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Paul L DeAngelis

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Phone405/271-2227
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    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MABA06/1984Biochemical Sciences
    University of California, Irvine, CAPhD07/1990Biological Sciences
    University of Texas, Galveston, TXPostdoc1993Biochemistry/Molecular Biology

    Collapse Research 
    Collapse research activities and funding
    R43CA159494     (JING, WEI)Aug 1, 2011 - Jul 31, 2014
    NIH/NCI
    HEPylated G-CSF: Drug with Safer, Enhanced Delivery for Neutropenia Treatment
    Role: Co-Principal Investigator
    R01HL062244     (LINHARDT, ROBERT J)Dec 15, 2000 - Dec 31, 2016
    NIH/NHLBI
    Synthetic Heparan Sulfate: Probing Biosynthesis to Prepare Defined Drugs
    Role: Co-Principal Investigator
    R01GM056497     (DEANGELIS, PAUL L)Jul 1, 1997 - Jun 30, 2003
    NIH/NIGMS
    EUKARYOTIC HYALURONAN SYNTHASES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rivas F, Zahid OK, Reesink HL, Peal BT, Nixon AJ, DeAngelis PL, Skardal A, Rahbar E, Hall AR. Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor. Nat Commun. 2018 03 12; 9(1):1037. PMID: 29531292.
      View in: PubMed
    2. Lane RS, Haller FM, Chavaroche AAE, Almond A, DeAngelis PL. Heparosan-coated liposomes for drug delivery. Glycobiology. 2017 11 01; 27(11):1062-1074. PMID: 29044377.
      View in: PubMed
    3. Jing W, Roberts JW, Green DE, Almond A, DeAngelis PL. Synthesis and characterization of heparosan-granulocyte-colony stimulating factor conjugates: a natural sugar-based drug delivery system to treat neutropenia. Glycobiology. 2017 11 01; 27(11):1052-1061. PMID: 28973394.
      View in: PubMed
    4. Zhang X, Green DE, Schultz VL, Lin L, Han X, Wang R, Yaksic A, Kim SY, DeAngelis PL, Linhardt RJ. Synthesis of 4-Azido-N-acetylhexosamine Uridine Diphosphate Donors: Clickable Glycosaminoglycans. J Org Chem. 2017 09 15; 82(18):9910-9915. PMID: 28813597.
      View in: PubMed
    5. Lane RS, St Ange K, Zolghadr B, Liu X, Schäffer C, Linhardt RJ, DeAngelis PL. Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs. Glycobiology. 2017 07 01; 27(7):646-656. PMID: 28334971.
      View in: PubMed
    6. Green DE, DeAngelis PL. Identification of a chondroitin synthase from an unexpected source, the green sulfur bacterium Chlorobium phaeobacteroides. Glycobiology. 2017 05 01; 27(5):469-476. PMID: 28104786.
      View in: PubMed
    7. Schultz VL, Zhang X, Linkens K, Rimel J, Green DE, DeAngelis PL, Linhardt RJ. Chemoenzymatic Synthesis of 4-Fluoro-N-Acetylhexosamine Uridine Diphosphate Donors: Chain Terminators in Glycosaminoglycan Synthesis. J Org Chem. 2017 02 17; 82(4):2243-2248. PMID: 28128958.
      View in: PubMed
    8. Schultz V, Suflita M, Liu X, Zhang X, Yu Y, Li L, Green DE, Xu Y, Zhang F, DeAngelis PL, Liu J, Linhardt RJ. Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c. J Biol Chem. 2017 02 10; 292(6):2495-2509. PMID: 28031461.
      View in: PubMed
    9. DeAngelis PL. Heparosan, a promising 'naturally good' polymeric conjugating vehicle for delivery of injectable therapeutics. Expert Opin Drug Deliv. 2015 Mar; 12(3):349-52. PMID: 25363378.
      View in: PubMed
    10. Lauer ME, Hascall VC, Green DE, DeAngelis PL, Calabro A. Irreversible heavy chain transfer to chondroitin. J Biol Chem. 2014 Oct 17; 289(42):29171-9. PMID: 25135638.
      View in: PubMed
    11. Sterner E, Masuko S, Li G, Li L, Green DE, Otto NJ, Xu Y, DeAngelis PL, Liu J, Dordick JS, Linhardt RJ. Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing. J Biol Chem. 2014 Apr 04; 289(14):9754-65. PMID: 24563485.
      View in: PubMed
    12. Higman VA, Briggs DC, Mahoney DJ, Blundell CD, Sattelle BM, Dyer DP, Green DE, DeAngelis PL, Almond A, Milner CM, Day AJ. A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function. J Biol Chem. 2014 Feb 28; 289(9):5619-34. PMID: 24403066.
      View in: PubMed
    13. Li G, Masuko S, Green DE, Xu Y, Li L, Zhang F, Xue C, Liu J, DeAngelis PL, Linhardt RJ. N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation. Biopolymers. 2013 Oct; 99(10):675-85. PMID: 23606289.
      View in: PubMed
    14. DeAngelis PL, Liu J, Linhardt RJ. Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains. Glycobiology. 2013 Jul; 23(7):764-77. PMID: 23481097.
      View in: PubMed
    15. DeAngelis PL. Methods for the Pasteurella glycosaminoglycan synthases: enzymes that polymerize hyaluronan, chondroitin, or heparosan chains. Methods Mol Biol. 2013; 1022:215-27. PMID: 23765665.
      View in: PubMed
    16. Lauer ME, Glant TT, Mikecz K, DeAngelis PL, Haller FM, Husni ME, Hascall VC, Calabro A. Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6. J Biol Chem. 2013 Jan 04; 288(1):205-14. PMID: 23166324.
      View in: PubMed
    17. Siiskonen H, Rilla K, Kärnä R, Bart G, Jing W, Haller MF, DeAngelis PL, Tammi RH, Tammi MI. Hyaluronan in cytosol--microinjection-based probing of its existence and suggested functions. Glycobiology. 2013 Feb; 23(2):222-31. PMID: 23086746.
      View in: PubMed
    18. DeAngelis PL. Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow. Appl Microbiol Biotechnol. 2012 Apr; 94(2):295-305. PMID: 22391966.
      View in: PubMed
    19. Masuko S, Bera S, Green DE, Weïwer M, Liu J, DeAngelis PL, Linhardt RJ. Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans. J Org Chem. 2012 Feb 03; 77(3):1449-56. PMID: 22239739.
      View in: PubMed
    20. Otto NJ, Green DE, Masuko S, Mayer A, Tanner ME, Linhardt RJ, DeAngelis PL. Structure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts. J Biol Chem. 2012 Mar 02; 287(10):7203-12. PMID: 22235128.
      View in: PubMed
    21. Otto NJ, Solakyildirim K, Linhardt RJ, DeAngelis PL. Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog. Glycobiology. 2011 Oct; 21(10):1331-40. PMID: 21610195.
      View in: PubMed
    22. Alvarez-Barreto JF, Landy B, VanGordon S, Place L, DeAngelis PL, Sikavitsas VI. Enhanced osteoblastic differentiation of mesenchymal stem cells seeded in RGD-functionalized PLLA scaffolds and cultured in a flow perfusion bioreactor. J Tissue Eng Regen Med. 2011 Jun; 5(6):464-75. PMID: 20878644.
      View in: PubMed
    23. Liu R, Xu Y, Chen M, Weïwer M, Zhou X, Bridges AS, DeAngelis PL, Zhang Q, Linhardt RJ, Liu J. Chemoenzymatic design of heparan sulfate oligosaccharides. J Biol Chem. 2010 Oct 29; 285(44):34240-9. PMID: 20729556.
      View in: PubMed
    24. Weïwer M, Sherwood T, Green DE, Chen M, DeAngelis PL, Liu J, Linhardt RJ. Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin. J Org Chem. 2008 Oct 03; 73(19):7631-7. PMID: 18759479.
      View in: PubMed
    25. DeAngelis PL. Monodisperse hyaluronan polymers: synthesis and potential applications. Curr Pharm Biotechnol. 2008 Aug; 9(4):246-8. PMID: 18691084.
      View in: PubMed
    26. DeAngelis PL. Hot topic: hyaluronan, a very useful sugar polymer. Curr Pharm Biotechnol. 2008 Aug; 9(4):235. PMID: 18691080.
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    27. Weigel PH, DeAngelis PL. Hyaluronan synthases: a decade-plus of novel glycosyltransferases. J Biol Chem. 2007 Dec 21; 282(51):36777-81. PMID: 17981795.
      View in: PubMed
    28. Sismey-Ragatz AE, Green DE, Otto NJ, Rejzek M, Field RA, DeAngelis PL. Chemoenzymatic synthesis with distinct Pasteurella heparosan synthases: monodisperse polymers and unnatural structures. J Biol Chem. 2007 Sep 28; 282(39):28321-7. PMID: 17627940.
      View in: PubMed
    29. Linhardt RJ, Dordick JS, Deangelis PL, Liu J. Enzymatic synthesis of glycosaminoglycan heparin. Semin Thromb Hemost. 2007 Jul; 33(5):453-65. PMID: 17629842.
      View in: PubMed
    30. Alvarez-Barreto JF, Shreve MC, Deangelis PL, Sikavitsas VI. Preparation of a functionally flexible, three-dimensional, biomimetic poly(L-lactic acid) scaffold with improved cell adhesion. Tissue Eng. 2007 Jun; 13(6):1205-17. PMID: 17518730.
      View in: PubMed
    31. Tracy BS, Avci FY, Linhardt RJ, DeAngelis PL. Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans. J Biol Chem. 2007 Jan 05; 282(1):337-44. PMID: 17099217.
      View in: PubMed
    32. Pummill PE, Kane TA, Kempner ES, DeAngelis PL. The functional molecular mass of the Pasteurella hyaluronan synthase is a monomer. Biochim Biophys Acta. 2007 Feb; 1770(2):286-90. PMID: 17095162.
      View in: PubMed
    33. Kane TA, White CL, DeAngelis PL. Functional characterization of PmHS1, a Pasteurella multocida heparosan synthase. J Biol Chem. 2006 Nov 03; 281(44):33192-7. PMID: 16959770.
      View in: PubMed
    34. Jing W, Haller FM, Almond A, DeAngelis PL. Defined megadalton hyaluronan polymer standards. Anal Biochem. 2006 Aug 15; 355(2):183-8. PMID: 16842731.
      View in: PubMed
    35. Blundell CD, Deangelis PL, Almond A. Hyaluronan: the absence of amide-carboxylate hydrogen bonds and the chain conformation in aqueous solution are incompatible with stable secondary and tertiary structure models. Biochem J. 2006 Jun 15; 396(3):487-98. PMID: 16506956.
      View in: PubMed
    36. Almond A, Deangelis PL, Blundell CD. Hyaluronan: the local solution conformation determined by NMR and computer modeling is close to a contracted left-handed 4-fold helix. J Mol Biol. 2006 May 19; 358(5):1256-69. PMID: 16584748.
      View in: PubMed
    37. Williams KJ, Halkes KM, Kamerling JP, DeAngelis PL. Critical elements of oligosaccharide acceptor substrates for the Pasteurella multocida hyaluronan synthase. J Biol Chem. 2006 Mar 03; 281(9):5391-7. PMID: 16361253.
      View in: PubMed
    38. Colebrooke SA, Blundell CD, DeAngelis PL, Campbell ID, Almond A. Exploiting the carboxylate chemical shift to resolve degenerate resonances in spectra of 13C-labelled glycosaminoglycans. Magn Reson Chem. 2005 Oct; 43(10):805-15. PMID: 15996005.
      View in: PubMed
    39. Widner B, Behr R, Von Dollen S, Tang M, Heu T, Sloma A, Sternberg D, Deangelis PL, Weigel PH, Brown S. Hyaluronic acid production in Bacillus subtilis. Appl Environ Microbiol. 2005 Jul; 71(7):3747-52. PMID: 16000785.
      View in: PubMed
    40. Blundell CD, Almond A, Mahoney DJ, DeAngelis PL, Campbell ID, Day AJ. Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy: insights into other members of the link module superfamily. J Biol Chem. 2005 May 06; 280(18):18189-201. PMID: 15718240.
      View in: PubMed
    41. Almond A, DeAngelis PL, Blundell CD. Dynamics of hyaluronan oligosaccharides revealed by 15N relaxation. J Am Chem Soc. 2005 Feb 02; 127(4):1086-7. PMID: 15669832.
      View in: PubMed
    42. Bodevin-Authelet S, Kusche-Gullberg M, Pummill PE, DeAngelis PL, Lindahl U. Biosynthesis of hyaluronan: direction of chain elongation. J Biol Chem. 2005 Mar 11; 280(10):8813-8. PMID: 15623518.
      View in: PubMed
    43. Deangelis PL, White CL. Identification of a distinct, cryptic heparosan synthase from Pasteurella multocida types A, D, and F. J Bacteriol. 2004 Dec; 186(24):8529-32. PMID: 15576804.
      View in: PubMed
    44. Jing W, DeAngelis PL. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem. 2004 Oct 01; 279(40):42345-9. PMID: 15299014.
      View in: PubMed
    45. Blundell CD, DeAngelis PL, Day AJ, Almond A. Use of 15N-NMR to resolve molecular details in isotopically-enriched carbohydrates: sequence-specific observations in hyaluronan oligomers up to decasaccharides. Glycobiology. 2004 Nov; 14(11):999-1009. PMID: 15215231.
      View in: PubMed
    46. Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ. The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. J Biol Chem. 2003 Dec 05; 278(49):49261-70. PMID: 12972412.
      View in: PubMed
    47. DeAngelis PL, Oatman LC, Gay DF. Rapid chemoenzymatic synthesis of monodisperse hyaluronan oligosaccharides with immobilized enzyme reactors. J Biol Chem. 2003 Sep 12; 278(37):35199-203. PMID: 12840012.
      View in: PubMed
    48. Jing W, DeAngelis PL. Analysis of the two active sites of the hyaluronan synthase and the chondroitin synthase of Pasteurella multocida. Glycobiology. 2003 Oct; 13(10):661-71. PMID: 12799342.
      View in: PubMed
    49. Pummill PE, DeAngelis PL. Alteration of polysaccharide size distribution of a vertebrate hyaluronan synthase by mutation. J Biol Chem. 2003 May 30; 278(22):19808-14. PMID: 12654925.
      View in: PubMed
    50. DeAngelis PL. Evolution of glycosaminoglycans and their glycosyltransferases: Implications for the extracellular matrices of animals and the capsules of pathogenic bacteria. Anat Rec. 2002 Nov 01; 268(3):317-26. PMID: 12382327.
      View in: PubMed
    51. DeAngelis PL, Gunay NS, Toida T, Mao WJ, Linhardt RJ. Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively. Carbohydr Res. 2002 Sep 27; 337(17):1547-52. PMID: 12350324.
      View in: PubMed
    52. Pummill PE, DeAngelis PL. Evaluation of critical structural elements of UDP-sugar substrates and certain cysteine residues of a vertebrate hyaluronan synthase. J Biol Chem. 2002 Jun 14; 277(24):21610-6. PMID: 11943783.
      View in: PubMed
    53. DeAngelis PL. Microbial glycosaminoglycan glycosyltransferases. Glycobiology. 2002 Jan; 12(1):9R-16R. PMID: 11825882.
      View in: PubMed
    54. DeAngelis PL, White CL. Identification and molecular cloning of a heparosan synthase from Pasteurella multocida type D. J Biol Chem. 2002 Mar 01; 277(9):7209-13. PMID: 11756462.
      View in: PubMed
    55. DeAngelis PL. Polysaccharide labeling with N-methylisatoic anhydride: generation of ultraviolet chromophores and blue fluorophores. Anal Biochem. 2000 Aug 15; 284(1):167-9. PMID: 10933873.
      View in: PubMed
    56. DeAngelis PL. Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses. Cell Mol Life Sci. 1999 Nov 15; 56(7-8):670-82. PMID: 11212314.
      View in: PubMed
    57. DeAngelis PL. Molecular directionality of polysaccharide polymerization by the Pasteurella multocida hyaluronan synthase. J Biol Chem. 1999 Sep 10; 274(37):26557-62. PMID: 10473619.
      View in: PubMed
    58. DeAngelis PL, Jing W, Drake RR, Achyuthan AM. Identification and molecular cloning of a unique hyaluronan synthase from Pasteurella multocida. J Biol Chem. 1998 Apr 03; 273(14):8454-8. PMID: 9525958.
      View in: PubMed
    59. DeAngelis PL, Jing W, Graves MV, Burbank DE, Van Etten JL. Hyaluronan synthase of chlorella virus PBCV-1. Science. 1997 Dec 05; 278(5344):1800-3. PMID: 9388183.
      View in: PubMed
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