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Paul H Weigel

TitleGeorge L Cross Research Professor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-2227
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    R01GM030218     (WEIGEL, PAUL H)Feb 1, 1982 - Dec 31, 1990
    NIH/NIGMS
    ENDOCYTOSIS AND RECYCLING OF THE GALACTOSYL RECEPTOR
    Role: Principal Investigator

    R01GM035978     (WEIGEL, PAUL H)Jan 1, 1986 - Jan 31, 2015
    NIH/NIGMS
    STRUCTURE AND FUNCTION OF HYALURONAN SYNTHASES
    Role: Principal Investigator

    R01GM049695     (WEIGEL, PAUL H)Aug 1, 1993 - Jul 31, 2002
    NIH/NIGMS
    STRUCTURE/FUNCTION OF ENDOCYTIC, RECYCLING RECEPTORS
    Role: Principal Investigator

    P20RR011822     (WEIGEL, PAUL H)Sep 30, 1996 - Aug 31, 2000
    NIH/NCRR
    ENHANCEMENT OF PHYSICAL BIOCHEMISTRY IN OKLAHOMA
    Role: Principal Investigator

    R01GM069961     (WEIGEL, PAUL H)Jul 1, 2004 - Jun 30, 2010
    NIH/NIGMS
    STRUCTURE-FUNCTION OF THE HA RECEPTOR FOR ENDOCYTOSIS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Weigel PH. Planning, evaluating, and vetting receptor signaling studies to assesshyaluronan size-dependence and specificity. Glycobiology. 2017 Jun 13. PMID: 28633290.
      View in: PubMed
    2. Weigel PH, Baggenstoss BA, Washburn JL. Hyaluronan synthase assembles hyaluronan on a [GlcNAc(ß1,4)]n-GlcNAc(a1?)UDP primer and hyaluronan retains this residual chitin oligomer as a cap at the nonreducing end. Glycobiology. 2017 Jun 01; 27(6):536-554. PMID: 28138013.
      View in: PubMed
    3. Weigel PH, Baggenstoss BA. What is special about 200 kDa hyaluronan that activates hyaluronan receptor signaling? Glycobiology. 2017 May 09. PMID: 28486620.
      View in: PubMed
    4. Baggenstoss BA, Harris EN, Washburn JL, Medina AP, Nguyen L, Weigel PH. Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X7-B motif. Glycobiology. 2017 Jan; 27(2):154-164. PMID: 27558839.
      View in: PubMed
    5. Pandey MS, Miller CM, Harris EN, Weigel PH. Activation of ERK and NF-?B during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs. PLoS One. 2016; 11(4):e0154124. PMID: 27100626; PMCID: PMC4839745.
    6. Simpson MA, de la Motte C, Sherman LS, Weigel PH. Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms. Int J Cell Biol. 2015; 2015:690572. PMID: 26446415; PMCID: PMC4584047.
    7. Weigel PH. Hyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell Exterior. Int J Cell Biol. 2015; 2015:367579. PMID: 26472958; PMCID: PMC4581545.
    8. Pandey MS, Harris EN, Weigel PH. HARE-Mediated Endocytosis of Hyaluronan and Heparin Is Targeted by Different Subsets of Three Endocytic Motifs. Int J Cell Biol. 2015; 2015:524707. PMID: 25883656; PMCID: PMC4390207.
    9. Weigel PH, West CM, Zhao P, Wells L, Baggenstoss BA, Washburn JL. Hyaluronan synthase assembles chitin oligomers with -GlcNAc(a1?)UDP at the reducing end. Glycobiology. 2015 Jun; 25(6):632-43. PMID: 25583822; PMCID: PMC4410831.
    10. Pandey MS, Weigel PH. A hyaluronan receptor for endocytosis (HARE) link domain N-glycan is required for extracellular signal-regulated kinase (ERK) and nuclear factor-?B (NF-?B) signaling in response to the uptake of hyaluronan but not heparin, dermatan sulfate, or acetylated low density lipoprotein (LDL). J Biol Chem. 2014 Aug 08; 289(32):21807-17. PMID: 24942734; PMCID: PMC4139201.
    11. Pandey MS, Weigel PH. Hyaluronic acid receptor for endocytosis (HARE)-mediated endocytosis of hyaluronan, heparin, dermatan sulfate, and acetylated low density lipoprotein (AcLDL), but not chondroitin sulfate types A, C, D, or E, activates NF-?B-regulated gene expression. J Biol Chem. 2014 Jan 17; 289(3):1756-67. PMID: 24247245; PMCID: PMC3894352.
    12. Pandey MS, Baggenstoss BA, Washburn J, Harris EN, Weigel PH. The hyaluronan receptor for endocytosis (HARE) activates NF-?B-mediated gene expression in response to 40-400-kDa, but not smaller or larger, hyaluronans. J Biol Chem. 2013 May 17; 288(20):14068-79. PMID: 23530033; PMCID: PMC3656264.
    13. Preston M, Gong X, Su W, Matsumoto SG, Banine F, Winkler C, Foster S, Xing R, Struve J, Dean J, Baggenstoss B, Weigel PH, Montine TJ, Back SA, Sherman LS. Digestion products of the PH20 hyaluronidase inhibit remyelination. Ann Neurol. 2013 Feb; 73(2):266-80. PMID: 23463525; PMCID: PMC3608752.
    14. Weigel PH, Padgett-McCue AJ, Baggenstoss BA. Methods for measuring Class I membrane-bound hyaluronan synthase activity. Methods Mol Biol. 2013; 1022:229-47. PMID: 23765666.
      View in: PubMed
    15. Lauer ME, Cheng G, Swaidani S, Aronica MA, Weigel PH, Hascall VC. Tumor necrosis factor-stimulated gene-6 (TSG-6) amplifies hyaluronan synthesis by airway smooth muscle cells. J Biol Chem. 2013 Jan 04; 288(1):423-31. PMID: 23129777; PMCID: PMC3537040.
    16. Stephens EH, Saltarrelli JG, Balaoing LR, Baggett LS, Nandi I, Anderson KM, Morrisett JD, Reardon MJ, Simpson MA, Weigel PH, Olmsted-Davis EA, Davis AR, Grande-Allen KJ. Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves. Pathol Res Pract. 2012 Nov 15; 208(11):642-50. PMID: 23017666; PMCID: PMC3496006.
    17. Weigel PH, Baggenstoss BA. Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines. Glycobiology. 2012 Oct; 22(10):1302-10. PMID: 22745284; PMCID: PMC3425326.
    18. Simpson MA, Weigel JA, Weigel PH. Systemic blockade of the hyaluronan receptor for endocytosis prevents lymph node metastasis of prostate cancer. Int J Cancer. 2012 Sep 01; 131(5):E836-40. PMID: 22234863; PMCID: PMC4444783.
    19. Medina AP, Lin J, Weigel PH. Hyaluronan synthase mediates dye translocation across liposomal membranes. BMC Biochem. 2012 Jan 25; 13:2. PMID: 22276637; PMCID: PMC3331846.
    20. Tlapak-Simmons VL, Medina AP, Baggenstoss BA, Nguyen L, Baron CA, Weigel PH. Clustered Conserved Cysteines in Hyaluronan Synthase Mediate Cooperative Activation by Mg2+ Ions and Severe Inhibitory Effects of Divalent Cations. J Glycomics Lipidomics. 2011 Nov 15; Suppl 1:001. PMID: 25267933.
      View in: PubMed
    21. Weigel P, Hockenberry JM, Bentler SE, Obrizan M, Kaskie B, Jones MP, Ohsfeldt RL, Rosenthal GE, Wallace RB, Wolinsky FD. A longitudinal study of chiropractic use among older adults in the United States. Chiropr Osteopat. 2010 Dec 21; 18:34. PMID: 21176137; PMCID: PMC3019203.
    22. Rada JA, Wiechmann AF, Hollaway LR, Baggenstoss BA, Weigel PH. Increased hyaluronan synthase-2 mRNA expression and hyaluronan accumulation with choroidal thickening: response during recovery from induced myopia. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6172-9. PMID: 20574026; PMCID: PMC3055751.
    23. Harris EN, Parry S, Sutton-Smith M, Pandey MS, Panico M, Morris HR, Haslam SM, Dell A, Weigel PH. N-Glycans on the link domain of human HARE/Stabilin-2 are needed for hyaluronan binding to purified ecto-domain, but not for cellular endocytosis of hyaluronan. Glycobiology. 2010 Aug; 20(8):991-1001. PMID: 20466649; PMCID: PMC2895729.
    24. Harris EN, Baggenstoss BA, Weigel PH. Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1191-9. PMID: 19359419; PMCID: PMC2697953.
    25. Gupta V, Barzilla JE, Mendez JS, Stephens EH, Lee EL, Collard CD, Laucirica R, Weigel PH, Grande-Allen KJ. Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves. Cardiovasc Pathol. 2009 Jul-Aug; 18(4):191-7. PMID: 18621549; PMCID: PMC2706283.
    26. Pandey MS, Harris EN, Weigel JA, Weigel PH. The cytoplasmic domain of the hyaluronan receptor for endocytosis (HARE) contains multiple endocytic motifs targeting coated pit-mediated internalization. J Biol Chem. 2008 Aug 01; 283(31):21453-61. PMID: 18539600; PMCID: PMC2490790.
    27. Harris EN, Weigel PH. The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E. Glycobiology. 2008 Aug; 18(8):638-48. PMID: 18499864; PMCID: PMC2561176.
    28. Harris EN, Weigel JA, Weigel PH. The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin. J Biol Chem. 2008 Jun 20; 283(25):17341-50. PMID: 18434317; PMCID: PMC2427350.
    29. Kyosseva SV, Harris EN, Weigel PH. The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases. J Biol Chem. 2008 May 30; 283(22):15047-55. PMID: 18387958; PMCID: PMC2397479.
    30. Weigel PH, DeAngelis PL. Hyaluronan synthases: a decade-plus of novel glycosyltransferases. J Biol Chem. 2007 Dec 21; 282(51):36777-81. PMID: 17981795.
      View in: PubMed
    31. Kyossev Z, Weigel PH. An enzyme capture assay for analysis of active hyaluronan synthases. Anal Biochem. 2007 Dec 01; 371(1):62-70. PMID: 17904513.
      View in: PubMed
    32. Harris EN, Kyosseva SV, Weigel JA, Weigel PH. Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE). J Biol Chem. 2007 Feb 02; 282(5):2785-97. PMID: 17145755.
      View in: PubMed
    33. Weigel PH, Kyossev Z, Torres LC. Phospholipid dependence and liposome reconstitution of purified hyaluronan synthase. J Biol Chem. 2006 Dec 01; 281(48):36542-51. PMID: 16984914.
      View in: PubMed
    34. Goentzel BJ, Weigel PH, Steinberg RA. Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells. Biochem J. 2006 Jun 01; 396(2):347-54. PMID: 16522194; PMCID: PMC1462723.
    35. Kumari K, Baggenstoss BA, Parker AL, Weigel PH. Mutation of two intramembrane polar residues conserved within the hyaluronan synthase family alters hyaluronan product size. J Biol Chem. 2006 Apr 28; 281(17):11755-60. PMID: 16505475.
      View in: PubMed
    36. Wein RO, McGary CT, Doerr TD, Popat SR, Howard JL, Weigel JA, Weigel PH. Hyaluronan and its receptors in mucoepidermoid carcinoma. Head Neck. 2006 Feb; 28(2):176-81. PMID: 16355387.
      View in: PubMed
    37. Baggenstoss BA, Weigel PH. Size exclusion chromatography-multiangle laser light scattering analysis of hyaluronan size distributions made by membrane-bound hyaluronan synthase. Anal Biochem. 2006 May 15; 352(2):243-51. PMID: 16476403; PMCID: PMC1586112.
    38. Widner B, Behr R, Von Dollen S, Tang M, Heu T, Sloma A, Sternberg D, Deangelis PL, Weigel PH, Brown S. Hyaluronic acid production in Bacillus subtilis. Appl Environ Microbiol. 2005 Jul; 71(7):3747-52. PMID: 16000785; PMCID: PMC1168996.
    39. Tlapak-Simmons VL, Baron CA, Gotschall R, Haque D, Canfield WM, Weigel PH. Hyaluronan biosynthesis by class I streptococcal hyaluronan synthases occurs at the reducing end. J Biol Chem. 2005 Apr 01; 280(13):13012-8. PMID: 15668242; PMCID: PMC1592226.
    40. Kumari K, Weigel PH. Identification of a membrane-localized cysteine cluster near the substrate-binding sites of the Streptococcus equisimilis hyaluronan synthase. Glycobiology. 2005 May; 15(5):529-39. PMID: 15616126; PMCID: PMC1242197.
    41. Tlapak-Simmons VL, Baron CA, Weigel PH. Characterization of the purified hyaluronan synthase from Streptococcus equisimilis. Biochemistry. 2004 Jul 20; 43(28):9234-42. PMID: 15248781; PMCID: PMC1586113.
    42. Harris EN, Weigel JA, Weigel PH. Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE). J Biol Chem. 2004 Aug 27; 279(35):36201-9. PMID: 15208308.
      View in: PubMed
    43. Grammas P, Ottman T, Reimann-Philipp U, Larabee J, Weigel PH. Injured brain endothelial cells release neurotoxic thrombin. J Alzheimers Dis. 2004 Jun; 6(3):275-81. PMID: 15201482.
      View in: PubMed
    44. Weigel JA, Weigel PH. Characterization of the recombinant rat 175-kDa hyaluronan receptor for endocytosis (HARE). J Biol Chem. 2003 Oct 31; 278(44):42802-11. PMID: 12933790.
      View in: PubMed
    45. Weigel JA, Raymond RC, McGary C, Singh A, Weigel PH. A blocking antibody to the hyaluronan receptor for endocytosis (HARE) inhibits hyaluronan clearance by perfused liver. J Biol Chem. 2003 Mar 14; 278(11):9808-12. PMID: 12645574.
      View in: PubMed
    46. McGary CT, Weigel JA, Weigel PH. Study of hyaluronan-binding proteins and receptors using iodinated hyaluronan derivatives. Methods Enzymol. 2003; 363:354-65. PMID: 14579588.
      View in: PubMed
    47. Weigel PH, McGary CT, Weigel JA. Use of iodinated hyaluronan derivatives to study hyaluronan binding, endocytosis, and metabolism by cultured cells. Methods Enzymol. 2003; 363:382-91. PMID: 14579591.
      View in: PubMed
    48. Zhou B, McGary CT, Weigel JA, Saxena A, Weigel PH. Purification and molecular identification of the human hyaluronan receptor for endocytosis. Glycobiology. 2003 May; 13(5):339-49. PMID: 12626425.
      View in: PubMed
    49. Yik JH, Saxena A, Weigel JA, Weigel PH. Palmitoylation-defective asialoglycoprotein receptors are normal in their cellular distribution and ability to bind ligand, but are defective in ligand uptake and degradation. Biochem Biophys Res Commun. 2002 Oct 04; 297(4):980-6. PMID: 12359251.
      View in: PubMed
    50. Yik JH, Weigel PH. The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor. J Biol Chem. 2002 Dec 06; 277(49):47305-12. PMID: 12370180.
      View in: PubMed
    51. Kakizaki I, Takagaki K, Endo Y, Kudo D, Ikeya H, Miyoshi T, Baggenstoss BA, Tlapak-Simmons VL, Kumari K, Nakane A, Weigel PH, Endo M. Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone. Eur J Biochem. 2002 Oct; 269(20):5066-75. PMID: 12383266.
      View in: PubMed
    52. Weigel PH. Functional characteristics and catalytic mechanisms of the bacterial hyaluronan synthases. IUBMB Life. 2002 Oct; 54(4):201-11. PMID: 12512859.
      View in: PubMed
    53. Weigel PH, Yik JH. Glycans as endocytosis signals: the cases of the asialoglycoprotein and hyaluronan/chondroitin sulfate receptors. Biochim Biophys Acta. 2002 Sep 19; 1572(2-3):341-63. PMID: 12223279.
      View in: PubMed
    54. Yik JH, Saxena A, Weigel JA, Weigel PH. Nonpalmitoylated human asialoglycoprotein receptors recycle constitutively but are defective in coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. J Biol Chem. 2002 Oct 25; 277(43):40844-52. PMID: 12171918.
      View in: PubMed
    55. Zhou B, Weigel JA, Saxena A, Weigel PH. Molecular cloning and functional expression of the rat 175-kDa hyaluronan receptor for endocytosis. Mol Biol Cell. 2002 Aug; 13(8):2853-68. PMID: 12181351; PMCID: PMC117947.
    56. Saxena A, Yik JH, Weigel PH. H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid. J Biol Chem. 2002 Sep 20; 277(38):35297-304. PMID: 12089159.
      View in: PubMed
    57. Weigel JA, Raymond RC, Weigel PH. The hyaluronan receptor for endocytosis (HARE) is not CD44 or CD54 (ICAM-1). Biochem Biophys Res Commun. 2002 Jun 21; 294(4):918-22. PMID: 12061795.
      View in: PubMed
    58. Yik JH, Saxena A, Weigel PH. The minor subunit splice variants, H2b and H2c, of the human asialoglycoprotein receptor are present with the major subunit H1 in different hetero-oligomeric receptor complexes. J Biol Chem. 2002 Jun 21; 277(25):23076-83. PMID: 11943787.
      View in: PubMed
    59. Duff B, Weigel JA, Bourne P, Weigel PH, McGary CT. Endothelium in hepatic cavernous hemangiomas does not express the hyaluronan receptor for endocytosis. Hum Pathol. 2002 Mar; 33(3):265-9. PMID: 11979365.
      View in: PubMed
    60. Kumari K, Tlapak-Simmons VL, Baggenstoss BA, Weigel PH. The streptococcal hyaluronan synthases are inhibited by sulfhydryl-modifying reagents, but conserved cysteine residues are not essential for enzyme function. J Biol Chem. 2002 Apr 19; 277(16):13943-51. PMID: 11799120.
      View in: PubMed
    61. Weigel PH, Oka JA. The dual coated pit pathway hypothesis: vertebrate cells have both ancient and modern coated pit pathways for receptor mediated endocytosis. Biochem Biophys Res Commun. 1998 May 29; 246(3):563-9. PMID: 9618251.
      View in: PubMed
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