed
    19. Sawalha AH, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol. 2007 May; 37(5):1407-13. PMID: 17429846.
      View in: PubMed
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