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Megan Ross Lerner

TitleProf,Asst of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Surgery
Address1122 NE 13th St
Oklahoma City OK 73117-1039
Phone405/271-2601
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hocker JR, Deb SJ, Li M, Lerner MR, Lightfoot SA, Quillet AA, Hanas RJ, Reinersman M, Thompson JL, Vu NT, Kupiec TC, Brackett DJ, Peyton MD, Dubinett SM, Burkhart HM, Postier RG, Hanas JS. Serum Monitoring and Phenotype Identification of Stage I Non-Small Cell Lung Cancer Patients. Cancer Invest. 2017 Sep 26; 1-13. PMID: 28949774.
      View in: PubMed
    2. Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol. 2017 02 01; 19(2):175-185. PMID: 27416955.
      View in: PubMed
    3. Awwad HO, Durand CD, Gonzalez LP, Tompkins P, Zhang Y, Lerner MR, Brackett DJ, Sherry DM, Awasthi V, Standifer KM. Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions. Behav Brain Res. 2016 Oct 25. PMID: 27793733.
      View in: PubMed
    4. Jiang J, Azevedo-Pouly AC, Redis RS, Lee EJ, Gusev Y, Allard D, Sutaria DS, Badawi M, Elgamal OA, Lerner MR, Brackett DJ, Calin GA, Schmittgen TD. Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma. Oncotarget. 2016 Aug 16; 7(33):53165-53177. PMID: 27363020.
      View in: PubMed
    5. Brock AJ, Kasus-Jacobi A, Lerner M, Logan S, Adesina AM, Anne Pereira H. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. Histochem Cell Biol. 2015 Oct; 144(4):293-308. PMID: 26170148; PMCID: PMC4575391.
    6. Coutinho de Souza P, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, Ehrenshaft M, Mason RP, Meek B, Plafker SM, Saunders D, Mamedova N, Towner RA. OKN-007 decreases free radical levels in a preclinical F98 rat glioma model. Free Radic Biol Med. 2015 Oct; 87:157-68. PMID: 26119786.
      View in: PubMed
    7. Awwad HO, Gonzalez LP, Tompkins P, Lerner M, Brackett DJ, Awasthi V, Standifer KM. Blast Overpressure Waves Induce Transient Anxiety and Regional Changes in Cerebral Glucose Metabolism and Delayed Hyperarousal in Rats. Front Neurol. 2015; 6:132. PMID: 26136722; PMCID: PMC4470265.
    8. Hocker JR, Postier RG, Li M, Lerner MR, Lightfoot SA, Peyton MD, Deb SJ, Baker CM, Williams TL, Hanas RJ, Stowell DE, Lander TJ, Brackett DJ, Hanas JS. Discriminating patients with early-stage pancreatic cancer or chronic pancreatitis using serum electrospray mass profiling. Cancer Lett. 2015 Apr 10; 359(2):314-24. PMID: 25637792; PMCID: PMC4347843.
    9. Kesinger JW, Mehta M, Lerner MR, Brackett DJ, Brueggemeier RW, Li PK, Pento JT. Oncolytic potential of a novel KGFR tyrosine kinase inhibitor using a KGFR-selective breast cancer xenograft model. Anticancer Res. 2015 Jan; 35(1):47-52. PMID: 25550534.
      View in: PubMed
    10. Griffith GL, Kasus-Jacobi A, Lerner MR, Pereira HA. Corneal wound healing, a newly identified function of CAP37, is mediated by protein kinase C delta (PKCd). Invest Ophthalmol Vis Sci. 2014 Jul 15; 55(8):4886-95. PMID: 25028358; PMCID: PMC4126793.
    11. Saxena R, Bjonnes A, Prescott J, Dib P, Natt P, Lane J, Lerner M, Cooper JA, Ye Y, Li KW, Maubaret CG, Codd V, Brackett D, Mirabello L, Kraft P, Dinney CP, Stowell D, Peyton M, Ralhan S, Wander GS, Mehra NK, Salpea KD, Gu J, Wu X, Mangino M, Hunter DJ, De Vivo I, Humphries SE, Samani NJ, Spector TD, Savage SA, Sanghera DK. Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. Circ Cardiovasc Genet. 2014 Jun; 7(3):287-95. PMID: 24795349; PMCID: PMC4106467.
    12. Hanas JS, Peyton MD, Lerner MR, Lightfoot SA, Deb SJ, Hanas RJ, Vu NT, Kupiec TC, Stowell DE, Brackett DJ, Dubinett SM, Hocker JR. Distinguishing patients with stage I lung cancer versus control individuals using serum mass profiling. Cancer Invest. 2014 May; 32(4):136-43. PMID: 24579933.
      View in: PubMed
    13. Campbell SC, Bakhshalian N, Sadaat RL, Lerner MR, Lightfoot SA, Brackett D, Arjmandi BH. Flaxseed reverses atherosclerotic lesion formation and lowers lipoprotein(a) in ovarian hormone deficiency. Menopause. 2013 Nov; 20(11):1176-83. PMID: 23571520.
      View in: PubMed
    14. Tompkins P, Tesiram Y, Lerner M, Gonzalez LP, Lightfoot S, Rabb CH, Brackett DJ. Brain injury: neuro-inflammation, cognitive deficit, and magnetic resonance imaging in a model of blast induced traumatic brain injury. J Neurotrauma. 2013 Nov 15; 30(22):1888-97. PMID: 23777197.
      View in: PubMed
    15. He T, Smith N, Saunders D, Pittman BP, Lerner M, Lightfoot S, Silasi-Mansat R, Lupu F, Towner RA. Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models. Am J Nucl Med Mol Imaging. 2013; 3(4):300-11. PMID: 23901356; PMCID: PMC3715774.
    16. Howard EW, Been LF, Lerner M, Brackett D, Lightfoot S, Bullen EC, Sanghera DK. Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2. BMC Genet. 2013 Apr 23; 14:28. PMID: 23617586; PMCID: PMC3675375.
    17. Qiu P, Qu X, Brackett DJ, Lerner MR, Li D, Mao C. Silica-based branched hollow microfibers as a biomimetic extracellular matrix for promoting tumor cell growth in vitro and in vivo. Adv Mater. 2013 May 07; 25(17):2492-6. PMID: 23450784; PMCID: PMC3731149.
    18. Johnson JJ, Alex Jacocks M, Gauthier SC, Irwin DA, Wolf RF, Garwe T, Lerner MR, Lees JS. Establishing a swine model to compare vascular prostheses in a contaminated field. J Surg Res. 2013 May; 181(2):355-8. PMID: 22795350.
      View in: PubMed
    19. Tesiram YA, Lerner M, Stewart C, Njoku C, Brackett DJ. Utility of nuclear magnetic resonance spectroscopy for pancreatic cancer studies. Pancreas. 2012 Apr; 41(3):474-80. PMID: 22422139.
      View in: PubMed
    20. Hocker JR, Bishop EA, Lightfoot SA, Lerner MR, Peyton MD, Brackett DJ, Hanas RJ, McMeekin DS, Walker JL, Hanas JS. Serum profiling to distinguish early- and late-stage ovarian cancer patients from disease-free individuals. Cancer Invest. 2012 Feb; 30(2):189-97. PMID: 22149058.
      View in: PubMed
    21. Hocker JR, Peyton MD, Lerner MR, Lightfoot SA, Hanas RJ, Brackett DJ, Hanas JS. Distinguishing non-small cell lung adenocarcinoma patients from squamous cell carcinoma patients and control individuals using serum profiling. Cancer Invest. 2012 Feb; 30(2):180-8. PMID: 22149138.
      View in: PubMed
    22. Doblas S, He T, Saunders D, Hoyle J, Smith N, Pye Q, Lerner M, Jensen RL, Towner RA. In vivo characterization of several rodent glioma models by 1H MRS. NMR Biomed. 2012 Apr; 25(4):685-94. PMID: 21954105; PMCID: PMC3780579.
    23. Hocker JR, Peyton MD, Lerner MR, Mitchell SL, Lightfoot SA, Lander TJ, Bates-Albers LM, Vu NT, Hanas RJ, Kupiec TC, Brackett DJ, Hanas JS. Serum discrimination of early-stage lung cancer patients using electrospray-ionization mass spectrometry. Lung Cancer. 2011 Nov; 74(2):206-11. PMID: 21529985.
      View in: PubMed
    24. He T, Doblas S, Saunders D, Casteel R, Lerner M, Ritchey JW, Snider T, Floyd RA, Towner RA. Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy. Free Radic Biol Med. 2011 Jul 15; 51(2):490-502. PMID: 21600283.
      View in: PubMed
    25. He T, Smith N, Saunders D, Doblas S, Watanabe Y, Hoyle J, Silasi-Mansat R, Lupu F, Lerner M, Brackett DJ, Towner RA. Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas. J Cell Mol Med. 2011 Apr; 15(4):837-49. PMID: 20497492; PMCID: PMC2951496.
    26. Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011 Mar 25; 406(4):518-23. PMID: 21329664; PMCID: PMC3069485.
    27. Hocker JR, Lerner MR, Mitchell SL, Lightfoot SA, Lander TJ, Quillet AA, Hanas RJ, Peyton MD, Postier RG, Brackett DJ, Hanas JS. Distinguishing early-stage pancreatic cancer patients from disease-free individuals using serum profiling. Cancer Invest. 2011 Feb; 29(2):173-9. PMID: 21261478.
      View in: PubMed
    28. Sureban SM, May R, Lightfoot SA, Hoskins AB, Lerner M, Brackett DJ, Postier RG, Ramanujam R, Mohammed A, Rao CV, Wyche JH, Anant S, Houchen CW. DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. Cancer Res. 2011 Mar 15; 71(6):2328-38. PMID: 21285251; PMCID: PMC3072762.
    29. Doblas S, He T, Saunders D, Pearson J, Hoyle J, Smith N, Lerner M, Towner RA. Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography. J Magn Reson Imaging. 2010 Aug; 32(2):267-75. PMID: 20677250; PMCID: PMC2915452.
    30. Hanas JS, Bruce Briggs G, Lerner MR, Lightfoot SA, Larabee JL, Karsies TJ, Epstein RB, Hanas RJ, Brackett DJ, Hocker JR. Systemic molecular and cellular changes induced in rats upon inhalation of JP-8 petroleum fuel vapor. Toxicol Mech Methods. 2010 May; 20(4):204-12. PMID: 20233090.
      View in: PubMed
    31. Garteiser P, Doblas S, Watanabe Y, Saunders D, Hoyle J, Lerner M, He T, Floyd RA, Towner RA. Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging. J Magn Reson Imaging. 2010 Apr; 31(4):796-806. PMID: 20373422.
      View in: PubMed
    32. Zang XP, Lerner M, Brackett D, Pento JT. Influence of KGF on the progression of pancreatic cancer. Anticancer Res. 2009 Aug; 29(8):3417-20. PMID: 19661366.
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    33. Watanabe E, Muenzer JT, Hawkins WG, Davis CG, Dixon DJ, McDunn JE, Brackett DJ, Lerner MR, Swanson PE, Hotchkiss RS. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest. 2009 May; 89(5):549-61. PMID: 19188912; PMCID: PMC3822608.
    34. Allen TD, Moore DR, Wang X, Casu V, May R, Lerner MR, Houchen C, Brackett DJ, Huycke MM. Dichotomous metabolism of Enterococcus faecalis induced by haematin starvation modulates colonic gene expression. J Med Microbiol. 2008 Oct; 57(Pt 10):1193-204. PMID: 18809545; PMCID: PMC2692828.
    35. Shelton L, Troilo D, Lerner MR, Gusev Y, Brackett DJ, Rada JS. Microarray analysis of choroid/RPE gene expression in marmoset eyes undergoing changes in ocular growth and refraction. Mol Vis. 2008 Aug 11; 14:1465-79. PMID: 18698376; PMCID: PMC2504533.
    36. Drevets DA, Schawang JE, Dillon MJ, Lerner MR, Bronze MS, Brackett DJ. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J Immunol. 2008 Jul 01; 181(1):529-36. PMID: 18566419.
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    37. Bu SY, Lerner M, Stoecker BJ, Boldrin E, Brackett DJ, Lucas EA, Smith BJ. Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATc1 and inflammatory mediators. Calcif Tissue Int. 2008 Jun; 82(6):475-88. PMID: 18509698.
      View in: PubMed
    38. Hanas JS, Hocker JR, Cheung JY, Larabee JL, Lerner MR, Lightfoot SA, Morgan DL, Denson KD, Prejeant KC, Gusev Y, Smith BJ, Hanas RJ, Postier RG, Brackett DJ. Biomarker identification in human pancreatic cancer sera. Pancreas. 2008 Jan; 36(1):61-9. PMID: 18192883.
      View in: PubMed
    39. Gusev Y, Schmittgen TD, Lerner M, Postier R, Brackett D. Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer. BMC Bioinformatics. 2007 Nov 01; 8 Suppl 7:S16. PMID: 18047715; PMCID: PMC2099484.
    40. Smith BJ, Lightfoot SA, Lerner MR, Denson KD, Morgan DL, Hanas JS, Bronze MS, Postier RG, Brackett DJ. Induction of cardiovascular pathology in a novel model of low-grade chronic inflammation. Cardiovasc Pathol. 2009 Jan-Feb; 18(1):1-10. PMID: 18402801.
      View in: PubMed
    41. Lee EJ, Gusev Y, Jiang J, Nuovo GJ, Lerner MR, Frankel WL, Morgan DL, Postier RG, Brackett DJ, Schmittgen TD. Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer. 2007 Mar 01; 120(5):1046-54. PMID: 17149698; PMCID: PMC2680248.
    42. Zang XP, Palwai NR, Lerner MR, Brackett DJ, Pento JT, Harrison RG. Targeting a methioninase-containing fusion protein to breast cancer urokinase receptors inhibits growth and migration. Anticancer Res. 2006 May-Jun; 26(3A):1745-51. PMID: 16827102.
      View in: PubMed
    43. Hassan R, Laszik ZG, Lerner M, Raffeld M, Postier R, Brackett D. Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Am J Clin Pathol. 2005 Dec; 124(6):838-45. PMID: 16416732.
      View in: PubMed
    44. Boros LG, Lerner MR, Morgan DL, Taylor SL, Smith BJ, Postier RG, Brackett DJ. [1,2-13C2]-D-glucose profiles of the serum, liver, pancreas, and DMBA-induced pancreatic tumors of rats. Pancreas. 2005 Nov; 31(4):337-43. PMID: 16258367.
      View in: PubMed
    45. Schmittgen TD, Gissel KA, Zakrajsek BA, Lawrence BP, Liu Q, Jupe ER, Lerner MR, Do SV, Brackett DJ. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. Int J Oncol. 2005 Aug; 27(2):297-306. PMID: 16010409.
      View in: PubMed
    46. Liu Y, Chen GD, Lerner MR, Brackett DJ, Matsumoto RR. Cocaine up-regulates Fra-2 and sigma-1 receptor gene and protein expression in brain regions involved in addiction and reward. J Pharmacol Exp Ther. 2005 Aug; 314(2):770-9. PMID: 15879001.
      View in: PubMed
    47. Manjeshwar S, Lerner MR, Zang XP, Branam DE, Pento JT, Lane MM, Lightfoot SA, Brackett DJ, Jupe ER. Expression of prohibitin 3' untranslated region suppressor RNA alters morphology and inhibits motility of breast cancer cells. J Mol Histol. 2004 Aug; 35(6):639-46. PMID: 15614618.
      View in: PubMed
    48. Zang XP, Lerner MR, Dunn ST, Brackett DJ, Pento JT. Antisense KGFR oligonucleotide inhibition of KGF-induced motility in breast cancer cells. Anticancer Res. 2003 Nov-Dec; 23(6C):4913-9. PMID: 14981945.
      View in: PubMed
    49. Brackett DJ, Smith BJ, Lerner MR, Hanas JS, Postier RG. Gene activity associated with cancers treated by surgical oncologists. J Okla State Med Assoc. 2003 Oct; 96(10):485-94. PMID: 14619604.
      View in: PubMed
    50. Manjeshwar S, Branam DE, Lerner MR, Brackett DJ, Jupe ER. Tumor suppression by the prohibitin gene 3'untranslated region RNA in human breast cancer. Cancer Res. 2003 Sep 01; 63(17):5251-6. PMID: 14500355.
      View in: PubMed
    51. Matsumoto RR, Liu Y, Lerner M, Howard EW, Brackett DJ. Sigma receptors: potential medications development target for anti-cocaine agents. Eur J Pharmacol. 2003 May 23; 469(1-3):1-12. PMID: 12782179.
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    52. Postier RG, Lerner MR, Lightfoot SA, Vannarath R, Lane MM, Hanas JS, Brackett DJ. DNA ploidy and markovian analysis of neoplastic progression in experimental pancreatic cancer. J Histochem Cytochem. 2003 Mar; 51(3):303-9. PMID: 12588958.
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    53. Trachte AL, Suthers SE, Lerner MR, Hanas JS, Jupe ER, Sienko AE, Adesina AM, Lightfoot SA, Brackett DJ, Postier RG. Increased expression of alpha-1-antitrypsin, glutathione S-transferase pi and vascular endothelial growth factor in human pancreatic adenocarcinoma. Am J Surg. 2002 Dec; 184(6):642-7; discussion 647-8. PMID: 12488200.
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    54. Hassan R, Lerner MR, Benbrook D, Lightfoot SA, Brackett DJ, Wang QC, Pastan I. Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro. Clin Cancer Res. 2002 Nov; 8(11):3520-6. PMID: 12429643.
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    55. Hanas JS, Hocker JR, Cheng YG, Lerner MR, Brackett DJ, Lightfoot SA, Hanas RJ, Madhusudhan KT, Moreland RJ. cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA. Gene. 2002 Jan 09; 282(1-2):43-52. PMID: 11814676.
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