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Xin Zhang

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPhysiology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-8001
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    Collapse Biography 
    Collapse education and training
    Huazhong University of Science & Technology, CHINAMS1988Medicine
    University of Geneva, SwitzerlandPhD1992Medicine

    Collapse Research 
    Collapse research activities and funding
    R01HL137819     (ZHANG, XIN A)Sep 1, 2017 - Aug 31, 2021
    NIH/NHLBI
    How Tetraspanins Regulate Vascular Morphogenesis
    Role: Principal Investigator

    R01HL132553     (ZHANG, XIN A)Dec 15, 2016 - Jan 31, 2021
    NIH/NHLBI
    Tetraspanin-enriched microdomains and endothelial barrier function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Tarantini S, Valcarcel-Ares MN, Yabluchanskiy A, Tucsek Z, Hertelendy P, Kiss T, Gautam T, Zhang XA, Sonntag WE, de Cabo R, Farkas E, Elliott MH, Kinter MT, Deak F, Ungvari Z, Csiszar A. Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. J Gerontol A Biol Sci Med Sci. 2018 Jun 14; 73(7):853-863. PMID: 29905772.
      View in: PubMed
    2. Huang C, Fu C, Wren JD, Wang X, Zhang F, Zhang YH, Connel SA, Chen T, Zhang XA. Tetraspanin-enriched microdomains regulate digitation junctions. Cell Mol Life Sci. 2018 Sep; 75(18):3423-3439. PMID: 29589089.
      View in: PubMed
    3. Zhao Y, Yan M, Chen C, Gong W, Yin Z, Li H, Fan J, Zhang XA, Wang DW, Zuo H. MiR-124 aggravates failing hearts by suppressing CD151-facilitated angiogenesis in heart. Oncotarget. 2018 Mar 06; 9(18):14382-14396. PMID: 29581851.
      View in: PubMed
    4. Zhang J, Wu T, Zhan S, Qiao N, Zhang X, Zhu Y, Yang N, Sun Y, Zhang XA, Bleich D, Han X. TIMP-1 and CD82, a promising combined evaluation marker for PDAC. Oncotarget. 2017 Jan 24; 8(4):6496-6512. PMID: 28030805.
      View in: PubMed
    5. Dai Y, Prithiviraj N, Gan J, Zhang XA, Yan J. Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Sci Rep. 2016 12 15; 6:38693. PMID: 27974833.
      View in: PubMed
    6. Si X, Liu Y, Lv J, Ding H, Zhang XA, Shao L, Yang N, Cheng H, Sun L, Zhu D, Yang Y, Li A, Han X, Sun Y. ERa propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells. Oncotarget. 2016 Apr 12; 7(15):20966-80. PMID: 26980709; PMCID: PMC4991505.
    7. Feng J, Huang C, Wren JD, Wang DW, Yan J, Zhang J, Sun Y, Han X, Zhang XA. Tetraspanin CD82: a suppressor of solid tumors and a modulator of membrane heterogeneity. Cancer Metastasis Rev. 2015 Dec; 34(4):619-33. PMID: 26335499.
      View in: PubMed
    8. Yang Y, Wang Z, Sun L, Shao L, Yang N, Yu D, Zhang X, Han X, Sun Y. SATB1 Mediates Long-Range Chromatin Interactions: A Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes. PLoS One. 2015; 10(9):e0139170. PMID: 26422397; PMCID: PMC4589335.
    9. Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents. Bioorg Med Chem. 2015 May 15; 23(10):2408-23. PMID: 25882519; PMCID: PMC4410085.
    10. Zhang H, Wang X, Lyu K, Gao S, Wang G, Fan C, Zhang XA, Yan J. Time point-based integrative analyses of deep-transcriptome identify four signal pathways in blastemal regeneration of zebrafish lower jaw. Stem Cells. 2015 Mar; 33(3):806-18. PMID: 25420467.
      View in: PubMed
    11. Huang C, Dai J, Zhang XA. Environmental physical cues determine the lineage specification of mesenchymal stem cells. Biochim Biophys Acta. 2015 Jun; 1850(6):1261-6. PMID: 25727396; PMCID: PMC4411082.
    12. Wei Q, Zhang F, Richardson MM, Roy NH, Rodgers W, Liu Y, Zhao W, Fu C, Ding Y, Huang C, Chen Y, Sun Y, Ding L, Hu Y, Ma JX, Boulton ME, Pasula S, Wren JD, Tanaka S, Huang X, Thali M, Hämmerling GJ, Zhang XA. CD82 restrains pathological angiogenesis by altering lipid raft clustering and CD44 trafficking in endothelial cells. Circulation. 2014 Oct 21; 130(17):1493-504. PMID: 25149363; PMCID: PMC4411083.
    13. Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents. Bioorg Med Chem. 2014 Jul 15; 22(14):3753-72. PMID: 24890652.
      View in: PubMed
    14. Sun D, Zhang Y, Wang C, Hua X, Zhang XA, Yan J. Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell Death Dis. 2013 Nov 21; 4:e930. PMID: 24263104; PMCID: PMC3847332.
    15. Scheffer KD, Gawlitza A, Spoden GA, Zhang XA, Lambert C, Berditchevski F, Florin L. Tetraspanin CD151 mediates papillomavirus type 16 endocytosis. J Virol. 2013 Mar; 87(6):3435-46. PMID: 23302890; PMCID: PMC3592167.
    16. Peng D, Zuo H, Liu Z, Qin J, Zhou Y, Li P, Wang D, Zeng H, Zhang XA. The tetraspanin CD151-ARSA mutant inhibits angiogenesis via the YRSL sequence. Mol Med Rep. 2013 Mar; 7(3):836-42. PMID: 23292489; PMCID: PMC3981038.
    17. Liu WM, Zhang F, Moshiach S, Zhou B, Huang C, Srinivasan K, Khurana S, Zheng Y, Lahti JM, Zhang XA. Tetraspanin CD82 inhibits protrusion and retraction in cell movement by attenuating the plasma membrane-dependent actin organization. PLoS One. 2012; 7(12):e51797. PMID: 23251627; PMCID: PMC3522597.
    18. Wang X, He H, Tang W, Zhang XA, Hua X, Yan J. Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw. PLoS One. 2012; 7(9):e45380. PMID: 23028974; PMCID: PMC3448660.
    19. Guo Q, Xia B, Zhang F, Richardson MM, Li M, Zhang JS, Chen F, Zhang XA. Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesions. PLoS One. 2012; 7(6):e38464. PMID: 22679508; PMCID: PMC3367972.
    20. Bari R, Guo Q, Xia B, Zhang YH, Giesert EE, Levy S, Zheng JJ, Zhang XA. Tetraspanins regulate the protrusive activities of cell membrane. Biochem Biophys Res Commun. 2011 Dec 02; 415(4):619-26. PMID: 22079629; PMCID: PMC3245733.
    21. Zhang F, Michaelson JE, Moshiach S, Sachs N, Zhao W, Sun Y, Sonnenberg A, Lahti JM, Huang H, Zhang XA. Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension. Blood. 2011 Oct 13; 118(15):4274-84. PMID: 21832275; PMCID: PMC3204742.
    22. Montpellier C, Tews BA, Poitrimole J, Rocha-Perugini V, D'Arienzo V, Potel J, Zhang XA, Rubinstein E, Dubuisson J, Cocquerel L. Interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection. J Biol Chem. 2011 Apr 22; 286(16):13954-65. PMID: 21343309; PMCID: PMC3077596.
    23. Wei Q, Huang XL, Lin JY, Fei YJ, Liu ZX, Zhang XA. Adeno associated viral vector-delivered and hypoxia response element-regulated CD151 expression in ischemic rat heart. Acta Pharmacol Sin. 2011 Feb; 32(2):201-8. PMID: 21240296; PMCID: PMC4009936.
    24. Yang J, Zhang Z, Zhang XA, Luo Q. A ligation-independent cloning method using nicking DNA endonuclease. Biotechniques. 2010 Nov; 49(5):817-21. PMID: 21091446.
      View in: PubMed
    25. Zhang X, Fan G. Dual gait generative models for human motion estimation from a single camera. IEEE Trans Syst Man Cybern B Cybern. 2010 Aug; 40(4):1034-49. PMID: 20409996.
      View in: PubMed
    26. Zuo H, Liu Z, Liu X, Yang J, Liu T, Wen S, Zhang XA, Cianflone K, Wang D. CD151 gene delivery after myocardial infarction promotes functional neovascularization and activates FAK signaling. Mol Med. 2009 Sep-Oct; 15(9-10):307-15. PMID: 19603100.
      View in: PubMed
    27. Kim S, Gaber MW, Zawaski JA, Zhang F, Richardson M, Zhang XA, Yang Y. The inhibition of glioma growth in vitro and in vivo by a chitosan/ellagic acid composite biomaterial. Biomaterials. 2009 Sep; 30(27):4743-51. PMID: 19501395.
      View in: PubMed
    28. Xu C, Zhang YH, Thangavel M, Richardson MM, Liu L, Zhou B, Zheng Y, Ostrom RS, Zhang XA. CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts. FASEB J. 2009 Oct; 23(10):3273-88. PMID: 19497983; PMCID: PMC2747672.
    29. Grandy D, Shan J, Zhang X, Rao S, Akunuru S, Li H, Zhang Y, Alpatov I, Zhang XA, Lang RA, Shi DL, Zheng JJ. Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem. 2009 Jun 12; 284(24):16256-63. PMID: 19383605; PMCID: PMC2713547.
    30. Bari R, Zhang YH, Zhang F, Wang NX, Stipp CS, Zheng JJ, Zhang XA. Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis. Am J Pathol. 2009 Feb; 174(2):647-60. PMID: 19116362; PMCID: PMC2630572.
    31. Zuo HJ, Liu ZX, Liu XC, Yang J, Liu T, Wen S, Wang DW, Zhang X. Assessment of myocardial blood perfusion improved by CD151 in a pig myocardial infarction model. Acta Pharmacol Sin. 2009 Jan; 30(1):70-7. PMID: 19079294; PMCID: PMC4006534.
    32. Guo Q, Xia B, Moshiach S, Xu C, Jiang Y, Chen Y, Sun Y, Lahti JM, Zhang XA. The microenvironmental determinants for kidney epithelial cyst morphogenesis. Eur J Cell Biol. 2008 Apr; 87(4):251-66. PMID: 18191498; PMCID: PMC4141498.
    33. Liu L, He B, Liu WM, Zhou D, Cox JV, Zhang XA. Tetraspanin CD151 promotes cell migration by regulating integrin trafficking. J Biol Chem. 2007 Oct 26; 282(43):31631-42. PMID: 17716972.
      View in: PubMed
    34. Jiang JG, Ning YG, Chen C, Ma D, Liu ZJ, Yang S, Zhou J, Xiao X, Zhang XA, Edin ML, Card JW, Wang J, Zeldin DC, Wang DW. Cytochrome p450 epoxygenase promotes human cancer metastasis. Cancer Res. 2007 Jul 15; 67(14):6665-74. PMID: 17638876.
      View in: PubMed
    35. Yuan G, Deng J, Wang T, Zhao C, Xu X, Wang P, Voltz JW, Edin ML, Xiao X, Chao L, Chao J, Zhang XA, Zeldin DC, Wang DW. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5'-monophosphate-activated protein kinase signaling pathways. Endocrinology. 2007 May; 148(5):2016-26. PMID: 17272402.
      View in: PubMed
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