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Last Name

Michael Ihnat

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
Address1110 N Stonewall Ave
Oklahoma City OK 73117-1200
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    Collapse Biography 
    Collapse education and training
    Dartmouth Medical SchoolPhD1997Pharmacology & Toxicology
    Fred Hutchinson Cancer CenterPostdoc1999Molecular Pharmacology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK. Transition from androgenic to neurosteroidal action of 5a-androstane-3a, 17ß-diol through the type A ?-aminobutyric acid receptor in prostate cancer progression. J Steroid Biochem Mol Biol. 2018 Apr; 178:89-98. PMID: 29155210.
      View in: PubMed
    2. Eckert J, Scott B, Lawrence SM, Ihnat M, Chaaban H. FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis. J Inflamm Res. 2017; 10:75-81. PMID: 28652797.
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    3. Ziegler J, Bastian A, Lerner M, Bailey-Downs L, Saunders D, Smith N, Sutton J, Battiste JD, Ihnat MA, Gangjee A, Towner RA. AG488 as a therapy against gliomas. Oncotarget. 2017 Sep 22; 8(42):71833-71844. PMID: 29069750.
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    4. Luckett-Chastain LR, Cottrell ML, Kawar BM, Ihnat MA, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-ß receptor I and II (TGF-ßRI and II) function in epidermal keratinocytes. Exp Dermatol. 2017 08; 26(8):697-704. PMID: 27892604.
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    5. Zaware N, Kisliuk R, Bastian A, Ihnat MA, Gangjee A. Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett. 2017 04 01; 27(7):1602-1607. PMID: 28258797.
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    6. Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA. AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1a stabilization. Cancer Lett. 2017 03 01; 388:149-157. PMID: 27939695.
      View in: PubMed
    7. Pavana RK, Choudhary S, Bastian A, Ihnat MA, Bai R, Hamel E, Gangjee A. Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents. Bioorg Med Chem. 2017 01 15; 25(2):545-556. PMID: 27894589.
      View in: PubMed
    8. Hurst RE, Bastian A, Bailey-Downs L, Ihnat MA. Targeting dormant micrometastases: rationale, evidence to date and clinical implications. Ther Adv Med Oncol. 2016 Mar; 8(2):126-37. PMID: 26929788; PMCID: PMC4753353.
    9. Towner RA, Ihnat M, Saunders D, Bastian A, Smith N, Pavana RK, Gangjee A. A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model. BMC Cancer. 2015 Jul 17; 15:522. PMID: 26177924; PMCID: PMC4504175.
    10. Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA. Identification of novel drugs to target dormant micrometastases. BMC Cancer. 2015 May 14; 15:404. PMID: 25971923; PMCID: PMC4434572.
    11. Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents. Bioorg Med Chem. 2015 May 15; 23(10):2408-23. PMID: 25882519; PMCID: PMC4410085.
    12. Crosby HA, Ihnat M, Miller KE. Evaluating the Toxicity of the Analgesic Glutaminase Inhibitor 6-Diazo-5-Oxo-L-Norleucine in vitro and on Rat Dermal Skin Fibroblasts. MOJ Toxicol. 2015; 1(1). PMID: 29750203.
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    13. Bastian A, Thorpe JE, Disch BC, Bailey-Downs LC, Gangjee A, Devambatla RK, Henthorn J, Humphries KM, Vadvalkar SS, Ihnat MA. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther. 2015 May; 353(2):392-404. PMID: 25720766; PMCID: PMC4407723.
    14. Bailey-Downs LC, Thorpe JE, Disch BC, Bastian A, Hauser PJ, Farasyn T, Berry WL, Hurst RE, Ihnat MA. Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression. PLoS One. 2014; 9(5):e98624. PMID: 24878664; PMCID: PMC4039511.
    15. Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res. 2014; 6(3):236-47. PMID: 24936217; PMCID: PMC4058306.
    16. Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. Bioorg Med Chem. 2014 Jul 15; 22(14):3753-72. PMID: 24890652.
      View in: PubMed
    17. Gangjee A, Pavana RK, Ihnat MA, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Hamel E, Bai R. Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential. ACS Med Chem Lett. 2014 May 08; 5(5):480-4. PMID: 24900865; PMCID: PMC4027584.
    18. Pathuri G, Hedrick AF, Awasthi V, Ihnat MA, Gali H. Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT. Bioorg Med Chem Lett. 2013 Sep 15; 23(18):5049-52. PMID: 23937983.
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    19. Hurst RE, Hauser PJ, Kyker KD, Heinlen JE, Hodde JP, Hiles MC, Kosanke SD, Dozmorov M, Ihnat MA. Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy". PLoS One. 2013; 8(5):e64181. PMID: 23717563; PMCID: PMC3663841.
    20. Pathuri G, Thorpe JE, Disch BC, Bailey-Downs LC, Ihnat MA, Gali H. Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor. Bioorg Med Chem Lett. 2013 Jun 15; 23(12):3561-4. PMID: 23664876.
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    21. Gangjee A, Zaware N, Raghavan S, Disch BC, Thorpe JE, Bastian A, Ihnat MA. Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents. Bioorg Med Chem. 2013 Apr 01; 21(7):1857-64. PMID: 23434139; PMCID: PMC3602277.
    22. Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Bailey-Downs LC. N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents. Bioorg Med Chem. 2013 Mar 01; 21(5):1312-23. PMID: 23375090; PMCID: PMC3574204.
    23. Pathuri G, Hedrick AF, Disch BC, Ihnat MA, Awasthi V, Gali H. Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates. Bioorg Med Chem Lett. 2012 Jul 15; 22(14):4567-70. PMID: 22727671.
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    24. Gangjee A, Zhao Y, Ihnat MA, Thorpe JE, Bailey-Downs LC, Kisliuk RL. Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents. Bioorg Med Chem. 2012 Jul 15; 20(14):4217-25. PMID: 22739090; PMCID: PMC3397428.
    25. Luckett-Chastain LR, Ihnat MA, Mickle-Kawar BM, Gallucci RM. SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. J Interferon Cytokine Res. 2012 May; 32(5):207-15. PMID: 22313262; PMCID: PMC3354580.
    26. Gangjee A, Zaware N, Raghavan S, Yang J, Thorpe JE, Ihnat MA. N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. Bioorg Med Chem. 2012 Apr 01; 20(7):2444-54. PMID: 22370340; PMCID: PMC3310894.
    27. Pathuri G, Hedrick AF, Disch BC, Doan JT, Ihnat MA, Awasthi V, Gali H. Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo. Bioconjug Chem. 2012 Jan 18; 23(1):115-24. PMID: 22148582; PMCID: PMC3261373.
    28. Gangjee A, Kurup S, Ihnat MA, Thorpe JE, Disch B. N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2012 Jan 15; 20(2):910-4. PMID: 22204741; PMCID: PMC3276368.
    29. Longeras R, Farjo K, Ihnat M, Ma JX. A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells. Exp Diabetes Res. 2012; 2012:518426. PMID: 21754923; PMCID: PMC3132462.
    30. Mondalek FG, Ashley RA, Roth CC, Kibar Y, Shakir N, Ihnat MA, Fung KM, Grady BP, Kropp BP, Lin HK. Enhanced angiogenesis of modified porcine small intestinal submucosa with hyaluronic acid-poly(lactide-co-glycolide) nanoparticles: from fabrication to preclinical validation. J Biomed Mater Res A. 2010 Sep 01; 94(3):712-9. PMID: 20213816.
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    31. Gangjee A, Zhao Y, Raghavan S, Ihnat MA, Disch BC. Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2010 Jul 15; 18(14):5261-73. PMID: 20558072; PMCID: PMC2910361.
    32. Gangjee A, Kurup S, Ihnat MA, Thorpe JE, Shenoy SS. Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents. Bioorg Med Chem. 2010 May 15; 18(10):3575-87. PMID: 20403700; PMCID: PMC2868963.
    33. Gangjee A, Namjoshi OA, Ihnat MA, Buchanan A. The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. Bioorg Med Chem Lett. 2010 May 15; 20(10):3177-81. PMID: 20403693; PMCID: PMC2866134.
    34. Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E, Pandit B, Ihnat MA, Shenoy SS, Kulp S, Li PK, Li C, Fuchs J, Lin J. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 2010 Mar 15; 70(6):2445-54. PMID: 20215512; PMCID: PMC2843552.
    35. Pantazis P, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo. Altern Ther Health Med. 2010 Mar-Apr; 16(2):12-4. PMID: 20232614.
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    36. Gangjee A, Zaware N, Raghavan S, Ihnat M, Shenoy S, Kisliuk RL. Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. J Med Chem. 2010 Feb 25; 53(4):1563-78. PMID: 20092323; PMCID: PMC2825747.
    37. Gangjee A, Li W, Lin L, Zeng Y, Ihnat M, Warnke LA, Green DW, Cody V, Pace J, Queener SF. Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem. 2009 Oct 15; 17(20):7324-36. PMID: 19748785; PMCID: PMC2779540.
    38. Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol. 2009 Sep; 76(3):588-95. PMID: 19528198.
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    39. Ceriello A, Esposito K, Ihnat M, Thorpe J, Giugliano D. Long-term glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 diabetes. J Clin Endocrinol Metab. 2009 Aug; 94(8):2751-6. PMID: 19491221.
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    40. Kozul CD, Hampton TH, Davey JC, Gosse JA, Nomikos AP, Eisenhauer PL, Weiss DJ, Thorpe JE, Ihnat MA, Hamilton JW. Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ Health Perspect. 2009 Jul; 117(7):1108-15. PMID: 19654921; PMCID: PMC2717138.
    41. Ceriello A, Ihnat MA, Thorpe JE. Clinical review 2: The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications? J Clin Endocrinol Metab. 2009 Feb; 94(2):410-5. PMID: 19066300.
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    42. Ceriello A, Esposito K, Piconi L, Ihnat M, Thorpe J, Testa R, Bonfigli AR, Giugliano D. Glucose "peak" and glucose "spike": Impact on endothelial function and oxidative stress. Diabetes Res Clin Pract. 2008 Nov; 82(2):262-7. PMID: 18950890.
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    43. Corgnali M, Piconi L, Ihnat M, Ceriello A. Evaluation of gliclazide ability to attenuate the hyperglycaemic 'memory' induced by high glucose in isolated human endothelial cells. Diabetes Metab Res Rev. 2008 May-Jun; 24(4):301-9. PMID: 18088078.
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    44. Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Warnke LA. Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2008 May 15; 16(10):5514-28. PMID: 18467105; PMCID: PMC2474725.
    45. Wu M, Chen Y, Wilson K, Chirindel A, Ihnat MA, Yu Y, Boulton ME, Szweda LI, Ma JX, Lyons TJ. Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2679-85. PMID: 18362112.
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    46. Kozul CD, Nomikos AP, Hampton TH, Warnke LA, Gosse JA, Davey JC, Thorpe JE, Jackson BP, Ihnat MA, Hamilton JW. Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem Biol Interact. 2008 May 28; 173(2):129-40. PMID: 18396267.
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    47. Ceriello A, Esposito K, Piconi L, Ihnat MA, Thorpe JE, Testa R, Boemi M, Giugliano D. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes. 2008 May; 57(5):1349-54. PMID: 18299315.
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    48. Saban MR, Hellmich HL, Simpson C, Davis CA, Lang ML, Ihnat MA, O'Donnell MA, Wu XR, Saban R. Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins. BMC Cancer. 2007 Nov 02; 7:204. PMID: 17980030; PMCID: PMC2212656.
    49. Sarasam AR, Samli AI, Hess L, Ihnat MA, Madihally SV. Blending chitosan with polycaprolactone: porous scaffolds and toxicity. Macromol Biosci. 2007 Sep 11; 7(9-10):1160-7. PMID: 17703475.
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    50. Saban R, Simpson C, Davis CA, Dozmorov I, Maier J, Fowler B, Ihnat MA, Hurst RE, Wershil BK, Saban MR. Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol. 2007 Aug 17; 8:17. PMID: 17705868; PMCID: PMC2000913.
    51. Andrew AS, Bernardo V, Warnke LA, Davey JC, Hampton T, Mason RA, Thorpe JE, Ihnat MA, Hamilton JW. Exposure to arsenic at levels found inU.S. drinking water modifies expression in the mouse lung. Toxicol Sci. 2007 Nov; 100(1):75-87. PMID: 17682005.
      View in: PubMed
    52. Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Simpson C, Saban MR. Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol. 2007 Mar 30; 7:3. PMID: 17397547; PMCID: PMC1853107.
    53. Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Davis CA, Simpson C, Saban MR. Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol. 2007 Mar 30; 7:4. PMID: 17397548; PMCID: PMC1853108.
    54. Azzarello J, Ihnat MA, Kropp BP, Warnke LA, Lin HK. Assessment of angiogenic properties of biomaterials using the chicken embryo chorioallantoic membrane assay. Biomed Mater. 2007 Jun; 2(2):55-61. PMID: 18458436.
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    55. Kamat CD, Thorpe JE, Shenoy SS, Ceriello A, Green DE, Warnke LA, Ihnat MA. A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization. BMC Cardiovasc Disord. 2007 Jan 18; 7:4. PMID: 17233898; PMCID: PMC1783864.
    56. Kamat CD, Green DE, Warnke L, Thorpe JE, Ceriello A, Ihnat MA. Mutant p53 facilitates pro-angiogenic, hyperproliferative phenotype in response to chronic relative hypoxia. Cancer Lett. 2007 May 08; 249(2):209-19. PMID: 16997458.
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    57. Gangjee A, Zeng Y, Ihnat M, Warnke LA, Green DW, Kisliuk RL, Lin FT. Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity. Bioorg Med Chem. 2005 Sep 15; 13(18):5475-91. PMID: 16039863.
      View in: PubMed
    58. Kamat CD, Green DE, Curilla S, Warnke L, Hamilton JW, Sturup S, Clark C, Ihnat MA. Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration. Toxicol Sci. 2005 Aug; 86(2):248-57. PMID: 15888669.
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    59. Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA. A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel. Cancer Lett. 2005 Jan 20; 217(2):171-80. PMID: 15617834.
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    60. Gangjee A, Yang J, Ihnat MA, Kamat S. Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases. Bioorg Med Chem. 2003 Nov 17; 11(23):5155-70. PMID: 14604679.
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    61. Soucy NV, Ihnat MA, Kamat CD, Hess L, Post MJ, Klei LR, Clark C, Barchowsky A. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci. 2003 Dec; 76(2):271-9. PMID: 12970581.
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    62. Shi J, Xiao Z, Ihnat MA, Kamat C, Pandit B, Hu Z, Li PK. Structure-activity relationships studies of the anti-angiogenic activities of linomide. Bioorg Med Chem Lett. 2003 Mar 24; 13(6):1187-9. PMID: 12643940.
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    63. Marks MG, Shi J, Fry MO, Xiao Z, Trzyna M, Pokala V, Ihnat MA, Li PK. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May; 25(5):597-604. PMID: 12033499.
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