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Robert H Cichewicz

TitleProfessor
InstitutionUniversity of Oklahoma, Norman
DepartmentChemistry/Biochemistry
Address620 Parrington Oval
Norman OK
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    Collapse Research 
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    R21NS064313     (CICHEWICZ, ROBERT HENRY)May 1, 2009 - Apr 30, 2011
    NIH/NINDS
    Translating Natural Products into Therapeutic Leads for Huntington's Disease
    Role: Principal Investigator

    R01AI085161     (CICHEWICZ, ROBERT HENRY)Jan 15, 2010 - Dec 31, 2015
    NIH/NIAID
    Chemically diverse antimicrobials from silent biosynthetic pathways
    Role: Principal Investigator

    R01GM092219     (CICHEWICZ, ROBERT HENRY)Aug 15, 2010 - May 31, 2014
    NIH/NIGMS
    Accessing Natural Products from Silent Biosynthetic Pathways
    Role: Principal Investigator

    R21AI101487     (CICHEWICZ, ROBERT HENRY)Jul 15, 2012 - Jun 30, 2014
    NIH/NIAID
    Antimicrobials from Mammalian Microbiomes
    Role: Principal Investigator

    R01GM107490     (CICHEWICZ, ROBERT HENRY)Jul 1, 2014 - Apr 30, 2018
    NIH/NIGMS
    Sourcing Bioactive Secondary Metabolites from Great Lakes Fungi
    Role: Principal Investigator

    U01CA182740     (MOOBERRY, SUSAN L)Sep 22, 2014 - Aug 31, 2019
    NIH/NCI
    New Leads for Triple Negative Breast Cancer from Diverse Natural Sources
    Role: Co-Principal Investigator

    R21AI115390     (CICHEWICZ, ROBERT HENRY)May 15, 2015 - Apr 30, 2017
    NIH/NIAID
    Procuring Native Natural Product Producers by In Situ Chimera Assembly
    Role: Principal Investigator

    R21AI119713     (CICHEWICZ, ROBERT HENRY)Jun 12, 2015 - May 31, 2017
    NIH/NIAID
    Early Stage Discovery of Natural Products Targeting Anaerobic Protozoal Pathogen
    Role: Principal Investigator

    R33AI119713     (CICHEWICZ, ROBERT HENRY)Jun 12, 2015 - May 31, 2020
    NIH/NIAID
    Early Stage Discovery of Natural Products Targeting Anaerobic Protozoal Pathogen
    Role: Principal Investigator

    R21AI126068     (ROHDE, KYLE H)Jan 20, 2017 - Dec 31, 2018
    NIH/NIAID
    Exploiting Fungal Natural Products to Discover Novel Scaffolds That Inhibit Dormant and Drug-Resistant TB
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cho N, Ransom TT, Sigmund J, Tran T, Cichewicz RH, Goetz M, Beutler JA. Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species. J Nat Prod. 2017 Jul 28; 80(7):2037-2044. PMID: 28654255.
      View in: PubMed
    2. Cichewicz RH, Cragg GM, Linington RG, Wright AE. Special Issue in Honor of Professor Phil Crews. J Nat Prod. 2017 Mar 24; 80(3):579-581. PMID: 28335607.
      View in: PubMed
    3. Motley JL, Stamps BW, Mitchell CA, Thompson AT, Cross J, You J, Powell DR, Stevenson BS, Cichewicz RH. Correction to Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-Anthropoidal Mammalian Microbiomes. J Nat Prod. 2017 Apr 28; 80(4):1233. PMID: 28339197.
      View in: PubMed
    4. Risinger AL, Li J, Du L, Benavides R, Robles AJ, Cichewicz RH, Kuhn JG, Mooberry SL. Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ. J Nat Prod. 2017 Feb 24; 80(2):409-414. PMID: 28112516.
      View in: PubMed
    5. Garg N, Zeng Y, Edlund A, Melnik AV, Sanchez LM, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner PA, Cichewicz RH, Alexandrov T, Dorrestein PC. Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. mSystems. 2016 Nov-Dec; 1(6). PMID: 28028548.
      View in: PubMed
    6. Robles AJ, Cai S, Cichewicz RH, Mooberry SL. Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer. Breast Cancer Res Treat. 2016 Jun; 157(3):475-88. PMID: 27255535; PMCID: PMC4937748 [Available on 06/02/17].
    7. Foxley MA, Friedline AW, Jensen JM, Nimmo SL, Scull EM, King JB, Strange S, Xiao MT, Smith BE, Thomas Iii KJ, Glatzhofer DT, Cichewicz RH, Rice CV. Efficacy of ampicillin against methicillin-resistant Staphylococcus aureus restored through synergy with branched poly(ethylenimine). J Antibiot (Tokyo). 2016 Dec; 69(12):871-878. PMID: 27189119.
      View in: PubMed
    8. Van Kanegan MJ, Dunn DE, Kaltenbach LS, Shah B, He DN, McCoy DD, Yang P, Peng J, Shen L, Du L, Cichewicz RH, Newman RA, Lo DC. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. Sci Rep. 2016 May 12; 6:25626. PMID: 27172999; PMCID: PMC4865873.
    9. Du L, You J, Nicholas KM, Cichewicz RH. Chemoreactive Natural Products that Afford Resistance Against Disparate Antibiotics and Toxins. Angew Chem Int Ed Engl. 2016 Mar 18; 55(13):4220-5. PMID: 26928999; PMCID: PMC4959538 [Available on 03/18/17].
    10. Shaffer CV, Cai S, Peng J, Robles AJ, Hartley RM, Powell DR, Du L, Cichewicz RH, Mooberry SL. Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells. J Nat Prod. 2016 Mar 25; 79(3):531-40. PMID: 26785306; PMCID: PMC4860899 [Available on 03/25/17].
    11. Cai S, Risinger AL, Nair S, Peng J, Anderson TJ, Du L, Powell DR, Mooberry SL, Cichewicz RH. Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants. J Nat Prod. 2016 Mar 25; 79(3):490-8. PMID: 26722868.
      View in: PubMed
    12. Niu G, Wang B, Zhang G, King JB, Cichewicz RH, Li J. Targeting mosquito FREP1 with a fungal metabolite blocks malaria transmission. Sci Rep. 2015 Oct 06; 5:14694. PMID: 26437882; PMCID: PMC4593950.
    13. Wang B, Park EM, King JB, Mattes AO, Nimmo SL, Clendinen C, Edison AS, Anklin C, Cichewicz RH. Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite Production. J Nat Prod. 2015 Jun 26; 78(6):1415-21. PMID: 26061478.
      View in: PubMed
    14. Du L, Robles AJ, King JB, Powell DR, Miller AN, Mooberry SL, Cichewicz RH. Corrigendum: Crowdsourcing Natural Products Discovery to Access Uncharted Dimensions of Fungal Metabolite Diversity. Angew Chem Int Ed Engl. 2015 Jun 01; 54(23):6671. PMID: 26055200.
      View in: PubMed
    15. Du L, King JB, Cichewicz RH. Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid. J Nat Prod. 2014 Nov 26; 77(11):2454-8. PMID: 25338315; PMCID: PMC4251535.
    16. Wang B, You J, King JB, Cai S, Park E, Powell DR, Cichewicz RH. Polyketide glycosides from Bionectria ochroleuca inhibit Candida albicans biofilm formation. J Nat Prod. 2014 Oct 24; 77(10):2273-9. PMID: 25302529; PMCID: PMC4208675.
    17. Cai S, King JB, Du L, Powell DR, Cichewicz RH. Bioactive sulfur-containing sulochrin dimers and other metabolites from an Alternaria sp. isolate from a Hawaiian soil sample. J Nat Prod. 2014 Oct 24; 77(10):2280-7. PMID: 25265160; PMCID: PMC4208674.
    18. Du L, Risinger AL, King JB, Powell DR, Cichewicz RH. A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. J Nat Prod. 2014 Jul 25; 77(7):1753-7. PMID: 24999749; PMCID: PMC4113265.
    19. Williams RB, Du L, Norman VL, Goering MG, O'Neil-Johnson M, Woodbury S, Albrecht MA, Powell DR, Cichewicz RH, Eldridge GR, Starks CM. Diterpenes from the endangered goldenrod Solidago shortii. J Nat Prod. 2014 Jun 27; 77(6):1438-44. PMID: 24922615.
      View in: PubMed
    20. Du L, Robles AJ, King JB, Mooberry SL, Cichewicz RH. Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum. J Nat Prod. 2014 Jun 27; 77(6):1459-66. PMID: 24893224; PMCID: PMC4073660.
    21. Theodore CM, Stamps BW, King JB, Price LS, Powell DR, Stevenson BS, Cichewicz RH. Genomic and metabolomic insights into the natural product biosynthetic diversity of a feral-hog-associated Brevibacillus laterosporus strain. PLoS One. 2014; 9(3):e90124. PMID: 24595070; PMCID: PMC3940840.
    22. Du L, Robles AJ, King JB, Powell DR, Miller AN, Mooberry SL, Cichewicz RH. Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. Angew Chem Int Ed Engl. 2014 Jan 13; 53(3):804-9. PMID: 24285637; PMCID: PMC4028707.
    23. Cai S, Du L, Gerea AL, King JB, You J, Cichewicz RH. Spiro fused diterpene-indole alkaloids from a creek-bottom-derived Aspergillus terreus. Org Lett. 2013 Aug 16; 15(16):4186-9. PMID: 23924243; PMCID: PMC3786142.
    24. You J, Du L, King JB, Hall BE, Cichewicz RH. Small-molecule suppressors of Candida albicans biofilm formation synergistically enhance the antifungal activity of amphotericin B against clinical Candida isolates. ACS Chem Biol. 2013 Apr 19; 8(4):840-8. PMID: 23387427; PMCID: PMC3631451.
    25. Theodore CM, King JB, You J, Cichewicz RH. Production of cytotoxic glidobactins/luminmycins by Photorhabdus asymbiotica in liquid media and live crickets. J Nat Prod. 2012 Nov 26; 75(11):2007-11. PMID: 23095088; PMCID: PMC3570697.
    26. Du L, King JB, Morrow BH, Shen JK, Miller AN, Cichewicz RH. Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. J Nat Prod. 2012 Oct 26; 75(10):1819-23. PMID: 23046341; PMCID: PMC3483373.
    27. Gerea AL, Branscum KM, King JB, You J, Powell DR, Miller AN, Spear JR, Cichewicz RH. Secondary metabolites produced by fungi derived from a microbial mat encountered in an iron-rich natural spring. Tetrahedron Lett. 2012 Aug 08; 53(32):4202-4205. PMID: 22844162.
      View in: PubMed
    28. Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, Peng Q, Jiang M, Arbez N, Hotaling K, Ross CA, Duan W. trans-(-)-e-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. J Biol Chem. 2012 Jul 13; 287(29):24460-72. PMID: 22648412; PMCID: PMC3397871.
    29. Wang X, You J, King JB, Powell DR, Cichewicz RH. Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans. J Nat Prod. 2012 Apr 27; 75(4):707-15. PMID: 22400916; PMCID: PMC3338887.
    30. Wang X, Du L, You J, King JB, Cichewicz RH. Fungal biofilm inhibitors from a human oral microbiome-derived bacterium. Org Biomol Chem. 2012 Mar 14; 10(10):2044-50. PMID: 22281750.
      View in: PubMed
    31. Miao FP, Li XD, Liu XH, Cichewicz RH, Ji NY. Secondary metabolites from an algicolous Aspergillus versicolor strain. Mar Drugs. 2012 Jan; 10(1):131-9. PMID: 22363226; PMCID: PMC3280527.
    32. Jiang M, Wang J, Fu J, Du L, Jeong H, West T, Xiang L, Peng Q, Hou Z, Cai H, Seredenina T, Arbez N, Zhu S, Sommers K, Qian J, Zhang J, Mori S, Yang XW, Tamashiro KL, Aja S, Moran TH, Luthi-Carter R, Martin B, Maudsley S, Mattson MP, Cichewicz RH, Ross CA, Holtzman DM, Krainc D, Duan W. Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med. 2011 Dec 18; 18(1):153-8. PMID: 22179319; PMCID: PMC4551453.
    33. Henrikson JC, Ellis TK, King JB, Cichewicz RH. Reappraising the structures and distribution of metabolites from black aspergilli containing uncommon 2-benzyl-4H-pyran-4-one and 2-benzylpyridin-4(1H)-one systems. J Nat Prod. 2011 Sep 23; 74(9):1959-64. PMID: 21854017; PMCID: PMC3179785.
    34. Joyner PM, Waters AL, Williams RB, Powell DR, Janakiram NB, Rao CV, Cichewicz RH. Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells. J Nat Prod. 2011 Apr 25; 74(4):857-61. PMID: 21438584.
      View in: PubMed
    35. Joyner PM, Cichewicz RH. Bringing natural products into the fold - exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases. Nat Prod Rep. 2011 Jan; 28(1):26-47. PMID: 20927454.
      View in: PubMed
    36. Joyner PM, Liu J, Zhang Z, Merritt J, Qi F, Cichewicz RH. Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. Org Biomol Chem. 2010 Dec 21; 8(24):5486-9. PMID: 20852771; PMCID: PMC2992086.
    37. Wu C, Cichewicz R, Li Y, Liu J, Roe B, Ferretti J, Merritt J, Qi F. Genomic island TnSmu2 of Streptococcus mutans harbors a nonribosomal peptide synthetase-polyketide synthase gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance. Appl Environ Microbiol. 2010 Sep; 76(17):5815-26. PMID: 20639370; PMCID: PMC2935078.
    38. Wang X, Sena Filho JG, Hoover AR, King JB, Ellis TK, Powell DR, Cichewicz RH. Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum. J Nat Prod. 2010 May 28; 73(5):942-8. PMID: 20450206; PMCID: PMC2878378.
    39. Cichewicz RH, Hambright KD. A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity. Toxicon. 2010 May; 55(5):1035-7; author reply 1038-43. PMID: 20223344.
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    40. Henrikson JC, Gharfeh MS, Easton AC, Easton JD, Glenn KL, Shadfan M, Mooberry SL, Hambright KD, Cichewicz RH. Reassessing the ichthyotoxin profile of cultured Prymnesium parvum (golden algae) and comparing it to samples collected from recent freshwater bloom and fish kill events in North America. Toxicon. 2010 Jun 15; 55(7):1396-404. PMID: 20184911.
      View in: PubMed
    41. Cichewicz RH, Hambright KD. WITHDRAWN: A revised amino group pK(a) for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity. Toxicon. 2010 Feb 13. PMID: 20156471.
      View in: PubMed
    42. Joyner PM, Matheke RM, Smith LM, Cichewicz RH. Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice. J Proteome Res. 2010 Jan; 9(1):404-12. PMID: 19908918; PMCID: PMC2801778.
    43. Cichewicz RH. Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat Prod Rep. 2010 Jan; 27(1):11-22. PMID: 20024091; PMCID: PMC2958777.
    44. Sena Filho JG, Nimmo SL, Xavier HS, Barbosa-Filho JM, Cichewicz RH. Phenylethanoid and lignan glycosides from polar extracts of Lantana, a genus of verbenaceous plants widely used in traditional herbal therapies. J Nat Prod. 2009 Jul; 72(7):1344-7. PMID: 19485331.
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    45. Henrikson JC, Hoover AR, Joyner PM, Cichewicz RH. A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger. Org Biomol Chem. 2009 Feb 07; 7(3):435-8. PMID: 19156306.
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    46. Amagata T, Johnson TA, Cichewicz RH, Tenney K, Mooberry SL, Media J, Edelstein M, Valeriote FA, Crews P. Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges. J Med Chem. 2008 Nov 27; 51(22):7234-42. PMID: 18942825; PMCID: PMC2772107.
    47. Williams RB, Henrikson JC, Hoover AR, Lee AE, Cichewicz RH. Epigenetic remodeling of the fungal secondary metabolome. Org Biomol Chem. 2008 Jun 07; 6(11):1895-7. PMID: 18480899.
      View in: PubMed
    48. Williams RB, Gutekunst WR, Joyner PM, Duan W, Li Q, Ross CA, Williams TD, Cichewicz RH. Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity. J Agric Food Chem. 2007 Nov 14; 55(23):9450-6. PMID: 17944533.
      View in: PubMed
    49. Johnson TA, Tenney K, Cichewicz RH, Morinaka BI, White KN, Amagata T, Subramanian B, Media J, Mooberry SL, Valeriote FA, Crews P. Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties. J Med Chem. 2007 Aug 09; 50(16):3795-803. PMID: 17622130; PMCID: PMC2772109.
    50. Cichewicz RH, Clifford LJ, Lassen PR, Cao X, Freedman TB, Nafie LA, Deschamps JD, Kenyon VA, Flanary JR, Holman TR, Crews P. Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis. Bioorg Med Chem. 2005 Oct 01; 13(19):5600-12. PMID: 16039133.
      View in: PubMed
    51. Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors. J Am Chem Soc. 2004 Nov 17; 126(45):14910-20. PMID: 15535718.
      View in: PubMed
    52. Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29; 47(16):4060-5. PMID: 15267244.
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    53. Zhang Y, Cichewicz RH, Nair MG. Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves. Life Sci. 2004 Jun 25; 75(6):753-63. PMID: 15172183.
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    54. Cichewicz RH, Valeriote FA, Crews P. Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family. Org Lett. 2004 Jun 10; 6(12):1951-4. PMID: 15176791.
      View in: PubMed
    55. Cichewicz RH, Zhang Y, Seeram NP, Nair MG. Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies. Life Sci. 2004 Feb 20; 74(14):1791-9. PMID: 14741736.
      View in: PubMed
    56. Cichewicz RH, Kouzi SA. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev. 2004 Jan; 24(1):90-114. PMID: 14595673.
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    57. Seeram NP, Cichewicz RH, Chandra A, Nair MG. Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits. J Agric Food Chem. 2003 Mar 26; 51(7):1948-51. PMID: 12643656.
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    58. Cichewicz RH, Nair MG. Isolation and characterization of stelladerol, a new antioxidant naphthalene glycoside, and other antioxidant glycosides from edible daylily (hemerocallis) flowers. J Agric Food Chem. 2002 Jan 02; 50(1):87-91. PMID: 11754548.
      View in: PubMed
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