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Vibhudutta Awasthi

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
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    Collapse Biography 
    Collapse education and training
    Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, IndiaPhD1994Nuclear Medicine/Radiopharmacy
    University of Sagar, Madhya Pradesh, INDIAMPharm1990Pharmaceutics
    University of TX Health Sciences Center, San Antonio, TXPostdoc1997Radiology
    University of TX Health Science Center, San Antonio, TXPostdoc2000Physiology
    Brookhaven National Laboratory, Long Island, NYPostdoc2001Radiopharmaceuticals

    Collapse Research 
    Collapse research activities and funding
    R41HL140919     (AWASTHI, VIBHUDUTTA)Aug 20, 2018 - Jul 31, 2019
    PET Imaging Agent for Myocardial Infarction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rao G, Nkepang G, Xu J, Yari H, Houson H, Teng C, Awasthi V. Ubiquitin Receptor RPN13 Mediates the Inhibitory Interaction of Diphenyldihaloketones CLEFMA and EF24 With the 26S Proteasome. Front Chem. 2018; 6:392. PMID: 30280096.
      View in: PubMed
    2. Rao G, Houson H, Nkepang G, Yari H, Teng C, Awasthi V. Induction of gut proteasome activity in hemorrhagic shock and its recovery by treatment with diphenyldihaloketones CLEFMA and EF24. Am J Physiol Gastrointest Liver Physiol. 2018 Aug 01; 315(2):G318-G327. PMID: 29746173.
      View in: PubMed
    3. Houson HA, Nkepang GN, Hedrick AF, Awasthi V. Imaging of isoproterenol-induced myocardial injury with 18F labeled fluoroglucaric acid in a rat model. Nucl Med Biol. 2018 04; 59:9-15. PMID: 29413753.
      View in: PubMed
    4. Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP. Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol. 2018 02; 55(2):1795-1813. PMID: 29168048.
      View in: PubMed
    5. Awwad HO, Durand CD, Gonzalez LP, Tompkins P, Zhang Y, Lerner MR, Brackett DJ, Sherry DM, Awasthi V, Standifer KM. Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions. Behav Brain Res. 2018 03 15; 340:183-194. PMID: 27793733.
      View in: PubMed
    6. Yadav VR, Rao G, Houson H, Hedrick A, Awasthi S, Roberts PR, Awasthi V. Nanovesicular liposome-encapsulated hemoglobin (LEH) prevents multi-organ injuries in a rat model of hemorrhagic shock. Eur J Pharm Sci. 2016 Oct 10; 93:97-106. PMID: 27503458; PMCID: PMC5035221 [Available on 10/10/17].
    7. Pathuri G, Hedrick AF, Awasthi V, Cowley BD, Gali H. Synthesis and in vivo evaluation of ortho-[(124)I]iodohippurate for PET renography in healthy rats. Appl Radiat Isot. 2016 Sep; 115:251-255. PMID: 27434486.
      View in: PubMed
    8. Rao G, Yadav VR, Awasthi S, Roberts PR, Awasthi V. Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G180-91. PMID: 27288424.
      View in: PubMed
    9. Nkepang GN, Hedrick AF, Awasthi V, Gali H. Facile synthesis of para-[(18)F]fluorohippurate via iodonium ylide-mediated radiofluorination for PET renography. Bioorg Med Chem Lett. 2016 Jan 15; 26(2):479-483. PMID: 26675438.
      View in: PubMed
    10. Pathuri G, Hedrick AF, Awasthi V, Cowley BD, Gali H. Evaluation of [¹8F]PFH PET renography to predict future disease progression in a rat model of autosomal dominant polycystic kidney disease. Nucl Med Biol. 2016 Jan; 43(1):1-5. PMID: 26702780.
      View in: PubMed
    11. Vilekar P, Rao G, Awasthi S, Awasthi V. Diphenyldifluoroketone EF24 Suppresses Pro-inflammatory Interleukin-1 receptor 1 and Toll-like Receptor 4 in lipopolysaccharide-stimulated dendritic cells. J Inflamm (Lond). 2015; 12:55. PMID: 26401121; PMCID: PMC4580149.
    12. Rao G, Croft B, Teng C, Awasthi V. Ubiquitin-Proteasome System in Neurodegenerative Disorders. J Drug Metab Toxicol. 2015; 6(4). PMID: 30761219.
      View in: PubMed
    13. Rao G, Xie J, Hedrick A, Awasthi V. Hemorrhagic shock-induced cerebral bioenergetic imbalance is corrected by pharmacologic treatment with EF24 in a rat model. Neuropharmacology. 2015 Dec; 99:318-27. PMID: 26232641; PMCID: PMC4655172 [Available on 12/01/16].
    14. Awwad HO, Gonzalez LP, Tompkins P, Lerner M, Brackett DJ, Awasthi V, Standifer KM. Blast Overpressure Waves Induce Transient Anxiety and Regional Changes in Cerebral Glucose Metabolism and Delayed Hyperarousal in Rats. Front Neurol. 2015; 6:132. PMID: 26136722; PMCID: PMC4470265.
    15. Rao G, Hedrick AF, Yadav VR, Xie J, Hussain A, Awasthi V. The brain metabolic activity after resuscitation with liposome-encapsulated hemoglobin in a rat model of hypovolemic shock. J Cereb Blood Flow Metab. 2015 Sep; 35(9):1528-36. PMID: 25944591; PMCID: PMC4640343.
    16. Yadav VR, Hussain A, Xie J, Kosanke S, Awasthi V. The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model. Scand J Trauma Resusc Emerg Med. 2015 Feb 03; 23:8. PMID: 25645333; PMCID: PMC4324433.
    17. Jackson KW, Christiansen VJ, Yadav VR, Silasi-Mansat R, Lupu F, Awasthi V, Zhang RR, McKee PA. Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase. Neoplasia. 2015 Jan; 17(1):43-54. PMID: 25622898; PMCID: PMC4309729.
    18. Pathuri G, Hedrick AF, January SE, Galbraith WK, Awasthi V, Arnold CD, Cowley BD, Gali H. Synthesis and in vivo evaluation of gallium-68-labeled glycine and hippurate conjugates for positron emission tomography renography. J Labelled Comp Radiopharm. 2015 Jan; 58(1):14-9. PMID: 25545452.
      View in: PubMed
    19. Nag OK, Yadav VR, Croft B, Hedrick A, Awasthi V. Liposomes modified with superhydrophilic polymer linked to a nonphospholipid anchor exhibit reduced complement activation and enhanced circulation. J Pharm Sci. 2015 Jan; 104(1):114-23. PMID: 25393628.
      View in: PubMed
    20. Yadav VR, Hussain A, Sahoo K, Awasthi V. Remediation of hemorrhagic shock-induced intestinal barrier dysfunction by treatment with diphenyldihaloketones EF24 and CLEFMA. J Pharmacol Exp Ther. 2014 Nov; 351(2):413-22. PMID: 25204337; PMCID: PMC4201268.
    21. Pathuri G, Madka V, Hedrick AF, Lightfoot SA, Awasthi V, Cowley BD, Rao CV, Gali H. Evaluation of (99m)Tc-probestin SPECT as a novel technique for noninvasive imaging of kidney aminopeptidase N expression. Mol Pharm. 2014 Aug 04; 11(8):2948-53. PMID: 24988047; PMCID: PMC4144757.
    22. Yadav VR, Nag O, Awasthi V. Biological evaluation of liposome-encapsulated hemoglobin surface-modified with a novel PEGylated nonphospholipid amphiphile. Artif Organs. 2014 Aug; 38(8):625-33. PMID: 24749870; PMCID: PMC4146621.
    23. Yadav VR, Vilekar P, Awasthi S, Awasthi V. Hemorrhage-induced interleukin-1 receptor pathway in lung is suppressed by 3,5-bis(2-fluorobenzylidene)-4-piperidone in a rat model of hypovolemic shock. Artif Organs. 2014 Aug; 38(8):675-83. PMID: 24749913; PMCID: PMC4146623.
    24. Yadav VR, Sahoo K, Awasthi V. Preclinical evaluation of 4-[3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl]-4-oxo-2-butenoic acid, in a mouse model of lung cancer xenograft. Br J Pharmacol. 2013 Dec; 170(7):1436-48. PMID: 24102070; PMCID: PMC3838689.
    25. Yadav VR, Sahoo K, Roberts PR, Awasthi V. Pharmacologic suppression of inflammation by a diphenyldifluoroketone, EF24, in a rat model of fixed-volume hemorrhage improves survival. J Pharmacol Exp Ther. 2013 Nov; 347(2):346-56. PMID: 23995597; PMCID: PMC3807066.
    26. Aravindan S, Natarajan M, Awasthi V, Herman TS, Aravindan N. Novel synthetic monoketone transmute radiation-triggered NF?B-dependent TNFa cross-signaling feedback maintained NF?B and favors neuroblastoma regression. PLoS One. 2013; 8(8):e72464. PMID: 23967300.
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    27. Pathuri G, Hedrick AF, Awasthi V, Ihnat MA, Gali H. Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT. Bioorg Med Chem Lett. 2013 Sep 15; 23(18):5049-52. PMID: 23937983.
      View in: PubMed
    28. Aravindan S, Natarajan M, Herman TS, Awasthi V, Aravindan N. Molecular basis of 'hypoxic' breast cancer cell radio-sensitization: phytochemicals converge on radiation induced Rel signaling. Radiat Oncol. 2013 Mar 04; 8:46. PMID: 23452621; PMCID: PMC3599951.
    29. Nag OK, Yadav VR, Hedrick A, Awasthi V. Post-modification of preformed liposomes with novel non-phospholipid poly(ethylene glycol)-conjugated hexadecylcarbamoylmethyl hexadecanoic acid for enhanced circulation persistence in vivo. Int J Pharm. 2013 Mar 25; 446(1-2):119-29. PMID: 23419666; PMCID: PMC3635076.
    30. Awasthi V, Yadav VR, Goins B, Phillips WT. Modulation of oxidative stability of haemoglobin inside liposome-encapsulated haemoglobin. J Microencapsul. 2013; 30(5):471-8. PMID: 23231644; PMCID: PMC3696053.
    31. Pathuri G, Hedrick AF, Awasthi V, Gali H. Single-step radiosynthesis and in vivo evaluation of a novel fluorine-18 labeled hippurate for use as a PET renal agent. Nucl Med Biol. 2012 Nov; 39(8):1195-201. PMID: 22898317.
      View in: PubMed
    32. Pathuri G, Hedrick AF, Disch BC, Ihnat MA, Awasthi V, Gali H. Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates. Bioorg Med Chem Lett. 2012 Jul 15; 22(14):4567-70. PMID: 22727671.
      View in: PubMed
    33. Vilekar P, Awasthi S, Natarajan A, Anant S, Awasthi V. EF24 suppresses maturation and inflammatory response in dendritic cells. Int Immunol. 2012 Jul; 24(7):455-64. PMID: 22378503; PMCID: PMC3385421.
    34. Pathuri G, Hedrick AF, Disch BC, Doan JT, Ihnat MA, Awasthi V, Gali H. Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo. Bioconjug Chem. 2012 Jan 18; 23(1):115-24. PMID: 22148582.
      View in: PubMed
    35. Veeraraghavan J, Natarajan M, Lagisetty P, Awasthi V, Herman TS, Aravindan N. Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells. Pancreas. 2011 Oct; 40(7):1107-19. PMID: 21697760.
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    36. Pathuri G, Sahoo K, Awasthi V, Gali H. Renogram comparison of p-[(18)F]fluorohippurate with o-[(125)I]iodohippurate and [(99m)Tc]MAG3 in normal rats. Nucl Med Commun. 2011 Oct; 32(10):908-12. PMID: 21876402.
      View in: PubMed
    37. Veeraraghavan J, Aravindan S, Natarajan M, Awasthi V, Herman TS, Aravindan N. Neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway. Anticancer Res. 2011 Jan; 31(1):161-70. PMID: 21273594.
      View in: PubMed
    38. Sahoo K, Dozmorov MG, Anant S, Awasthi V. The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress. Invest New Drugs. 2012 Apr; 30(2):558-67. PMID: 21181232; PMCID: PMC3110543.
    39. Awasthi S, Brown K, King C, Awasthi V, Bondugula R. A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-a release from mouse JAWS II dendritic cells. J Pharmacol Exp Ther. 2011 Mar; 336(3):672-81. PMID: 21159752; PMCID: PMC3061537.
    40. Awasthi V, Pathuri G, Agashe HB, Gali H. Synthesis and in vivo evaluation of p-18F-Fluorohippurate as a new radiopharmaceutical for assessment of renal function by PET. J Nucl Med. 2011 Jan; 52(1):147-53. PMID: 21149490.
      View in: PubMed
    41. Vilekar P, Awasthi V, Lagisetty P, King C, Shankar N, Awasthi S. In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine. BMC Immunol. 2010 Dec 10; 11:60. PMID: 21143974; PMCID: PMC3018378.
    42. Pathuri G, Sahoo K, Awasthi V, Gali H. Synthesis and in vivo evaluation of Tc-99m-labeled cyclic CisoDGRC peptide conjugates for targeting avß3 integrin expression. Bioorg Med Chem Lett. 2010 Oct 15; 20(20):5969-72. PMID: 20829039.
      View in: PubMed
    43. Lagisetty P, Vilekar P, Sahoo K, Anant S, Awasthi V. CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones. Bioorg Med Chem. 2010 Aug 15; 18(16):6109-20. PMID: 20638855; PMCID: PMC2945829.
    44. Awasthi V, Agashe H, Doblas S, Towner R. Magnetic resonance spectroscopy for evaluation of liposome-encapsulated hemoglobin as a resuscitation fluid. Artif Cells Blood Substit Immobil Biotechnol. 2010 Apr; 38(2):69-78. PMID: 20196685; PMCID: PMC3794435.
    45. Awasthi V, Holter J, Thorp K, Anderson S, Epstein R. F-18-fluorothymidine-PET evaluation of bone marrow transplant in a rat model. Nucl Med Commun. 2010 Feb; 31(2):152-8. PMID: 19966596.
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    46. Madhusoodhanan R, Natarajan M, Singh JV, Jamgade A, Awasthi V, Anant S, Herman TS, Aravindan N. Effect of black raspberry extract in inhibiting NFkappa B dependent radioprotection in human breast cancer cells. Nutr Cancer. 2010; 62(1):93-104. PMID: 20043264.
      View in: PubMed
    47. Agashe H, Lagisetty P, Awasthi S, Awasthi V. Improved formulation of liposome-encapsulated hemoglobin with an anionic non-phospholipid. Colloids Surf B Biointerfaces. 2010 Feb 01; 75(2):573-83. PMID: 19896346; PMCID: PMC2821743.
    48. Lagisetty P, Vilekar P, Awasthi V. Synthesis of radiolabeled cytarabine conjugates. Bioorg Med Chem Lett. 2009 Aug 15; 19(16):4764-7. PMID: 19574048.
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    49. Awasthi V, Yee SH, Jerabek P, Goins B, Phillips WT. Cerebral oxygen delivery by liposome-encapsulated hemoglobin: a positron-emission tomographic evaluation in a rat model of hemorrhagic shock. J Appl Physiol (1985). 2007 Jul; 103(1):28-38. PMID: 17615284.
      View in: PubMed
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