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Sanjay I Bidichandani

TitleDavid L Boren Professor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Pediatrics
Address975 NE 10th St
Oklahoma City OK 73104-5419
Phone405/271-1358
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    Collapse Research 
    Collapse research activities and funding
    R01NS047596     (BIDICHANDANI, SANJAY I)Jan 1, 2004 - Dec 31, 2013
    NIH/NINDS
    Properties and determinants of GAA repeat instability
    Role: Principal Investigator

    R01NS072418     (BIDICHANDANI, SANJAY I)Sep 30, 2010 - Aug 31, 2015
    NIH/NINDS
    RNA-induced transcriptional gene silencing in Friedreich ataxia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chutake YK, Lam CC, Costello WN, Anderson MP, Bidichandani SI. Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor. Nucleic Acids Res. 2016 Jun 20; 44(11):5095-104. PMID: 26896803; PMCID: PMC4914082.
    2. Chutake YK, Costello WN, Lam CC, Parikh AC, Hughes TT, Michalopulos MG, Pook MA, Bidichandani SI. FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia. PLoS One. 2015; 10(9):e0138437. PMID: 26393353; PMCID: PMC4579136.
    3. Chutake YK, Lam C, Costello WN, Anderson M, Bidichandani SI. Epigenetic promoter silencing in Friedreich ataxia is dependent on repeat length. Ann Neurol. 2014 Oct; 76(4):522-8. PMID: 25112975; PMCID: PMC4191993.
    4. Chutake YK, Costello WN, Lam C, Bidichandani SI. Altered nucleosome positioning at the transcription start site and deficient transcriptional initiation in Friedreich ataxia. J Biol Chem. 2014 May 30; 289(22):15194-202. PMID: 24737321; PMCID: PMC4140879.
    5. Chad DA, Bidichandani S, Bruijn L, Capra JD, Dickie B, Ferguson J, Figlewicz D, Forsythe M, Kaufmann P, Kirshner A, Monti W. Funding agencies and disease organizations: resources and recommendations to facilitate ALS clinical research. Amyotroph Lateral Scler Frontotemporal Degener. 2013 May; 14 Suppl 1:62-6. PMID: 23678881.
      View in: PubMed
    6. Bourn RL, De Biase I, Pinto RM, Sandi C, Al-Mahdawi S, Pook MA, Bidichandani SI. Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues. PLoS One. 2012; 7(10):e47085. PMID: 23071719; PMCID: PMC3469490.
    7. Rindler PM, Bidichandani SI. Role of transcript and interplay between transcription and replication in triplet-repeat instability in mammalian cells. Nucleic Acids Res. 2011 Jan; 39(2):526-35. PMID: 20843782; PMCID: PMC3025579.
    8. Rasmussen A, Alonso E, Ochoa A, De Biase I, Familiar I, Yescas P, Sosa AL, Rodríguez Y, Chávez M, López-López M, Bidichandani SI. Uptake of genetic testing and long-term tumor surveillance in von Hippel-Lindau disease. BMC Med Genet. 2010 Jan 12; 11:4. PMID: 20064270; PMCID: PMC2822817.
    9. De Biase I, Chutake YK, Rindler PM, Bidichandani SI. Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription. PLoS One. 2009 Nov 19; 4(11):e7914. PMID: 19956589; PMCID: PMC2780319.
    10. Bourn RL, Rindler PM, Pollard LM, Bidichandani SI. E. coli mismatch repair acts downstream of replication fork stalling to stabilize the expanded (GAA.TTC)(n) sequence. Mutat Res. 2009 Feb 10; 661(1-2):71-7. PMID: 19046977; PMCID: PMC2637364.
    11. Zakhary GM, Clark RM, Bidichandani SI, Owen WL, Slayton RL, Levine M. Acidic proline-rich protein Db and caries in young children. J Dent Res. 2007 Dec; 86(12):1176-80. PMID: 18037651.
      View in: PubMed
    12. Pollard LM, Bourn RL, Bidichandani SI. Repair of DNA double-strand breaks within the (GAA*TTC)n sequence results in frequent deletion of the triplet-repeat sequence. Nucleic Acids Res. 2008 Feb; 36(2):489-500. PMID: 18045804; PMCID: PMC2241870.
    13. Pollard LM, Chutake YK, Rindler PM, Bidichandani SI. Deficiency of RecA-dependent RecFOR and RecBCD pathways causes increased instability of the (GAA*TTC)n sequence when GAA is the lagging strand template. Nucleic Acids Res. 2007; 35(20):6884-94. PMID: 17932052; PMCID: PMC2175318.
    14. Rasmussen A, De Biase I, Fragoso-Benítez M, Macías-Flores MA, Yescas P, Ochoa A, Ashizawa T, Alonso ME, Bidichandani SI. Anticipation and intergenerational repeat instability in spinocerebellar ataxia type 17. Ann Neurol. 2007 Jun; 61(6):607-10. PMID: 17474109.
      View in: PubMed
    15. Alonso E, Martínez-Ruano L, De Biase I, Mader C, Ochoa A, Yescas P, Gutiérrez R, White M, Ruano L, Fragoso-Benítez M, Ashizawa T, Bidichandani SI, Rasmussen A. Distinct distribution of autosomal dominant spinocerebellar ataxia in the Mexican population. Mov Disord. 2007 May 15; 22(7):1050-3. PMID: 17427938.
      View in: PubMed
    16. De Biase I, Rasmussen A, Monticelli A, Al-Mahdawi S, Pook M, Cocozza S, Bidichandani SI. Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich ataxia progresses throughout life. Genomics. 2007 Jul; 90(1):1-5. PMID: 17498922.
      View in: PubMed
    17. De Biase I, Rasmussen A, Endres D, Al-Mahdawi S, Monticelli A, Cocozza S, Pook M, Bidichandani SI. Progressive GAA expansions in dorsal root ganglia of Friedreich's ataxia patients. Ann Neurol. 2007 Jan; 61(1):55-60. PMID: 17262846.
      View in: PubMed
    18. Rasmussen A, Gómez M, Alonso E, Bidichandani SI. Clinical heterogeneity of recessive ataxia in the Mexican population. J Neurol Neurosurg Psychiatry. 2006 Dec; 77(12):1370-2. PMID: 17110750; PMCID: PMC2077434.
    19. M Rindler P, Clark RM, Pollard LM, De Biase I, Bidichandani SI. Replication in mammalian cells recapitulates the locus-specific differences in somatic instability of genomic GAA triplet-repeats. Nucleic Acids Res. 2006; 34(21):6352-61. PMID: 17142224; PMCID: PMC1669776.
    20. Clark RM, De Biase I, Malykhina AP, Al-Mahdawi S, Pook M, Bidichandani SI. The GAA triplet-repeat is unstable in the context of the human FXN locus and displays age-dependent expansions in cerebellum and DRG in a transgenic mouse model. Hum Genet. 2007 Jan; 120(5):633-40. PMID: 17024371.
      View in: PubMed
    21. Clark RM, Bhaskar SS, Miyahara M, Dalgliesh GL, Bidichandani SI. Expansion of GAA trinucleotide repeats in mammals. Genomics. 2006 Jan; 87(1):57-67. PMID: 16316739.
      View in: PubMed
    22. Sharma R, De Biase I, Gómez M, Delatycki MB, Ashizawa T, Bidichandani SI. Friedreich ataxia in carriers of unstable borderline GAA triplet-repeat alleles. Ann Neurol. 2004 Dec; 56(6):898-901. PMID: 15562408.
      View in: PubMed
    23. Pollard LM, Sharma R, Gómez M, Shah S, Delatycki MB, Pianese L, Monticelli A, Keats BJ, Bidichandani SI. Replication-mediated instability of the GAA triplet repeat mutation in Friedreich ataxia. Nucleic Acids Res. 2004; 32(19):5962-71. PMID: 15534367; PMCID: PMC528813.
    24. Gómez M, Clark RM, Nath SK, Bhatti S, Sharma R, Alonso E, Rasmussen A, Bidichandani SI. Genetic admixture of European FRDA genes is the cause of Friedreich ataxia in the Mexican population. Genomics. 2004 Nov; 84(5):779-84. PMID: 15475256.
      View in: PubMed
    25. Clark RM, Dalgliesh GL, Endres D, Gomez M, Taylor J, Bidichandani SI. Expansion of GAA triplet repeats in the human genome: unique origin of the FRDA mutation at the center of an Alu. Genomics. 2004 Mar; 83(3):373-83. PMID: 14962663.
      View in: PubMed
    26. Potaman VN, Oussatcheva EA, Lyubchenko YL, Shlyakhtenko LS, Bidichandani SI, Ashizawa T, Sinden RR. Length-dependent structure formation in Friedreich ataxia (GAA)n*(TTC)n repeats at neutral pH. Nucleic Acids Res. 2004; 32(3):1224-31. PMID: 14978261; PMCID: PMC373408.
    27. Hern LM, Bidichandani SI. What Mendel did not discover: exceptions in Mendelian genetics and their role in inherited human disease. J Okla State Med Assoc. 2004 Jan; 97(1):12-7. PMID: 14998061.
      View in: PubMed
    28. Gomes-Pereira M, Bidichandani SI, Monckton DG. Analysis of unstable triplet repeats using small-pool polymerase chain reaction. Methods Mol Biol. 2004; 277:61-76. PMID: 15201449.
      View in: PubMed
    29. Sharma R, Bhatti S, Gomez M, Clark RM, Murray C, Ashizawa T, Bidichandani SI. The GAA triplet-repeat sequence in Friedreich ataxia shows a high level of somatic instability in vivo, with a significant predilection for large contractions. Hum Mol Genet. 2002 Sep 01; 11(18):2175-87. PMID: 12189170.
      View in: PubMed
    30. Hai M, Bidichandani SI, Patel PI. Identification of a positive regulatory element in the myelin-specific promoter of the PMP22 gene. J Neurosci Res. 2001 Sep 15; 65(6):508-19. PMID: 11550219.
      View in: PubMed
    31. Hai M, Bidichandani SI, Hogan ME, Patel PI. Competitive binding of triplex-forming oligonucleotides in the two alternate promoters of the PMP22 gene. Antisense Nucleic Acid Drug Dev. 2001 Aug; 11(4):233-46. PMID: 11572600.
      View in: PubMed
    32. Désarnaud F, Bidichandani S, Patel PI, Baulieu EE, Schumacher M. Glucocorticosteroids stimulate the activity of the promoters of peripheral myelin protein-22 and protein zero genes in Schwann cells. Brain Res. 2000 May 19; 865(1):12-6. PMID: 10814728.
      View in: PubMed
    33. Bidichandani SI, Garcia CA, Patel PI, Dimachkie MM. Very late-onset Friedreich ataxia despite large GAA triplet repeat expansions. Arch Neurol. 2000 Feb; 57(2):246-51. PMID: 10681084.
      View in: PubMed
    34. Bidichandani SI, Purandare SM, Taylor EE, Gumin G, Machkhas H, Harati Y, Gibbs RA, Ashizawa T, Patel PI. Somatic sequence variation at the Friedreich ataxia locus includes complete contraction of the expanded GAA triplet repeat, significant length variation in serially passaged lymphoblasts and enhanced mutagenesis in the flanking sequence. Hum Mol Genet. 1999 Dec; 8(13):2425-36. PMID: 10556290.
      View in: PubMed
    35. Machkhas H, Bidichandani SI, Patel PI, Harati Y. A mild case of Friedreich ataxia: lymphocyte and sural nerve analysis for GAA repeat length reveals somatic mosaicism. Muscle Nerve. 1998 Mar; 21(3):390-3. PMID: 9486868.
      View in: PubMed
    36. Bidichandani SI, Ashizawa T, Patel PI. The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure. Am J Hum Genet. 1998 Jan; 62(1):111-21. PMID: 9443873; PMCID: PMC1376805.
    37. Bidichandani SI, Ashizawa T, Patel PI. Atypical Friedreich ataxia caused by compound heterozygosity for a novel missense mutation and the GAA triplet-repeat expansion. Am J Hum Genet. 1997 May; 60(5):1251-6. PMID: 9150176; PMCID: PMC1712428.
    38. Yang SP, Bidichandani SI, Figuera LE, Juyal RC, Saxon PJ, Baldini A, Patel PI. Molecular analysis of deletion (17)(p11.2p11.2) in a family segregating a 17p paracentric inversion: implications for carriers of paracentric inversions. Am J Hum Genet. 1997 May; 60(5):1184-93. PMID: 9150166; PMCID: PMC1712444.
    39. Cossée M, Campuzano V, Koutnikova H, Fischbeck K, Mandel JL, Koenig M, Bidichandani SI, Patel PI, Moltè MD, Cañizares J, De Frutos R, Pianese L, Cavalcanti F, Monticelli A, Cocozza S, Montermini L, Pandolfo M. Frataxin fracas. Nat Genet. 1997 Apr; 15(4):337-8. PMID: 9090376.
      View in: PubMed
    40. Campuzano V, Montermini L, Moltò MD, Pianese L, Cossée M, Cavalcanti F, Monros E, Rodius F, Duclos F, Monticelli A, Zara F, Cañizares J, Koutnikova H, Bidichandani SI, Gellera C, Brice A, Trouillas P, De Michele G, Filla A, De Frutos R, Palau F, Patel PI, Di Donato S, Mandel JL, Cocozza S, Koenig M, Pandolfo M. Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science. 1996 Mar 08; 271(5254):1423-7. PMID: 8596916.
      View in: PubMed
    41. Alexander MY, Bidichandani SI, Cousins FM, Robinson CJ, Duffie E, Akhurst RJ. Circulating human factor IX produced in keratin-promoter transgenic mice: a feasibility study for gene therapy of haemophilia B. Hum Mol Genet. 1995 Jun; 4(6):993-9. PMID: 7544665.
      View in: PubMed
    42. Bidichandani SI, Lanyon WG, Shiach CR, Lowe GD, Connor JM. Detection of mutations in ectopic factor VIII transcripts from nine haemophilia A patients and the correlation with phenotype. Hum Genet. 1995 May; 95(5):531-8. PMID: 7759074.
      View in: PubMed
    43. Tuddenham EG, Schwaab R, Seehafer J, Millar DS, Gitschier J, Higuchi M, Bidichandani S, Connor JM, Hoyer LW, Yoshioka A, et al. Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition. Nucleic Acids Res. 1994 Nov 11; 22(22):4851-68. PMID: 7984443; PMCID: PMC308545.
    44. Bidichandani SI, Lanyon WG, Connor JM. Characterisation of a 5-bp deletion in exon 4 of the factor VIII gene: concordance with slipped-mispairing at DNA replication. Hum Genet. 1994 Oct; 94(4):447-9. PMID: 7927348.
      View in: PubMed
    45. Tuddenham EG, Schwaab R, Seehafer J, Millar DS, Gitschier J, Higuchi M, Bidichandani S, Connor JM, Hoyer LW, Yoshioka A, et al. Haemophilia A: database of nucleotide substitutions, deletions, insertions and rearrangements of the factor VIII gene, second edition. Nucleic Acids Res. 1994 Sep; 22(17):3511-33. PMID: 7937051; PMCID: PMC308313.
    46. Bidichandani SI, Shiach CR, Lanyon WG, Connor JM. A novel splice donor mutation affecting position +3 in intron 6 of the factor VIII gene. Hum Mol Genet. 1994 Apr; 3(4):651-3. PMID: 8069313.
      View in: PubMed
    47. Alexander MY, Bidichandani S, Robinson C, Trainer AH, Akhurst RJ. Physical methods of gene delivery using keratinocytes as a target for somatic cell gene therapy. Gene Ther. 1994; 1 Suppl 1:S57. PMID: 8542402.
      View in: PubMed
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