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Noah S Butler

TitleAssistant Professor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-2133
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    Collapse Research 
    Collapse research activities and funding
    K22AI099070     (BUTLER, NOAH SULLIVAN)Jan 18, 2013 - Dec 31, 2014
    NIH/NIAID
    Role of CD4 T cell inhibitor receptors during Plasmodium blood stage infection
    Role: Principal Investigator

    R01AI125446     (BUTLER, NOAH SULLIVAN)Jun 15, 2016 - May 31, 2021
    NIH/NIAID
    Development and function of CD4+ memory T cells during malaria
    Role: Principal Investigator

    R01AI127481     (BUTLER, NOAH SULLIVAN)Sep 26, 2016 - Aug 31, 2021
    NIH/NIAID
    Regulation of Plasmodium-specific CD4+ T Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Huggins MA, Johnson HL, Jin F, N Songo A, Hanson LM, LaFrance SJ, Butler NS, Harty JT, Johnson AJ. Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria. Infect Immun. 2017 May; 85(5). PMID: 28264905.
      View in: PubMed
    2. Guthmiller JJ, Graham AC, Zander RA, Pope RL, Butler NS. Cutting Edge: IL-10 Is Essential for the Generation of Germinal Center B Cell Responses and Anti-Plasmodium Humoral Immunity. J Immunol. 2017 Jan 15; 198(2):617-622. PMID: 27940658.
      View in: PubMed
    3. Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ, Butler NS. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLoS Pathog. 2016 Oct; 12(10):e1005945. PMID: 27732671.
      View in: PubMed
    4. Richer MJ, Lang ML, Butler NS. T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and Function. J Immunol. 2016 Aug 15; 197(4):1009-15. PMID: 27496973; PMCID: PMC4978142 [Available on 08/15/17].
    5. Butler NS, Schmidt NW. Erythropoietin-producing hepatocellular receptor B2 receptor tyrosine kinase: A novel regulator of infection- and inflammation-induced liver fibrosis. Hepatology. 2015 Sep; 62(3):680-3. PMID: 25914283; PMCID: PMC4549189.
    6. Zhang G, Niu G, Franca CM, Dong Y, Wang X, Butler NS, Dimopoulos G, Li J. Anopheles Midgut FREP1 Mediates Plasmodium Invasion. J Biol Chem. 2015 Jul 03; 290(27):16490-501. PMID: 25991725; PMCID: PMC4505404.
    7. Zander RA, Obeng-Adjei N, Guthmiller JJ, Kulu DI, Li J, Ongoiba A, Traore B, Crompton PD, Butler NS. PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host Microbe. 2015 May 13; 17(5):628-41. PMID: 25891357; PMCID: PMC4433434.
    8. Butler NS, Kulu DI. The regulation of T follicular helper responses during infection. Curr Opin Immunol. 2015 Jun; 34:68-74. PMID: 25726751; PMCID: PMC4444382.
    9. Guthmiller JJ, Zander RA, Butler NS. Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice. Methods Mol Biol. 2015; 1325:19-37. PMID: 26450376.
      View in: PubMed
    10. Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler NS, Fett C, Tscharke DC, Rossjohn J, Perlman S, Purcell AW. The cellular redox environment alters antigen presentation. J Biol Chem. 2014 Oct 03; 289(40):27979-91. PMID: 25135637; PMCID: PMC4183829.
    11. Doll KL, Butler NS, Harty JT. CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii. Vaccine. 2014 Jan 16; 32(4):483-91. PMID: 24321740; PMCID: PMC3923319.
    12. Butler NS, Harris TH, Blader IJ. Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions? Trends Parasitol. 2013 Dec; 29(12):593-602. PMID: 24184186; PMCID: PMC3883126.
    13. Zander RA, Butler NS. Dysfunctional adaptive immunity during parasitic infections. Curr Immunol Rev. 2013 Aug 01; 9(3):179-189. PMID: 24839433.
      View in: PubMed
    14. Doll KL, Butler NS, Harty JT. Tracking the total CD8 T cell response following whole Plasmodium vaccination. Methods Mol Biol. 2013; 923:493-504. PMID: 22990800.
      View in: PubMed
    15. Illingworth J, Butler NS, Roetynck S, Mwacharo J, Pierce SK, Bejon P, Crompton PD, Marsh K, Ndungu FM. Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. J Immunol. 2013 Feb 01; 190(3):1038-47. PMID: 23264654; PMCID: PMC3549224.
    16. Butler NS, Vaughan AM, Harty JT, Kappe SH. Whole parasite vaccination approaches for prevention of malaria infection. Trends Immunol. 2012 May; 33(5):247-54. PMID: 22405559.
      View in: PubMed
    17. Butler NS, Moebius J, Pewe LL, Traore B, Doumbo OK, Tygrett LT, Waldschmidt TJ, Crompton PD, Harty JT. Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol. 2011 Dec 11; 13(2):188-95. PMID: 22157630; PMCID: PMC3262959.
    18. Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe. 2011 Jun 16; 9(6):451-62. PMID: 21669394; PMCID: PMC3117254.
    19. Butler NS, Nolz JC, Harty JT. Immunologic considerations for generating memory CD8 T cells through vaccination. Cell Microbiol. 2011 Jul; 13(7):925-33. PMID: 21501363; PMCID: PMC3116979.
    20. Schmidt NW, Butler NS, Harty JT. Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity. J Immunol. 2011 May 15; 186(10):5873-84. PMID: 21460205; PMCID: PMC3087867.
    21. Schmidt NW, Butler NS, Badovinac VP, Harty JT. Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. PLoS Pathog. 2010 Jul 15; 6(7):e1000998. PMID: 20657824; PMCID: PMC2904779.
    22. Butler NS, Schmidt NW, Harty JT. Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites. J Immunol. 2010 Mar 01; 184(5):2528-38. PMID: 20097864; PMCID: PMC2904689.
    23. Butler NS, Harty JT. The role of inflammation in the generation and maintenance of memory T cells. Adv Exp Med Biol. 2010; 684:42-56. PMID: 20795539.
      View in: PubMed
    24. Schmidt NW, Butler NS, Harty JT. CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge. Vaccine. 2009 Oct 19; 27(44):6103-6. PMID: 19712771; PMCID: PMC2759845.
    25. Butler NS, Harty JT. A "memorable" NK cell discovery. Cell Res. 2009 Mar; 19(3):277-8. PMID: 19252510.
      View in: PubMed
    26. Butler NS, Theodossis A, Webb AI, Nastovska R, Ramarathinam SH, Dunstone MA, Rossjohn J, Purcell AW, Perlman S. Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant. PLoS Pathog. 2008 Oct; 4(10):e1000186. PMID: 18949029; PMCID: PMC2563037.
    27. Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, Bahjat KS, Lauer P, Reyes-Sandoval A, Hutchings CL, Moore AC, Gilbert SC, Hill AV, Bartholomay LC, Harty JT. Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14017-22. PMID: 18780790; PMCID: PMC2544571.
    28. Butler NS, Theodossis A, Webb AI, Dunstone MA, Nastovska R, Ramarathinam SH, Rossjohn J, Purcell AW, Perlman S. Structural and biological basis of CTL escape in coronavirus-infected mice. J Immunol. 2008 Mar 15; 180(6):3926-37. PMID: 18322201.
      View in: PubMed
    29. Butler NS, Dandekar AA, Perlman S. Antiviral antibodies are necessary to prevent cytotoxic T-lymphocyte escape in mice infected with a coronavirus. J Virol. 2007 Dec; 81(24):13291-8. PMID: 17913802; PMCID: PMC2168833.
    30. Yarovinsky TO, Butler NS, Monick MM, Hunninghake GW. Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR. J Immunol. 2006 Oct 01; 177(7):4426-35. PMID: 16982877.
      View in: PubMed
    31. Butler N, Pewe L, Trandem K, Perlman S. Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology. 2006 Apr 10; 347(2):410-21. PMID: 16413043.
      View in: PubMed
    32. Butler N, Pewe L, Trandem K, Perlman S. HCoV-OC43-induced encephalitis is in part immune-mediated. Adv Exp Med Biol. 2006; 581:531-4. PMID: 17037592.
      View in: PubMed
    33. Ashare A, Powers LS, Butler NS, Doerschug KC, Monick MM, Hunninghake GW. Anti-inflammatory response is associated with mortality and severity of infection in sepsis. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L633-40. PMID: 15579629.
      View in: PubMed
    34. Monick MM, Cameron K, Powers LS, Butler NS, McCoy D, Mallampalli RK, Hunninghake GW. Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am J Respir Cell Mol Biol. 2004 Jun; 30(6):844-52. PMID: 14742298.
      View in: PubMed
    35. Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J Immunol. 2003 Nov 15; 171(10):5107-15. PMID: 14607909.
      View in: PubMed
    36. Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem. 2003 Dec 26; 278(52):53035-44. PMID: 14565959.
      View in: PubMed
    37. Yarovinsky TO, Powers LS, Butler NS, Bradford MA, Monick MM, Hunninghake GW. Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance. J Immunol. 2003 Sep 01; 171(5):2453-60. PMID: 12928393.
      View in: PubMed
    38. Monick MM, Powers LS, Butler NS, Hunninghake GW. Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. J Immunol. 2003 Sep 01; 171(5):2625-30. PMID: 12928415.
      View in: PubMed
    39. Nyunoya T, Powers LS, Yarovinsky TO, Butler NS, Monick MM, Hunninghake GW. Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein. J Biol Chem. 2003 Sep 19; 278(38):36099-106. PMID: 12847100.
      View in: PubMed
    40. Chung MP, Monick MM, Hamzeh NY, Butler NS, Powers LS, Hunninghake GW. Role of repeated lung injury and genetic background in bleomycin-induced fibrosis. Am J Respir Cell Mol Biol. 2003 Sep; 29(3 Pt 1):375-80. PMID: 12676806.
      View in: PubMed
    41. Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW. Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J Immunol. 2002 Oct 01; 169(7):3700-9. PMID: 12244163.
      View in: PubMed
    42. Monick MM, Powers L, Butler N, Yarovinsky T, Hunninghake GW. Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation. Am J Physiol Lung Cell Mol Physiol. 2002 Aug; 283(2):L390-402. PMID: 12114201.
      View in: PubMed
    43. Monick MM, Robeff PK, Butler NS, Flaherty DM, Carter AB, Peterson MW, Hunninghake GW. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem. 2002 Sep 06; 277(36):32992-3000. PMID: 12072439.
      View in: PubMed
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