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Michael Hale Elliott

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentOphthalmology
Address608 Stanton L Young Blvd
Oklahoma City OK 73104-5014
Phone405/271-8001
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    Collapse Research 
    Collapse research activities and funding
    F32EY013674     (ELLIOTT, MICHAEL H)Sep 13, 2001
    NIH/NEI
    Caveolin in Mammalian Photoreceptor Outer Segements
    Role: Principal Investigator

    R01EY019494     (ELLIOTT, MICHAEL H)Apr 1, 2009 - Jun 30, 2020
    NIH/NEI
    Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier Integrity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Masser DR, Otalora L, Clark NW, Kinter MT, Elliott MH, Freeman WM. Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy. J Neurochem. 2017 Sep 13. PMID: 28902411.
      View in: PubMed
    2. McClellan ME, Elliott MH. Analysis of Fatty Acid and Cholesterol Content from Detergent-Resistant and Detergent-Free Membrane Microdomains. Methods Mol Biol. 2017; 1609:185-194. PMID: 28660583.
      View in: PubMed
    3. Elliott MH, Ashpole NE, Gu X, Herrnberger L, McClellan ME, Griffith GL, Reagan AM, Boyce TM, Tanito M, Tamm ER, Stamer WD. Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. Sci Rep. 2016 Nov 14; 6:37127. PMID: 27841369.
      View in: PubMed
    4. Gu X, Reagan AM, McClellan ME, Elliott MH. Caveolins and caveolae in ocular physiology and pathophysiology. Prog Retin Eye Res. 2017 Jan; 56:84-106. PMID: 27664379.
      View in: PubMed
    5. Yu JY, Du M, Elliott MH, Wu M, Fu D, Yang S, Basu A, Gu X, Ma JX, Aston CE, Lyons TJ. Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes. Diabetologia. 2016 Sep; 59(9):2026-35. PMID: 27306616; PMCID: PMC4969344.
    6. Coburn PS, Wiskur BJ, Miller FC, LaGrow AL, Astley RA, Elliott MH, Callegan MC. Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction. PLoS One. 2016; 11(5):e0154560. PMID: 27195776; PMCID: PMC4873292.
    7. Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ. The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem. 2016 Apr 15; 291(16):8721-34. PMID: 26893377; PMCID: PMC4861441 [Available on 04/15/17].
    8. Sethna S, Chamakkala T, Gu X, Thompson TC, Cao G, Elliott MH, Finnemann SC. Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision. J Biol Chem. 2016 Mar 18; 291(12):6494-506. PMID: 26814131; PMCID: PMC4813570 [Available on 03/18/17].
    9. Reagan A, Gu X, Hauck SM, Ash JD, Cao G, Thompson TC, Elliott MH. Retinal Caveolin-1 Modulates Neuroprotective Signaling. Adv Exp Med Biol. 2016; 854:411-8. PMID: 26427439.
      View in: PubMed
    10. Li X, Gu X, Boyce TM, Zheng M, Reagan AM, Qi H, Mandal N, Cohen AW, Callegan MC, Carr DJ, Elliott MH. Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation. Invest Ophthalmol Vis Sci. 2014 Aug 26; 55(10):6224-34. PMID: 25159208; PMCID: PMC4183075.
    11. Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor a protects capillary pericytes in the retina. Am J Pathol. 2014 Oct; 184(10):2709-20. PMID: 25108226; PMCID: PMC4188867.
    12. Bennett LD, Brush RS, Chan M, Lydic TA, Reese K, Reid GE, Busik JV, Elliott MH, Anderson RE. Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors. Invest Ophthalmol Vis Sci. 2014 Apr 10; 55(5):3150-7. PMID: 24722693; PMCID: PMC4027810.
    13. Gu X, Reagan A, Yen A, Bhatti F, Cohen AW, Elliott MH. Spatial and temporal localization of caveolin-1 protein in the developing retina. Adv Exp Med Biol. 2014; 801:15-21. PMID: 24664676; PMCID: PMC4311519.
    14. Gu X, Fliesler SJ, Zhao YY, Stallcup WB, Cohen AW, Elliott MH. Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration. Am J Pathol. 2014 Feb; 184(2):541-55. PMID: 24326256; PMCID: PMC3906491.
    15. Chen H, Tran JT, Eckerd A, Huynh TP, Elliott MH, Brush RS, Mandal NA. Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration. J Lipid Res. 2013 Jun; 54(6):1616-29. PMID: 23468130; PMCID: PMC3646463.
    16. Wu M, Yang S, Elliott MH, Fu D, Wilson K, Zhang J, Du M, Chen J, Lyons T. Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells. Invest Ophthalmol Vis Sci. 2012 Jul 09; 53(8):4595-604. PMID: 22678501; PMCID: PMC3394695.
    17. Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium. J Biol Chem. 2012 Jul 13; 287(29):24092-102. PMID: 22645143; PMCID: PMC3397836.
    18. Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem. 2012 May 11; 287(20):16424-34. PMID: 22451674; PMCID: PMC3351350.
    19. Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem. 2011 Sep 16; 286(37):32491-501. PMID: 21785167; PMCID: PMC3173208.
    20. Li F, Marchette LD, Brush RS, Elliott MH, Davis KR, Anderson AG, Anderson RE. High levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice. Mol Vis. 2010 Aug 18; 16:1669-79. PMID: 20806040; PMCID: PMC2927381.
    21. Wang J, Xu X, Elliott MH, Zhu M, Le YZ. Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes. 2010 Sep; 59(9):2297-305. PMID: 20530741; PMCID: PMC2927953.
    22. Brush RS, Tran JT, Henry KR, McClellan ME, Elliott MH, Mandal MN. Retinal sphingolipids and their very-long-chain fatty acid-containing species. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4422-31. PMID: 20393115; PMCID: PMC2941185.
    23. Agbaga MP, Brush RS, Mandal MN, Elliott MH, Al-Ubaidi MR, Anderson RE. Role of Elovl4 protein in the biosynthesis of docosahexaenoic acid. Adv Exp Med Biol. 2010; 664:233-42. PMID: 20238022; PMCID: PMC4350578.
    24. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration. Adv Exp Med Biol. 2010; 664:567-73. PMID: 20238060.
      View in: PubMed
    25. Li F, Marchette LD, Brush RS, Elliott MH, Le YZ, Henry KA, Anderson AG, Zhao C, Sun X, Zhang K, Anderson RE. DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol Vis. 2009 Jun 13; 15:1185-93. PMID: 19536303; PMCID: PMC2697457.
    26. Mandal MN, Patlolla JM, Zheng L, Agbaga MP, Tran JT, Wicker L, Kasus-Jacobi A, Elliott MH, Rao CV, Anderson RE. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic Biol Med. 2009 Mar 01; 46(5):672-9. PMID: 19121385; PMCID: PMC2810836.
    27. Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE. High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration. J Lipid Res. 2009 May; 50(5):807-19. PMID: 19023138; PMCID: PMC2666167.
    28. Agbaga MP, Brush RS, Mandal MN, Henry K, Elliott MH, Anderson RE. Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12843-8. PMID: 18728184; PMCID: PMC2525561.
    29. Ding XQ, Fitzgerald JB, Matveev AV, McClellan ME, Elliott MH. Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains. Biochemistry. 2008 Mar 25; 47(12):3677-87. PMID: 18303857.
      View in: PubMed
    30. Elliott MH, Ghalayini AJ. Phosphorylation of caveolin-1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase. Adv Exp Med Biol. 2008; 613:335-41. PMID: 18188962.
      View in: PubMed
    31. Elliott MH, Nash ZA, Takemori N, Fliesler SJ, McClellan ME, Naash MI. Differential distribution of proteins and lipids in detergent-resistant and detergent-soluble domains in rod outer segment plasma membranes and disks. J Neurochem. 2008 Jan; 104(2):336-52. PMID: 17944869; PMCID: PMC2823591.
    32. Tanito M, Li F, Elliott MH, Dittmar M, Anderson RE. Protective effect of TEMPOL derivatives against light-induced retinal damage in rats. Invest Ophthalmol Vis Sci. 2007 Apr; 48(4):1900-5. PMID: 17389526.
      View in: PubMed
    33. Tanito M, Haniu H, Elliott MH, Singh AK, Matsumoto H, Anderson RE. Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. Free Radic Biol Med. 2006 Dec 15; 41(12):1847-59. PMID: 17157187.
      View in: PubMed
    34. Rajala RV, Elliott MH, McClellan ME, Anderson RE. Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. Adv Exp Med Biol. 2006; 572:491-7. PMID: 17249614.
      View in: PubMed
    35. Tanito M, Elliott MH, Kotake Y, Anderson RE. Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci. 2005 Oct; 46(10):3859-68. PMID: 16186375.
      View in: PubMed
    36. Martin RE, Elliott MH, Brush RS, Anderson RE. Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes. Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1147-54. PMID: 15790872.
      View in: PubMed
    37. Elliott MH, Fliesler SJ, Ghalayini AJ. Cholesterol-dependent association of caveolin-1 with the transducin alpha subunit in bovine photoreceptor rod outer segments: disruption by cyclodextrin and guanosine 5'-O-(3-thiotriphosphate). Biochemistry. 2003 Jul 08; 42(26):7892-903. PMID: 12834341.
      View in: PubMed
    38. Ghalayini AJ, Desai N, Smith KR, Holbrook RM, Elliott MH, Kawakatsu H. Light-dependent association of Src with photoreceptor rod outer segment membrane proteins in vivo. J Biol Chem. 2002 Jan 11; 277(2):1469-76. PMID: 11705988.
      View in: PubMed
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