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Shannon M Conley

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
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    F32EY018512     (CONLEY, SHANNON M)Feb 1, 2009 - Jan 31, 2012
    The role of the photoreceptor tetraspanin Rds in outer segment morphogenesis
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Conley SM, Stuck MW, Watson JN, Zulliger R, Burnett JL, Naash MI. Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization. Hum Mol Genet. 2019 Feb 01; 28(3):459-475. PMID: 30307502.
      View in: PubMed
    2. Zulliger R, Conley SM, Mwoyosvi ML, Al-Ubaidi MR, Naash MI. Oligomerization of Prph2 and Rom1 is essential for photoreceptor outer segment formation. Hum Mol Genet. 2018 10 15; 27(20):3507-3518. PMID: 29961824.
      View in: PubMed
    3. Agbaga MP, Merriman DK, Brush RS, Lydic TA, Conley SM, Naash MI, Jackson S, Woods AS, Reid GE, Busik JV, Anderson RE. Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors. J Lipid Res. 2018 Sep; 59(9):1586-1596. PMID: 29986998.
      View in: PubMed
    4. Fulop GA, Ramirez-Perez FI, Kiss T, Tarantini S, Valcarcel Ares MN, Toth P, Yabluchanskiy A, Conley SM, Ballabh P, Martinez-Lemus LA, Ungvari Z, Csiszar A. IGF-1 deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging. J Gerontol A Biol Sci Med Sci. 2018 Jun 21. PMID: 29931048.
      View in: PubMed
    5. Kelley RA, Conley SM, Makkia R, Watson JN, Han Z, Cooper MJ, Naash MI. DNA nanoparticles are safe and nontoxic in non-human primate eyes. Int J Nanomedicine. 2018; 13:1361-1379. PMID: 29563793.
      View in: PubMed
    6. Conley SM, Stuck MW, Watson JN, Naash MI. Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa. Hum Mol Genet. 2017 02 01; 26(3):509-518. PMID: 28053051.
      View in: PubMed
    7. Chakraborty D, Conley SM, Zulliger R, Naash MI. The K153Del PRPH2 mutation differentially impacts photoreceptor structure and function. Hum Mol Genet. 2016 08 15; 25(16):3500-3514. PMID: 27365499.
      View in: PubMed
    8. Chakraborty D, Conley SM, Pittler SJ, Naash MI. Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):787-97. PMID: 26934134; PMCID: PMC4777275.
    9. Stuck MW, Conley SM, Naash MI. PRPH2/RDS and ROM-1: Historical context, current views and future considerations. Prog Retin Eye Res. 2016 05; 52:47-63. PMID: 26773759; PMCID: PMC4842342 [Available on 05/01/17].
    10. Mitra RN, Conley SM, Naash MI. Therapeutic Approach of Nanotechnology for Oxidative Stress Induced Ocular Neurodegenerative Diseases. Adv Exp Med Biol. 2016; 854:463-9. PMID: 26427447.
      View in: PubMed
    11. Conley SM, Whalen P, Lewin AS, Naash MI. Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation. Adv Exp Med Biol. 2016; 854:509-15. PMID: 26427453.
      View in: PubMed
    12. Stuck MW, Conley SM, Naash MI. RDS Functional Domains and Dysfunction in Disease. Adv Exp Med Biol. 2016; 854:217-22. PMID: 26427414.
      View in: PubMed
    13. Chakraborty D, Conley SM, DeRamus ML, Pittler SJ, Naash MI. Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function. Invest Ophthalmol Vis Sci. 2015 Dec; 56(13):8187-98. PMID: 26720471; PMCID: PMC4699412.
    14. Zulliger R, Conley SM, Naash MI. Non-viral therapeutic approaches to ocular diseases: An overview and future directions. J Control Release. 2015 Dec 10; 219:471-487. PMID: 26439665; PMCID: PMC4699668 [Available on 12/10/16].
    15. Stuck MW, Conley SM, Naash MI. Retinal Degeneration Slow (RDS) Glycosylation Plays a Role in Cone Function and in the Regulation of RDS┬ĚROM-1 Protein Complex Formation. J Biol Chem. 2015 Nov 13; 290(46):27901-13. PMID: 26420485; PMCID: PMC4646032 [Available on 11/13/16].
    16. Zulliger R, Conley SM, Mwoyosvi ML, Stuck MW, Azadi S, Naash MI. SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PLoS One. 2015; 10(9):e0138508. PMID: 26406599; PMCID: PMC4583372.
    17. Han Z, Banworth MJ, Makkia R, Conley SM, Al-Ubaidi MR, Cooper MJ, Naash MI. Genomic DNA nanoparticles rescue rhodopsin-associated retinitis pigmentosa phenotype. FASEB J. 2015 Jun; 29(6):2535-44. PMID: 25713057; PMCID: PMC4447225.
    18. Conley SM, Naash MI. Gene therapy for PRPH2-associated ocular disease: challenges and prospects. Cold Spring Harb Perspect Med. 2014 Aug 28; 4(11):a017376. PMID: 25167981.
      View in: PubMed
    19. Mitra RN, Merwin MJ, Han Z, Conley SM, Al-Ubaidi MR, Naash MI. Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration. Free Radic Biol Med. 2014 Oct; 75:140-8. PMID: 25066531; PMCID: PMC4171208.
    20. Stuck MW, Conley SM, Naash MI. The Y141C knockin mutation in RDS leads to complex phenotypes in the mouse. Hum Mol Genet. 2014 Dec 01; 23(23):6260-74. PMID: 25001182; PMCID: PMC4222364.
    21. Chakraborty D, Conley SM, Al-Ubaidi MR, Naash MI. Initiation of rod outer segment disc formation requires RDS. PLoS One. 2014; 9(6):e98939. PMID: 24897172; PMCID: PMC4045911.
    22. Conley SM, Al-Ubaidi MR, Han Z, Naash MI. Rim formation is not a prerequisite for distribution of cone photoreceptor outer segment proteins. FASEB J. 2014 Aug; 28(8):3468-79. PMID: 24736412; PMCID: PMC4101662.
    23. Conley SM, Stuck MW, Burnett JL, Chakraborty D, Azadi S, Fliesler SJ, Naash MI. Insights into the mechanisms of macular degeneration associated with the R172W mutation in RDS. Hum Mol Genet. 2014 Jun 15; 23(12):3102-14. PMID: 24463884; PMCID: PMC4030767.
    24. Stuck MW, Conley SM, Shaw RA, Wolf R, Naash MI. Electrophysiological characterization of rod and cone responses in the baboon nonhuman primate model. Adv Exp Med Biol. 2014; 801:67-73. PMID: 24664682.
      View in: PubMed
    25. Koirala A, Conley SM, Naash MI. Episomal maintenance of S/MAR-containing non-viral vectors for RPE-based diseases. Adv Exp Med Biol. 2014; 801:703-9. PMID: 24664761.
      View in: PubMed
    26. Han Z, Conley SM, Naash MI. Gene therapy for Stargardt disease associated with ABCA4 gene. Adv Exp Med Biol. 2014; 801:719-24. PMID: 24664763.
      View in: PubMed
    27. Al-Ubaidi MR, Naash MI, Conley SM. A perspective on the role of the extracellular matrix in progressive retinal degenerative disorders. Invest Ophthalmol Vis Sci. 2013 Dec 17; 54(13):8119-24. PMID: 24346621; PMCID: PMC4587794.
    28. Mitra RN, Han Z, Merwin M, Al Taai M, Conley SM, Naash MI. Synthesis and characterization of glycol chitosan DNA nanoparticles for retinal gene delivery. ChemMedChem. 2014 Jan; 9(1):189-96. PMID: 24203490; PMCID: PMC4019313.
    29. Koirala A, Conley SM, Makkia R, Liu Z, Cooper MJ, Sparrow JR, Naash MI. Persistence of non-viral vector mediated RPE65 expression: case for viability as a gene transfer therapy for RPE-based diseases. J Control Release. 2013 Dec 28; 172(3):745-52. PMID: 24035979; PMCID: PMC3858392.
    30. Koirala A, Conley SM, Naash MI. A review of therapeutic prospects of non-viral gene therapy in the retinal pigment epithelium. Biomaterials. 2013 Sep; 34(29):7158-67. PMID: 23796578; PMCID: PMC3742069.
    31. Chakraborty D, Conley SM, Naash MI. Overexpression of retinal degeneration slow (RDS) protein adversely affects rods in the rd7 model of enhanced S-cone syndrome. PLoS One. 2013; 8(5):e63321. PMID: 23650562; PMCID: PMC3641132.
    32. Koirala A, Makkia RS, Conley SM, Cooper MJ, Naash MI. S/MAR-containing DNA nanoparticles promote persistent RPE gene expression and improvement in RPE65-associated LCA. Hum Mol Genet. 2013 Apr 15; 22(8):1632-42. PMID: 23335596; PMCID: PMC3605833.
    33. Han Z, Guo J, Conley SM, Naash MI. Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2013 Jan 17; 54(1):574-84. PMID: 23221078; PMCID: PMC3558298.
    34. Han Z, Conley SM, Makkia R, Guo J, Cooper MJ, Naash MI. Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery. PLoS One. 2012; 7(12):e52189. PMID: 23272225; PMCID: PMC3525534.
    35. Chakraborty D, Rodgers KK, Conley SM, Naash MI. Structural characterization of the second intra-discal loop of the photoreceptor tetraspanin RDS. FEBS J. 2013 Jan; 280(1):127-38. PMID: 23121719; PMCID: PMC3652632.
    36. Han Z, Conley SM, Makkia RS, Cooper MJ, Naash MI. DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice. J Clin Invest. 2012 Sep; 122(9):3221-6. PMID: 22886305; PMCID: PMC3428101.
    37. Vuong L, Conley SM, Al-Ubaidi MR. Expression and role of p53 in the retina. Invest Ophthalmol Vis Sci. 2012 Mar 15; 53(3):1362-71. PMID: 22427613.
      View in: PubMed
    38. Stuck MW, Conley SM, Naash MI. Defects in the outer limiting membrane are associated with rosette development in the Nrl-/- retina. PLoS One. 2012; 7(3):e32484. PMID: 22427845; PMCID: PMC3299663.
    39. Chakraborty D, Conley SM, Nash Z, Ding XQ, Naash MI. Overexpression of ROM-1 in the cone-dominant retina. Adv Exp Med Biol. 2012; 723:633-9. PMID: 22183387.
      View in: PubMed
    40. Conley SM, Chakraborty D, Naash MI. Mislocalization of oligomerization-incompetent RDS is associated with mislocalization of cone opsins and cone transducin. Adv Exp Med Biol. 2012; 723:657-62. PMID: 22183390.
      View in: PubMed
    41. Conley SM, Cai X, Makkia R, Wu Y, Sparrow JR, Naash MI. Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy. Biochim Biophys Acta. 2012 Jul; 1822(7):1169-79. PMID: 22033104; PMCID: PMC3351560.
    42. Conley SM, Stuck MW, Naash MI. Structural and functional relationships between photoreceptor tetraspanins and other superfamily members. Cell Mol Life Sci. 2012 Apr; 69(7):1035-47. PMID: 21655915; PMCID: PMC3224198.
    43. Han Z, Conley SM, Naash MI. AAV and compacted DNA nanoparticles for the treatment of retinal disorders: challenges and future prospects. Invest Ophthalmol Vis Sci. 2011 May 10; 52(6):3051-9. PMID: 21558483; PMCID: PMC3109015.
    44. Chakraborty D, Conley SM, Stuck MW, Naash MI. Differences in RDS trafficking, assembly and function in cones versus rods: insights from studies of C150S-RDS. Hum Mol Genet. 2010 Dec 15; 19(24):4799-812. PMID: 20858597; PMCID: PMC2989890.
    45. Conley SM, Naash MI. Nanoparticles for retinal gene therapy. Prog Retin Eye Res. 2010 Sep; 29(5):376-97. PMID: 20452457; PMCID: PMC2907107.
    46. Cai X, Conley SM, Cheng T, Al-Ubaidi MR, Naash MI. A 350 bp region of the proximal promoter of Rds drives cell-type specific gene expression. Exp Eye Res. 2010 Aug; 91(2):186-94. PMID: 20447394; PMCID: PMC2937571.
    47. Conley SM, Stricker HM, Naash MI. Biochemical analysis of phenotypic diversity associated with mutations in codon 244 of the retinal degeneration slow gene. Biochemistry. 2010 Feb 09; 49(5):905-11. PMID: 20055437; PMCID: PMC2937569.
    48. Chakraborty D, Conley SM, Fliesler SJ, Naash MI. The function of oligomerization-incompetent RDS in rods. Adv Exp Med Biol. 2010; 664:39-46. PMID: 20238000; PMCID: PMC3161506.
    49. Conley SM, Ding XQ, Naash MI. RDS in cones does not interact with the beta subunit of the cyclic nucleotide gated channel. Adv Exp Med Biol. 2010; 664:63-70. PMID: 20238003; PMCID: PMC3161508.
    50. Cai X, Conley SM, Naash MI. Gene therapy in the Retinal Degeneration Slow model of retinitis pigmentosa. Adv Exp Med Biol. 2010; 664:611-9. PMID: 20238065; PMCID: PMC3161507.
    51. Cai X, Conley SM, Nash Z, Fliesler SJ, Cooper MJ, Naash MI. Gene delivery to mitotic and postmitotic photoreceptors via compacted DNA nanoparticles results in improved phenotype in a mouse model of retinitis pigmentosa. FASEB J. 2010 Apr; 24(4):1178-91. PMID: 19952284; PMCID: PMC2845431.
    52. Ding XQ, Quiambao AB, Fitzgerald JB, Cooper MJ, Conley SM, Naash MI. Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina. PLoS One. 2009 Oct 12; 4(10):e7410. PMID: 19823583.
      View in: PubMed
    53. Cai X, Conley SM, Naash MI. RPE65: role in the visual cycle, human retinal disease, and gene therapy. Ophthalmic Genet. 2009 Jun; 30(2):57-62. PMID: 19373675; PMCID: PMC2821785.
    54. Cai X, Nash Z, Conley SM, Fliesler SJ, Cooper MJ, Naash MI. A partial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles. PLoS One. 2009; 4(4):e5290. PMID: 19390689; PMCID: PMC2669177.
    55. Conley SM, Naash MI. Focus on molecules: RDS. Exp Eye Res. 2009 Sep; 89(3):278-9. PMID: 19366620; PMCID: PMC2764256.
    56. Chakraborty D, Ding XQ, Conley SM, Fliesler SJ, Naash MI. Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet. 2009 Mar 01; 18(5):797-808. PMID: 19050038; PMCID: PMC2640204.
    57. Conley SM, Cai X, Naash MI. Nonviral ocular gene therapy: assessment and future directions. Curr Opin Mol Ther. 2008 Oct; 10(5):456-63. PMID: 18830921; PMCID: PMC2938038.
    58. Stamer WD, Chan DW, Conley SM, Coons S, Ethier CR. Aquaporin-1 expression and conventional aqueous outflow in human eyes. Exp Eye Res. 2008 Oct; 87(4):349-55. PMID: 18657536; PMCID: PMC2577040.
    59. Conley S, Nour M, Fliesler SJ, Naash MI. Late-onset cone photoreceptor degeneration induced by R172W mutation in Rds and partial rescue by gene supplementation. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5397-407. PMID: 18055786; PMCID: PMC2263142.
    60. Cai X, Conley S, Naash M. Nanoparticle applications in ocular gene therapy. Vision Res. 2008 Feb; 48(3):319-24. PMID: 17825344; PMCID: PMC2423345.
    61. Conley SM, McKay BS, Gandolfi AJ, Stamer WD. Alterations in human trabecular meshwork cell homeostasis by selenium. Exp Eye Res. 2006 Apr; 82(4):637-47. PMID: 16289047.
      View in: PubMed
    62. Hoffman EA, Conley SM, Stamer WD, McKay BS. Barriers to productive transfection of trabecular meshwork cells. Mol Vis. 2005 Oct 26; 11:869-75. PMID: 16270026.
      View in: PubMed
    63. Burgess JL, Fierro MA, Lantz RC, Hysong TA, Fleming JE, Gerkin R, Hnizdo E, Conley SM, Klimecki W. Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters. J Occup Environ Med. 2004 Oct; 46(10):1013-22. PMID: 15602175.
      View in: PubMed
    64. Conley SM, Bruhn RL, Morgan PV, Stamer WD. Selenium's effects on MMP-2 and TIMP-1 secretion by human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):473-9. PMID: 14744887.
      View in: PubMed
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