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Raju VS Rajala

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentOphthalmology
Phone405/271-8255
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    Collapse Research 
    Collapse research activities and funding
    R01EY016507     (RAJALA, RAJU VS)Apr 1, 2005 - Aug 31, 2014
    NIH/NEI
    Light Activation of Retinal Insulin Receptor Signaling
    Role: Principal Investigator

    R01EY000871     (RAJALA, RAJU VS)Feb 1, 1978 - Mar 31, 2021
    NIH/NEI
    Second Messengers in the Retina
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rajala A, Wang Y, Soni K, Rajala RVS. Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration. Cell Death Dis. 2018 Jul 03; 9(7):737. PMID: 29970877.
      View in: PubMed
    2. Rajala A, Wang Y, Brush RS, Tsantilas K, Jankowski CSR, Lindsay KJ, Linton JD, Hurley JB, Anderson RE, Rajala RVS. Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death Dis. 2018 02 14; 9(2):240. PMID: 29445082.
      View in: PubMed
    3. Wang Y, Rajala A, Rajala RVS. Nanoparticles as Delivery Vehicles for the Treatment of Retinal Degenerative Diseases. Adv Exp Med Biol. 2018; 1074:117-123. PMID: 29721935.
      View in: PubMed
    4. Rajala RVS, Rajala A. Redundant and Nonredundant Functions of Akt Isoforms in the Retina. Adv Exp Med Biol. 2018; 1074:585-591. PMID: 29721991.
      View in: PubMed
    5. Rajala A, Wang Y, Rajala RVS. Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice. Adv Exp Med Biol. 2018; 1074:491-497. PMID: 29721981.
      View in: PubMed
    6. Rajala A, Wang Y, Abcouwer SF, Gardner TW, Rajala RVS. Developmental and light regulation of tumor suppressor protein PP2A in the retina. Oncotarget. 2018 Jan 05; 9(2):1505-1523. PMID: 29416710.
      View in: PubMed
    7. Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RVS, Yang Y, Moran E, Ma JX. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARa. Diabetes. 2017 06; 66(6):1671-1682. PMID: 28270521.
      View in: PubMed
    8. Rajala RV, Rajala A, Kooker C, Wang Y, Anderson RE. The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina. Sci Rep. 2016 11 24; 6:37727. PMID: 27883057.
      View in: PubMed
    9. Rajala A, Wang Y, Rajala RV. Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival. Oncotarget. 2016 Jul 26; 7(30):46924-46942. PMID: 27391439.
      View in: PubMed
    10. Wang Y, Rajala A, Cao B, Ranjo-Bishop M, Agbaga MP, Mao C, Rajala RV. Cell-Specific Promoters Enable Lipid-Based Nanoparticles to Deliver Genes to Specific Cells of the Retina In Vivo. Theranostics. 2016; 6(10):1514-27. PMID: 27446487.
      View in: PubMed
    11. Rajala RV, Gardner TW. Burning fat fuels photoreceptors. Nat Med. 2016 Apr; 22(4):342-3. PMID: 27050587.
      View in: PubMed
    12. Rao KN, Li L, Zhang W, Brush RS, Rajala RV, Khanna H. Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina. Hum Mol Genet. 2016 Apr 01; 25(7):1345-56. PMID: 26908598.
      View in: PubMed
    13. Azadi S, Brush RS, Anderson RE, Rajala RV. Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina. Adv Exp Med Biol. 2016; 854:363-9. PMID: 26427433.
      View in: PubMed
    14. Rajala RV, Kanan Y, Anderson RE. Photoreceptor Neuroprotection: Regulation of Akt Activation Through Serine/Threonine Phosphatases, PHLPP and PHLPPL. Adv Exp Med Biol. 2016; 854:419-24. PMID: 26427440.
      View in: PubMed
    15. Wang Y, Rajala A, Rajala RV. Lipid Nanoparticles for Ocular Gene Delivery. J Funct Biomater. 2015 Jun 08; 6(2):379-94. PMID: 26062170.
      View in: PubMed
    16. Takahashi Y, Chen Q, Rajala RVS, Ma JX. MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett. 2015 Apr 28; 589(10):1143-1149. PMID: 25796186.
      View in: PubMed
    17. Rajala RV, Ranjo-Bishop M, Wang Y, Rajala A, Anderson RE. The p110a isoform of phosphoinositide 3-kinase is essential for cone photoreceptor survival. Biochimie. 2015 May; 112:35-40. PMID: 25742742.
      View in: PubMed
    18. Gupta VK, Rajala A, Rajala RV. Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cells. Cell Commun Signal. 2015 Feb 03; 13:7. PMID: 25644171.
      View in: PubMed
    19. Woodruff ML, Rajala A, Fain GL, Rajala RV. Effect of knocking down the insulin receptor on mouse rod responses. Sci Rep. 2015 Jan 19; 5:7858. PMID: 25598343.
      View in: PubMed
    20. Zulliger R, Naash MI, Rajala RV, Molday RS, Azadi S. Impaired association of retinal degeneration-3 with guanylate cyclase-1 and guanylate cyclase-activating protein-1 leads to leber congenital amaurosis-1. J Biol Chem. 2015 Feb 06; 290(6):3488-99. PMID: 25477517.
      View in: PubMed
    21. Rajala A, Wang Y, Zhu Y, Ranjo-Bishop M, Ma JX, Mao C, Rajala RV. Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano Lett. 2014 Sep 10; 14(9):5257-63. PMID: 25115433.
      View in: PubMed
    22. Rajala RV, Rajala A, Morris AJ, Anderson RE. Phosphoinositides: minor lipids make a major impact on photoreceptor cell functions. Sci Rep. 2014 Jun 26; 4:5463. PMID: 24964953.
      View in: PubMed
    23. Rajala RV, Basavarajappa DK, Dighe R, Rajala A. Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Commun Signal. 2013 Dec 18; 11:96. PMID: 24350791.
      View in: PubMed
    24. Rajala RV, Rajala A. Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons. Protein Cell. 2013 Dec; 4(12):890-2. PMID: 24203758.
      View in: PubMed
    25. Woodruff ML, Rajala A, Fain GL, Rajala RV. Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem. 2014 Jan 03; 289(1):358-64. PMID: 24273167.
      View in: PubMed
    26. Rajala A, Gupta VK, Anderson RE, Rajala RV. Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection. Mitochondrion. 2013 Nov; 13(6):566-76. PMID: 23993956.
      View in: PubMed
    27. Rajala A, Dighe R, Agbaga MP, Anderson RE, Rajala RV. Insulin receptor signaling in cones. J Biol Chem. 2013 Jul 05; 288(27):19503-15. PMID: 23673657.
      View in: PubMed
    28. Rajala A, Dilly AK, Rajala RV. Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina. Cell Commun Signal. 2013 Mar 22; 11(1):20. PMID: 23521888.
      View in: PubMed
    29. Gupta VK, Rajala A, Rajala RV. Insulin receptor regulates photoreceptor CNG channel activity. Am J Physiol Endocrinol Metab. 2012 Dec 01; 303(11):E1363-72. PMID: 23032687.
      View in: PubMed
    30. Rajala RV, Rajala A, Gupta VK. Conservation and divergence of Grb7 family of Ras-binding domains. Protein Cell. 2012 Jan; 3(1):60-70. PMID: 22271596.
      View in: PubMed
    31. Gupta VK, Rajala A, Rajala RV. Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators. Adv Exp Med Biol. 2012; 723:777-82. PMID: 22183406.
      View in: PubMed
    32. Basavarajappa DK, Gupta VK, Rajala RV. Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases. Adv Exp Med Biol. 2012; 723:829-34. PMID: 22183413.
      View in: PubMed
    33. Gupta VK, Rajala A, Rodgers KK, Rajala RV. Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell. 2011 Nov; 2(11):906-17. PMID: 22180090.
      View in: PubMed
    34. Ivanovic I, Allen DT, Dighe R, Le YZ, Anderson RE, Rajala RV. Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug 11; 52(9):6355-62. PMID: 21730346.
      View in: PubMed
    35. Basavarajappa DK, Gupta VK, Dighe R, Rajala A, Rajala RV. Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14. Mol Cell Biol. 2011 Oct; 31(19):3975-87. PMID: 21791607.
      View in: PubMed
    36. Ivanovic I, Anderson RE, Le YZ, Fliesler SJ, Sherry DM, Rajala RV. Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3775-83. PMID: 21398281.
      View in: PubMed
    37. Gupta VK, Rajala A, Daly RJ, Rajala RV. Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel. EMBO Rep. 2010 Nov; 11(11):861-7. PMID: 20890309.
      View in: PubMed
    38. Rajala RV, Anderson RE. Focus on molecules: phosphatidylinositol-4,5-bisphosphate (PIP2). Exp Eye Res. 2010 Sep; 91(3):324-5. PMID: 20457154.
      View in: PubMed
    39. Rajala RV, Anderson RE. Rhodopsin-regulated insulin receptor signaling pathway in rod photoreceptor neurons. Mol Neurobiol. 2010 Aug; 42(1):39-47. PMID: 20407846.
      View in: PubMed
    40. Huang Z, Anderson RE, Cao W, Wiechmann AF, Rajala RV. Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II a phosphatidylinositol-5-phosphate 4-kinase. Neurochem Res. 2011 Apr; 36(4):627-35. PMID: 20204506.
      View in: PubMed
    41. Kanan Y, Matsumoto H, Song H, Sokolov M, Anderson RE, Rajala RV. Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. J Neurochem. 2010 Apr; 113(2):477-88. PMID: 20089132.
      View in: PubMed
    42. Rajala RV, Tanito M, Neel BG, Rajala A. Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. J Biol Chem. 2010 Mar 19; 285(12):8894-904. PMID: 20061388.
      View in: PubMed
    43. Rajala RV. Phosphoinositide 3-kinase signaling in the vertebrate retina. J Lipid Res. 2010 Jan; 51(1):4-22. PMID: 19638643.
      View in: PubMed
    44. Rajala RV, Rajala A, Brush RS, Rotstein NP, Politi LE. Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors. J Neurochem. 2009 Sep; 110(5):1648-60. PMID: 19575708.
      View in: PubMed
    45. Rajala A, Daly RJ, Tanito M, Allen DT, Holt LJ, Lobanova ES, Arshavsky VY, Rajala RV. Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry. 2009 Jun 23; 48(24):5563-72. PMID: 19438210.
      View in: PubMed
    46. Rajala RV, Rajala A. Cytoskeletal components enhance the autophosphorylation of retinal insulin receptor. Chem Biol Interact. 2009 Jul 15; 180(2):245-53. PMID: 19497423.
      View in: PubMed
    47. Rajala RV, Ivanovic I, Dilly AK. Retinal insulin receptor signaling in hyperosmotic stress. Vitam Horm. 2009; 80:583-612. PMID: 19251051.
      View in: PubMed
    48. Rajala RV, Wiskur B, Tanito M, Callegan M, Rajala A. Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1033-40. PMID: 19029027.
      View in: PubMed
    49. Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV. Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides. J Neurochem. 2008 Dec; 107(5):1382-97. PMID: 18823366.
      View in: PubMed
    50. Rajala RV. Phospho-Site-Specific Antibody Microarray to Study the State of Protein Phosphorylation in the Retina. J Proteomics Bioinform. 2008 Aug 13; 1:242. PMID: 20151040.
      View in: PubMed
    51. Dilly AK, Rajala RV. Insulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4765-73. PMID: 18566464.
      View in: PubMed
    52. Rajala A, Tanito M, Le YZ, Kahn CR, Rajala RV. Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells. J Biol Chem. 2008 Jul 11; 283(28):19781-92. PMID: 18480052.
      View in: PubMed
    53. Rajaiya J, Xiao J, Rajala RV, Chodosh J. Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression. Virol J. 2008 Jan 25; 5:17. PMID: 18221537.
      View in: PubMed
    54. Rajala A, Anderson RE, Ma JX, Lem J, Al-Ubaidi MR, Rajala RV. G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J Biol Chem. 2007 Mar 30; 282(13):9865-73. PMID: 17272282.
      View in: PubMed
    55. Li G, Anderson RE, Tomita H, Adler R, Liu X, Zack DJ, Rajala RV. Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J Neurosci. 2007 Jan 03; 27(1):203-11. PMID: 17202487.
      View in: PubMed
    56. Rajala RV, Elliott MH, McClellan ME, Anderson RE. Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. Adv Exp Med Biol. 2006; 572:491-7. PMID: 17249614.
      View in: PubMed
    57. Rajala RV, Chan MD, Rajala A. Lipid-protein interactions of growth factor receptor-bound protein 14 in insulin receptor signaling. Biochemistry. 2005 Nov 29; 44(47):15461-71. PMID: 16300394.
      View in: PubMed
    58. Rajala MS, Rajala RV, Astley RA, Butt AL, Chodosh J. Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation. J Virol. 2005 Oct; 79(19):12332-41. PMID: 16160160.
      View in: PubMed
    59. Rajala RV. How does the biological function of N-myristoylation differ from that of N-palmitoylation? IUBMB Life. 2005 Aug; 57(8):597-8. PMID: 16118118.
      View in: PubMed
    60. Rajala RV, Chan MD. Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1. Biochemistry. 2005 Jun 07; 44(22):7929-35. PMID: 15924411.
      View in: PubMed
    61. Dumonceaux T, Rajala RV, Sharma R, Selvaraj G, Datla R. Molecular characterization of a gene encoding N-myristoyl transferase (NMT) from Triticum aestivum (bread wheat). Genome. 2004 Dec; 47(6):1036-42. PMID: 15644961.
      View in: PubMed
    62. Rajala RV, McClellan ME, Chan MD, Tsiokas L, Anderson RE. Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase. Biochemistry. 2004 May 18; 43(19):5637-50. PMID: 15134438.
      View in: PubMed
    63. Rundle DR, Rajala RV, Alvarez RA, Anderson RE. Myristoyl-CoA:protein N-myristoyltransferases: isoform identification and gene expression in retina. Mol Vis. 2004 Mar 22; 10:177-85. PMID: 15041955.
      View in: PubMed
    64. Yu X, Rajala RV, McGinnis JF, Li F, Anderson RE, Yan X, Li S, Elias RV, Knapp RR, Zhou X, Cao W. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection. J Biol Chem. 2004 Mar 26; 279(13):13086-94. PMID: 14711819.
      View in: PubMed
    65. Rajala RV, Anderson RE. Light regulation of the insulin receptor in the retina. Mol Neurobiol. 2003 Oct; 28(2):123-38. PMID: 14576451.
      View in: PubMed
    66. Rajala RV, McClellan ME, Ash JD, Anderson RE. Regulation of retinal phosphoinositide 3-kinase activity in p85alpha-subunit knockout mice. Adv Exp Med Biol. 2003; 533:369-76. PMID: 15180287.
      View in: PubMed
    67. Cao W, Rajala RV, Li F, Anderson RE, Wei N, Soliman CE, McGinnis JF. Neuroprotective effect of estrogen upon retinal neurons in vitro. Adv Exp Med Biol. 2003; 533:395-402. PMID: 15180290.
      View in: PubMed
    68. Rajala RV, McClellan ME, Ash JD, Anderson RE. In vivo regulation of phosphoinositide 3-kinase in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit. J Biol Chem. 2002 Nov 08; 277(45):43319-26. PMID: 12213821.
      View in: PubMed
    69. Rundle DR, Rajala RV, Anderson RE. Characterization of Type I and Type II myristoyl-CoA:protein N-myristoyltransferases with the Acyl-CoAs found on heterogeneously acylated retinal proteins. Exp Eye Res. 2002 Jul; 75(1):87-97. PMID: 12123640.
      View in: PubMed
    70. Kakkar R, Seitz DP, Kanthan R, Rajala RV, Radhi JM, Wang X, Pasha MK, Wang R, Sharma RK. Calmodulin-dependent cyclic nucleotide phosphodiesterase in an experimental rat model of cardiac ischemia-reperfusion. Can J Physiol Pharmacol. 2002 Jan; 80(1):59-66. PMID: 11926171.
      View in: PubMed
    71. Rajala RV, Kakkar R, Kanthan R, Radhi JM, Wang X, Wang R, Datla RS, Sharma RK. Altered expression and localization of N-myristoyltransferase in experimentally induced rat model of ischemia-reperfusion. J Cell Biochem. 2002; 86(3):509-19. PMID: 12210757.
      View in: PubMed
    72. Rajala RV, Anderson RE. Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS. Invest Ophthalmol Vis Sci. 2001 Dec; 42(13):3110-7. PMID: 11726610.
      View in: PubMed
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