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Last Name

Takemi Tanaka

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
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    Collapse Biography 
    Collapse education and training
    University of Shizuoka, Shizuoka, JAPANPhD1999Biology

    Collapse Research 
    Collapse research activities and funding
    R01CA160271     (TANAKA, TAKEMI)Apr 1, 2012 - Mar 31, 2017
    Anti-Migration Therapy for Prevention and Treatment of Breast Tumor
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Morita Y, Kamal M, Kang SA, Zhang R, Lokesh GL, Thiviyanathan V, Hasan N, Woo S, Zhao D, Leslie M, Suh S, Razaq W, Rui H, Gorenstein DG, Volk DE, Tanaka T. E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases. Mol Ther Nucleic Acids. 2016 Dec 13; 5(12):e399. PMID: 27959340.
      View in: PubMed
    2. Mangala LS, Wang H, Jiang D, Wu SY, Somasunderam A, Volk DE, Lokesh GL, Li X, Pradeep S, Yang X, Haemmerle M, Rodriguez-Aguayo C, Nagaraja AS, Rupaimoole R, Bayraktar E, Bayraktar R, Li L, Tanaka T, Hu W, Ivan C, Gharpure KM, McGuire MH, Thiviyanathan V, Zhang X, Maiti SN, Bulayeva N, Choi HJ, Dorniak PL, Cooper LJ, Rosenblatt KP, Lopez-Berestein G, Gorenstein DG, Sood AK. Improving vascular maturation using noncoding RNAs increases antitumor effect of chemotherapy. JCI Insight. 2016 10 20; 1(17):e87754. PMID: 27777972.
      View in: PubMed
    3. Kang SA, Blache CA, Bajana S, Hasan N, Kamal M, Morita Y, Gupta V, Tsolmon B, Suh KS, Gorenstein DG, Razaq W, Rui H, Tanaka T. Erratum to: The effect of soluble E-selectin on tumor progression and metastasis. BMC Cancer. 2016 06 28; 16(1):370. PMID: 27353033.
      View in: PubMed
    4. Kang SA, Blache CA, Bajana S, Hasan N, Kamal M, Morita Y, Gupta V, Tsolmon B, Suh KS, Gorenstein DG, Razaq W, Rui H, Tanaka T. The effect of soluble E-selectin on tumor progression and metastasis. BMC Cancer. 2016 05 24; 16:331. PMID: 27220365; PMCID: PMC4879723.
    5. Tamir A, Gangadharan A, Balwani S, Tanaka T, Patel U, Hassan A, Benke S, Agas A, D'Agostino J, Shin D, Yoon S, Goy A, Pecora A, Suh KS. The serine protease prostasin (PRSS8) is a potential biomarker for early detection of ovarian cancer. J Ovarian Res. 2016 Mar 31; 9:20. PMID: 27036110; PMCID: PMC4815131.
    6. Kang SA, Bajana S, Tanaka T. In vitro Flow Adhesion Assay for Analyzing Shear-resistant Adhesion of Metastatic Cancer Cells to Endothelial Cells. Bio Protoc. 2016 Feb 20; 6(4). PMID: 29333476.
      View in: PubMed
    7. Morita Y, Kamal M, Kang SA, Zhang R, Lokesh GL, Thiviyanathan V, Hasan N, Woo S, Zhao D, Leslie M, Suh S, Razaq W, Rui H, Gorenstein DG, Volk DE, Tanaka T. E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases. Mol Ther Nucleic Acids. 2016; 5:e399. PMID: 28131283.
      View in: PubMed
    8. Kang SA, Tsolmon B, Mann AP, Zheng W, Zhao L, Zhao YD, Volk DE, Lokesh GL, Morris L, Gupta V, Razaq W, Rui H, Suh KS, Gorenstein DG, Tanaka T. Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice. Toxicol Appl Pharmacol. 2015 Aug 15; 287(1):86-92. PMID: 26048585; PMCID: PMC4966538.
    9. Kang SA, Hasan N, Mann AP, Zheng W, Zhao L, Morris L, Zhu W, Zhao YD, Suh KS, Dooley WC, Volk D, Gorenstein DG, Cristofanilli M, Rui H, Tanaka T. Blocking the adhesion cascade at the premetastatic niche for prevention of breast cancer metastasis. Mol Ther. 2015 Jun; 23(6):1044-1054. PMID: 25815697; PMCID: PMC4817749.
    10. Tamir A, Jag U, Sarojini S, Schindewolf C, Tanaka T, Gharbaran R, Patel H, Sood A, Hu W, Patwa R, Blake P, Chirina P, Oh Jeong J, Lim H, Goy A, Pecora A, Suh KS. Kallikrein family proteases KLK6 and KLK7 are potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes. J Ovarian Res. 2014 Dec 05; 7:109. PMID: 25477184.
      View in: PubMed
    11. Gharbaran R, Goy A, Tanaka T, Park J, Kim C, Hasan N, Vemulapalli S, Sarojini S, Tuluc M, Nalley K, Bhattacharyya P, Pecora A, Suh KS. Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients. J Hematol Oncol. 2013 Aug 29; 6:62. PMID: 23988031; PMCID: PMC3766006.
    12. Suh KS, Tanaka T, Sarojini S, Nightingale G, Gharbaran R, Pecora A, Goy A. The role of the ubiquitin proteasome system in lymphoma. Crit Rev Oncol Hematol. 2013 Sep; 87(3):306-22. PMID: 23541070.
      View in: PubMed
    13. Hasan N, Mann A, Ferrari M, Tanaka T. Mesoporous silicon particles for sustained gene silencing. Methods Mol Biol. 2013; 1049:481-93. PMID: 23913239.
      View in: PubMed
    14. Yang N, Liu C, Peck AR, Girondo MA, Yanac AF, Tran TH, Utama FE, Tanaka T, Freydin B, Chervoneva I, Hyslop T, Kovatich AJ, Hooke JA, Shriver CD, Rui H. Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment. Breast Cancer Res. 2013; 15(5):R73. PMID: 24004716; PMCID: PMC3978581.
    15. Mann AP, Tanaka T, Somasunderam A, Liu X, Gorenstein DG, Ferrari M. E-selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow. Adv Mater. 2011 Sep 22; 23(36):H278-82. PMID: 21833996.
      View in: PubMed
    16. Guleria RS, Choudhary R, Tanaka T, Baker KM, Pan J. Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system. J Cell Physiol. 2011 May; 226(5):1292-307. PMID: 20945395; PMCID: PMC3043168.
    17. Mann AP, Bhavane RC, Somasunderam A, Liz Montalvo-Ortiz B, Ghaghada KB, Volk D, Nieves-Alicea R, Suh KS, Ferrari M, Annapragada A, Gorenstein DG, Tanaka T. Thioaptamer conjugated liposomes for tumor vasculature targeting. Oncotarget. 2011 Apr; 2(4):298-304. PMID: 21666286; PMCID: PMC3248173.
    18. Serda RE, Blanco E, Mack A, Stafford SJ, Amra S, Li Q, van de Ven A, Tanaka T, Torchilin VP, Wiktorowicz JE, Ferrari M. Proteomic analysis of serum opsonins impacting biodistribution and cellular association of porous silicon microparticles. Mol Imaging. 2011 Feb; 10(1):43-55. PMID: 21303614; PMCID: PMC4154307.
    19. Somasunderam A, Thiviyanathan V, Tanaka T, Li X, Neerathilingam M, Lokesh GL, Mann A, Peng Y, Ferrari M, Klostergaard J, Gorenstein DG. Combinatorial selection of DNA thioaptamers targeted to the HA binding domain of human CD44. Biochemistry. 2010 Oct 26; 49(42):9106-12. PMID: 20843027; PMCID: PMC2981344.
    20. Mann AP, Somasunderam A, Nieves-Alicea R, Li X, Hu A, Sood AK, Ferrari M, Gorenstein DG, Tanaka T. Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting. PLoS One. 2010 Sep 30; 5(9). PMID: 20927342; PMCID: PMC2948018.
    21. Tanaka T, Godin B, Bhavane R, Nieves-Alicea R, Gu J, Liu X, Chiappini C, Fakhoury JR, Amra S, Ewing A, Li Q, Fidler IJ, Ferrari M. In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice. Int J Pharm. 2010 Dec 15; 402(1-2):190-7. PMID: 20883755; PMCID: PMC2982888.
    22. Jones GL, Walton R, Czernuszka J, Griffiths SL, El Haj AJ, Cartmell SH. Primary human osteoblast culture on 3D porous collagen-hydroxyapatite scaffolds. J Biomed Mater Res A. 2010 Sep 15; 94(4):1244-50. PMID: 20694991.
      View in: PubMed
    23. Godin B, Gu J, Serda RE, Bhavane R, Tasciotti E, Chiappini C, Liu X, Tanaka T, Decuzzi P, Ferrari M. Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation. J Biomed Mater Res A. 2010 Sep 15; 94(4):1236-43. PMID: 20694990; PMCID: PMC2920054.
    24. Tanaka T, Mangala LS, Vivas-Mejia PE, Nieves-Alicea R, Mann AP, Mora E, Han HD, Shahzad MM, Liu X, Bhavane R, Gu J, Fakhoury JR, Chiappini C, Lu C, Matsuo K, Godin B, Stone RL, Nick AM, Lopez-Berestein G, Sood AK, Ferrari M. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res. 2010 May 01; 70(9):3687-96. PMID: 20430760; PMCID: PMC3202607.
    25. Buchner M, Fuchs S, Prinz G, Pfeifer D, Bartholomé K, Burger M, Chevalier N, Vallat L, Timmer J, Gribben JG, Jumaa H, Veelken H, Dierks C, Zirlik K. Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res. 2009 Jul 01; 69(13):5424-32. PMID: 19549911.
      View in: PubMed
    26. Tanaka T, De Luca LM. Therapeutic potential of "rexinoids" in cancer prevention and treatment. Cancer Res. 2009 Jun 15; 69(12):4945-7. PMID: 19509234.
      View in: PubMed
    27. Mangala LS, Zuzel V, Schmandt R, Leshane ES, Halder JB, Armaiz-Pena GN, Spannuth WA, Tanaka T, Shahzad MM, Lin YG, Nick AM, Danes CG, Lee JW, Jennings NB, Vivas-Mejia PE, Wolf JK, Coleman RL, Siddik ZH, Lopez-Berestein G, Lutsenko S, Sood AK. Therapeutic Targeting of ATP7B in Ovarian Carcinoma. Clin Cancer Res. 2009 Jun 01; 15(11):3770-80. PMID: 19470734; PMCID: PMC2752981.
    28. Tanaka T, Decuzzi P, Cristofanilli M, Sakamoto JH, Tasciotti E, Robertson FM, Ferrari M. Nanotechnology for breast cancer therapy. Biomed Microdevices. 2009 Feb; 11(1):49-63. PMID: 18663578.
      View in: PubMed
    29. Tanaka T, Suzuki A, Kuranuki S, Mochizuki K, Suruga K, Takase S, Goda T. Higher expression of jejunal LPH gene in rats fed the high-carbohydrate/low-fat diet compared with those fed the low-carbohydrate/high-fat diet is associated with in vitro binding of Cdx-2 in nuclear proteins to its promoter regions. Life Sci. 2008 Jul 18; 83(3-4):122-7. PMID: 18573506.
      View in: PubMed
    30. Godin B, Gu J, Serda RE, Ferrati S, Liu X, Chiappini C, Tanaka T, Decuzzi P, Ferrari M. Multistage Mesoporous Silicon-based Nanocarriers: Biocompatibility with Immune Cells and Controlled Degradation in Physiological Fluids. Controll Release Newsl. 2008 Jan 01; 25(4):9-11. PMID: 21853161.
      View in: PubMed
    31. Ono M, Oda E, Tanaka T, Iida Y, Yamasaki T, Masuoka C, Ikeda T, Nohara T. DPPH radical-scavenging effect on some constituents from the aerial parts of Lippia triphylla. J Nat Med. 2008 Jan; 62(1):101-6. PMID: 18404353.
      View in: PubMed
    32. Tanaka T, Suh KS, Lo AM, De Luca LM. p21WAF1/CIP1 is a common transcriptional target of retinoid receptors: pleiotropic regulatory mechanism through retinoic acid receptor (RAR)/retinoid X receptor (RXR) heterodimer and RXR/RXR homodimer. J Biol Chem. 2007 Oct 12; 282(41):29987-97. PMID: 17656367.
      View in: PubMed
    33. Suh KS, Crutchley JM, Koochek A, Ryscavage A, Bhat K, Tanaka T, Oshima A, Fitzgerald P, Yuspa SH. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. Clin Cancer Res. 2007 Jan 01; 13(1):121-31. PMID: 17200346.
      View in: PubMed
    34. Kuranuki S, Mochizuki K, Tanaka T, Goda T. The possible roles of homeobox protein, Cdx-2 for the expression of LPH gene during postnatal development. Life Sci. 2007 Jan 30; 80(8):795-9. PMID: 17161847.
      View in: PubMed
    35. DeCicco KL, Tanaka T, Andreola F, De Luca LM. The effect of thalidomide on non-small cell lung cancer (NSCLC) cell lines: possible involvement in the PPARgamma pathway. Carcinogenesis. 2004 Oct; 25(10):1805-12. PMID: 15205358.
      View in: PubMed
    36. Tanaka T, Dancheck BL, Trifiletti LC, Birnkrant RE, Taylor BJ, Garfield SH, Thorgeirsson U, De Luca LM. Altered localization of retinoid X receptor alpha coincides with loss of retinoid responsiveness in human breast cancer MDA-MB-231 cells. Mol Cell Biol. 2004 May; 24(9):3972-82. PMID: 15082790; PMCID: PMC387734.
    37. Hansen LA, Brown D, Virador V, Tanaka T, Andreola F, Strain K, Dancheck B, Riley R, Arbeit JM, De Luca LM, Kogan S, Yuspa SH. A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis. Cancer Res. 2003 Sep 01; 63(17):5257-65. PMID: 14500356.
      View in: PubMed
    38. Tanaka T, Rodríguez de la Concepción ML, De Luca LM. Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors alpha and gamma through proteasomes in MCF-7 human breast cancer cells. Biochem Pharmacol. 2001 Jun 01; 61(11):1347-55. PMID: 11331070.
      View in: PubMed
    39. Goda T, Yasutake H, Tanaka T, Takase S. Lactase-phlorizin hydrolase and sucrase-isomaltase genes are expressed differently along the villus-crypt axis of rat jejunum. J Nutr. 1999 Jun; 129(6):1107-13. PMID: 10356073.
      View in: PubMed
    40. Tanaka T, Kishi K, Igawa M, Takase S, Goda T. Dietary carbohydrates enhance lactase/phlorizin hydrolase gene expression at a transcription level in rat jejunum. Biochem J. 1998 Apr 01; 331 ( Pt 1):225-30. PMID: 9512483; PMCID: PMC1219342.
    41. Tanaka T, Takase S, Goda T. A possible role of a nuclear factor NF-LPH1 in the regional expression of lactase-phlorizin hydrolase along the small intestine. J Nutr Sci Vitaminol (Tokyo). 1997 Oct; 43(5):565-73. PMID: 9505241.
      View in: PubMed
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