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Xi-Qin Ding

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
Address940 Stanton L Young Blvd
Oklahoma City OK 73104-5020
Phone405/271-8001
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    Collapse Research 
    Collapse research activities and funding
    R21EY017031     (DING, XI-QIN)Aug 1, 2006 - Jul 31, 2009
    NIH/NEI
    Using Nanotechnology to Rescue Visual Loss in A Model of Human Blinding Disorder
    Role: Principal Investigator

    R01EY019490     (DING, XI-QIN)Aug 1, 2010 - Jun 30, 2015
    NIH/NEI
    Mechanism of Cone Degeneration Resulting from CNG Channel Deficiency
    Role: Principal Investigator

    R21EY024583     (DING, XI-QIN)Sep 30, 2014 - Sep 29, 2016
    NIH/NEI
    Suppressing thyroid hormone signaling to protect cones in retinal degeneration
    Role: Principal Investigator

    R01EY027754     (DING, XI-QIN)Sep 1, 2017 - Jun 30, 2021
    NIH/NEI
    The Role of Endoplasmic Reticulum Calcium Channels in Cone Degeneration Resulting from CNG Channel Deficiency
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ma H, Yang F, Butler MR, Belcher J, Redmond TM, Placzek AT, Scanlan TS, Ding XQ. Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration. FASEB J. 2017 Aug; 31(8):3425-3438. PMID: 28428265.
      View in: PubMed
    2. Yang F, Ma H, Belcher J, Butler MR, Redmond TM, Boye SL, Hauswirth WW, Ding XQ. Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration. FASEB J. 2016 Dec; 30(12):4313-4325. PMID: 27623928.
      View in: PubMed
    3. Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ. The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem. 2016 Apr 15; 291(16):8721-34. PMID: 26893377; PMCID: PMC4861441 [Available on 04/15/17].
    4. Ma H, Ding XQ. Thyroid Hormone Signaling and Cone Photoreceptor Viability. Adv Exp Med Biol. 2016; 854:613-8. PMID: 26427466.
      View in: PubMed
    5. Boye SL, Peterson JJ, Choudhury S, Min SH, Ruan Q, McCullough KT, Zhang Z, Olshevskaya EV, Peshenko IV, Hauswirth WW, Ding XQ, Dizhoor AM, Boye SE. Gene Therapy Fully Restores Vision to the All-Cone Nrl(-/-) Gucy2e(-/-) Mouse Model of Leber Congenital Amaurosis-1. Hum Gene Ther. 2015 Sep; 26(9):575-92. PMID: 26247368; PMCID: PMC4575531.
    6. Ma H, Butler MR, Thapa A, Belcher J, Yang F, Baehr W, Biel M, Michalakis S, Ding XQ. cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice. J Biol Chem. 2015 Aug 21; 290(34):20880-92. PMID: 26124274; PMCID: PMC4543649.
    7. Du W, Tao Y, Deng WT, Zhu P, Li J, Dai X, Zhang Y, Shi W, Liu X, Chiodo VA, Ding XQ, Zhao C, Michalakis S, Biel M, Zhang Z, Qu J, Hauswirth WW, Pang JJ. Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia. Hum Mol Genet. 2015 Jul 01; 24(13):3699-707. PMID: 25855802; PMCID: PMC4459390.
    8. Ma H, Thapa A, Morris L, Redmond TM, Baehr W, Ding XQ. Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration. Proc Natl Acad Sci U S A. 2014 Mar 04; 111(9):3602-7. PMID: 24550448; PMCID: PMC3948228.
    9. Ding XQ, Matveev A, Singh A, Komori N, Matsumoto H. Exploration of cone cyclic nucleotide-gated channel-interacting proteins using affinity purification and mass spectrometry. Adv Exp Med Biol. 2014; 801:57-65. PMID: 24664681.
      View in: PubMed
    10. Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ. cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. J Neurosci. 2013 Sep 11; 33(37):14939-48. PMID: 24027293; PMCID: PMC3771030.
    11. Ma H, Thapa A, Morris LM, Michalakis S, Biel M, Frank MB, Bebak M, Ding XQ. Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study. Hum Mol Genet. 2013 Oct 01; 22(19):3906-19. PMID: 23740940; PMCID: PMC3766184.
    12. Nikonov SS, Lyubarsky A, Fina ME, Nikonova ES, Sengupta A, Chinniah C, Ding XQ, Smith RG, Pugh EN, Vardi N, Dhingra A. Cones respond to light in the absence of transducin ß subunit. J Neurosci. 2013 Mar 20; 33(12):5182-94. PMID: 23516284; PMCID: PMC3866503.
    13. Michalakis S, Xu J, Biel M, Ding XQ. Detection of cGMP in the degenerating retina. Methods Mol Biol. 2013; 1020:235-45. PMID: 23709038.
      View in: PubMed
    14. Thapa A, Morris L, Xu J, Ma H, Michalakis S, Biel M, Ding XQ. Endoplasmic reticulum stress-associated cone photoreceptor degeneration in cyclic nucleotide-gated channel deficiency. J Biol Chem. 2012 May 25; 287(22):18018-29. PMID: 22493484; PMCID: PMC3365688.
    15. Xu J, Morris LM, Michalakis S, Biel M, Fliesler SJ, Sherry DM, Ding XQ. CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration. Invest Ophthalmol Vis Sci. 2012 Mar 01; 53(3):1117-29. PMID: 22247469; PMCID: PMC3339899.
    16. Chakraborty D, Conley SM, Nash Z, Ding XQ, Naash MI. Overexpression of ROM-1 in the cone-dominant retina. Adv Exp Med Biol. 2012; 723:633-9. PMID: 22183387.
      View in: PubMed
    17. Ding XQ, Matveev A, Singh A, Komori N, Matsumoto H. Biochemical characterization of cone cyclic nucleotide-gated (CNG) channel using the infrared fluorescence detection system. Adv Exp Med Biol. 2012; 723:769-75. PMID: 22183405; PMCID: PMC3370941.
    18. Xu J, Morris L, Fliesler SJ, Sherry DM, Ding XQ. Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3557-66. PMID: 21273547; PMCID: PMC3109041.
    19. Carvalho LS, Xu J, Pearson RA, Smith AJ, Bainbridge JW, Morris LM, Fliesler SJ, Ding XQ, Ali RR. Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy. Hum Mol Genet. 2011 Aug 15; 20(16):3161-75. PMID: 21576125; PMCID: PMC3140821.
    20. Matveev AV, Fitzgerald JB, Xu J, Malykhina AP, Rodgers KK, Ding XQ. The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry. 2010 Mar 02; 49(8):1628-39. PMID: 20088482; PMCID: PMC2829136.
    21. Conley SM, Ding XQ, Naash MI. RDS in cones does not interact with the beta subunit of the cyclic nucleotide gated channel. Adv Exp Med Biol. 2010; 664:63-70. PMID: 20238003; PMCID: PMC3161508.
    22. Ding XQ, Fitzgerald JB, Quiambao AB, Harry CS, Malykhina AP. Molecular pathogenesis of achromatopsia associated with mutations in the cone cyclic nucleotide-gated channel CNGA3 subunit. Adv Exp Med Biol. 2010; 664:245-53. PMID: 20238023; PMCID: PMC3370940.
    23. Ding XQ, Quiambao AB, Fitzgerald JB, Cooper MJ, Conley SM, Naash MI. Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina. PLoS One. 2009 Oct 12; 4(10):e7410. PMID: 19823583; PMCID: PMC2756629.
    24. Ding XQ, Harry CS, Umino Y, Matveev AV, Fliesler SJ, Barlow RB. Impaired cone function and cone degeneration resulting from CNGB3 deficiency: down-regulation of CNGA3 biosynthesis as a potential mechanism. Hum Mol Genet. 2009 Dec 15; 18(24):4770-80. PMID: 19767295; PMCID: PMC2778372.
    25. Chakraborty D, Ding XQ, Conley SM, Fliesler SJ, Naash MI. Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones. Hum Mol Genet. 2009 Mar 01; 18(5):797-808. PMID: 19050038; PMCID: PMC2640204.
    26. Matveev AV, Quiambao AB, Browning Fitzgerald J, Ding XQ. Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice. J Neurochem. 2008 Sep; 106(5):2042-55. PMID: 18665891; PMCID: PMC2756101.
    27. Ding XQ, Fitzgerald JB, Matveev AV, McClellan ME, Elliott MH. Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains. Biochemistry. 2008 Mar 25; 47(12):3677-87. PMID: 18303857.
      View in: PubMed
    28. Chakraborty D, Ding XQ, Fliesler SJ, Naash MI. Outer segment oligomerization of Rds: evidence from mouse models and subcellular fractionation. Biochemistry. 2008 Jan 29; 47(4):1144-56. PMID: 18171083; PMCID: PMC2788309.
    29. Fitzgerald JB, Malykhina AP, Al-Ubaidi MR, Ding XQ. Functional expression of cone cyclic nucleotide-gated channel in cone photoreceptor-derived 661W cells. Adv Exp Med Biol. 2008; 613:327-34. PMID: 18188961.
      View in: PubMed
    30. Dong M, Ding XQ, Thomas SE, Gao F, Lam PC, Abagyan R, Miller LJ. Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction. Biochemistry. 2007 Apr 17; 46(15):4522-31. PMID: 17381074; PMCID: PMC2580722.
    31. Ding XQ, Naash MI. Transgenic animal studies of human retinal disease caused by mutations in peripherin/rds. Adv Exp Med Biol. 2006; 572:141-6. PMID: 17249567; PMCID: PMC2793174.
    32. Stricker HM, Ding XQ, Quiambao A, Fliesler SJ, Naash MI. The Cys214-->Ser mutation in peripherin/rds causes a loss-of-function phenotype in transgenic mice. Biochem J. 2005 Jun 01; 388(Pt 2):605-13. PMID: 15656787; PMCID: PMC1138968.
    33. Ding XQ, Stricker HM, Naash MI. Role of the second intradiscal loop of peripherin/rds in homo and hetero associations. Biochemistry. 2005 Mar 29; 44(12):4897-904. PMID: 15779916; PMCID: PMC2823589.
    34. Naash MI, Wu TH, Chakraborty D, Fliesler SJ, Ding XQ, Nour M, Peachey NS, Lem J, Qtaishat N, Al-Ubaidi MR, Ripps H. Retinal abnormalities associated with the G90D mutation in opsin. J Comp Neurol. 2004 Oct 11; 478(2):149-63. PMID: 15349976.
      View in: PubMed
    35. Arlander SJ, Dong M, Ding XQ, Pinon DI, Miller LJ. Key differences in molecular complexes of the cholecystokinin receptor with structurally related peptide agonist, partial agonist, and antagonist. Mol Pharmacol. 2004 Sep; 66(3):545-52. PMID: 15322246.
      View in: PubMed
    36. Nour M, Ding XQ, Stricker H, Fliesler SJ, Naash MI. Modulating expression of peripherin/rds in transgenic mice: critical levels and the effect of overexpression. Invest Ophthalmol Vis Sci. 2004 Aug; 45(8):2514-21. PMID: 15277471; PMCID: PMC2937570.
    37. Ding XQ, Nour M, Ritter LM, Goldberg AF, Fliesler SJ, Naash MI. The R172W mutation in peripherin/rds causes a cone-rod dystrophy in transgenic mice. Hum Mol Genet. 2004 Sep 15; 13(18):2075-87. PMID: 15254014.
      View in: PubMed
    38. Tan E, Ding XQ, Saadi A, Agarwal N, Naash MI, Al-Ubaidi MR. Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice. Invest Ophthalmol Vis Sci. 2004 Mar; 45(3):764-8. PMID: 14985288; PMCID: PMC2937568.
    39. Li C, Ding XQ, O'Brien J, Al-Ubaidi MR, Naash MI. Molecular characterization of the skate peripherin/rds gene: relationship to its orthologues and paralogues. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2433-41. PMID: 12766040; PMCID: PMC2991160.
    40. Zang M, Dong M, Pinon DI, Ding XQ, Hadac EM, Li Z, Lybrand TP, Miller LJ. Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor. Mol Pharmacol. 2003 May; 63(5):993-1001. PMID: 12695527.
      View in: PubMed
    41. Ding XQ, Dolu V, Hadac EM, Schuetz M, Miller LJ. Disulfide bond structure and accessibility of cysteines in the ectodomain of the cholecystokinin receptor: specific mono-reactive receptor constructs examine charge-sensitivity of loop regions. Receptors Channels. 2003; 9(2):83-91. PMID: 12916469.
      View in: PubMed
    42. Naash MI, Ding XQ, Li C, O'Brien J, Al-Ubaidi MR. Peripherin/rds in skate retina. Adv Exp Med Biol. 2003; 533:377-83. PMID: 15180288.
      View in: PubMed
    43. Ding XQ, Pinon DI, Furse KE, Lybrand TP, Miller LJ. Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor. Mol Pharmacol. 2002 May; 61(5):1041-52. PMID: 11961122.
      View in: PubMed
    44. Ding XQ, Ding WQ, Miller LJ. Receptor biology and signal transduction. Curr Opin Gastroenterol. 2001 Sep; 17(5):410-5. PMID: 17031193.
      View in: PubMed
    45. Ding XQ, Miller LJ. Characterization of the type A cholecystokinin receptor hormone-binding domain: use of contrasting and complementary methodologies. Peptides. 2001 Aug; 22(8):1223-8. PMID: 11457514.
      View in: PubMed
    46. Holicky EL, Hadac EM, Ding XQ, Miller LJ. Molecular characterization and organ distribution of type A and B cholecystokinin receptors in cynomolgus monkey. Am J Physiol Gastrointest Liver Physiol. 2001 Aug; 281(2):G507-14. PMID: 11447031.
      View in: PubMed
    47. Miller LJ, Ding XQ. Insights into the molecular basis of ligand binding by the cholecystokinin receptor. Pancreatology. 2001; 1(4):336-42. PMID: 12120212.
      View in: PubMed
    48. Ding XQ, Rao RV, Kuntz SM, Holicky EL, Miller LJ. Impaired resensitization and recycling of the cholecystokinin receptor by co-expression of its second intracellular loop. Mol Pharmacol. 2000 Dec; 58(6):1424-33. PMID: 11093782.
      View in: PubMed
    49. Ding XQ, Dolu V, Hadac EM, Holicky EL, Pinon DI, Lybrand TP, Miller LJ. Refinement of the structure of the ligand-occupied cholecystokinin receptor using a photolabile amino-terminal probe. J Biol Chem. 2001 Feb 09; 276(6):4236-44. PMID: 11050076.
      View in: PubMed
    50. Kitano M, Norlén P, Ding XQ, Nakamura S, Håkanson R. Long-lasting cholecystokinin(2) receptor blockade after a single subcutaneous injection of YF476 or YM022. Br J Pharmacol. 2000 Jun; 130(3):699-705. PMID: 10821801; PMCID: PMC1572102.
    51. Chen D, Zhao CM, Norlén P, Björkqvist M, Ding XQ, Kitano M, Håkanson R. Effect of cholecystokinin-2 receptor blockade on rat stomach ECL cells. A histochemical, electron-microscopic and chemical study. Cell Tissue Res. 2000 Jan; 299(1):81-95. PMID: 10654072.
      View in: PubMed
    52. Norlén P, Lindström E, Ding XQ, Kitano M, Håkanson R. Reversibility of cholecystokinin-B/gastrin receptor blockade: a study of the gastrin-ECL cell axis in the rat. Pharmacol Toxicol. 1999 Apr; 84(4):159-64. PMID: 10227066.
      View in: PubMed
    53. Håkanson R, Ding XQ, Norlén P, Lindström E. CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis. Regul Pept. 1999 Mar 17; 80(1-2):1-12. PMID: 10235629.
      View in: PubMed
    54. Dong M, Ding XQ, Pinon DI, Hadac EM, Oda RP, Landers JP, Miller LJ. Structurally related peptide agonist, partial agonist, and antagonist occupy a similar binding pocket within the cholecystokinin receptor. Rapid analysis using fluorescent photoaffinity labeling probes and capillary electrophoresis. J Biol Chem. 1999 Feb 19; 274(8):4778-85. PMID: 9988716.
      View in: PubMed
    55. Ding XQ, Kitano M, Håkanson R. Sustained cholecystokinin-B/gastrin receptor blockade does not impair basal or histamine-stimulated acid secretion in chronic gastric fistula rats. Pharmacol Toxicol. 1998 Apr; 82(4):177-82. PMID: 9584331.
      View in: PubMed
    56. Ding XQ, Lindström E, Håkanson R. Evaluation of three novel cholecystokinin-B/gastrin receptor antagonists: a study of their effects on rat stomach enterochromaffin-like cell activity. Pharmacol Toxicol. 1997 Nov; 81(5):232-7. PMID: 9396089.
      View in: PubMed
    57. Ding XQ, Lindström E, Håkanson R. Time-course of deactivation of rat stomach ECL cells following cholecystokinin B/gastrin receptor blockade. Br J Pharmacol. 1997 Sep; 122(1):1-6. PMID: 9298521; PMCID: PMC1564891.
    58. Ding XQ, Lindström E, Håkanson R. Cholecystokinin-B/gastrin receptor blockade suppresses the activity of rat stomach ECL cells. Pharmacol Toxicol. 1997 Jul; 81(1):19-25. PMID: 9258980.
      View in: PubMed
    59. Nylander AG, Chen D, Ding XQ, Norlén P, Håkanson R. The trophic response of rat pancreas to sulfated cholecystokinin-8 is dose- and time-dependent and not affected by vagotomy or atropine. Pharmacol Toxicol. 1997 Mar; 80(3):142-6. PMID: 9101587.
      View in: PubMed
    60. Ding XQ, Håkanson R. Effect of cholecystokinin-B/gastrin receptor blockade on gastric acid secretion in conscious rats. Pharmacol Toxicol. 1996 Dec; 79(6):324-30. PMID: 9000260.
      View in: PubMed
    61. Ding XQ, Håkanson R. Evaluation of the specificity and potency of a series of cholecystokinin-B/gastrin receptor antagonists in vivo. Pharmacol Toxicol. 1996 Sep; 79(3):124-30. PMID: 8884870.
      View in: PubMed
    62. Ding XQ, Chen D, Rosengren E, Persson L, Hakanson R. Comparison between activation of ornithine decarboxylase and histidine decarboxylase in rat stomach. Am J Physiol. 1996 Mar; 270(3 Pt 1):G476-86. PMID: 8638714.
      View in: PubMed
    63. Zhao CM, Chen D, Monstein HJ, Ding XQ, Sundler F, Håkanson R. Rat stomach enterochromaffin-like cells are not stimulated by pylorus ligation. A biochemical and ultrastructural study. Scand J Gastroenterol. 1996 Jan; 31(1):31-7. PMID: 8927937.
      View in: PubMed
    64. Ding XQ, Chen D, Håkanson R. Cholecystokinin-B receptor ligands of the dipeptoid series act as agonists on rat stomach histidine decarboxylase. Gastroenterology. 1995 Oct; 109(4):1181-7. PMID: 7557084.
      View in: PubMed
    65. Håkanson R, Ding XQ, Norlén P, Chen D. Circulating pancreastatin is a marker for the enterochromaffin-like cells of the rat stomach. Gastroenterology. 1995 May; 108(5):1445-52. PMID: 7729637.
      View in: PubMed
    66. Chen D, Ding XQ, Rehfeld JF, Håkanson R. Endogenous gastrin and cholecystokinin do not promote growth of rat liver. Scand J Gastroenterol. 1994 Aug; 29(8):688-92. PMID: 7973428.
      View in: PubMed
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