Blaine H Mooers
Title | Prof,Asoc |
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Institution | University of Oklahoma Health Sciences Center |
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Department | Biochemistry/Molecular Biology |
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Phone | 405/271-8300 |
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vCard | Download vCard |
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Biography Oregon State University, Corvallis, OR | Ph.D. | 06/1997 | Nucleic Acid Structure | University of Oregon/HHMI, Eugene, OR | postdoc | 07/2003 | Protein Folding and Engineering | University of Oregon, Eugene, OR | research associate | 07/2006 | RNA Structure |
Research MCB-1616845 (Jorge Cruz-Reyes)Aug 15, 2016 - Jul 31, 2019 NSF Collaborative Research: RNA processing in trypanosome mitochondria Role Description: The Mooers Lab is making and providing pure RNA editing proteins for this project. Role: CO-PI |
| P20GM103640 (WEST, ANN H)Aug 1, 2012 - May 31, 2022 NIH Oklahoma COBRE in Structural Biology Role: Co-Investigator |
| R01AI088011 (MOOERS, BLAINE H. M.)Jul 1, 2012 - Jun 30, 2016 NIH/NIAID The role of non-canonical base pairs in RNA editing Role: Principal Investigator |
Bibliographic
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Cruz-Reyes J, Mooers BHM, Doharey PK, Meehan J, Gulati S. Dynamic RNA holo-editosomes with subcomplex variants: Insights into the control of trypanosome editing. Wiley Interdiscip Rev RNA. 2018 11; 9(6):e1502. PMID: 30101566.
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Liu X, Shen T, Mooers BHM, Hilberg F, Wu J. Drug resistance profiles of mutations in the RET kinase domain. Br J Pharmacol. 2018 Sep; 175(17):3504-3515. PMID: 29908090.
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Mooers BH. Simplifying and enhancing the use of PyMOL with horizontal scripts. Protein Sci. 2016 10; 25(10):1873-82. PMID: 27488983.
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Cruz-Reyes J, Mooers BH, Abu-Adas Z, Kumar V, Gulati S. DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. RNA Dis. 2016; 3(2). PMID: 27540585.
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Mooers BH. Direct-methods structure determination of a trypanosome RNA-editing substrate fragment with translational pseudosymmetry. Acta Crystallogr D Struct Biol. 2016 Apr; 72(Pt 4):477-87. PMID: 27050127.
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Kumar V, Madina BR, Gulati S, Vashisht AA, Kanyumbu C, Pieters B, Shakir A, Wohlschlegel JA, Read LK, Mooers BH, Cruz-Reyes J. REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes. J Biol Chem. 2016 Mar 11; 291(11):5753-64. PMID: 26769962; PMCID: PMC4786712 [Available on 03/11/17].
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Gu X, Mooers BH, Thomas LM, Malone J, Harris S, Schroeder SJ. Structures and Energetics of Four Adjacent G·U Pairs That Stabilize an RNA Helix. J Phys Chem B. 2015 Oct 22; 119(42):13252-61. PMID: 26425937; PMCID: PMC4830635 [Available on 10/22/16].
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Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86. PMID: 26013825.
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Madina BR, Kumar V, Mooers BH, Cruz-Reyes J. Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA Editing. PLoS One. 2015; 10(4):e0123441. PMID: 25928631; PMCID: PMC4415780.
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Criswell A, Mooers BH. Structural studies of a double-stranded RNA from trypanosome RNA editing by small-angle X-ray scattering. Methods Mol Biol. 2015; 1240:165-89. PMID: 25352145.
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Mooers BH. Fusion RNAs in crystallographic studies of double-stranded RNA from trypanosome RNA editing. Methods Mol Biol. 2015; 1240:191-216. PMID: 25352146.
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Madina BR, Kumar V, Metz R, Mooers BH, Bundschuh R, Cruz-Reyes J. Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition. RNA. 2014 Jul; 20(7):1142-52. PMID: 24865612; PMCID: PMC4114691.
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Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J. After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem. 2014 Apr 25; 289(17):11873-96. PMID: 24616095.
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Sheikh MO, Schafer CM, Powell JT, Rodgers KK, Mooers BH, West CM. Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry. 2014 Mar 18; 53(10):1657-69. PMID: 24506136.
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West MB, Chen Y, Wickham S, Heroux A, Cahill K, Hanigan MH, Mooers BH. Novel insights into eukaryotic ?-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem. 2013 Nov 01; 288(44):31902-13. PMID: 24047895; PMCID: PMC3814782.
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Venkatramani L, Johnson ES, Kolavi G, Air GM, Brouillette WJ, Mooers BH. Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6. BMC Struct Biol. 2012 May 06; 12:7. PMID: 22559154; PMCID: PMC3416664.
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Mooers BH, Singh A. The crystal structure of an oligo(U):pre-mRNA duplex from a trypanosome RNA editing substrate. RNA. 2011 Oct; 17(10):1870-83. PMID: 21878548; PMCID: PMC3185919.
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Mooers BH, Tronrud DE, Matthews BW. Evaluation at atomic resolution of the role of strain in destabilizing the temperature-sensitive T4 lysozyme mutant Arg 96 --> His. Protein Sci. 2009 May; 18(5):863-70. PMID: 19384984; PMCID: PMC2771290.
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Mooers BH, Baase WA, Wray JW, Matthews BW. Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme. Protein Sci. 2009 May; 18(5):871-80. PMID: 19384988.
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Mooers BH. Crystallographic studies of DNA and RNA. Methods. 2009 Mar; 47(3):168-76. PMID: 18848992.
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Mooers BH, Matthews BW. Extension to 2268 atoms of direct methods in the ab initio determination of the unknown structure of bacteriophage P22 lysozyme. Acta Crystallogr D Biol Crystallogr. 2006 Feb; 62(Pt 2):165-76. PMID: 16421448.
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Mooers BH, Logue JS, Berglund JA. The structural basis of myotonic dystrophy from the crystal structure of CUG repeats. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16626-31. PMID: 16269545; PMCID: PMC1283809.
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Mooers BH, Matthews BW. Use of an ion-binding site to bypass the 1000-atom limit to structure determination by direct methods. Acta Crystallogr D Biol Crystallogr. 2004 Oct; 60(Pt 10):1726-37. PMID: 15388918.
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Sagermann M, Baase WA, Mooers BH, Gay L, Matthews BW. Relocation or duplication of the helix A sequence of T4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding. Biochemistry. 2004 Feb 10; 43(5):1296-301. PMID: 14756565.
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Mooers BH, Datta D, Baase WA, Zollars ES, Mayo SL, Matthews BW. Repacking the Core of T4 lysozyme by automated design. J Mol Biol. 2003 Sep 19; 332(3):741-56. PMID: 12963380.
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Gassner NC, Baase WA, Mooers BH, Busam RD, Weaver LH, Lindstrom JD, Quillin ML, Matthews BW. Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability. Biophys Chem. 2003; 100(1-3):325-40. PMID: 12646375.
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Eichman BF, Mooers BH, Alberti M, Hearst JE, Ho PS. The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions. J Mol Biol. 2001 Apr 20; 308(1):15-26. PMID: 11302703.
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Eichman BF, Vargason JM, Mooers BH, Ho PS. The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):3971-6. PMID: 10760268.
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Mooers BH, Eichman BF, Ho PS. The structures and relative stabilities of d(G x G) reverse Hoogsteen, d(G x T) reverse wobble, and d(G x C) reverse Watson-Crick base-pairs in DNA crystals. J Mol Biol. 1997 Jun 27; 269(5):796-810. PMID: 9223642.
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Ho PS, Mooers BH. Z-DNA crystallography . Biopolymers. 1997; 14(1):65-90. PMID: 19174848.
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Mooers BH, Schroth GP, Baxter WW, Ho PS. Alternating and non-alternating dG-dC hexanucleotides crystallize as canonical A-DNA. J Mol Biol. 1995 Jun 16; 249(4):772-84. PMID: 7602589.
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Year | Publications |
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1995 | 1 | 1997 | 2 | 2000 | 1 | 2001 | 1 | 2003 | 2 | 2004 | 2 | 2005 | 1 | 2006 | 1 | 2008 | 1 | 2009 | 2 | 2011 | 1 | 2012 | 1 | 2013 | 1 | 2014 | 3 | 2015 | 5 | 2016 | 4 | 2018 | 2 |
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