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Rheal A Towner

TitleProf,Asoc of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPhysiology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-2226
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    Collapse Research 
    Collapse research activities and funding
    S10OD023508     (TOWNER, RHEAL A)Apr 1, 2017 - Mar 31, 2018
    NIH
    Pre-Clinical 7T MRI for Oklahoma
    Role: Principal Investigator

    R01NS092458     (MORTON, KATHRYN ANN)Apr 1, 2015 - Mar 31, 2020
    NIH/NINDS
    Causes, consequences, imaging and mitigation of sepsis-induced encephalopathy
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang LM, Wu Q, Kirk RA, Horn KP, Ebada Salem AH, Hoffman JM, Yap JT, Sonnen JA, Towner RA, Bozza FA, Rodrigues RS, Morton KA. Lipopolysaccharide endotoxemia induces amyloid-ß and p-tau formation in the rat brain. Am J Nucl Med Mol Imaging. 2018; 8(2):86-99. PMID: 29755842.
      View in: PubMed
    2. Greenwood-Van Meerveld B, Mohammadi E, Latorre R, Truitt ER, Jay GD, Sullivan BD, Schmidt TA, Smith N, Saunders D, Ziegler J, Lerner M, Hurst R, Towner RA. Preclinical Animal Studies of Intravesical Recombinant Human Proteoglycan 4 as a Novel Potential Therapy for Diseases Resulting From Increased Bladder Permeability. Urology. 2018 Jun; 116:230.e1-230.e7. PMID: 29545038.
      View in: PubMed
    3. Towner RA, Saunders D, Smith N, Towler W, Cruz M, Do S, Maher JE, Whitaker K, Lerner M, Morton KA. Assessing long-term neuroinflammatory responses to encephalopathy using MRI approaches in a rat endotoxemia model. Geroscience. 2018 02; 40(1):49-60. PMID: 29417380.
      View in: PubMed
    4. Dong J, Saunders D, Silasi-Mansat R, Yu L, Zhu H, Lupu F, Towner R, Dong Y, Chen H. Therapeutic efficacy of a synthetic epsin mimetic peptide in glioma tumor model: uncovering multiple mechanisms beyond the VEGF-associated tumor angiogenesis. J Neurooncol. 2018 May; 138(1):17-27. PMID: 29357089.
      View in: PubMed
    5. Towner RA, Smith N. In Vivo and In Situ Detection of Macromolecular Free Radicals Using Immuno-Spin Trapping and Molecular Magnetic Resonance Imaging. Antioxid Redox Signal. 2018 May 20; 28(15):1404-1415. PMID: 29084431.
      View in: PubMed
    6. Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP. Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol. 2018 02; 55(2):1795-1813. PMID: 29168048.
      View in: PubMed
    7. Vargas VE, Gurung S, Grant B, Hyatt K, Singleton K, Myers SM, Saunders D, Njoku C, Towner R, Myers DA. Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat. PLoS One. 2017; 12(9):e0185272. PMID: 28957383.
      View in: PubMed
    8. Yang Q, Xia D, Towner RA, Smith N, Saunders D, Fung KM, Aston CE, Greenwood-Van Meerveld B, Hurst RE, Madihally SV, Kropp BP, Lin HK. Reduced urothelial regeneration in rat bladders augmented with permeable porcine small intestinal submucosa assessed by magnetic resonance imaging. J Biomed Mater Res B Appl Biomater. 2018 Jul; 106(5):1778-1787. PMID: 28901710.
      View in: PubMed
    9. Ziegler J, Bastian A, Lerner M, Bailey-Downs L, Saunders D, Smith N, Sutton J, Battiste JD, Ihnat MA, Gangjee A, Towner RA. AG488 as a therapy against gliomas. Oncotarget. 2017 Sep 22; 8(42):71833-71844. PMID: 29069750.
      View in: PubMed
    10. Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM. Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity. Arthritis Rheumatol. 2017 06; 69(6):1221-1232. PMID: 28141918.
      View in: PubMed
    11. Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol. 2017 02 01; 19(2):175-185. PMID: 27416955.
      View in: PubMed
    12. Dong Y, Fernandes C, Liu Y, Wu Y, Wu H, Brophy ML, Deng L, Song K, Wen A, Wong S, Yan D, Towner R, Chen H. Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis. Diab Vasc Dis Res. 2017 01; 14(1):14-23. PMID: 27941052.
      View in: PubMed
    13. Rajagopalan V, Zhang Y, Ojamaa K, Chen YF, Pingitore A, Pol CJ, Saunders D, Balasubramanian K, Towner RA, Gerdes AM. Safe Oral Triiodo-L-Thyronine Therapy Protects from Post-Infarct Cardiac Dysfunction and Arrhythmias without Cardiovascular Adverse Effects. PLoS One. 2016; 11(3):e0151413. PMID: 26981865; PMCID: PMC4794221.
    14. Hurst RE, Van Gordon S, Tyler K, Kropp B, Towner R, Lin H, Marentette JO, McHowat J, Mohammedi E, Greenwood-Van Meerveld B. In the absence of overt urothelial damage, chondroitinase ABC digestion of the GAG layer increases bladder permeability in ovariectomized female rats. Am J Physiol Renal Physiol. 2016 05 01; 310(10):F1074-80. PMID: 26911855.
      View in: PubMed
    15. Mohammadi E, Prusator DK, Healing E, Hurst R, Towner RA, Wisniewski AB, Greenwood-Van Meerveld B. Sexually dimorphic effects of early life stress in rat pups on urinary bladder detrusor muscle contractility in adulthood. Biol Sex Differ. 2016; 7:8. PMID: 26823967; PMCID: PMC4730611.
    16. Du X, West MB, Cheng W, Ewert DL, Li W, Saunders D, Towner RA, Floyd RA, Kopke RD. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxid Med Cell Longev. 2016; 2016:4159357. PMID: 27034735; PMCID: PMC4806690.
    17. Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Patlolla JM, Lightfoot S, Towner RA, Wu XR, Steele VE, Kopelovich L, Rao CV. Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. Cancer Prev Res (Phila). 2016 Jan; 9(1):53-62. PMID: 26577454.
      View in: PubMed
    18. Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2015 Dec; 125(12):4349-64. PMID: 26571402; PMCID: PMC4665789.
    19. Hurst RE, Greenwood-Van Meerveld B, Wisniewski AB, VanGordon S, Lin H, Kropp BP, Towner RA. Increased bladder permeability in interstitial cystitis/painful bladder syndrome. Transl Androl Urol. 2015 10; 4(5):563-571. PMID: 26751576.
      View in: PubMed
    20. Towner RA, Wisniewski AB, Wu DH, Van Gordon SB, Smith N, North JC, McElhaney R, Aston CE, Shobeiri SA, Kropp BP, Greenwood-Van Meerveld B, Hurst RE. A Feasibility Study to Determine Whether Clinical Contrast Enhanced Magnetic Resonance Imaging can Detect Increased Bladder Permeability in Patients with Interstitial Cystitis. J Urol. 2016 Mar; 195(3):631-8. PMID: 26307161; PMCID: PMC4760854 [Available on 03/01/17].
    21. Coutinho de Souza P, Mallory S, Smith N, Saunders D, Li XN, McNall-Knapp RY, Fung KM, Towner RA. Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. PLoS One. 2015; 10(8):e0134276. PMID: 26248280; PMCID: PMC4527837.
    22. Towner RA, Ihnat M, Saunders D, Bastian A, Smith N, Pavana RK, Gangjee A. A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model. BMC Cancer. 2015 Jul 17; 15:522. PMID: 26177924; PMCID: PMC4504175.
    23. Tarantini S, Hertelendy P, Tucsek Z, Valcarcel-Ares MN, Smith N, Menyhart A, Farkas E, Hodges EL, Towner R, Deak F, Sonntag WE, Csiszar A, Ungvari Z, Toth P. Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice. J Cereb Blood Flow Metab. 2015 Nov; 35(11):1871-81. PMID: 26174328; PMCID: PMC4635246 [Available on 11/01/16].
    24. Coutinho de Souza P, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, Ehrenshaft M, Mason RP, Meek B, Plafker SM, Saunders D, Mamedova N, Towner RA. OKN-007 decreases free radical levels in a preclinical F98 rat glioma model. Free Radic Biol Med. 2015 Oct; 87:157-68. PMID: 26119786.
      View in: PubMed
    25. de Souza PC, Smith N, Pody R, He T, Njoku C, Silasi-Mansat R, Lupu F, Meek B, Chen H, Dong Y, Saunders D, Orock A, Hodges E, Colijn S, Mamedova N, Towner RA. OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model. Am J Nucl Med Mol Imaging. 2015; 5(4):363-78. PMID: 26269774; PMCID: PMC4529590.
    26. de Souza PC, Ranjan A, Towner RA. Nanoformulations for therapy of pancreatic and liver cancers. Nanomedicine (Lond). 2015 May; 10(9):1515-34. PMID: 25996122.
      View in: PubMed
    27. de Souza PC, Balasubramanian K, Njoku C, Smith N, Gillespie DL, Schwager A, Abdullah O, Ritchey JW, Fung KM, Saunders D, Jensen RL, Towner RA. OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model. J Magn Reson Imaging. 2015 Dec; 42(6):1582-91. PMID: 25920494.
      View in: PubMed
    28. Greenwood-Van Meerveld B, Mohammadi E, Tyler K, Van Gordon S, Parker A, Towner R, Hurst R. Mechanisms of Visceral Organ Crosstalk: Importance of Alterations in Permeability in Rodent Models. J Urol. 2015 Sep; 194(3):804-11. PMID: 25776913; PMCID: PMC4699674.
    29. Seong J, Jeong W, Smith N, Towner RA. Hemodynamic effects of long-term morphological changes in the human carotid sinus. J Biomech. 2015 Apr 13; 48(6):956-62. PMID: 25702250; PMCID: PMC4385792.
    30. Towner RA, Smith N, Saunders D, Van Gordon SB, Wisniewski AB, Tyler KR, Greenwood-Van Meerveld B, Hurst RE. Contrast enhanced magnetic resonance imaging as a diagnostic tool to assess bladder permeability and associated colon cross talk: preclinical studies in a rat model. J Urol. 2015 Apr; 193(4):1394-400. PMID: 25463988; PMCID: PMC4706081.
    31. Zhao Y, Ling F, Griffin TM, He T, Towner R, Ruan H, Sun XH. Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor ? coactivator-1a (PGC-1a) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance. J Biol Chem. 2014 Oct 17; 289(42):29112-22. PMID: 25190816; PMCID: PMC4200265.
    32. Towner RA, Wren JD. Prioritizing uncharacterized genes in the search for glioma biomarkers. CNS Oncol. 2014 Mar; 3(2):93-5. PMID: 25055012.
      View in: PubMed
    33. Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD. Experimental validation of 5 in-silico predicted glioma biomarkers. Neuro Oncol. 2013 Dec; 15(12):1625-34. PMID: 24158112; PMCID: PMC3829592.
    34. Towner RA, Garteiser P, Bozza F, Smith N, Saunders D, D'Avila JCP, Magno F, Oliveira MF, Ehrenshaft M, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Mason RP, Castro Faria-Neto HC. In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping. Free Radic Biol Med. 2013 12; 65:828-837. PMID: 23978375.
      View in: PubMed
    35. Towner RA, Smith N, Saunders D, De Souza PC, Henry L, Lupu F, Silasi-Mansat R, Ehrenshaft M, Mason RP, Gomez-Mejiba SE, Ramirez DC. Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas. Biochim Biophys Acta. 2013 Dec; 1832(12):2153-61. PMID: 23959048.
      View in: PubMed
    36. Garteiser P, Doblas S, Towner RA, Griffin TM. Calibration of a semi-automated segmenting method for quantification of adipose tissue compartments from magnetic resonance images of mice. Metabolism. 2013 Nov; 62(11):1686-95. PMID: 23890668; PMCID: PMC3809152.
    37. He T, Smith N, Saunders D, Pittman BP, Lerner M, Lightfoot S, Silasi-Mansat R, Lupu F, Towner RA. Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models. Am J Nucl Med Mol Imaging. 2013; 3(4):300-11. PMID: 23901356; PMCID: PMC3715774.
    38. Piao D, Towner RA, Smith N, Chen WR. Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: a theoretical feasibility analysis. Med Phys. 2013 Jun; 40(6):063301. PMID: 23718611; PMCID: PMC3669145.
    39. Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radic Biol Med. 2013 Oct; 63:351-60. PMID: 23722162.
      View in: PubMed
    40. Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Muñoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC. Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta. 2014 Feb; 1840(2):722-9. PMID: 23644035; PMCID: PMC4078024.
    41. Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA. Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic Biol Med. 2013 Sep; 62:145-156. PMID: 23419732.
      View in: PubMed
    42. Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL. Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol. 2013 Mar; 15(3):330-40. PMID: 23328810; PMCID: PMC3578492.
    43. Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, a potential new biomarker for gliomas. Neurosurgery. 2013 Jan; 72(1):77-90; discussion 91. PMID: 23096411; PMCID: PMC3555701.
    44. Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec; 122(12):4424-38. PMID: 23187125; PMCID: PMC3533553.
    45. Towner RA, Smith N, Saunders D, Henderson M, Downum K, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Ehrenshaft M, Mason RP. In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model. Diabetes. 2012 Oct; 61(10):2405-13. PMID: 22698922; PMCID: PMC3447912.
    46. Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem. 2012 May 11; 287(20):16424-34. PMID: 22451674; PMCID: PMC3351350.
    47. Le K, Li X, Figueroa D, Towner RA, Garteiser P, Saunders D, Smith N, Liu H, Hode T, Nordquist RE, Chen WR. Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method. J Biomed Opt. 2011 Dec; 16(12):128001. PMID: 22191937; PMCID: PMC3245746.
    48. Niu C, Smith N, Garteiser P, Towner R, Verchot J. Comparative analysis of protein transport in the N. benthamiana vasculature reveals different destinations. Plant Signal Behav. 2011 Nov; 6(11):1793-808. PMID: 22057341; PMCID: PMC3329354.
    49. Doblas S, He T, Saunders D, Hoyle J, Smith N, Pye Q, Lerner M, Jensen RL, Towner RA. In vivo characterization of several rodent glioma models by 1H MRS. NMR Biomed. 2012 Apr; 25(4):685-94. PMID: 21954105; PMCID: PMC3780579.
    50. Floyd RA, Chandru HK, He T, Towner R. Anti-cancer activity of nitrones and observations on mechanism of action. Anticancer Agents Med Chem. 2011 May 01; 11(4):373-9. PMID: 21651461; PMCID: PMC3246679.
    51. He T, Doblas S, Saunders D, Casteel R, Lerner M, Ritchey JW, Snider T, Floyd RA, Towner RA. Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy. Free Radic Biol Med. 2011 Jul 15; 51(2):490-502. PMID: 21600283.
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    52. Floyd RA, Towner RA, He T, Hensley K, Maples KR. Translational research involving oxidative stress and diseases of aging. Free Radic Biol Med. 2011 Sep 01; 51(5):931-41. PMID: 21549833; PMCID: PMC3156308.
    53. He T, Smith N, Saunders D, Doblas S, Watanabe Y, Hoyle J, Silasi-Mansat R, Lupu F, Lerner M, Brackett DJ, Towner RA. Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas. J Cell Mol Med. 2011 Apr; 15(4):837-49. PMID: 20497492; PMCID: PMC2951496.
    54. Qiu P, Jensen C, Charity N, Towner R, Mao C. Oil phase evaporation-induced self-assembly of hydrophobic nanoparticles into spherical clusters with controlled surface chemistry in an oil-in-water dispersion and comparison of behaviors of individual and clustered iron oxide nanoparticles. J Am Chem Soc. 2010 Dec 22; 132(50):17724-32. PMID: 21117657; PMCID: PMC3005370.
    55. Doblas S, Pathuri G, Towner RA, Gali H. Feasibility Evaluation of Detecting Hydroxymethylphosphine Oxide In Vivo by (31)P-MRS. Int J Biomed Sci. 2010 Sep; 6(3):228-32. PMID: 23675197; PMCID: PMC3615273.
    56. Doblas S, He T, Saunders D, Pearson J, Hoyle J, Smith N, Lerner M, Towner RA. Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography. J Magn Reson Imaging. 2010 Aug; 32(2):267-75. PMID: 20677250; PMCID: PMC2915452.
    57. Garteiser P, Doblas S, Watanabe Y, Saunders D, Hoyle J, Lerner M, He T, Floyd RA, Towner RA. Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging. J Magn Reson Imaging. 2010 Apr; 31(4):796-806. PMID: 20373422.
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    58. Towner RA, Smith N, Asano Y, He T, Doblas S, Saunders D, Silasi-Mansat R, Lupu F, Seeney CE. Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering. Tissue Eng Part A. 2010 Feb; 16(2):357-64. PMID: 19663584; PMCID: PMC2813148.
    59. Towner RA, Smith N, Asano Y, Doblas S, Saunders D, Silasi-Mansat R, Lupu F. Molecular magnetic resonance imaging approaches used to aid in the understanding of the tissue regeneration marker Met in vivo: implications for tissue engineering. Tissue Eng Part A. 2010 Feb; 16(2):365-71. PMID: 19905873; PMCID: PMC2813147.
    60. Johnson AC, Myers B, Lazovic J, Towner R, Greenwood-Van Meerveld B. Brain activation in response to visceral stimulation in rats with amygdala implants of corticosterone: an FMRI study. PLoS One. 2010 Jan 05; 5(1):e8573. PMID: 20052291; PMCID: PMC2797306.
    61. Floyd RA, Towner RA, Wu D, Abbott A, Cranford R, Branch D, Guo WX, Foster SB, Jones I, Alam R, Moore D, Allen T, Huycke M. Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer. Free Radic Res. 2010 Jan; 44(1):108-17. PMID: 19886748; PMCID: PMC2884269.
    62. Towner RA, Smith N, Doblas S, Garteiser P, Watanabe Y, He T, Saunders D, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of inducible nitric oxide synthase in rodent gliomas. Free Radic Biol Med. 2010 Mar 01; 48(5):691-703. PMID: 20034558.
      View in: PubMed
    63. Bozza FA, Garteiser P, Oliveira MF, Doblas S, Cranford R, Saunders D, Jones I, Towner RA, Castro-Faria-Neto HC. Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab. 2010 Feb; 30(2):440-8. PMID: 19844239; PMCID: PMC2949132.
    64. Condac E, Dale GL, Bender-Neal D, Ferencz B, Towner R, Hinsdale ME. Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum. Glycobiology. 2009 Aug; 19(8):829-33. PMID: 19389916; PMCID: PMC2704898.
    65. Gomez-Mejiba SE, Zhai Z, Akram H, Deterding LJ, Hensley K, Smith N, Towner RA, Tomer KB, Mason RP, Ramirez DC. Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox process. Free Radic Biol Med. 2009 Apr 01; 46(7):853-65. PMID: 19159679; PMCID: PMC2692890.
    66. Asanuma T, Doblas S, Tesiram YA, Saunders D, Cranford R, Yasui H, Inanami O, Smith N, Floyd RA, Kotake Y, Towner RA. Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography. J Magn Reson Imaging. 2008 Sep; 28(3):574-87. PMID: 18777527.
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    67. Asanuma T, Doblas S, Tesiram YA, Saunders D, Cranford R, Pearson J, Abbott A, Smith N, Towner RA. Diffusion tensor imaging and fiber tractography of C6 rat glioma. J Magn Reson Imaging. 2008 Sep; 28(3):566-73. PMID: 18777530.
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    68. Floyd RA, Kopke RD, Choi CH, Foster SB, Doblas S, Towner RA. Nitrones as therapeutics. Free Radic Biol Med. 2008 Nov 15; 45(10):1361-74. PMID: 18793715; PMCID: PMC2796547.
    69. Chen Y, Gnyawali SC, Wu F, Liu H, Tesiram YA, Abbott A, Towner RA, Chen WR. Magnetic resonance imaging guidance for laser photothermal therapy. J Biomed Opt. 2008 Jul-Aug; 13(4):044033. PMID: 19021360.
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    70. Tesiram YA, Saunders D, Towner RA. Chemical speciation by selective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds. NMR Biomed. 2008 May; 21(4):345-56. PMID: 17854108.
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    71. Saban MR, Towner R, Smith N, Abbott A, Neeman M, Davis CA, Simpson C, Maier J, Mémet S, Wu XR, Saban R. Lymphatic vessel density and function in experimental bladder cancer. BMC Cancer. 2007 Nov 29; 7:219. PMID: 18047671; PMCID: PMC2241841.
    72. Doblas S, Saunders D, Kshirsagar P, Pye Q, Oblander J, Gordon B, Kosanke S, Floyd RA, Towner RA. Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model. Free Radic Biol Med. 2008 Jan 01; 44(1):63-72. PMID: 18045548.
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    73. Inoue Y, Asanuma T, Smith N, Saunders D, Oblander J, Kotake Y, Floyd RA, Towner RA. Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. Free Radic Res. 2007 Sep; 41(9):972-80. PMID: 17729114.
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    74. Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME. Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9416-21. PMID: 17517600; PMCID: PMC1890509.
    75. Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, Kem DC. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol. 2007 Feb 19; 6:6. PMID: 17309798; PMCID: PMC1805425.
    76. Towner RA, Smith N, Tesiram YA, Abbott A, Saunders D, Blindauer R, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging. Mol Imaging. 2007 Jan-Feb; 6(1):18-29. PMID: 17311762.
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    77. Asada K, Kotake Y, Asada R, Saunders D, Broyles RH, Towner RA, Fukui H, Floyd RA. LINE-1 hypomethylation in a choline-deficiency-induced liver cancer in rats: dependence on feeding period. J Biomed Biotechnol. 2006; 2006(1):17142. PMID: 16877811; PMCID: PMC1479888.
    78. Towner RA, Foley LM, Painter DM. Hepatocarcinogenesis tumor grading correlated with in vivo image-guided 1H-NMR spectroscopy in a rat model. Toxicol Appl Pharmacol. 2005 Sep 01; 207(2 Suppl):237-44. PMID: 16023158.
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