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Last Name

Umesh Deshmukh

TitleAssociate Member
InstitutionOklahoma Medical Research Foundation
DepartmentArthritis and Clinical Immunology
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    Collapse Research 
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    R01DE025030     (DESHMUKH, UMESH S)Dec 7, 2015 - Nov 30, 2020
    Innate immunity and autoantibodies in the pathogenesis of Sjogren's Syndrome
    Role: Principal Investigator

    R21DE022977     (DESHMUKH, UMESH S)Jul 10, 2012 - Jun 30, 2014
    Adenosine Receptors and Restoration of Salivary Gland in Sjogren's Syndrome
    Role: Principal Investigator

    R21DE019883     (DESHMUKH, UMESH S)May 1, 2010 - Apr 30, 2013
    Innate Immunity Activation In Pathogenesis of Sjogren's Syndrome
    Role: Principal Investigator

    R01AI079621     (FU, SHU MAN)Jul 16, 2009 - Jun 30, 2014
    T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Role: Co-Investigator

    K01AR051391     (DESHMUKH, UMESH S)Jul 20, 2004 - Mar 31, 2010
    Genetics of Autontibody Diversification
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Trzeciak M, Bagavant H, Papinska J, Deshmukh US. Immune Response Targeting Sjögren's Syndrome Antigen Ro52 Suppresses Tear Production in Female Mice. Int J Mol Sci. 2018 Sep 27; 19(10). PMID: 30261673.
      View in: PubMed
    2. Bagavant H, Dunkleberger ML, Wolska N, Sroka M, Rasmussen A, Adrianto I, Montgomery C, Sivils K, Guthridge JM, James JA, Merrill JT, Deshmukh US. Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients. Clin Exp Rheumatol. 2019 Jan-Feb; 37(1):106-111. PMID: 29998833.
      View in: PubMed
    3. Sroka M, Bagavant H, Biswas I, Ballard A, Deshmukh US. Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction. Clin Exp Rheumatol. 2018 May-Jun; 36 Suppl 112(3):41-46. PMID: 29465352.
      View in: PubMed
    4. Bagavant H, Trzeciak M, Papinska J, Biswas I, Dunkleberger ML, Sosnowska A, Deshmukh US. A Method for the Measurement of Salivary Gland Function in Mice. J Vis Exp. 2018 01 25; (131). PMID: 29443033.
      View in: PubMed
    5. Danda D, Sharma R, Truong D, Koelsch KA, Kurien BT, Bagavant H, Deshmukh U, Kaufman CE, Lewis DM, Stone DU, Radfar L, Rasmussen A, Sivils KL, Scofield RH. Anti-La positive, anti-Ro negative subset of primary Sjögren's syndrome: anti-La is a reality but is the disease? Clin Exp Rheumatol. 2017 May-Jun; 35(3):438-444. PMID: 28229827.
      View in: PubMed
    6. Wolska N, Rybakowska P, Rasmussen A, Brown M, Montgomery C, Klopocki A, Grundahl K, Scofield RH, Radfar L, Stone DU, Anaya JM, Ice JA, Lessard CJ, Lewis DM, Rhodus NL, Gopalakrishnan R, Huang AJ, Hughes PJ, Rohrer MD, Weisman MH, Venuturupalli S, Guthridge JM, James JA, Sivils KL, Bagavant H, Deshmukh US. Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity. Arthritis Rheumatol. 2016 Mar; 68(3):724-9. PMID: 26636433; PMCID: PMC4767665 [Available on 03/01/17].
    7. Szczerba BM, Kaplonek P, Wolska N, Podsiadlowska A, Rybakowska PD, Dey P, Rasmussen A, Grundahl K, Hefner KS, Stone DU, Young S, Lewis DM, Radfar L, Scofield RH, Sivils KL, Bagavant H, Deshmukh US. Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice. Ann Rheum Dis. 2016 Mar; 75(3):617-22. PMID: 25906316; PMCID: PMC4526450 [Available on 03/01/17].
    8. Maier-Moore JS, Koelsch KA, Smith K, Lessard CJ, Radfar L, Lewis D, Kurien BT, Wolska N, Deshmukh U, Rasmussen A, Sivils KL, James JA, Farris AD, Scofield RH. Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjögren's syndrome. Arthritis Rheumatol. 2014 Dec; 66(12):3445-56. PMID: 25199908; PMCID: PMC4245382.
    9. Nackiewicz D, Dey P, Szczerba B, Mohammad S, Kaplan JL, McNamara CA, Deshmukh US, Bagavant H. Inhibitor of differentiation 3, a transcription factor, regulates hyperlipidemia-associated kidney disease. Nephron Exp Nephrol. 2014; 126(3):141-7. PMID: 24854879; PMCID: PMC4113412.
    10. Szymula A, Rosenthal J, Szczerba BM, Bagavant H, Fu SM, Deshmukh US. T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria. Clin Immunol. 2014 May-Jun; 152(1-2):1-9. PMID: 24576620; PMCID: PMC4004658.
    11. Deshmukh US, Bagavant H. When killers become helpers. Sci Transl Med. 2013 Jul 24; 5(195):195fs29. PMID: 23884464; PMCID: PMC3955842.
    12. Scindia Y, Nackiewicz D, Dey P, Szymula A, Bajwa A, Rosin DL, Bolton WK, Okusa MD, Deshmukh U, Bagavant H. Activated CD4+ T cells target mesangial antigens and initiate glomerulonephritis. Nephron Exp Nephrol. 2012; 121(1-2):e1-9. PMID: 23095207; PMCID: PMC3606022.
    13. Nandula SR, Dey P, Corbin KL, Nunemaker CS, Bagavant H, Deshmukh US. Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling. J Oral Pathol Med. 2013 Jan; 42(1):66-72. PMID: 22672212.
      View in: PubMed
    14. Bagavant H, Scindia Y, Nackiewicz D, Nandula SR, Doran A, Cutchins A, Oldham S, Deshmukh U, McNamara C. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease. Am J Pathol. 2011 Aug; 179(2):651-60. PMID: 21801865.
      View in: PubMed
    15. Bagavant H, Kalantarinia K, Scindia Y, Deshmukh U. Novel therapeutic approaches to lupus glomerulonephritis: translating animal models to clinical practice. Am J Kidney Dis. 2011 Mar; 57(3):498-507. PMID: 21239097; PMCID: PMC3042497.
    16. Scindia YM, Deshmukh US, Bagavant H. Mesangial pathology in glomerular disease: targets for therapeutic intervention. Adv Drug Deliv Rev. 2010 Nov 30; 62(14):1337-43. PMID: 20828589; PMCID: PMC2992591.
    17. Jiang C, Deshmukh US, Gaskin F, Bagavant H, Hanson J, David CS, Fu SM. Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens. J Immunol. 2010 Jan 15; 184(2):1085-91. PMID: 20007529; PMCID: PMC2842881.
    18. Sim DL, Bagavant H, Scindia YM, Ge Y, Gaskin F, Fu SM, Deshmukh US. Genetic complementation results in augmented autoantibody responses to lupus-associated antigens. J Immunol. 2009 Sep 01; 183(5):3505-11. PMID: 19667095.
      View in: PubMed
    19. Deshmukh US, Nandula SR, Thimmalapura PR, Scindia YM, Bagavant H. Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function. J Oral Pathol Med. 2009 Jan; 38(1):42-7. PMID: 19192049; PMCID: PMC2763314.
    20. Scindia Y, Deshmukh U, Thimmalapura PR, Bagavant H. Anti-alpha8 integrin immunoliposomes in glomeruli of lupus-susceptible mice: a novel system for delivery of therapeutic agents to the renal glomerulus in systemic lupus erythematosus. Arthritis Rheum. 2008 Dec; 58(12):3884-91. PMID: 19035491; PMCID: PMC2678908.
    21. Deshmukh US, Ohyama Y, Bagavant H, Guo X, Gaskin F, Fu SM. Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 mice. Arthritis Rheum. 2008 May; 58(5):1318-23. PMID: 18438852; PMCID: PMC2721328.
    22. Deshmukh US, Bagavant H, Sim D, Pidiyar V, Fu SM. A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading. J Immunol. 2007 Feb 15; 178(4):2565-71. PMID: 17277166.
      View in: PubMed
    23. Bagavant H, Deshmukh US, Wang H, Ly T, Fu SM. Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes. J Immunol. 2006 Dec 01; 177(11):8258-65. PMID: 17114504.
      View in: PubMed
    24. Deshmukh US, Bagavant H, Fu SM. Role of anti-DNA antibodies in the pathogenesis of lupus nephritis. Autoimmun Rev. 2006 Jul; 5(6):414-8. PMID: 16890896.
      View in: PubMed
    25. Deshmukh US, Bagavant H, Lewis J, Gaskin F, Fu SM. Epitope spreading within lupus-associated ribonucleoprotein antigens. Clin Immunol. 2005 Nov; 117(2):112-20. PMID: 16095971.
      View in: PubMed
    26. Waters ST, McDuffie M, Bagavant H, Deshmukh US, Gaskin F, Jiang C, Tung KS, Fu SM. Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J Exp Med. 2004 Jan 19; 199(2):255-64. PMID: 14718514.
      View in: PubMed
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