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Arlan G. Richardson

TitleProf of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Phone405/456-3551
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    Collapse Biography 
    Collapse education and training
    Peru State College, Peru, NEBS1963Chemistry/Biology
    Oklahoma State University, Stillwater, OKPhD1968Chemistry/Biochemistry

    Collapse Research 
    Collapse research activities and funding
    IK6BX005238     (RICHARDSON, ARLAN G.)Apr 1, 2020 - Mar 31, 2027
    VA
    BLR&D Research Career Scientist Award Application
    Role: Principal Investigator

    IS1BX005032     (RICHARDSON, ARLAN G.)Sep 1, 2019 - Sep 30, 2020
    VA
    ShEEP Request for Cell Sorter
    Role: Principal Investigator

    R21AG062894     (RICHARDSON, ARLAN G.)May 1, 2019 - Jan 31, 2021
    NIH/NIA
    Does Dietary Restriction Alter Stem Cell Function Through An Epigenetic Mechanism?
    Role: Principal Investigator

    I01BX004538     (RICHARDSON, ARLAN G.)Apr 1, 2019 - Mar 31, 2023
    VA
    Does Necroptosis Play a Role in Inflammation and Aging
    Role: Principal Investigator

    R01AG057424     (RICHARDSON, ARLAN G.)Sep 15, 2017 - May 31, 2022
    NIH/NIA
    TESTING THE ABILITY OF NOVEL ASSAYS OF RESILIENCE TO PREDICT LIFESPAN
    Role: Principal Investigator

    P30AG050911     (RICHARDSON, ARLAN G.)Jul 15, 2015 - Jun 30, 2020
    NIH/NIA
    Oklahoma Nathan Shock Center of Excellence in Basic Biology of Aging
    Role: Principal Investigator

    R01AG045693     (RICHARDSON, ARLAN G.)Aug 1, 2014 - Apr 30, 2019
    NIH/NIA
    Interaction of Genotype and Level of Dietary Restriction on Lifespan and Aging
    Role: Principal Investigator

    R13AG012917     (RICHARDSON, ARLAN G.)Apr 1, 1995 - Nov 30, 2007
    NIH/NIA
    Summer Training Course in Aging Research
    Role: Principal Investigator

    P30AG013319     (STRONG, RANDY)Oct 31, 2009
    NIH/NIA
    San Antonio Nathan Shock Center of Excellence in the Biology of Aging
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Unnikrishnan A, Kurup K, Salmon AB, Richardson A. Is Rapamycin a Dietary Restriction Mimetic? J Gerontol A Biol Sci Med Sci. 2020 01 01; 75(1):4-13. PMID: 30854544.
      View in: PubMed
    2. Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2019 02 15; 74(3):290-298. PMID: 29893815.
      View in: PubMed
    3. Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H. Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. J Cachexia Sarcopenia Muscle. 2019 04; 10(2):411-428. PMID: 30706998.
      View in: PubMed
    4. Unnikrishnan A, Freeman WM, Jackson J, Wren JD, Porter H, Richardson A. The role of DNA methylation in epigenetics of aging. Pharmacol Ther. 2019 03; 195:172-185. PMID: 30419258.
      View in: PubMed
    5. Qaisar R, Bhaskaran S, Premkumar P, Ranjit R, Natarajan KS, Ahn B, Riddle K, Claflin DR, Richardson A, Brooks SV, Van Remmen H. Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness. J Cachexia Sarcopenia Muscle. 2018 10; 9(5):1003-1017. PMID: 30073804.
      View in: PubMed
    6. Deepa SS, Van Remmen H, Brooks SV, Faulkner JA, Larkin L, McArdle A, Jackson MJ, Vasilaki A, Richardson A. Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice. Free Radic Biol Med. 2019 02 20; 132:19-23. PMID: 30670156.
      View in: PubMed
    7. Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H. Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. Aging Cell. 2018 08; 17(4):e12769. PMID: 29696791.
      View in: PubMed
    8. Deepa SS, Unnikrishnan A, Matyi S, Hadad N, Richardson A. Necroptosis increases with age and is reduced by dietary restriction. Aging Cell. 2018 08; 17(4):e12770. PMID: 29696779.
      View in: PubMed
    9. Logan S, Owen D, Chen S, Chen WJ, Ungvari Z, Farley J, Csiszar A, Sharpe A, Loos M, Koopmans B, Richardson A, Sonntag WE. Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice. Geroscience. 2018 04; 40(2):123-137. PMID: 29687240.
      View in: PubMed
    10. Hadad N, Unnikrishnan A, Jackson JA, Masser DR, Otalora L, Stanford DR, Richardson A, Freeman WM. Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation. Neurobiol Aging. 2018 07; 67:53-66. PMID: 29631215.
      View in: PubMed
    11. Snider TA, Richardson A, Stoner JA, Deepa SS. The Geropathology Grading Platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging. Geroscience. 2018 04; 40(2):97-103. PMID: 29478190.
      View in: PubMed
    12. Unnikrishnan A, Hadad N, Masser DR, Jackson J, Freeman WM, Richardson A. Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci. 2018 04; 1418(1):69-79. PMID: 29363785.
      View in: PubMed
    13. Sakellariou GK, McDonagh B, Porter H, Giakoumaki II, Earl KE, Nye GA, Vasilaki A, Brooks SV, Richardson A, Van Remmen H, McArdle A, Jackson MJ. Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle. Antioxid Redox Signal. 2018 02 01; 28(4):275-295. PMID: 29065712.
      View in: PubMed
    14. Ross CN, Austad S, Brasky K, Brown CJ, Forney LJ, Gelfond JA, Lanford R, Richardson A, Tardif SD. The development of a specific pathogen free (SPF) barrier colony of marmosets (Callithrix jacchus) for aging research. Aging (Albany NY). 2017 12 07; 9(12):2544-2558. PMID: 29227963.
      View in: PubMed
    15. Masser DR, Hadad N, Porter HL, Mangold CA, Unnikrishnan A, Ford MM, Giles CB, Georgescu C, Dozmorov MG, Wren JD, Richardson A, Stanford DR, Freeman WM. Sexually divergent DNA methylation patterns with hippocampal aging. Aging Cell. 2017 12; 16(6):1342-1352. PMID: 28948711.
      View in: PubMed
    16. Vasilaki A, Richardson A, Van Remmen H, Brooks SV, Larkin L, McArdle A, Jackson MJ. Role of nerve-muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing. J Physiol. 2017 10 15; 595(20):6409-6415. PMID: 28792061.
      View in: PubMed
    17. Unnikrishnan A, Jackson J, Matyi SA, Hadad N, Wronowski B, Georgescu C, Garrett KP, Wren JD, Freeman WM, Richardson A. Role of DNA methylation in the dietary restriction mediated cellular memory. Geroscience. 2017 06; 39(3):331-345. PMID: 28477138.
      View in: PubMed
    18. Deepa SS, Bhaskaran S, Espinoza S, Brooks SV, McArdle A, Jackson MJ, Van Remmen H, Richardson A. A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse. Geroscience. 2017 04; 39(2):187-198. PMID: 28409332.
      View in: PubMed
    19. Etzler JC, Bollo M, Holstein D, Deng JJ, Perez V, Lin DT, Richardson A, Bai Y, Lechleiter JD. Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation. Arch Biochem Biophys. 2017 Jan 01; 613:61-68. PMID: 27916505.
      View in: PubMed
    20. Zhang Y, Unnikrishnan A, Deepa SS, Liu Y, Li Y, Ikeno Y, Sosnowska D, Van Remmen H, Richardson A. A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence. Redox Biol. 2017 04; 11:30-37. PMID: 27846439.
      View in: PubMed
    21. Salmon AB, Kim G, Liu C, Wren JD, Georgescu C, Richardson A, Levine RL. Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice. Redox Biol. 2016 12; 10:251-256. PMID: 27821326.
      View in: PubMed
    22. Fischer KE, Hoffman JM, Sloane LB, Gelfond JA, Soto VY, Richardson AG, Austad SN. A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated. Aging (Albany NY). 2016 10 02; 8(10):2370-2391. PMID: 27705904.
      View in: PubMed
    23. Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics Chromatin. 2016; 9:30. PMID: 27413395.
      View in: PubMed
    24. Masser DR, Stanford DR, Hadad N, Giles CB, Wren JD, Sonntag WE, Richardson A, Freeman WM. Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordr). 2016 Jun; 38(3):49. PMID: 27091453.
      View in: PubMed
    25. Lin AL, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, Galvan V, Richardson A. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab. 2017 01; 37(1):217-226. PMID: 26721390.
      View in: PubMed
    26. Sataranatarajan K, Ikeno Y, Bokov A, Feliers D, Yalamanchili H, Lee HJ, Mariappan MM, Tabatabai-Mir H, Diaz V, Prasad S, Javors MA, Ghosh Choudhury G, Hubbard GB, Barnes JL, Richardson A, Kasinath BS. Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes. J Gerontol A Biol Sci Med Sci. 2016 07; 71(7):850-7. PMID: 26442901.
      View in: PubMed
    27. Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, RenterĂ­a RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN. Measures of Healthspan as Indices of Aging in Mice-A Recommendation. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):427-30. PMID: 26297941.
      View in: PubMed
    28. Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB. Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Arch Biochem Biophys. 2015 Jun 15; 576:39-48. PMID: 25558793.
      View in: PubMed
    29. Richardson A, Galvan V, Lin AL, Oddo S. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Exp Gerontol. 2015 Aug; 68:51-8. PMID: 25481271.
      View in: PubMed
    30. Richardson AG, Schadt EE. The role of macromolecular damage in aging and age-related disease. J Gerontol A Biol Sci Med Sci. 2014 Jun; 69 Suppl 1:S28-32. PMID: 24833583.
      View in: PubMed
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