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Michael Hale Elliott

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentOphthalmology
Phone405/271-8001
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    Collapse Research 
    Collapse research activities and funding
    R01EY028608     (ELLIOTT, MICHAEL H)Sep 1, 2018 - Jun 30, 2022
    NIH/NEI
    Caveolae-based mechanosensors for conventional outflow regulation
    Role: Principal Investigator

    R01EY019494     (ELLIOTT, MICHAEL H)Apr 1, 2009 - Sep 29, 2016
    NIH/NEI
    Role of caveolin-1 in the maintenance of blood-retinal barrier integrity
    Role: Principal Investigator

    F32EY013674     (ELLIOTT, MICHAEL H)Sep 13, 2001
    NIH/NEI
    Caveolin in Mammalian Photoreceptor Outer Segements
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wilkerson JL, Stiles MA, Gurley JM, Grambergs RC, Gu X, Elliott MH, Proia RL, Mandal NA. Sphingosine Kinase-1 Is Essential for Maintaining External/Outer Limiting Membrane and Associated Adherens Junctions in the Aging Retina. Mol Neurobiol. 2019 Oct; 56(10):7188-7207. PMID: 30997640.
      View in: PubMed
    2. Gurley JM, Elliott MH. The Role of Caveolin-1 in Retinal Inflammation. Adv Exp Med Biol. 2019; 1185:169-173. PMID: 31884607.
      View in: PubMed
    3. Reagan AM, Gu X, Paudel S, Ashpole NM, Zalles M, Sonntag WE, Ungvari Z, Csiszar A, Otalora L, Freeman WM, Stout MB, Elliott MH. Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. Neurobiol Aging. 2018 11; 71:1-12. PMID: 30059797.
      View in: PubMed
    4. Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. J Gerontol A Biol Sci Med Sci. 2018 06 14; 73(7):853-863. PMID: 29905772.
      View in: PubMed
    5. Royer DJ, Elliott MH, Le YZ, Carr DJJ. Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II. Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1512-1522. PMID: 29625473.
      View in: PubMed
    6. Sudharsan R, Elliott MH, Dolgova N, Aguirre GD, Beltran WA. Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. Adv Exp Med Biol. 2018; 1074:593-601. PMID: 29721992.
      View in: PubMed
    7. Masser DR, Otalora L, Clark NW, Kinter MT, Elliott MH, Freeman WM. Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy. J Neurochem. 2017 12; 143(5):595-608. PMID: 28902411.
      View in: PubMed
    8. Du M, Mangold CA, Bixler GV, Brucklacher RM, Masser DR, Stout MB, Elliott MH, Freeman WM. Retinal gene expression responses to aging are sexually divergent. Mol Vis. 2017; 23:707-717. PMID: 29062222.
      View in: PubMed
    9. McClellan ME, Elliott MH. Analysis of Fatty Acid and Cholesterol Content from Detergent-Resistant and Detergent-Free Membrane Microdomains. Methods Mol Biol. 2017; 1609:185-194. PMID: 28660583.
      View in: PubMed
    10. Elliott MH, Ashpole NE, Gu X, Herrnberger L, McClellan ME, Griffith GL, Reagan AM, Boyce TM, Tanito M, Tamm ER, Stamer WD. Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. Sci Rep. 2016 11 14; 6:37127. PMID: 27841369.
      View in: PubMed
    11. Gu X, Reagan AM, McClellan ME, Elliott MH. Caveolins and caveolae in ocular physiology and pathophysiology. Prog Retin Eye Res. 2017 01; 56:84-106. PMID: 27664379.
      View in: PubMed
    12. Coburn PS, Wiskur BJ, Miller FC, LaGrow AL, Astley RA, Elliott MH, Callegan MC. Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction. PLoS One. 2016; 11(5):e0154560. PMID: 27195776.
      View in: PubMed
    13. Reagan A, Gu X, Hauck SM, Ash JD, Cao G, Thompson TC, Elliott MH. Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol. 2016; 854:411-8. PMID: 26427439.
      View in: PubMed
    14. Li X, Gu X, Boyce TM, Zheng M, Reagan AM, Qi H, Mandal N, Cohen AW, Callegan MC, Carr DJ, Elliott MH. Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation. Invest Ophthalmol Vis Sci. 2014 Aug 26; 55(10):6224-34. PMID: 25159208.
      View in: PubMed
    15. Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor a protects capillary pericytes in the retina. Am J Pathol. 2014 Oct; 184(10):2709-20. PMID: 25108226.
      View in: PubMed
    16. Bennett LD, Brush RS, Chan M, Lydic TA, Reese K, Reid GE, Busik JV, Elliott MH, Anderson RE. Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors. Invest Ophthalmol Vis Sci. 2014 Apr 10; 55(5):3150-7. PMID: 24722693.
      View in: PubMed
    17. Gu X, Reagan A, Yen A, Bhatti F, Cohen AW, Elliott MH. Spatial and temporal localization of caveolin-1 protein in the developing retina. Adv Exp Med Biol. 2014; 801:15-21. PMID: 24664676.
      View in: PubMed
    18. Gu X, Fliesler SJ, Zhao YY, Stallcup WB, Cohen AW, Elliott MH. Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration. Am J Pathol. 2014 Feb; 184(2):541-55. PMID: 24326256.
      View in: PubMed
    19. Chen H, Tran JT, Eckerd A, Huynh TP, Elliott MH, Brush RS, Mandal NA. Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration. J Lipid Res. 2013 Jun; 54(6):1616-29. PMID: 23468130.
      View in: PubMed
    20. Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium. J Biol Chem. 2012 Jul 13; 287(29):24092-102. PMID: 22645143.
      View in: PubMed
    21. Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem. 2012 May 11; 287(20):16424-34. PMID: 22451674.
      View in: PubMed
    22. Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem. 2011 Sep 16; 286(37):32491-501. PMID: 21785167.
      View in: PubMed
    23. Li F, Marchette LD, Brush RS, Elliott MH, Davis KR, Anderson AG, Anderson RE. High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. Mol Vis. 2010 Aug 18; 16:1669-79. PMID: 20806040.
      View in: PubMed
    24. Brush RS, Tran JT, Henry KR, McClellan ME, Elliott MH, Mandal MN. Retinal sphingolipids and their very-long-chain fatty acid-containing species. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4422-31. PMID: 20393115.
      View in: PubMed
    25. Agbaga MP, Brush RS, Mandal MN, Elliott MH, Al-Ubaidi MR, Anderson RE. Role of Elovl4 protein in the biosynthesis of docosahexaenoic acid. Adv Exp Med Biol. 2010; 664:233-42. PMID: 20238022.
      View in: PubMed
    26. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration. Adv Exp Med Biol. 2010; 664:567-73. PMID: 20238060.
      View in: PubMed
    27. Li F, Marchette LD, Brush RS, Elliott MH, Le YZ, Henry KA, Anderson AG, Zhao C, Sun X, Zhang K, Anderson RE. DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol Vis. 2009 Jun 13; 15:1185-93. PMID: 19536303.
      View in: PubMed
    28. Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT, Wicker L, Kasus-Jacobi A, Elliott MH, Rao CV, Anderson RE. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med. 2009 Mar 01; 46(5):672-9. PMID: 19121385.
      View in: PubMed
    29. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res. 2009 May; 50(5):807-19. PMID: 19023138.
      View in: PubMed
    30. Agbaga MP, Brush RS, Mandal MN, Henry K, Elliott MH, Anderson RE. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12843-8. PMID: 18728184.
      View in: PubMed
    31. Ding XQ, Fitzgerald JB, Matveev AV, McClellan ME, Elliott MH. Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains. Biochemistry. 2008 Mar 25; 47(12):3677-87. PMID: 18303857.
      View in: PubMed
    32. Elliott MH, Ghalayini AJ. Phosphorylation of caveolin-1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase. Adv Exp Med Biol. 2008; 613:335-41. PMID: 18188962.
      View in: PubMed
    33. Elliott MH, Nash ZA, Takemori N, Fliesler SJ, McClellan ME, Naash MI. Differential distribution of proteins and lipids in detergent-resistant and detergent-soluble domains in rod outer segment plasma membranes and disks. J Neurochem. 2008 Jan; 104(2):336-52. PMID: 17944869.
      View in: PubMed
    34. Tanito M, Li F, Elliott MH, Dittmar M, Anderson RE. Protective effect of TEMPOL derivatives against light-induced retinal damage in rats. Invest Ophthalmol Vis Sci. 2007 Apr; 48(4):1900-5. PMID: 17389526.
      View in: PubMed
    35. Tanito M, Haniu H, Elliott MH, Singh AK, Matsumoto H, Anderson RE. Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. Free Radic Biol Med. 2006 Dec 15; 41(12):1847-59. PMID: 17157187.
      View in: PubMed
    36. Rajala RV, Elliott MH, McClellan ME, Anderson RE. Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. Adv Exp Med Biol. 2006; 572:491-7. PMID: 17249614.
      View in: PubMed
    37. Tanito M, Elliott MH, Kotake Y, Anderson RE. Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3859-68. PMID: 16186375.
      View in: PubMed
    38. Martin RE, Elliott MH, Brush RS, Anderson RE. Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1147-54. PMID: 15790872.
      View in: PubMed
    39. Elliott MH, Fliesler SJ, Ghalayini AJ. Cholesterol-dependent association of caveolin-1 with the transducin alpha subunit in bovine photoreceptor rod outer segments: disruption by cyclodextrin and guanosine 5'-O-(3-thiotriphosphate). Biochemistry. 2003 Jul 08; 42(26):7892-903. PMID: 12834341.
      View in: PubMed
    40. Ghalayini AJ, Desai N, Smith KR, Holbrook RM, Elliott MH, Kawakatsu H. Light-dependent association of Src with photoreceptor rod outer segment membrane proteins in vivo. J Biol Chem. 2002 Jan 11; 277(2):1469-76. PMID: 11705988.
      View in: PubMed
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