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Paul F Cook

TitleProfessor Emeritus
InstitutionUniversity of Oklahoma, Norman
DepartmentChemistry/Biochemistry
Address620 Parrington Oval
Norman OK
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    K04AM001155     (COOK, PAUL F)Apr 1, 1983 - Mar 31, 1988
    NIH/NIADDK
    KINETIC AND CHEMICAL MECHANISM OF ENZYMES
    Role: Principal Investigator

    K04DK001155     (COOK, PAUL F)Apr 1, 1983 - Mar 31, 1988
    NIH/NIDDK
    KINETIC AND CHEMICAL MECHANISM OF ENZYMES
    Role: Principal Investigator

    R01GM032052     (COOK, PAUL F)Aug 1, 1984 - Nov 30, 1985
    NIH/NIGMS
    MECHANISM OF CYCLIC AMP DEPENDENT PROTEIN KINASE
    Role: Principal Investigator

    R01GM036799     (COOK, PAUL F)Sep 19, 1985 - Aug 31, 1999
    NIH/NIGMS
    STRUCTURE AND MECHANISM OF NAD-MALIC ENZYME
    Role: Principal Investigator

    R01GM037057     (COOK, PAUL F)Dec 1, 1985 - Aug 31, 1992
    NIH/NIGMS
    MECHANISM OF CAMP DEPENDENT PROTEIN KINASE 16.
    Role: Principal Investigator

    S15HL043958     (COOK, PAUL F)Sep 1, 1989 - Aug 31, 1990
    NIH/NHLBI
    SMALL INSTRUMENTATION PROGRAM
    Role: Principal Investigator

    S15HL047703     (COOK, PAUL F)Sep 1, 1991 - Aug 31, 1992
    NIH/NHLBI
    SMALL INSTRUMENTATION GRANT
    Role: Principal Investigator

    R01GM050872     (COOK, PAUL F)Dec 1, 1994 - Nov 30, 1999
    NIH/NIGMS
    STRUCTURE/MECHANISM OF 6-PHOSPHOGLUCONATE DEHYDROGENASE
    Role: Principal Investigator

    R01GM071417     (COOK, PAUL F)Sep 15, 2004 - Aug 31, 2009
    NIH/NIGMS
    Lysine Biosynthesis in Yeast
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wickham S, Regan N, West MB, Thai J, Cook PF, Terzyan SS, Li PK, Hanigan MH. Inhibition of human ?-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors. Biochem J. 2013 Mar 15; 450(3):547-57. PMID: 23301618; PMCID: PMC3836663.
    2. Spyrakis F, Felici P, Bayden AS, Salsi E, Miggiano R, Kellogg GE, Cozzini P, Cook PF, Mozzarelli A, Campanini B. Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase. Biochim Biophys Acta. 2013 Jan; 1834(1):169-81. PMID: 23000429.
      View in: PubMed
    3. Kumar VP, West AH, Cook PF. Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. Arch Biochem Biophys. 2012 Jun 01; 522(1):57-61. PMID: 22521736.
      View in: PubMed
    4. Kumar VP, Thomas LM, Bobyk KD, Andi B, Cook PF, West AH. Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2012 Jan 31; 51(4):857-66. PMID: 22243403; PMCID: PMC3297426.
    5. Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L. Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae. Arch Biochem Biophys. 2011 Dec 01; 516(1):67-74. PMID: 21982920.
      View in: PubMed
    6. Wickham S, Regan N, West MB, Kumar VP, Thai J, Li PK, Cook PF, Hanigan MH. Divergent effects of compounds on the hydrolysis and transpeptidation reactions of ?-glutamyl transpeptidase. J Enzyme Inhib Med Chem. 2012 Aug; 27(4):476-89. PMID: 21864033; PMCID: PMC3407035.
    7. Bobyk KD, Kim SG, Kumar VP, Kim SK, West AH, Cook PF. The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH. Arch Biochem Biophys. 2011 Sep 15; 513(2):71-80. PMID: 21798231.
      View in: PubMed
    8. Ekanayake DK, West AH, Cook PF. Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction. Arch Biochem Biophys. 2011 Oct; 514(1-2):8-15. PMID: 21819960; PMCID: PMC3174770.
    9. Kumar VP, West AH, Cook PF. Kinetic and chemical mechanisms of homocitrate synthase from Thermus thermophilus. J Biol Chem. 2011 Aug 19; 286(33):29428-39. PMID: 21733842; PMCID: PMC3190748.
    10. Mozzarelli A, Bettati S, Campanini B, Salsi E, Raboni S, Singh R, Spyrakis F, Kumar VP, Cook PF. The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase. Biochim Biophys Acta. 2011 Nov; 1814(11):1497-510. PMID: 21549222.
      View in: PubMed
    11. Wickham S, West MB, Cook PF, Hanigan MH. Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15; 414(2):208-14. PMID: 21447318; PMCID: PMC3099546.
    12. Schnackerz KD, Andi B, Cook PF. (31)P NMR spectroscopy senses the microenvironment of the 5'-phosphate group of enzyme-bound pyridoxal 5'-phosphate. Biochim Biophys Acta. 2011 Nov; 1814(11):1447-58. PMID: 21354475.
      View in: PubMed
    13. Tyapochkin E, Kumar VP, Cook PF, Chen G. Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation. Arch Biochem Biophys. 2011 Feb 15; 506(2):137-41. PMID: 21111704; PMCID: PMC3049928.
    14. Tian H, Guan R, Salsi E, Campanini B, Bettati S, Kumar VP, Karsten WE, Mozzarelli A, Cook PF. Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A. Biochemistry. 2010 Jul 27; 49(29):6093-103. PMID: 20550197.
      View in: PubMed
    15. Ekanayake DK, Andi B, Bobyk KD, West AH, Cook PF. Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts. J Biol Chem. 2010 Jul 02; 285(27):20756-68. PMID: 20427272; PMCID: PMC2898324.
    16. Kaserer AO, Andi B, Cook PF, West AH. Kinetic studies of the yeast His-Asp phosphorelay signaling pathway. Methods Enzymol. 2010; 471:59-75. PMID: 20946842; PMCID: PMC2957298.
    17. Kaserer AO, Andi B, Cook PF, West AH. Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae. Biochemistry. 2009 Aug 25; 48(33):8044-50. PMID: 19618914; PMCID: PMC2753885.
    18. Cook PF, Goto Y, Lottspeich F. Introduction to the special issue. Foreword. Biochim Biophys Acta. 2009 Sep; 1794(9):1277-9. PMID: 19695350.
      View in: PubMed
    19. Lin Y, West AH, Cook PF. Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2009 Aug 04; 48(30):7305-12. PMID: 19530703; PMCID: PMC2760458.
    20. Vashishtha AK, West AH, Cook PF. Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae. Biochemistry. 2009 Jun 30; 48(25):5899-907. PMID: 19449898.
      View in: PubMed
    21. Guan R, Nimmo SA, Schnackerz KD, Cook PF. (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium. Arch Biochem Biophys. 2009 Jul 15; 487(2):85-90. PMID: 19501038.
      View in: PubMed
    22. Aktas DF, Cook PF. A lysine-tyrosine pair carries out acid-base chemistry in the metal ion-dependent pyridine dinucleotide-linked beta-hydroxyacid oxidative decarboxylases. Biochemistry. 2009 Apr 28; 48(16):3565-77. PMID: 19281248.
      View in: PubMed
    23. Karsten WE, Cook PF. Detection of a gem-diamine and a stable quinonoid intermediate in the reaction catalyzed by serine-glyoxylate aminotransferase from Hyphomicrobium methylovorum. Biochim Biophys Acta. 2009 Jun; 1790(6):575-80. PMID: 19264108.
      View in: PubMed
    24. Lin Y, West AH, Cook PF. Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2008 Oct 07; 47(40):10809-15. PMID: 18785753; PMCID: PMC2760454.
    25. Aktas DF, Cook PF. Role of residues in the adenosine binding site of NAD of the Ascaris suum malic enzyme. Biochim Biophys Acta. 2008 Dec; 1784(12):2059-64. PMID: 18725329.
      View in: PubMed
    26. Qian J, Khandogin J, West AH, Cook PF. Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae. Biochemistry. 2008 Jul 01; 47(26):6851-8. PMID: 18533686.
      View in: PubMed
    27. Guan R, Roderick SL, Huang B, Cook PF. Roles of histidines 154 and 189 and aspartate 139 in the active site of serine acetyltransferase from Haemophilus influenzae. Biochemistry. 2008 Jun 17; 47(24):6322-8. PMID: 18498176; PMCID: PMC2854626.
    28. Vashishtha AK, West AH, Cook PF. Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae. Biochemistry. 2008 May 13; 47(19):5417-23. PMID: 18416559.
      View in: PubMed
    29. Valderas MW, Andi B, Barrow WW, Cook PF. Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthase. Biochim Biophys Acta. 2008 May; 1780(5):848-53. PMID: 18342015; PMCID: PMC2443783.
    30. Lin Y, Volkman J, Nicholas KM, Yamamoto T, Eguchi T, Nimmo SL, West AH, Cook PF. Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2008 Apr 01; 47(13):4169-80. PMID: 18321070.
      View in: PubMed
    31. Aktas DF, Cook PF. Proper positioning of the nicotinamide ring is crucial for the Ascaris suum malic enzyme reaction. Biochemistry. 2008 Feb 26; 47(8):2539-46. PMID: 18215074.
      View in: PubMed
    32. Tai CH, Rabeh WM, Guan R, Schnackerz KD, Cook PF. Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium. Biochim Biophys Acta. 2008 Apr; 1784(4):629-37. PMID: 18243146.
      View in: PubMed
    33. Karsten WE, Cook PF. Multiple roles of arginine 181 in binding and catalysis in the NAD-malic enzyme from Ascaris suum. Biochemistry. 2007 Dec 18; 46(50):14578-88. PMID: 18027982.
      View in: PubMed
    34. Andi B, Xu H, Cook PF, West AH. Crystal structures of ligand-bound saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Nov 06; 46(44):12512-21. PMID: 17939687.
      View in: PubMed
    35. Xu H, West AH, Cook PF. Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jun 26; 46(25):7625-36. PMID: 17542618; PMCID: PMC2527761.
    36. Xu H, Alguindigue SS, West AH, Cook PF. A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jan 23; 46(3):871-82. PMID: 17223709; PMCID: PMC2664737.
    37. Lin Y, Alguindigue SS, Volkman J, Nicholas KM, West AH, Cook PF. Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jan 23; 46(3):890-8. PMID: 17223711; PMCID: PMC2527762.
    38. Li L, Zhang L, Cook PF. Role of the S128, H186, and N187 triad in substrate binding and decarboxylation in the sheep liver 6-phosphogluconate dehydrogenase reaction. Biochemistry. 2006 Oct 24; 45(42):12680-6. PMID: 17042485.
      View in: PubMed
    39. Qian J, West AH, Cook PF. Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae. Biochemistry. 2006 Oct 03; 45(39):12136-43. PMID: 17002313.
      View in: PubMed
    40. Xu H, West AH, Cook PF. Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2006 Oct 03; 45(39):12156-66. PMID: 17002315.
      View in: PubMed
    41. Li L, Cook PF. The 2'-phosphate of NADP is responsible for proper orientation of the nicotinamide ring in the oxidative decarboxylation reaction catalyzed by sheep liver 6-phosphogluconate dehydrogenase. J Biol Chem. 2006 Dec 01; 281(48):36803-10. PMID: 16959777.
      View in: PubMed
    42. Karsten WE, Cook PF. An isothermal titration calorimetry study of the binding of substrates and ligands to the tartrate dehydrogenase from Pseudomonas putida reveals half-of-the-sites reactivity. Biochemistry. 2006 Jul 25; 45(29):9000-6. PMID: 16846243.
      View in: PubMed
    43. Li L, Dworkowski FS, Cook PF. Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase. J Biol Chem. 2006 Sep 01; 281(35):25568-76. PMID: 16803886.
      View in: PubMed
    44. Rabeh WM, Mather T, Cook PF. A three-dimensional homology model of the O-acetylserine sulfhydrylase-B from Salmonella typhimurium. Protein Pept Lett. 2006; 13(1):7-13. PMID: 16454663.
      View in: PubMed
    45. Karsten WE, Ohshiro T, Izumi Y, Cook PF. Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate. Biochemistry. 2005 Dec 06; 44(48):15930-6. PMID: 16313196.
      View in: PubMed
    46. Andi B, Cook PF. Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. II. Theory. J Biol Chem. 2005 Sep 09; 280(36):31633-40. PMID: 15897191.
      View in: PubMed
    47. Andi B, West AH, Cook PF. Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. I. Kinetic studies. J Biol Chem. 2005 Sep 09; 280(36):31624-32. PMID: 15897192.
      View in: PubMed
    48. Rabeh WM, Alguindigue SS, Cook PF. Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction. Biochemistry. 2005 Apr 12; 44(14):5541-50. PMID: 15807548.
      View in: PubMed
    49. Karsten WE, Liu D, Rao GS, Harris BG, Cook PF. A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme. Biochemistry. 2005 Mar 08; 44(9):3626-35. PMID: 15736972.
      View in: PubMed
    50. Janiak-Spens F, Cook PF, West AH. Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system. Biochemistry. 2005 Jan 11; 44(1):377-86. PMID: 15628880.
      View in: PubMed
    51. Johnson CM, Huang B, Roderick SL, Cook PF. Chemical mechanism of the serine acetyltransferase from Haemophilus influenzae. Biochemistry. 2004 Dec 14; 43(49):15534-9. PMID: 15581365.
      View in: PubMed
    52. Andi B, West AH, Cook PF. Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. Biochemistry. 2004 Sep 21; 43(37):11790-5. PMID: 15362863.
      View in: PubMed
    53. Schnackerz KD, Dobritzsch D, Lindqvist Y, Cook PF. Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters. Biochim Biophys Acta. 2004 Sep 01; 1701(1-2):61-74. PMID: 15450176.
      View in: PubMed
    54. Rabeh WM, Cook PF. Structure and mechanism of O-acetylserine sulfhydrylase. J Biol Chem. 2004 Jun 25; 279(26):26803-6. PMID: 15073190.
      View in: PubMed
    55. Andi B, West AH, Cook PF. Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. Arch Biochem Biophys. 2004 Jan 15; 421(2):243-54. PMID: 14984204.
      View in: PubMed
    56. Karsten WE, Pais JE, Rao GS, Harris BG, Cook PF. Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites. Biochemistry. 2003 Aug 19; 42(32):9712-21. PMID: 12911313.
      View in: PubMed
    57. Cook PF. Alpha,beta-elimination reaction of O-acetylserine sulfhydrylase. Is the pyridine ring required? Biochim Biophys Acta. 2003 Apr 11; 1647(1-2):66-9. PMID: 12686110.
      View in: PubMed
    58. Daum S, Tai CH, Cook PF. Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction. Biochemistry. 2003 Jan 14; 42(1):106-13. PMID: 12515544.
      View in: PubMed
    59. Karsten WE, Cook PF. Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase. Methods Enzymol. 2002; 354:223-37. PMID: 12418230.
      View in: PubMed
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