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Last Name

Shanjana Awasthi

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
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    Collapse Biography 
    Collapse education and training
    Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, IndiaPhD1995Microbiology
    Indian Institute of Technology, Roorkee, INDIAMSc1990Biosciences
    UTHSCSA, TexasPostdoc2000Physiology
    Feinstein Institute of Medical Research, Manhasset, NYPostdoc2002Molecular Medicine

    Collapse Research 
    Collapse research activities and funding
    R01HL136325     (AWASTHI, SHANJANA)Aug 8, 2017 - Jul 31, 2022
    Surfactant protein-A regions as TLR4-immunomodulators
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Awasthi S, Singh B, Ramani V, Xie J, Kosanke S. TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection. PLoS One. 2019; 14(1):e0210979. PMID: 30689633.
      View in: PubMed
    2. Awasthi S. Intranasal Antifungal Vaccination Using DNA-Transfected Dendritic Cells. Methods Mol Biol. 2017; 1625:75-83. PMID: 28584984.
      View in: PubMed
    3. Rao G, Yadav VR, Awasthi S, Roberts PR, Awasthi V. Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G180-91. PMID: 27288424.
      View in: PubMed
    4. Vilekar P, Rao G, Awasthi S, Awasthi V. Diphenyldifluoroketone EF24 Suppresses Pro-inflammatory Interleukin-1 receptor 1 and Toll-like Receptor 4 in lipopolysaccharide-stimulated dendritic cells. J Inflamm (Lond). 2015; 12:55. PMID: 26401121; PMCID: PMC4580149.
    5. Ramani V, Awasthi S. Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli. J Leukoc Biol. 2015 Dec; 98(6):1037-48. PMID: 26254306.
      View in: PubMed
    6. Awasthi S, Anbanandam A, Rodgers KK. Structure of a TLR4-interacting SPA4 peptide. RSC Adv. 2015; 5(35):27431-27438. PMID: 25870755.
      View in: PubMed
    7. Awasthi S. Toll-like receptor-4 modulation for cancer immunotherapy. Front Immunol. 2014; 5:328. PMID: 25120541; PMCID: PMC4110442.
    8. Yadav VR, Vilekar P, Awasthi S, Awasthi V. Hemorrhage-induced interleukin-1 receptor pathway in lung is suppressed by 3,5-bis(2-fluorobenzylidene)-4-piperidone in a rat model of hypovolemic shock. Artif Organs. 2014 Aug; 38(8):675-83. PMID: 24749913; PMCID: PMC4146623.
    9. Vilekar P, King C, Lagisetty P, Awasthi V, Awasthi S. Antibacterial activity of synthetic curcumin derivatives: 3,5-bis(benzylidene)-4-piperidone (EF24) and EF24-dimer linked via diethylenetriaminepentacetic acid (EF2DTPA). Appl Biochem Biotechnol. 2014 Apr; 172(7):3363-73. PMID: 24532443.
      View in: PubMed
    10. Ramani V, Madhusoodhanan R, Kosanke S, Awasthi S. A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation. Innate Immun. 2013 Dec; 19(6):596-610. PMID: 23475791.
      View in: PubMed
    11. Awasthi S, Singh B, Welliver RC, Dietert RR. Lung dendritic cell developmental programming, environmental stimuli, and asthma in early periods of life. J Allergy (Cairo). 2012; 2012:176468. PMID: 23209481; PMCID: PMC3503332.
    12. Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun. 2012 Dec; 80(12):4374-87. PMID: 23027535; PMCID: PMC3497415.
    13. Daw K, Baghdayan AS, Awasthi S, Shankar N. Biofilm and planktonic Enterococcus faecalis elicit different responses from host phagocytes in vitro. FEMS Immunol Med Microbiol. 2012 Jul; 65(2):270-82. PMID: 22333034; PMCID: PMC3366019.
    14. Vilekar P, Awasthi S, Natarajan A, Anant S, Awasthi V. EF24 suppresses maturation and inflammatory response in dendritic cells. Int Immunol. 2012 Jul; 24(7):455-64. PMID: 22378503; PMCID: PMC3385421.
    15. Chandrakesan P, Ahmed I, Chinthalapally A, Singh P, Awasthi S, Anant S, Umar S. Distinct compartmentalization of NF-?B activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection. Infect Immun. 2012 Feb; 80(2):753-67. PMID: 22144489; PMCID: PMC3264290.
    16. Awasthi S, Madhusoodhanan R, Wolf R. Surfactant protein-A and toll-like receptor-4 modulate immune functions of preterm baboon lung dendritic cell precursor cells. Cell Immunol. 2011; 268(2):87-96. PMID: 21439559; PMCID: PMC3104394.
    17. Awasthi S, Brown K, King C, Awasthi V, Bondugula R. A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-a release from mouse JAWS II dendritic cells. J Pharmacol Exp Ther. 2011 Mar; 336(3):672-81. PMID: 21159752; PMCID: PMC3061537.
    18. Vilekar P, Awasthi V, Lagisetty P, King C, Shankar N, Awasthi S. In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine. BMC Immunol. 2010 Dec 10; 11:60. PMID: 21143974; PMCID: PMC3018378.
    19. Awasthi S. Surfactant protein (SP)-A and SP-D as antimicrobial and immunotherapeutic agents. Recent Pat Antiinfect Drug Discov. 2010 Jun; 5(2):115-23. PMID: 20230362.
      View in: PubMed
    20. Awasthi S. Susceptibility of TLR4-defective C3H/HeJ mice to Coccidioides posadasii infection. Med Mycol. 2010 May; 48(3):470-5. PMID: 20370361.
      View in: PubMed
    21. Awasthi S, Wolf R, White G. Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol Cell Biol. 2009 Jul; 87(5):419-27. PMID: 19223853.
      View in: PubMed
    22. Awasthi S, Cropper J, Brown KM. Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung. Dev Comp Immunol. 2008; 32(9):1088-98. PMID: 18377992.
      View in: PubMed
    23. Metkar S, Awasthi S, Denamur E, Kim KS, Gangloff SC, Teichberg S, Haziot A, Silver J, Goyert SM. Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression. Infect Immun. 2007 Nov; 75(11):5415-24. PMID: 17709409.
      View in: PubMed
    24. Awasthi S. Dendritic cell-based vaccine against coccidioides infection. Ann N Y Acad Sci. 2007 Sep; 1111:269-74. PMID: 17363430.
      View in: PubMed
    25. Awasthi S, Cropper J. Immunophenotype and functions of fetal baboon bone-marrow derived dendritic cells. Cell Immunol. 2006 Mar; 240(1):31-40. PMID: 16842767.
      View in: PubMed
    26. Awasthi S, Awasthi V, Magee DM, Coalson JJ. Efficacy of antigen 2/proline-rich antigen cDNA-transfected dendritic cells in immunization of mice against Coccidioides posadasii. J Immunol. 2005 Sep 15; 175(6):3900-6. PMID: 16148136.
      View in: PubMed
    27. Awasthi S, Magee DM. Differences in expression of cell surface co-stimulatory molecules, Toll-like receptor genes and secretion of IL-12 by bone marrow-derived dendritic cells from susceptible and resistant mouse strains in response to Coccidioides posadasii. Cell Immunol. 2004 Sep-Oct; 231(1-2):49-55. PMID: 15919369.
      View in: PubMed
    28. Awasthi S, Magee DM, Coalson JJ. Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D. Respir Res. 2004 Dec 10; 5:28. PMID: 15588319; PMCID: PMC543449.
    29. Awasthi S, Cox RA. Transfection of murine dendritic cell line (JAWS II) by a nonviral transfection reagent. Biotechniques. 2003 Sep; 35(3):600-2, 604. PMID: 14513565.
      View in: PubMed
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