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Nathan Shankar

TitleProf & Vc Chair
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
Address1110 N Stonewall Ave
Oklahoma City OK 73117-1200
Phone405/271-6481
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    Collapse Research 
    Collapse research activities and funding
    R29AI040651     (SHANKAR, NATHAN)Jan 1, 1997 - Dec 31, 2002
    NIH/NIAID
    NEW POTENTIAL VIRULENCE FACTOR IN E FAECALIS
    Role: Principal Investigator

    R01AI059673     (SHANKAR, NATHAN)Jul 1, 2004 - Jun 30, 2010
    NIH/NIAID
    Role of E. faecalis Esp in biofilms and UTI
    Role: Principal Investigator

    R21DE020928     (SHANKAR, NATHAN)Aug 15, 2010 - Jan 31, 2013
    NIH/NIDCR
    Host immune response to E. faecalis bioflim
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zou J, Shankar N. The opportunistic pathogen Enterococcus faecalis resists phagosome acidification and autophagy to promote intracellular survival in macrophages. Cell Microbiol. 2016 06; 18(6):831-43. PMID: 26663775.
      View in: PubMed
    2. Zou J, Shankar N. Surface protein Esp enhances pro-inflammatory cytokine expression through NF-?B activation during enterococcal infection. Innate Immun. 2016 Jan; 22(1):31-9. PMID: 26503704.
      View in: PubMed
    3. Zou J, Shankar N. Roles of TLR/MyD88/MAPK/NF-?B Signaling Pathways in the Regulation of Phagocytosis and Proinflammatory Cytokine Expression in Response to E. faecalis Infection. PLoS One. 2015; 10(8):e0136947. PMID: 26317438; PMCID: PMC4552673.
    4. Zou J, Baghdayan AS, Payne SJ, Shankar N. A TIR domain protein from E. faecalis attenuates MyD88-mediated signaling and NF-?B activation. PLoS One. 2014; 9(11):e112010. PMID: 25369374; PMCID: PMC4219826.
    5. Zou J, Shankar N. Enterococcus faecalis infection activates phosphatidylinositol 3-kinase signaling to block apoptotic cell death in macrophages. Infect Immun. 2014 Dec; 82(12):5132-42. PMID: 25267834; PMCID: PMC4249289.
    6. Maddox SM, Coburn PS, Shankar N, Conway T. Transcriptional regulator PerA influences biofilm-associated, platelet binding, and metabolic gene expression in Enterococcus faecalis. PLoS One. 2012; 7(4):e34398. PMID: 22496800; PMCID: PMC3319582.
    7. Daw K, Baghdayan AS, Awasthi S, Shankar N. Biofilm and planktonic Enterococcus faecalis elicit different responses from host phagocytes in vitro. FEMS Immunol Med Microbiol. 2012 Jul; 65(2):270-82. PMID: 22333034; PMCID: PMC3366019.
    8. Vilekar P, Awasthi V, Lagisetty P, King C, Shankar N, Awasthi S. In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine. BMC Immunol. 2010 Dec 10; 11:60. PMID: 21143974; PMCID: PMC3018378.
    9. Coburn PS, Baghdayan AS, Craig N, Burroughs A, Tendolkar P, Miller K, Najar FZ, Roe BA, Shankar N. A novel conjugative plasmid from Enterococcus faecalis E99 enhances resistance to ultraviolet radiation. Plasmid. 2010 Jul; 64(1):18-25. PMID: 20307569; PMCID: PMC2891438.
    10. McBride SM, Coburn PS, Baghdayan AS, Willems RJ, Grande MJ, Shankar N, Gilmore MS. Genetic variation and evolution of the pathogenicity island of Enterococcus faecalis. J Bacteriol. 2009 May; 191(10):3392-402. PMID: 19270086; PMCID: PMC2687173.
    11. Coburn PS, Baghdayan AS, Dolan GT, Shankar N. An AraC-type transcriptional regulator encoded on the Enterococcus faecalis pathogenicity island contributes to pathogenesis and intracellular macrophage survival. Infect Immun. 2008 Dec; 76(12):5668-76. PMID: 18824537; PMCID: PMC2583563.
    12. Dozmorov MG, Kyker KD, Saban R, Shankar N, Baghdayan AS, Centola MB, Hurst RE. Systems biology approach for mapping the response of human urothelial cells to infection by Enterococcus faecalis. BMC Bioinformatics. 2007 Nov 01; 8 Suppl 7:S2. PMID: 18047719; PMCID: PMC2099488.
    13. Coburn PS, Baghdayan AS, Dolan GT, Shankar N. Horizontal transfer of virulence genes encoded on the Enterococcus faecalis pathogenicity island. Mol Microbiol. 2007 Jan; 63(2):530-44. PMID: 17163979.
      View in: PubMed
    14. Shankar N, Baghdayan AS, Willems R, Hammerum AM, Jensen LB. Presence of pathogenicity island genes in Enterococcus faecalis isolates from pigs in Denmark. J Clin Microbiol. 2006 Nov; 44(11):4200-3. PMID: 16957034; PMCID: PMC1698369.
    15. Tendolkar PM, Baghdayan AS, Shankar N. Putative surface proteins encoded within a novel transferable locus confer a high-biofilm phenotype to Enterococcus faecalis. J Bacteriol. 2006 Mar; 188(6):2063-72. PMID: 16513736; PMCID: PMC1428127.
    16. Tendolkar PM, Baghdayan AS, Shankar N. The N-terminal domain of enterococcal surface protein, Esp, is sufficient for Esp-mediated biofilm enhancement in Enterococcus faecalis. J Bacteriol. 2005 Sep; 187(17):6213-22. PMID: 16109963; PMCID: PMC1196143.
    17. Pultz NJ, Shankar N, Baghdayan AS, Donskey CJ. Enterococcal surface protein Esp does not facilitate intestinal colonization or translocation of Enterococcus faecalis in clindamycin-treated mice. FEMS Microbiol Lett. 2005 Jan 15; 242(2):217-9. PMID: 15621440.
      View in: PubMed
    18. Tendolkar PM, Baghdayan AS, Gilmore MS, Shankar N. Enterococcal surface protein, Esp, enhances biofilm formation by Enterococcus faecalis. Infect Immun. 2004 Oct; 72(10):6032-9. PMID: 15385507; PMCID: PMC517584.
    19. Shankar N, Coburn P, Pillar C, Haas W, Gilmore M. Enterococcal cytolysin: activities and association with other virulence traits in a pathogenicity island. Int J Med Microbiol. 2004 Apr; 293(7-8):609-18. PMID: 15149038.
      View in: PubMed
    20. Leavis H, Top J, Shankar N, Borgen K, Bonten M, van Embden J, Willems RJ. A novel putative enterococcal pathogenicity island linked to the esp virulence gene of Enterococcus faecium and associated with epidemicity. J Bacteriol. 2004 Feb; 186(3):672-82. PMID: 14729692; PMCID: PMC321477.
    21. Tendolkar PM, Baghdayan AS, Shankar N. Pathogenic enterococci: new developments in the 21st century. Cell Mol Life Sci. 2003 Dec; 60(12):2622-36. PMID: 14685687.
      View in: PubMed
    22. Vergis EN, Shankar N, Chow JW, Hayden MK, Snydman DR, Zervos MJ, Linden PK, Wagener MM, Muder RR. Association between the presence of enterococcal virulence factors gelatinase, hemolysin, and enterococcal surface protein and mortality among patients with bacteremia due to Enterococcus faecalis. Clin Infect Dis. 2002 Sep 01; 35(5):570-5. PMID: 12173131.
      View in: PubMed
    23. Shankar N, Baghdayan AS, Gilmore MS. Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis. Nature. 2002 Jun 13; 417(6890):746-50. PMID: 12066186.
      View in: PubMed
    24. Archimbaud C, Shankar N, Forestier C, Baghdayan A, Gilmore MS, Charbonné F, Joly B. In vitro adhesive properties and virulence factors of Enterococcusfaecalis strains. Res Microbiol. 2002 Mar; 153(2):75-80. PMID: 11900266.
      View in: PubMed
    25. Shankar N, Lockatell CV, Baghdayan AS, Drachenberg C, Gilmore MS, Johnson DE. Role of Enterococcus faecalis surface protein Esp in the pathogenesis of ascending urinary tract infection. Infect Immun. 2001 Jul; 69(7):4366-72. PMID: 11401975; PMCID: PMC98508.
    26. Shankar V, Baghdayan AS, Huycke MM, Lindahl G, Gilmore MS. Infection-derived Enterococcus faecalis strains are enriched in esp, a gene encoding a novel surface protein. Infect Immun. 1999 Jan; 67(1):193-200. PMID: 9864215; PMCID: PMC96296.
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