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Robert Evan Hurst

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Urology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-3930
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    Collapse Research 
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    R01CA037506     (HURST, ROBERT EVAN)Sep 1, 1983 - Dec 31, 1986
    NIH/NCI
    GAG AS BLADDER CANCER MARKERS IN HIGH RISK POPULATIONS
    Role: Principal Investigator

    R01CA075322     (HURST, ROBERT EVAN)Jul 1, 1999 - Apr 30, 2005
    NIH/NCI
    BLADDER CANCER BIOMARKERS GUIDES TO SURGERY AND THERAPY
    Role: Principal Investigator

    R21DK062889     (HURST, ROBERT EVAN)May 1, 2003 - Oct 31, 2006
    NIH/NIDDK
    Urothelial cell response to bacterial infection
    Role: Principal Investigator

    R01DK069808     (HURST, ROBERT EVAN)Apr 1, 2005 - Mar 31, 2011
    NIH/NIDDK
    Genes &Proteins of Urothelial-ECM Interaction
    Role: Principal Investigator

    P20DK097799     (HURST, ROBERT EVAN)Sep 29, 2012 - Jul 31, 2014
    NIH/NIDDK
    The Role of Altered Permeability in Bladder Diseases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yang Q, Xia D, Towner RA, Smith N, Saunders D, Fung KM, Aston CE, Greenwood-Van Meerveld B, Hurst RE, Madihally SV, Kropp BP, Lin HK. Reduced urothelial regeneration in rat bladders augmented with permeable porcine small intestinal submucosa assessed by magnetic resonance imaging. J Biomed Mater Res B Appl Biomater. 2017 Sep 13. PMID: 28901710.
      View in: PubMed
    2. Bio M, Rajaputra P, Lim I, Thapa P, Tienabeso B, Hurst RE, You Y. Efficient activation of a visible light-activatable CA4 prodrug through intermolecular photo-unclick chemistry in mitochondria. Chem Commun (Camb). 2017 Feb 07; 53(11):1884-1887. PMID: 28111669.
      View in: PubMed
    3. Hurst RE, Bastian A, Bailey-Downs L, Ihnat MA. Targeting dormant micrometastases: rationale, evidence to date and clinical implications. Ther Adv Med Oncol. 2016 Mar; 8(2):126-37. PMID: 26929788; PMCID: PMC4753353.
    4. Hurst RE, Van Gordon S, Tyler K, Kropp B, Towner R, Lin H, Marentette JO, McHowat J, Mohammedi E, Greenwood-Van Meerveld B. In the absence of overt urothelial damage, chondroitinase ABC digestion of the GAG layer increases bladder permeability in ovariectomized female rats. Am J Physiol Renal Physiol. 2016 May 01; 310(10):F1074-80. PMID: 26911855; PMCID: PMC5002059 [Available on 05/15/17].
    5. Mohammadi E, Prusator DK, Healing E, Hurst R, Towner RA, Wisniewski AB, Greenwood-Van Meerveld B. Sexually dimorphic effects of early life stress in rat pups on urinary bladder detrusor muscle contractility in adulthood. Biol Sex Differ. 2016; 7:8. PMID: 26823967; PMCID: PMC4730611.
    6. Hurst RE, Meerveld BG, Wisniewski AB, VanGordon S, Lin H, Kropp BP, Towner RA. Increased bladder permeability in interstitial cystitis/painful bladder syndrome. Transl Androl Urol. 2015 Oct; 4(5):563-571. PMID: 26751576.
      View in: PubMed
    7. Towner RA, Wisniewski AB, Wu DH, Van Gordon SB, Smith N, North JC, McElhaney R, Aston CE, Shobeiri SA, Kropp BP, Greenwood-Van Meerveld B, Hurst RE. A Feasibility Study to Determine Whether Clinical Contrast Enhanced Magnetic Resonance Imaging can Detect Increased Bladder Permeability in Patients with Interstitial Cystitis. J Urol. 2016 Mar; 195(3):631-8. PMID: 26307161; PMCID: PMC4760854 [Available on 03/01/17].
    8. Marentette JO, Hurst RE, McHowat J. Impaired Expression of Prostaglandin E2 (PGE2) Synthesis and Degradation Enzymes during Differentiation of Immortalized Urothelial Cells from Patients with Interstitial Cystitis/Painful Bladder Syndrome. PLoS One. 2015; 10(6):e0129466. PMID: 26057882; PMCID: PMC4461170.
    9. Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA. Identification of novel drugs to target dormant micrometastases. BMC Cancer. 2015 May 14; 15:404. PMID: 25971923; PMCID: PMC4434572.
    10. Greenwood-Van Meerveld B, Mohammadi E, Tyler K, Van Gordon S, Parker A, Towner R, Hurst R. Mechanisms of Visceral Organ Crosstalk: Importance of Alterations in Permeability in Rodent Models. J Urol. 2015 Sep; 194(3):804-11. PMID: 25776913; PMCID: PMC4699674.
    11. Hauser PJ, VanGordon SB, Seavey J, Sofinowski TM, Ramadan M, Abdullah S, Buffington CA, Hurst RE. Abnormalities in Expression of Structural, Barrier and Differentiation Related Proteins, and Chondroitin Sulfate in Feline and Human Interstitial Cystitis. J Urol. 2015 Aug; 194(2):571-7. PMID: 25636658; PMCID: PMC4699667.
    12. Towner RA, Smith N, Saunders D, Van Gordon SB, Wisniewski AB, Tyler KR, Greenwood-Van Meerveld B, Hurst RE. Contrast enhanced magnetic resonance imaging as a diagnostic tool to assess bladder permeability and associated colon cross talk: preclinical studies in a rat model. J Urol. 2015 Apr; 193(4):1394-400. PMID: 25463988; PMCID: PMC4706081.
    13. Mondalek FG, Fung KM, Yang Q, Wu W, Lu W, Palmer BW, Frimberger DC, Greenwood-Van Meerveld B, Hurst RE, Kropp BP, Lin HK. Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model. World J Urol. 2015 Aug; 33(8):1119-28. PMID: 25253654; PMCID: PMC4699683.
    14. Bailey-Downs LC, Thorpe JE, Disch BC, Bastian A, Hauser PJ, Farasyn T, Berry WL, Hurst RE, Ihnat MA. Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression. PLoS One. 2014; 9(5):e98624. PMID: 24878664; PMCID: PMC4039511.
    15. Marentette JO, Hauser PJ, Hurst RE, Klumpp DJ, Rickard A, McHowat J. Tryptase activation of immortalized human urothelial cell mitogen-activated protein kinase. PLoS One. 2013; 8(7):e69948. PMID: 23922867; PMCID: PMC3726738.
    16. Hurst RE, Hauser PJ, Kyker KD, Heinlen JE, Hodde JP, Hiles MC, Kosanke SD, Dozmorov M, Ihnat MA. Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy". PLoS One. 2013; 8(5):e64181. PMID: 23717563; PMCID: PMC3663841.
    17. Engles CD, Hauser PJ, Abdullah SN, Culkin DJ, Hurst RE. Intravesical chondroitin sulfate inhibits recruitment of inflammatory cells in an acute acid damage "leaky bladder" model of cystitis. Urology. 2012 Feb; 79(2):483.e13-7. PMID: 22137543; PMCID: PMC3274614.
    18. Saban MR, Davis CA, Avelino A, Cruz F, Maier J, Bjorling DE, Sferra TJ, Hurst RE, Saban R. VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG. BMC Physiol. 2011 Nov 07; 11:16. PMID: 22059553; PMCID: PMC3226567.
    19. Dozmorov M, Stone R, Clifford JL, Sabichi AL, Engles CD, Hauser PJ, Culkin DJ, Hurst RE. System level changes in gene expression in maturing bladder mucosa. J Urol. 2011 May; 185(5):1952-8. PMID: 21421225; PMCID: PMC3407683.
    20. Dozmorov MG, Azzarello JT, Wren JD, Fung KM, Yang Q, Davis JS, Hurst RE, Culkin DJ, Penning TM, Lin HK. Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression. BMC Cancer. 2010 Dec 06; 10:672. PMID: 21134280; PMCID: PMC3013086.
    21. Zhang D, Hudson AE, Delostrinos CF, Carmean N, Eastman R, Hicks B, Hurst RE, Bassuk JA. Dual sources of vitronectin in the human lower urinary tract: synthesis by urothelium vs. extravasation from the bloodstream. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F475-87. PMID: 21048021; PMCID: PMC3044012.
    22. Dozmorov MG, Guthridge JM, Hurst RE, Dozmorov IM. A comprehensive and universal method for assessing the performance of differential gene expression analyses. PLoS One. 2010 Sep 09; 5(9). PMID: 20844739; PMCID: PMC2936572.
    23. Hauser PJ, Buethe DA, Califano J, Sofinowski TM, Culkin DJ, Hurst RE. Restoring barrier function to acid damaged bladder by intravesical chondroitin sulfate. J Urol. 2009 Nov; 182(5):2477-82. PMID: 19765766; PMCID: PMC3157297.
    24. Dozmorov M, Wu W, Chakrabarty K, Booth JL, Hurst RE, Coggeshall KM, Metcalf JP. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen. BMC Infect Dis. 2009 Sep 10; 9:152. PMID: 19744333; PMCID: PMC2752459.
    25. Dozmorov MG, Hurst RE, Culkin DJ, Kropp BP, Frank MB, Osban J, Penning TM, Lin HK. Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells. Prostate. 2009 Jul 01; 69(10):1077-90. PMID: 19343732; PMCID: PMC2755240.
    26. Hurst RE. Does the biomarker search paradigm need re-booting? BMC Urol. 2009 Feb 27; 9:1. PMID: 19250539; PMCID: PMC2654904.
    27. Saban R, Saban MR, Maier J, Fowler B, Tengowski M, Davis CA, Wu XR, Culkin DJ, Hauser P, Backer J, Hurst RE. Urothelial expression of neuropilins and VEGF receptors in control and interstitial cystitis patients. Am J Physiol Renal Physiol. 2008 Dec; 295(6):F1613-23. PMID: 18815217; PMCID: PMC2604836.
    28. Dozmorov MG, Kyker KD, Hauser PJ, Saban R, Buethe DD, Dozmorov I, Centola MB, Culkin DJ, Hurst RE. From microarray to biology: an integrated experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells. BMC Bioinformatics. 2008 Aug 12; 9 Suppl 9:S4. PMID: 18793468; PMCID: PMC2537575.
    29. Saban MR, Backer JM, Backer MV, Maier J, Fowler B, Davis CA, Simpson C, Wu XR, Birder L, Freeman MR, Soker S, Hurst RE, Saban R. VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Am J Physiol Renal Physiol. 2008 Jul; 295(1):F60-72. PMID: 18463314; PMCID: PMC2494518.
    30. Dozmorov MG, Yang Q, Matwalli A, Hurst RE, Culkin DJ, Kropp BP, Lin HK. 5alpha-androstane-3alpha,17beta-diol selectively activates the canonical PI3K/AKT pathway: a bioinformatics-based evidence for androgen-activated cytoplasmic signaling. Genomic Med. 2007; 1(3-4):139-46. PMID: 18923939; PMCID: PMC2269037.
    31. Saban MR, O'Donnell MA, Hurst RE, Wu XR, Simpson C, Dozmorov I, Davis C, Saban R. Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha. BMC Immunol. 2008 Feb 11; 9:4. PMID: 18267009; PMCID: PMC2262873.
    32. Hauser PJ, Dozmorov MG, Bane BL, Slobodov G, Culkin DJ, Hurst RE. Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis. J Urol. 2008 Feb; 179(2):764-9. PMID: 18082196; PMCID: PMC2652890.
    33. Dozmorov MG, Kyker KD, Saban R, Shankar N, Baghdayan AS, Centola MB, Hurst RE. Systems biology approach for mapping the response of human urothelial cells to infection by Enterococcus faecalis. BMC Bioinformatics. 2007 Nov 01; 8 Suppl 7:S2. PMID: 18047719; PMCID: PMC2099488.
    34. Saban R, Simpson C, Davis CA, Dozmorov I, Maier J, Fowler B, Ihnat MA, Hurst RE, Wershil BK, Saban MR. Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol. 2007 Aug 17; 8:17. PMID: 17705868; PMCID: PMC2000913.
    35. Dozmorov MG, Kropp BP, Hurst RE, Cheng EY, Lin HK. Differentially expressed gene networks in cultured smooth muscle cells from normal and neuropathic bladder. J Smooth Muscle Res. 2007 Apr; 43(2):55-72. PMID: 17598958.
      View in: PubMed
    36. Hurst RE, Moldwin RM, Mulholland SG. Bladder defense molecules, urothelial differentiation, urinary biomarkers, and interstitial cystitis. Urology. 2007 Apr; 69(4 Suppl):17-23. PMID: 17462475.
      View in: PubMed
    37. Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Simpson C, Saban MR. Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol. 2007 Mar 30; 7:3. PMID: 17397547; PMCID: PMC1853107.
    38. Saban R, D'Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Davis CA, Simpson C, Saban MR. Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol. 2007 Mar 30; 7:4. PMID: 17397548; PMCID: PMC1853108.
    39. Hauser PJ, Han Z, Sindhwani P, Hurst RE. Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Anticancer Res. 2007 Mar-Apr; 27(2):737-40. PMID: 17465196; PMCID: PMC2604907.
    40. Hurst RE, Kyker KD, Dozmorov MG, Takemori N, Singh A, Matsumoto H, Saban R, Betgovargez E, Simonian MH. Proteome-level display by 2-dimensional chromatography of extracellular matrix-dependent modulation of the phenotype of bladder cancer cells. Proteome Sci. 2006 Jun 02; 4:13. PMID: 16749926; PMCID: PMC1534010.
    41. Saban MR, Hellmich HL, Turner M, Nguyen NB, Vadigepalli R, Dyer DW, Hurst RE, Centola M, Saban R. The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa. BMC Physiol. 2006 Jan 18; 6:1. PMID: 16420690; PMCID: PMC1382248.
    42. Dozmorov MG, Kyker KD, Saban R, Knowlton N, Dozmorov I, Centola MB, Hurst RE. Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells. BMC Cancer. 2006 Jan 13; 6:12. PMID: 16412233; PMCID: PMC1360102.
    43. Kyker KD, Coffman J, Hurst RE. Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder. BMC Urol. 2005 Mar 23; 5:4. PMID: 15788101; PMCID: PMC1079893.
    44. Khafif A, Hurst R, Kyker K, Fliss DM, Gil Z, Medina JE. Curcumin: a new radio-sensitizer of squamous cell carcinoma cells. Otolaryngol Head Neck Surg. 2005 Feb; 132(2):317-21. PMID: 15692547.
      View in: PubMed
    45. Hurst RE, Kamat CD, Kyker KD, Green DE, Ihnat MA. A novel multidrug resistance phenotype of bladder tumor cells grown on Matrigel or SIS gel. Cancer Lett. 2005 Jan 20; 217(2):171-80. PMID: 15617834.
      View in: PubMed
    46. Slobodov G, Feloney M, Gran C, Kyker KD, Hurst RE, Culkin DJ. Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis. J Urol. 2004 Apr; 171(4):1554-8. PMID: 15017219.
      View in: PubMed
    47. Hurst RE, Kyker KD, Bonner RB, Bowditch RD, Hemstreet GP. Matrix-dependent plasticity of the malignant phenotype of bladder cancer cells. Anticancer Res. 2003 Jul-Aug; 23(4):3119-28. PMID: 12926044; PMCID: PMC2561328.
    48. Kyker KD, Culkin DJ, Hurst RE. A model for 3-dimensional growth of bladder cancers to investigate cell-matrix interactions. Urol Oncol. 2003 Jul-Aug; 21(4):255-61. PMID: 12954494.
      View in: PubMed
    49. Saban MR, Nguyen NB, Hurst RE, Saban R. Gene expression profiling of inflammatory bladder disorders. Expert Rev Mol Diagn. 2003 Mar; 3(2):217-35. PMID: 12647997.
      View in: PubMed
    50. Erickson DR, Xie SX, Bhavanandan VP, Wheeler MA, Hurst RE, Demers LM, Kushner L, Keay SK. A comparison of multiple urine markers for interstitial cystitis. J Urol. 2002 Jun; 167(6):2461-9. PMID: 11992058.
      View in: PubMed
    51. Wehbi NK, Dugger AL, Bonner RB, Pitha JV, Hurst RE, Hemstreet GP. Pan-cadherin as a high level phenotypic biomarker for prostate cancer. J Urol. 2002 May; 167(5):2215-21. PMID: 11956481.
      View in: PubMed
    52. Hurst RE, Bonner RB. Mapping of the distribution of significant proteins and proteoglycans in small intestinal submucosa by fluorescence microscopy. J Biomater Sci Polym Ed. 2001; 12(11):1267-79. PMID: 11853391.
      View in: PubMed
    53. Hurst RE. Bexarotene ligand pharmaceuticals. Curr Opin Investig Drugs. 2000 Dec; 1(4):514-23. PMID: 11249708.
      View in: PubMed
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