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Tomoko Obara

TitleAssistant Professor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-8001
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    Collapse Research 
    Collapse research activities and funding
    R21DK069604     (OBARA, TOMOKO)Sep 30, 2004 - Aug 31, 2007
    NIH/NIDDK
    Kidney development and cystogenesis in Medaka
    Role: Principal Investigator

    R01DK078209     (OBARA, TOMOKO)May 1, 2007 - Jul 31, 2013
    NIH/NIDDK
    Polycystin2 function in zebrafish and medaka
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Powell R, Bubenshchikova E, Fukuyo Y, Hsu C, Lakiza O, Nomura H, Renfrew E, Garrity D, Obara T. Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish. Mol Med Rep. 2016 Sep; 14(3):2665-78. PMID: 27484451; PMCID: PMC4991684.
    2. Walter RB, Obara T. Workshop report: The medaka model for comparative assessment of human disease mechanisms. Comp Biochem Physiol C Toxicol Pharmacol. 2015 Dec; 178:156-62. PMID: 26099189; PMCID: PMC4662895 [Available on 12/01/16].
    3. Fukuyo Y, Nakamura T, Bubenshchikova E, Powell R, Tsuji T, Janknecht R, Obara T. Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Mol Med Rep. 2014 Feb; 9(2):457-65. PMID: 24337247; PMCID: PMC3896505.
    4. Ichimura K, Powell R, Nakamura T, Kurihara H, Sakai T, Obara T. Podocalyxin regulates pronephric glomerular development in zebrafish. Physiol Rep. 2013 Aug; 1(3). PMID: 24224085.
      View in: PubMed
    5. Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y, Terai S, Sakaida I, Kodera Y, Tsuji T, Ma JX, Sakai T, Matsumoto H, Obara T. Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy. Biochem Biophys Res Commun. 2013 Feb 22; 431(4):712-7. PMID: 23353086; PMCID: PMC3587682.
    6. Ichimura K, Fukuyo Y, Nakamura T, Powell R, Sakai T, Janknecht R, Obara T. Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus. J Histochem Cytochem. 2013 Apr; 61(4):313-24. PMID: 23324868; PMCID: PMC3636682.
    7. Ichimura K, Fukuyo Y, Nakamura T, Powell R, Sakai T, Obara T. Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant. Dev Dyn. 2012 Dec; 241(12):1922-32. PMID: 23027442; PMCID: PMC3504129.
    8. Ichimura K, Bubenshchikova E, Powell R, Fukuyo Y, Nakamura T, Tran U, Oda S, Tanaka M, Wessely O, Kurihara H, Sakai T, Obara T. A comparative analysis of glomerulus development in the pronephros of medaka and zebrafish. PLoS One. 2012; 7(9):e45286. PMID: 23028906; PMCID: PMC3445478.
    9. Bubenshchikova E, Ichimura K, Fukuyo Y, Powell R, Hsu C, Morrical SO, Sedor JR, Sakai T, Obara T. Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis. Biol Open. 2012 Jun 15; 1(6):588-96. PMID: 23213452; PMCID: PMC3509438.
    10. Kim S, Zaghloul NA, Bubenshchikova E, Oh EC, Rankin S, Katsanis N, Obara T, Tsiokas L. Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol. 2011 Apr; 13(4):351-60. PMID: 21394081; PMCID: PMC3077088.
    11. Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honoré E, Williamson MP, Obara T, Ong AC, Delmas P. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 07; 29(7):1176-91. PMID: 20168298; PMCID: PMC2857461.
    12. Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T, Ong AC. Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J Biol Chem. 2008 Oct 17; 283(42):28471-9. PMID: 18701462; PMCID: PMC2568912.
    13. Wessely O, Obara T. Fish and frogs: models for vertebrate cilia signaling. Front Biosci. 2008 Jan 01; 13:1866-80. PMID: 17981674; PMCID: PMC3709445.
    14. Pathak N, Obara T, Mangos S, Liu Y, Drummond IA. The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation. Mol Biol Cell. 2007 Nov; 18(11):4353-64. PMID: 17761526; PMCID: PMC2043541.
    15. Obara T, Mangos S, Liu Y, Zhao J, Wiessner S, Kramer-Zucker AG, Olale F, Schier AF, Drummond IA. Polycystin-2 immunolocalization and function in zebrafish. J Am Soc Nephrol. 2006 Oct; 17(10):2706-18. PMID: 16943304; PMCID: PMC3698611.
    16. Streets AJ, Moon DJ, Kane ME, Obara T, Ong AC. Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. Hum Mol Genet. 2006 May 01; 15(9):1465-73. PMID: 16551655; PMCID: PMC2424206.
    17. Low SH, Vasanth S, Larson CH, Mukherjee S, Sharma N, Kinter MT, Kane ME, Obara T, Weimbs T. Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease. Dev Cell. 2006 Jan; 10(1):57-69. PMID: 16399078.
      View in: PubMed
    18. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Krönig C, Schermer B, Benzing T, Cabello OA, Jenny A, Mlodzik M, Polok B, Driever W, Obara T, Walz G. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet. 2005 May; 37(5):537-43. PMID: 15852005; PMCID: PMC3733333.
    19. Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R. roundabout4 is essential for angiogenesis in vivo. Proc Natl Acad Sci U S A. 2005 May 03; 102(18):6373-8. PMID: 15849270; PMCID: PMC1088354.
    20. Otto EA, Schermer B, Obara T, O'Toole JF, Hiller KS, Mueller AM, Ruf RG, Hoefele J, Beekmann F, Landau D, Foreman JW, Goodship JA, Strachan T, Kispert A, Wolf MT, Gagnadoux MF, Nivet H, Antignac C, Walz G, Drummond IA, Benzing T, Hildebrandt F. Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet. 2003 Aug; 34(4):413-20. PMID: 12872123; PMCID: PMC3732175.
    21. Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development. 2002 Dec; 129(24):5839-46. PMID: 12421721.
      View in: PubMed
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