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Raju VS Rajala

TitleProfessor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentOphthalmology
Address608 Stanton L Young Blvd
Oklahoma City OK 73104-5014
Phone405/271-8255
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    Collapse Research 
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    R01EY000871     (RAJALA, RAJU VS)Feb 1, 1978 - Mar 31, 2021
    NIH/NEI
    Second Messengers in the Retina
    Role: Co-Principal Investigator

    R01EY016507     (RAJALA, RAJU VS)Apr 1, 2005 - Aug 31, 2014
    NIH/NEI
    Light Activation of Retinal Insulin Receptor Signaling
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RVS, Yang Y, Moran E, Ma JX. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARa. Diabetes. 2017 Jun; 66(6):1671-1682. PMID: 28270521.
      View in: PubMed
    2. Rajala RV, Rajala A, Kooker C, Wang Y, Anderson RE. The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina. Sci Rep. 2016 Nov 24; 6:37727. PMID: 27883057.
      View in: PubMed
    3. Rajala A, Wang Y, Rajala RV. Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival. Oncotarget. 2016 Jul 26; 7(30):46924-46942. PMID: 27391439.
      View in: PubMed
    4. Wang Y, Rajala A, Cao B, Ranjo-Bishop M, Agbaga MP, Mao C, Rajala RV. Cell-Specific Promoters Enable Lipid-Based Nanoparticles to Deliver Genes to Specific Cells of the Retina In Vivo. Theranostics. 2016; 6(10):1514-27. PMID: 27446487; PMCID: PMC4955052.
    5. Rajala RV, Gardner TW. Burning fat fuels photoreceptors. Nat Med. 2016 Apr; 22(4):342-3. PMID: 27050587.
      View in: PubMed
    6. Rao KN, Li L, Zhang W, Brush RS, Rajala RV, Khanna H. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Hum Mol Genet. 2016 Apr 01; 25(7):1345-56. PMID: 26908598; PMCID: PMC4787904 [Available on 04/01/17].
    7. Azadi S, Brush RS, Anderson RE, Rajala RV. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina. Adv Exp Med Biol. 2016; 854:363-9. PMID: 26427433.
      View in: PubMed
    8. Rajala RV, Kanan Y, Anderson RE. Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL. Adv Exp Med Biol. 2016; 854:419-24. PMID: 26427440.
      View in: PubMed
    9. Wang Y, Rajala A, Rajala RV. Lipid Nanoparticles for Ocular Gene Delivery. J Funct Biomater. 2015 Jun 08; 6(2):379-94. PMID: 26062170; PMCID: PMC4493518.
    10. Rajala RV, Ranjo-Bishop M, Wang Y, Rajala A, Anderson RE. The p110a isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival. Biochimie. 2015 May; 112:35-40. PMID: 25742742; PMCID: PMC4402270.
    11. Gupta VK, Rajala A, Rajala RV. Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells. Cell Commun Signal. 2015 Feb 03; 13:7. PMID: 25644171; PMCID: PMC4326362.
    12. Woodruff ML, Rajala A, Fain GL, Rajala RV. Effect of knocking down the insulin receptor on mouse rod responses. Sci Rep. 2015 Jan 19; 5:7858. PMID: 25598343; PMCID: PMC4297982.
    13. Zulliger R, Naash MI, Rajala RV, Molday RS, Azadi S. Impaired association of retinal degeneration-3 with guanylate cyclase-1 and guanylate cyclase-activating protein-1 leads to leber congenital amaurosis-1. J Biol Chem. 2015 Feb 06; 290(6):3488-99. PMID: 25477517; PMCID: PMC4319016.
    14. Rajala A, Wang Y, Zhu Y, Ranjo-Bishop M, Ma JX, Mao C, Rajala RV. Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano Lett. 2014 Sep 10; 14(9):5257-63. PMID: 25115433; PMCID: PMC4160266.
    15. Rajala RV, Rajala A, Morris AJ, Anderson RE. Phosphoinositides: minor lipids make a major impact on photoreceptor cell functions. Sci Rep. 2014 Jun 26; 4:5463. PMID: 24964953; PMCID: PMC4071336.
    16. Rajala RV, Basavarajappa DK, Dighe R, Rajala A. Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Commun Signal. 2013 Dec 18; 11:96. PMID: 24350791; PMCID: PMC3878334.
    17. Rajala RV, Rajala A. Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons. Protein Cell. 2013 Dec; 4(12):890-2. PMID: 24203758; PMCID: PMC4114312.
    18. Woodruff ML, Rajala A, Fain GL, Rajala RV. Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem. 2014 Jan 03; 289(1):358-64. PMID: 24273167; PMCID: PMC3879558.
    19. Rajala A, Gupta VK, Anderson RE, Rajala RV. Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion. 2013 Nov; 13(6):566-76. PMID: 23993956; PMCID: PMC3818532.
    20. Rajala A, Dighe R, Agbaga MP, Anderson RE, Rajala RV. Insulin receptor signaling in cones. J Biol Chem. 2013 Jul 05; 288(27):19503-15. PMID: 23673657; PMCID: PMC3707652.
    21. Rajala A, Dilly AK, Rajala RV. Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Commun Signal. 2013 Mar 22; 11(1):20. PMID: 23521888; PMCID: PMC3637500.
    22. Gupta VK, Rajala A, Rajala RV. Insulin receptor regulates photoreceptor CNG channel activity. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1363-72. PMID: 23032687; PMCID: PMC3774084.
    23. Rajala RV, Rajala A, Gupta VK. Conservation and divergence of Grb7 family of Ras-binding domains. Protein Cell. 2012 Jan; 3(1):60-70. PMID: 22271596; PMCID: PMC3402353.
    24. Gupta VK, Rajala A, Rajala RV. Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators. Adv Exp Med Biol. 2012; 723:777-82. PMID: 22183406; PMCID: PMC3402357.
    25. Basavarajappa DK, Gupta VK, Rajala RV. Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases. Adv Exp Med Biol. 2012; 723:829-34. PMID: 22183413; PMCID: PMC3398709.
    26. Gupta VK, Rajala A, Rodgers KK, Rajala RV. Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell. 2011 Nov; 2(11):906-17. PMID: 22180090; PMCID: PMC3405905.
    27. Ivanovic I, Allen DT, Dighe R, Le YZ, Anderson RE, Rajala RV. Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug 11; 52(9):6355-62. PMID: 21730346; PMCID: PMC3176013.
    28. Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV. Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14. Mol Cell Biol. 2011 Oct; 31(19):3975-87. PMID: 21791607; PMCID: PMC3187357.
    29. Ivanovic I, Anderson RE, Le YZ, Fliesler SJ, Sherry DM, Rajala RV. Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3775-83. PMID: 21398281; PMCID: PMC3109053.
    30. Gupta VK, Rajala A, Daly RJ, Rajala RV. Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel. EMBO Rep. 2010 Nov; 11(11):861-7. PMID: 20890309; PMCID: PMC2966952.
    31. Rajala RV, Anderson RE. Focus on molecules: phosphatidylinositol-4,5-bisphosphate (PIP2). Exp Eye Res. 2010 Sep; 91(3):324-5. PMID: 20457154; PMCID: PMC2926157.
    32. Rajala RV, Anderson RE. Rhodopsin-regulated insulin receptor signaling pathway in rod photoreceptor neurons. Mol Neurobiol. 2010 Aug; 42(1):39-47. PMID: 20407846; PMCID: PMC2962609.
    33. Huang Z, Anderson RE, Cao W, Wiechmann AF, Rajala RV. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II a phosphatidylinositol-5-phosphate 4-kinase. Neurochem Res. 2011 Apr; 36(4):627-35. PMID: 20204506; PMCID: PMC4227407.
    34. Kanan Y, Matsumoto H, Song H, Sokolov M, Anderson RE, Rajala RV. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. J Neurochem. 2010 Apr; 113(2):477-88. PMID: 20089132; PMCID: PMC2909469.
    35. Rajala RV, Tanito M, Neel BG, Rajala A. Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. J Biol Chem. 2010 Mar 19; 285(12):8894-904. PMID: 20061388; PMCID: PMC2838311.
    36. Rajala RV. Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res. 2010 Jan; 51(1):4-22. PMID: 19638643; PMCID: PMC2789784.
    37. Rajala RV, Rajala A, Brush RS, Rotstein NP, Politi LE. Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. J Neurochem. 2009 Sep; 110(5):1648-60. PMID: 19575708; PMCID: PMC2743900.
    38. Rajala A, Daly RJ, Tanito M, Allen DT, Holt LJ, Lobanova ES, Arshavsky VY, Rajala RV. Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry. 2009 Jun 23; 48(24):5563-72. PMID: 19438210; PMCID: PMC2763493.
    39. Rajala RV, Rajala A. Cytoskeletal components enhance the autophosphorylation of retinal insulin receptor. Chem Biol Interact. 2009 Jul 15; 180(2):245-53. PMID: 19497423; PMCID: PMC2749664.
    40. Rajala RV, Ivanovic I, Dilly AK. Retinal insulin receptor signaling in hyperosmotic stress. Vitam Horm. 2009; 80:583-612. PMID: 19251051; PMCID: PMC2670484.
    41. Rajala RV, Wiskur B, Tanito M, Callegan M, Rajala A. Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1033-40. PMID: 19029027; PMCID: PMC2694133.
    42. Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV. Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides. J Neurochem. 2008 Dec; 107(5):1382-97. PMID: 18823366; PMCID: PMC2596869.
    43. Rajala RV. Phospho-Site-Specific Antibody Microarray to Study the State of Protein Phosphorylation in the Retina. J Proteomics Bioinform. 2008 Aug 13; 1:242. PMID: 20151040.
      View in: PubMed
    44. Dilly AK, Rajala RV. Insulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4765-73. PMID: 18566464; PMCID: PMC2670430.
    45. Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem. 2008 Jul 11; 283(28):19781-92. PMID: 18480052; PMCID: PMC2443670.
    46. Rajaiya J, Xiao J, Rajala RV, Chodosh J. Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression. Virol J. 2008 Jan 25; 5:17. PMID: 18221537; PMCID: PMC2265692.
    47. Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J Biol Chem. 2007 Mar 30; 282(13):9865-73. PMID: 17272282.
      View in: PubMed
    48. Li G, Anderson RE, Tomita H, Adler R, Liu X, Zack DJ, Rajala RV. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J Neurosci. 2007 Jan 03; 27(1):203-11. PMID: 17202487.
      View in: PubMed
    49. Rajala RV, Elliott MH, McClellan ME, Anderson RE. Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. Adv Exp Med Biol. 2006; 572:491-7. PMID: 17249614.
      View in: PubMed
    50. Rajala RV, Chan MD, Rajala A. Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling. Biochemistry. 2005 Nov 29; 44(47):15461-71. PMID: 16300394.
      View in: PubMed
    51. Rajala MS, Rajala RV, Astley RA, Butt AL, Chodosh J. Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation. J Virol. 2005 Oct; 79(19):12332-41. PMID: 16160160; PMCID: PMC1211526.
    52. Rajala RV. How does the biological function of N-myristoylation differ from that of N-palmitoylation? IUBMB Life. 2005 Aug; 57(8):597-8. PMID: 16118118.
      View in: PubMed
    53. Rajala RV, Chan MD. Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1. Biochemistry. 2005 Jun 07; 44(22):7929-35. PMID: 15924411.
      View in: PubMed
    54. Dumonceaux T, Rajala RV, Sharma R, Selvaraj G, Datla R. Molecular characterization of a gene encoding N-myristoyl transferase (NMT) from Triticum aestivum (bread wheat). Genome. 2004 Dec; 47(6):1036-42. PMID: 15644961.
      View in: PubMed
    55. Rajala RV, McClellan ME, Chan MD, Tsiokas L, Anderson RE. Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase. Biochemistry. 2004 May 18; 43(19):5637-50. PMID: 15134438.
      View in: PubMed
    56. Rundle DR, Rajala RV, Alvarez RA, Anderson RE. Myristoyl-CoA:protein N-myristoyltransferases: isoform identification and gene expression in retina. Mol Vis. 2004 Mar 22; 10:177-85. PMID: 15041955.
      View in: PubMed
    57. Yu X, Rajala RV, McGinnis JF, Li F, Anderson RE, Yan X, Li S, Elias RV, Knapp RR, Zhou X, Cao W. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J Biol Chem. 2004 Mar 26; 279(13):13086-94. PMID: 14711819.
      View in: PubMed
    58. Rajala RV, Anderson RE. Light regulation of the insulin receptor in the retina. Mol Neurobiol. 2003 Oct; 28(2):123-38. PMID: 14576451.
      View in: PubMed
    59. Rajala RV, McClellan ME, Ash JD, Anderson RE. Regulation of retinal phosphoinositide 3-kinase activity in p85alpha-subunit knockout mice. Adv Exp Med Biol. 2003; 533:369-76. PMID: 15180287.
      View in: PubMed
    60. Cao W, Rajala RV, Li F, Anderson RE, Wei N, Soliman CE, McGinnis JF. Neuroprotective effect of estrogen upon retinal neurons in vitro. Adv Exp Med Biol. 2003; 533:395-402. PMID: 15180290.
      View in: PubMed
    61. Rajala RV, McClellan ME, Ash JD, Anderson RE. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. J Biol Chem. 2002 Nov 08; 277(45):43319-26. PMID: 12213821.
      View in: PubMed
    62. Rundle DR, Rajala RV, Anderson RE. Characterization of Type I and Type II myristoyl-CoA:protein N-myristoyltransferases with the Acyl-CoAs found on heterogeneously acylated retinal proteins. Exp Eye Res. 2002 Jul; 75(1):87-97. PMID: 12123640.
      View in: PubMed
    63. Rajala RV, Kakkar R, Kanthan R, Radhi JM, Wang X, Wang R, Datla RS, Sharma RK. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion. J Cell Biochem. 2002; 86(3):509-19. PMID: 12210757.
      View in: PubMed
    64. Kakkar R, Seitz DP, Kanthan R, Rajala RV, Radhi JM, Wang X, Pasha MK, Wang R, Sharma RK. Calmodulin-dependent cyclic nucleotide phosphodiesterase in an experimental rat model of cardiac ischemia-reperfusion. Can J Physiol Pharmacol. 2002 Jan; 80(1):59-66. PMID: 11926171.
      View in: PubMed
    65. Rajala RV, Anderson RE. Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS. Invest Ophthalmol Vis Sci. 2001 Dec; 42(13):3110-7. PMID: 11726610.
      View in: PubMed
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