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Rodney Kim Tweten

TitleProf,George L Cross Rsrch
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
Phone405/271-1205
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    Collapse Biography 
    Collapse education and training
    University of California, Irvine, CAPostdoc1984Bacterial Toxins
    Kansas State University, Manhattan, KSPhD1982Microbiology
    North Dakota State University, Fargo, NDMS1979Bacteriology
    Moorhead State University, Moorhead, MNBS1976Biology

    Collapse Research 
    Collapse research activities and funding
    R01AI063444     (TWETEN, RODNEY K.)Jan 15, 2005 - Dec 31, 2009
    NIH/NIAID
    A Novel Cholesterol-Dependent Cytolysin Receptor
    Role: Principal Investigator

    R37AI037657     (TWETEN, RODNEY K.)Apr 1, 1997 - Mar 31, 2021
    NIH/NIAID
    Pore Formation by Cholesterol Dependent Cytolysins
    Role: Principal Investigator

    R01AI037657     (TWETEN, RODNEY K.)Apr 1, 1997 - Mar 31, 2021
    NIH/NIAID
    Pore Formation by Cholesterol Dependent Cytolysins
    Role: Principal Investigator

    R01AI032097     (TWETEN, RODNEY K.)Jan 1, 1993 - Jun 30, 2005
    NIH/NIAID
    STUDIES ON CLOSTRIDIUM SEPTICUM LETHAL TOXIN
    Role: Principal Investigator

    R01AI026895     (TWETEN, RODNEY K.)Jul 1, 1988 - Jun 30, 1992
    NIH/NIAID
    STUDIES ON CLOSTRIDIUM DIFFICILE TOXIN B
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Burns JR, Morton CJ, Parker MW, Tweten RK. An Intermolecular p-Stacking Interaction Drives Conformational Changes Necessary to ß-Barrel Formation in a Pore-Forming Toxin. MBio. 2019 Jul 02; 10(4). PMID: 31266869.
      View in: PubMed
    2. Wade KR, Lawrence SL, Farrand AJ, Hotze EM, Kuiper MJ, Gorman MA, Christie MP, Panjikar S, Morton CJ, Parker MW, Tweten RK. The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin. MBio. 2019 04 23; 10(2). PMID: 31015325.
      View in: PubMed
    3. Christie MP, Johnstone BA, Tweten RK, Parker MW, Morton CJ. Cholesterol-dependent cytolysins: from water-soluble state to membrane pore. Biophys Rev. 2018 Oct; 10(5):1337-1348. PMID: 30117093.
      View in: PubMed
    4. Lawrence SL, Gorman MA, Feil SC, Mulhern TD, Kuiper MJ, Ratner AJ, Tweten RK, Morton CJ, Parker MW. Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins. Structure. 2016 09 06; 24(9):1488-98. PMID: 27499440.
      View in: PubMed
    5. Ellisdon AM, Reboul CF, Panjikar S, Huynh K, Oellig CA, Winter KL, Dunstone MA, Hodgson WC, Seymour J, Dearden PK, Tweten RK, Whisstock JC, McGowan S. Stonefish toxin defines an ancient branch of the perforin-like superfamily. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15360-5. PMID: 26627714.
      View in: PubMed
    6. Lawrence SL, Feil SC, Morton CJ, Farrand AJ, Mulhern TD, Gorman MA, Wade KR, Tweten RK, Parker MW. Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation. Sci Rep. 2015 Sep 25; 5:14352. PMID: 26403197.
      View in: PubMed
    7. Chen A, Mann B, Gao G, Heath R, King J, Maissoneuve J, Alderson M, Tate A, Hollingshead SK, Tweten RK, Briles DE, Tuomanen EI, Paton JC. Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection. Clin Vaccine Immunol. 2015 Oct; 22(10):1079-89. PMID: 26245351.
      View in: PubMed
    8. Farrand AJ, Hotze EM, Sato TK, Wade KR, Wimley WC, Johnson AE, Tweten RK. The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support ß-Barrel Pore Insertion. J Biol Chem. 2015 Jul 17; 290(29):17733-44. PMID: 26032415.
      View in: PubMed
    9. Wade KR, Tweten RK. The Apicomplexan CDC/MACPF-like pore-forming proteins. Curr Opin Microbiol. 2015 Aug; 26:48-52. PMID: 26025132.
      View in: PubMed
    10. Verherstraeten S, Goossens E, Valgaeren B, Pardon B, Timbermont L, Haesebrouck F, Ducatelle R, Deprez P, Wade KR, Tweten R, Van Immerseel F. Perfringolysin O: The Underrated Clostridium perfringens Toxin? Toxins (Basel). 2015 May 14; 7(5):1702-21. PMID: 26008232.
      View in: PubMed
    11. Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA. Conformational changes during pore formation by the perforin-related protein pleurotolysin. PLoS Biol. 2015 Feb; 13(2):e1002049. PMID: 25654333.
      View in: PubMed
    12. Wade KR, Hotze EM, Kuiper MJ, Morton CJ, Parker MW, Tweten RK. An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2204-9. PMID: 25646411.
      View in: PubMed
    13. Bolz DD, Li Z, McIndoo ER, Tweten RK, Bryant AE, Stevens DL. Cardiac myocyte dysfunction induced by streptolysin O is membrane pore and calcium dependent. Shock. 2015 Feb; 43(2):178-84. PMID: 25243426.
      View in: PubMed
    14. Tweten RK, Hotze EM, Wade KR. The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria. Annu Rev Microbiol. 2015; 69:323-40. PMID: 26488276.
      View in: PubMed
    15. Wade KR, Hotze EM, Briles DE, Tweten RK. Mouse, but not human, ApoB-100 lipoprotein cholesterol is a potent innate inhibitor of Streptococcus pneumoniae pneumolysin. PLoS Pathog. 2014 Sep; 10(9):e1004353. PMID: 25188225.
      View in: PubMed
    16. Harvey RM, Hughes CE, Paton AW, Trappetti C, Tweten RK, Paton JC. The impact of pneumolysin on the macrophage response to Streptococcus pneumoniae is strain-dependent. PLoS One. 2014; 9(8):e103625. PMID: 25105894.
      View in: PubMed
    17. Feil SC, Ascher DB, Kuiper MJ, Tweten RK, Parker MW. Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration. J Mol Biol. 2014 Feb 20; 426(4):785-92. PMID: 24316049.
      View in: PubMed
    18. Mann B, Thornton J, Heath R, Wade KR, Tweten RK, Gao G, El Kasmi K, Jordan JB, Mitrea DM, Kriwacki R, Maisonneuve J, Alderson M, Tuomanen EI. Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein. J Infect Dis. 2014 Apr 01; 209(7):1116-25. PMID: 24041791.
      View in: PubMed
    19. Sato TK, Tweten RK, Johnson AE. Disulfide-bond scanning reveals assembly state and ß-strand tilt angle of the PFO ß-barrel. Nat Chem Biol. 2013 Jun; 9(6):383-9. PMID: 23563525.
      View in: PubMed
    20. Lawrence SL, Feil SC, Holien JK, Kuiper MJ, Doughty L, Dolezal O, Mulhern TD, Tweten RK, Parker MW. Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin. Front Immunol. 2012; 3:330. PMID: 23181061.
      View in: PubMed
    21. Hotze EM, Le HM, Sieber JR, Bruxvoort C, McInerney MJ, Tweten RK. Identification and characterization of the first cholesterol-dependent cytolysins from Gram-negative bacteria. Infect Immun. 2013 Jan; 81(1):216-25. PMID: 23115036.
      View in: PubMed
    22. Dowd KJ, Farrand AJ, Tweten RK. The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly. PLoS Pathog. 2012; 8(7):e1002787. PMID: 22792065.
      View in: PubMed
    23. Dunstone MA, Tweten RK. Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins. Curr Opin Struct Biol. 2012 Jun; 22(3):342-9. PMID: 22658510.
      View in: PubMed
    24. Hotze EM, Wilson-Kubalek E, Farrand AJ, Bentsen L, Parker MW, Johnson AE, Tweten RK. Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem. 2012 Jul 13; 287(29):24534-43. PMID: 22645132.
      View in: PubMed
    25. Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW. Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure. 2012 Feb 08; 20(2):248-58. PMID: 22325774.
      View in: PubMed
    26. Vadia S, Arnett E, Haghighat AC, Wilson-Kubalek EM, Tweten RK, Seveau S. The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes. PLoS Pathog. 2011 Nov; 7(11):e1002356. PMID: 22072970.
      View in: PubMed
    27. Lencer WI, Tweten RK. To translocate or not: that is the problem. Cell Host Microbe. 2011 Sep 15; 10(3):179-80. PMID: 21925105.
      View in: PubMed
    28. Hotze EM, Tweten RK. Membrane assembly of the cholesterol-dependent cytolysin pore complex. Biochim Biophys Acta. 2012 Apr; 1818(4):1028-38. PMID: 21835159.
      View in: PubMed
    29. Wickham SE, Hotze EM, Farrand AJ, Polekhina G, Nero TL, Tomlinson S, Parker MW, Tweten RK. Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem. 2011 Jun 10; 286(23):20952-62. PMID: 21507937.
      View in: PubMed
    30. Farrand AJ, LaChapelle S, Hotze EM, Johnson AE, Tweten RK. Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4341-6. PMID: 20145114.
      View in: PubMed
    31. Flanagan JJ, Tweten RK, Johnson AE, Heuck AP. Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding. Biochemistry. 2009 May 12; 48(18):3977-87. PMID: 19292457.
      View in: PubMed
    32. LaChapelle S, Tweten RK, Hotze EM. Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis. J Biol Chem. 2009 May 08; 284(19):12719-26. PMID: 19293153.
      View in: PubMed
    33. Kennedy CL, Lyras D, Cordner LM, Melton-Witt J, Emmins JJ, Tweten RK, Rood JI. Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis. Infect Immun. 2009 Mar; 77(3):943-51. PMID: 19139192.
      View in: PubMed
    34. Farrand S, Hotze E, Friese P, Hollingshead SK, Smith DF, Cummings RD, Dale GL, Tweten RK. Characterization of a streptococcal cholesterol-dependent cytolysin with a lewis y and b specific lectin domain. Biochemistry. 2008 Jul 08; 47(27):7097-107. PMID: 18553932.
      View in: PubMed
    35. Miersch S, Espey MG, Chaube R, Akarca A, Tweten R, Ananvoranich S, Mutus B. Plasma membrane cholesterol content affects nitric oxide diffusion dynamics and signaling. J Biol Chem. 2008 Jul 04; 283(27):18513-21. PMID: 18445594.
      View in: PubMed
    36. Hu W, Ferris SP, Tweten RK, Wu G, Radaeva S, Gao B, Bronson RT, Halperin JA, Qin X. Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nat Med. 2008 Jan; 14(1):98-103. PMID: 18157141.
      View in: PubMed
    37. Soltani CE, Hotze EM, Johnson AE, Tweten RK. Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20226-31. PMID: 18077338.
      View in: PubMed
    38. Soltani CE, Hotze EM, Johnson AE, Tweten RK. Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin. J Biol Chem. 2007 May 25; 282(21):15709-16. PMID: 17412689.
      View in: PubMed
    39. Rossjohn J, Polekhina G, Feil SC, Morton CJ, Tweten RK, Parker MW. Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol. 2007 Apr 13; 367(5):1227-36. PMID: 17328912.
      View in: PubMed
    40. Melton-Witt JA, Bentsen LM, Tweten RK. Identification of functional domains of Clostridium septicum alpha toxin. Biochemistry. 2006 Dec 05; 45(48):14347-54. PMID: 17128973.
      View in: PubMed
    41. Salles II, Voth DE, Ward SC, Averette KM, Tweten RK, Bradley KA, Ballard JD. Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1. Cell Microbiol. 2006 Aug; 8(8):1272-81. PMID: 16882031.
      View in: PubMed
    42. Tweten RK. Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun. 2005 Oct; 73(10):6199-209. PMID: 16177291.
      View in: PubMed
    43. Dang TX, Milligan RA, Tweten RK, Wilson-Kubalek EM. Helical crystallization on nickel-lipid nanotubes: perfringolysin O as a model protein. J Struct Biol. 2005 Nov; 152(2):129-39. PMID: 16242343.
      View in: PubMed
    44. Schuerch DW, Wilson-Kubalek EM, Tweten RK. Molecular basis of listeriolysin O pH dependence. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12537-42. PMID: 16105950.
      View in: PubMed
    45. Ramachandran R, Tweten RK, Johnson AE. The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7139-44. PMID: 15878993.
      View in: PubMed
    46. Dang TX, Hotze EM, Rouiller I, Tweten RK, Wilson-Kubalek EM. Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy. J Struct Biol. 2005 Apr; 150(1):100-8. PMID: 15797734.
      View in: PubMed
    47. Zheng Z, Tweten RK, Mensa-Wilmot K. Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major. Eukaryot Cell. 2005 Mar; 4(3):556-66. PMID: 15755918.
      View in: PubMed
    48. Polekhina G, Giddings KS, Tweten RK, Parker MW. Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):600-5. PMID: 15637162.
      View in: PubMed
    49. Giddings KS, Zhao J, Sims PJ, Tweten RK. Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol. 2004 Dec; 11(12):1173-8. PMID: 15543155.
      View in: PubMed
    50. Czajkowsky DM, Hotze EM, Shao Z, Tweten RK. Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane. EMBO J. 2004 Aug 18; 23(16):3206-15. PMID: 15297878.
      View in: PubMed
    51. Zheng Z, Butler KD, Tweten RK, Mensa-Wilmot K. Endosomes, glycosomes, and glycosylphosphatidylinositol catabolism in Leishmania major. J Biol Chem. 2004 Oct 01; 279(40):42106-13. PMID: 15254033.
      View in: PubMed
    52. Ramachandran R, Tweten RK, Johnson AE. Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment. Nat Struct Mol Biol. 2004 Aug; 11(8):697-705. PMID: 15235590.
      View in: PubMed
    53. Polekhina G, Giddings KS, Tweten RK, Parker MW. Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin. Acta Crystallogr D Biol Crystallogr. 2004 Feb; 60(Pt 2):347-9. PMID: 14747721.
      View in: PubMed
    54. Melton JA, Parker MW, Rossjohn J, Buckley JT, Tweten RK. The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J Biol Chem. 2004 Apr 02; 279(14):14315-22. PMID: 14715670.
      View in: PubMed
    55. Mourez M, Yan M, Lacy DB, Dillon L, Bentsen L, Marpoe A, Maurin C, Hotze E, Wigelsworth D, Pimental RA, Ballard JD, Collier RJ, Tweten RK. Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13803-8. PMID: 14623961.
      View in: PubMed
    56. Giddings KS, Johnson AE, Tweten RK. Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11315-20. PMID: 14500900.
      View in: PubMed
    57. Heuck AP, Tweten RK, Johnson AE. Assembly and topography of the prepore complex in cholesterol-dependent cytolysins. J Biol Chem. 2003 Aug 15; 278(33):31218-25. PMID: 12777381.
      View in: PubMed
    58. Ramachandran R, Heuck AP, Tweten RK, Johnson AE. Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin. Nat Struct Biol. 2002 Nov; 9(11):823-7. PMID: 12368903.
      View in: PubMed
    59. Wichroski MJ, Melton JA, Donahue CG, Tweten RK, Ward GE. Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins. Infect Immun. 2002 Aug; 70(8):4353-61. PMID: 12117945.
      View in: PubMed
    60. Hotze EM, Heuck AP, Czajkowsky DM, Shao Z, Johnson AE, Tweten RK. Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin. J Biol Chem. 2002 Mar 29; 277(13):11597-605. PMID: 11799121.
      View in: PubMed
    61. Tweten RK. Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenesis. Vet Microbiol. 2001 Sep 03; 82(1):1-9. PMID: 11423190.
      View in: PubMed
    62. Heuck AP, Tweten RK, Johnson AE. Beta-barrel pore-forming toxins: intriguing dimorphic proteins. Biochemistry. 2001 Aug 07; 40(31):9065-73. PMID: 11478872.
      View in: PubMed
    63. Tweten RK, Parker MW, Johnson AE. The cholesterol-dependent cytolysins. Curr Top Microbiol Immunol. 2001; 257:15-33. PMID: 11417120.
      View in: PubMed
    64. Hotze EM, Wilson-Kubalek EM, Rossjohn J, Parker MW, Johnson AE, Tweten RK. Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate. J Biol Chem. 2001 Mar 16; 276(11):8261-8. PMID: 11102453.
      View in: PubMed
    65. Heuck AP, Hotze EM, Tweten RK, Johnson AE. Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes. Mol Cell. 2000 Nov; 6(5):1233-42. PMID: 11106760.
      View in: PubMed
    66. Shatursky O, Bayles R, Rogers M, Jost BH, Songer JG, Tweten RK. Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers. Infect Immun. 2000 Oct; 68(10):5546-51. PMID: 10992452.
      View in: PubMed
    67. Shepard LA, Shatursky O, Johnson AE, Tweten RK. The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins. Biochemistry. 2000 Aug 22; 39(33):10284-93. PMID: 10956018.
      View in: PubMed
    68. Shatursky O, Heuck AP, Shepard LA, Rossjohn J, Parker MW, Johnson AE, Tweten RK. The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins. Cell. 1999 Oct 29; 99(3):293-9. PMID: 10555145.
      View in: PubMed
    69. Gordon VM, Nelson KL, Buckley JT, Stevens VL, Tweten RK, Elwood PC, Leppla SH. Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors. J Biol Chem. 1999 Sep 17; 274(38):27274-80. PMID: 10480947.
      View in: PubMed
    70. Diep DB, Nelson KL, Lawrence TS, Sellman BR, Tweten RK, Buckley JT. Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein. Mol Microbiol. 1999 Feb; 31(3):785-94. PMID: 10048023.
      View in: PubMed
    71. Gilbert RJ, Rossjohn J, Parker MW, Tweten RK, Morgan PJ, Mitchell TJ, Errington N, Rowe AJ, Andrew PW, Byron O. Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae. J Mol Biol. 1998 Dec 11; 284(4):1223-37. PMID: 9837740.
      View in: PubMed
    72. Rossjohn J, Gilbert RJ, Crane D, Morgan PJ, Mitchell TJ, Rowe AJ, Andrew PW, Paton JC, Tweten RK, Parker MW. The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae. J Mol Biol. 1998 Nov 27; 284(2):449-61. PMID: 9813129.
      View in: PubMed
    73. Shepard LA, Heuck AP, Hamman BD, Rossjohn J, Parker MW, Ryan KR, Johnson AE, Tweten RK. Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy. Biochemistry. 1998 Oct 13; 37(41):14563-74. PMID: 9772185.
      View in: PubMed
    74. Gordon VM, Benz R, Fujii K, Leppla SH, Tweten RK. Clostridium septicum alpha-toxin is proteolytically activated by furin. Infect Immun. 1997 Oct; 65(10):4130-4. PMID: 9317018.
      View in: PubMed
    75. Sellman BR, Tweten RK. The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin-dependent cytolysis. Mol Microbiol. 1997 Aug; 25(3):429-40. PMID: 9302006.
      View in: PubMed
    76. Stevens DL, Tweten RK, Awad MM, Rood JI, Bryant AE. Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis. J Infect Dis. 1997 Jul; 176(1):189-95. PMID: 9207366.
      View in: PubMed
    77. Rossjohn J, Feil SC, McKinstry WJ, Tweten RK, Parker MW. Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell. 1997 May 30; 89(5):685-92. PMID: 9182756.
      View in: PubMed
    78. Sellman BR, Kagan BL, Tweten RK. Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin. Mol Microbiol. 1997 Feb; 23(3):551-8. PMID: 9044288.
      View in: PubMed
    79. Feil SC, Rossjohn J, Rohde K, Tweten RK, Parker MW. Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin. FEBS Lett. 1996 Nov 18; 397(2-3):290-2. PMID: 8955365.
      View in: PubMed
    80. Asmuth DM, Olson RD, Hackett SP, Bryant AE, Tweten RK, Tso JY, Zollman T, Stevens DL. Effects of Clostridium perfringens recombinant and crude phospholipase C and theta-toxin on rabbit hemodynamic parameters. J Infect Dis. 1995 Nov; 172(5):1317-23. PMID: 7594670.
      View in: PubMed
    81. Gottschalk S, Tweten RK, Smith LC, Woo SL. Efficient gene delivery and expression in mammalian cells using DNA coupled with perfringolysin O. Gene Ther. 1995 Sep; 2(7):498-503. PMID: 7584129.
      View in: PubMed
    82. Ballard J, Crabtree J, Roe BA, Tweten RK. The primary structure of Clostridium septicum alpha-toxin exhibits similarity with that of Aeromonas hydrophila aerolysin. Infect Immun. 1995 Jan; 63(1):340-4. PMID: 7806374.
      View in: PubMed
    83. Johnson S, Driks MR, Tweten RK, Ballard J, Stevens DL, Anderson DJ, Janoff EN. Clinical courses of seven survivors of Clostridium septicum infection and their immunologic responses to alpha toxin. Clin Infect Dis. 1994 Oct; 19(4):761-4. PMID: 7803645.
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    84. Bryant AE, Bergstrom R, Zimmerman GA, Salyer JL, Hill HR, Tweten RK, Sato H, Stevens DL. Clostridium perfringens invasiveness is enhanced by effects of theta toxin upon PMNL structure and function: the roles of leukocytotoxicity and expression of CD11/CD18 adherence glycoprotein. FEMS Immunol Med Microbiol. 1993 Dec; 7(4):321-36. PMID: 7907907.
      View in: PubMed
    85. Ballard J, Sokolov Y, Yuan WL, Kagan BL, Tweten RK. Activation and mechanism of Clostridium septicum alpha toxin. Mol Microbiol. 1993 Nov; 10(3):627-34. PMID: 7968539.
      View in: PubMed
    86. Portnoy DA, Tweten RK, Kehoe M, Bielecki J. Capacity of listeriolysin O, streptolysin O, and perfringolysin O to mediate growth of Bacillus subtilis within mammalian cells. Infect Immun. 1992 Jul; 60(7):2710-7. PMID: 1612739.
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    87. Ballard J, Bryant A, Stevens D, Tweten RK. Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum. Infect Immun. 1992 Mar; 60(3):784-90. PMID: 1541552.
      View in: PubMed
    88. Tweten RK, Harris RW, Sims PJ. Isolation of a tryptic fragment from Clostridium perfringens theta-toxin that contains sites for membrane binding and self-aggregation. J Biol Chem. 1991 Jul 05; 266(19):12449-54. PMID: 2061320.
      View in: PubMed
    89. Harris RW, Sims PJ, Tweten RK. Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes. Infect Immun. 1991 Jul; 59(7):2499-501. PMID: 2050414.
      View in: PubMed
    90. Harris RW, Sims PJ, Tweten RK. Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study. J Biol Chem. 1991 Apr 15; 266(11):6936-41. PMID: 2016307.
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    91. Tweten RK. Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin. Infect Immun. 1988 Dec; 56(12):3235-40. PMID: 2903128.
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    92. Tweten RK. Cloning and expression in Escherichia coli of the perfringolysin O (theta-toxin) gene from Clostridium perfringens and characterization of the gene product. Infect Immun. 1988 Dec; 56(12):3228-34. PMID: 2903127.
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    93. Meador J, Tweten RK. Purification and characterization of toxin B from Clostridium difficile. Infect Immun. 1988 Jul; 56(7):1708-14. PMID: 3384474.
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    94. Tweten RK, Barbieri JT, Collier RJ. Diphtheria toxin. Effect of substituting aspartic acid for glutamic acid 148 on ADP-ribosyltransferase activity. J Biol Chem. 1985 Sep 05; 260(19):10392-4. PMID: 2863266.
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    95. Tweten RK, Collier RJ. Molecular cloning and expression of gene fragments from corynebacteriophage beta encoding enzymatically active peptides of diphtheria toxin. J Bacteriol. 1983 Nov; 156(2):680-5. PMID: 6313613.
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