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Blaine H Mooers

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
Phone405/271-8300
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    Collapse Biography 
    Collapse education and training
    Oregon State University, Corvallis, ORPhD06/1997Nucleic Acid Structure
    University of Oregon/HHMI, Eugene, ORPostdoc07/2003Protein Folding and Engineering
    University of Oregon, Eugene, ORresearch associate07/2006RNA Structure

    Collapse Research 
    Collapse research activities and funding
    MCB-1616845     (Jorge Cruz-Reyes)Aug 15, 2016 - Jul 31, 2019
    NSF
    Collaborative Research: RNA processing in trypanosome mitochondria
    Role Description: The Mooers Lab is making and providing pure RNA editing proteins for this project.
    Role: CO-PI
    P20GM103640     (WEST, ANN H)Aug 1, 2012 - May 31, 2022
    NIH
    Oklahoma COBRE in Structural Biology
    Role: Co-Investigator
    R01AI088011     (MOOERS, BLAINE H. M.)Jul 1, 2012 - Jun 30, 2016
    NIH/NIAID
    The role of non-canonical base pairs in RNA editing
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Terzyan SS, Shen T, Liu X, Huang Q, Teng P, Zhou M, Hilberg F, Cai J, Mooers BHM, Wu J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 Jul 05; 294(27):10428-10437. PMID: 31118272.
      View in: PubMed
    2. Kumar V, Doharey PK, Gulati S, Meehan J, Martinez MG, Hughes K, Mooers BHM, Cruz-Reyes J. Protein features for assembly of the RNA editing helicase 2 subcomplex (REH2C) in Trypanosome holo-editosomes. PLoS One. 2019; 14(4):e0211525. PMID: 31034523.
      View in: PubMed
    3. Cruz-Reyes J, Mooers BHM, Doharey PK, Meehan J, Gulati S. Dynamic RNA holo-editosomes with subcomplex variants: Insights into the control of trypanosome editing. Wiley Interdiscip Rev RNA. 2018 11; 9(6):e1502. PMID: 30101566.
      View in: PubMed
    4. Liu X, Shen T, Mooers BHM, Hilberg F, Wu J. Drug resistance profiles of mutations in the RET kinase domain. Br J Pharmacol. 2018 09; 175(17):3504-3515. PMID: 29908090.
      View in: PubMed
    5. Mooers BH. Simplifying and enhancing the use of PyMOL with horizontal scripts. Protein Sci. 2016 10; 25(10):1873-82. PMID: 27488983.
      View in: PubMed
    6. Cruz-Reyes J, Mooers BH, Abu-Adas Z, Kumar V, Gulati S. DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. RNA Dis. 2016; 3(2). PMID: 27540585.
      View in: PubMed
    7. Mooers BH. Direct-methods structure determination of a trypanosome RNA-editing substrate fragment with translational pseudosymmetry. Acta Crystallogr D Struct Biol. 2016 Apr; 72(Pt 4):477-87. PMID: 27050127.
      View in: PubMed
    8. Kumar V, Madina BR, Gulati S, Vashisht AA, Kanyumbu C, Pieters B, Shakir A, Wohlschlegel JA, Read LK, Mooers BH, Cruz-Reyes J. REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes. J Biol Chem. 2016 Mar 11; 291(11):5753-64. PMID: 26769962.
      View in: PubMed
    9. Gu X, Mooers BH, Thomas LM, Malone J, Harris S, Schroeder SJ. Structures and Energetics of Four Adjacent G·U Pairs That Stabilize an RNA Helix. J Phys Chem B. 2015 Oct 22; 119(42):13252-61. PMID: 26425937.
      View in: PubMed
    10. Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86. PMID: 26013825.
      View in: PubMed
    11. Madina BR, Kumar V, Mooers BH, Cruz-Reyes J. Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA Editing. PLoS One. 2015; 10(4):e0123441. PMID: 25928631.
      View in: PubMed
    12. Criswell A, Mooers BH. Structural studies of a double-stranded RNA from trypanosome RNA editing by small-angle X-ray scattering. Methods Mol Biol. 2015; 1240:165-89. PMID: 25352145.
      View in: PubMed
    13. Mooers BH. Fusion RNAs in crystallographic studies of double-stranded RNA from trypanosome RNA editing. Methods Mol Biol. 2015; 1240:191-216. PMID: 25352146.
      View in: PubMed
    14. Madina BR, Kumar V, Metz R, Mooers BH, Bundschuh R, Cruz-Reyes J. Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition. RNA. 2014 Jul; 20(7):1142-52. PMID: 24865612.
      View in: PubMed
    15. Ding J, Mooers BH, Zhang Z, Kale J, Falcone D, McNichol J, Huang B, Zhang XC, Xing C, Andrews DW, Lin J. After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem. 2014 Apr 25; 289(17):11873-96. PMID: 24616095.
      View in: PubMed
    16. Sheikh MO, Schafer CM, Powell JT, Rodgers KK, Mooers BH, West CM. Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry. 2014 Mar 18; 53(10):1657-69. PMID: 24506136.
      View in: PubMed
    17. West MB, Chen Y, Wickham S, Heroux A, Cahill K, Hanigan MH, Mooers BH. Novel insights into eukaryotic ?-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem. 2013 Nov 01; 288(44):31902-13. PMID: 24047895.
      View in: PubMed
    18. Venkatramani L, Johnson ES, Kolavi G, Air GM, Brouillette WJ, Mooers BH. Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6. BMC Struct Biol. 2012 May 06; 12:7. PMID: 22559154.
      View in: PubMed
    19. Mooers BH, Singh A. The crystal structure of an oligo(U):pre-mRNA duplex from a trypanosome RNA editing substrate. RNA. 2011 Oct; 17(10):1870-83. PMID: 21878548.
      View in: PubMed
    20. Mooers BH, Tronrud DE, Matthews BW. Evaluation at atomic resolution of the role of strain in destabilizing the temperature-sensitive T4 lysozyme mutant Arg 96 --> His. Protein Sci. 2009 May; 18(5):863-70. PMID: 19384984.
      View in: PubMed
    21. Mooers BH, Baase WA, Wray JW, Matthews BW. Contributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozyme. Protein Sci. 2009 May; 18(5):871-80. PMID: 19384988.
      View in: PubMed
    22. Mooers BH. Crystallographic studies of DNA and RNA. Methods. 2009 Mar; 47(3):168-76. PMID: 18848992.
      View in: PubMed
    23. Mooers BH, Matthews BW. Extension to 2268 atoms of direct methods in the ab initio determination of the unknown structure of bacteriophage P22 lysozyme. Acta Crystallogr D Biol Crystallogr. 2006 Feb; 62(Pt 2):165-76. PMID: 16421448.
      View in: PubMed
    24. Mooers BH, Logue JS, Berglund JA. The structural basis of myotonic dystrophy from the crystal structure of CUG repeats. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16626-31. PMID: 16269545.
      View in: PubMed
    25. Mooers BH, Matthews BW. Use of an ion-binding site to bypass the 1000-atom limit to structure determination by direct methods. Acta Crystallogr D Biol Crystallogr. 2004 Oct; 60(Pt 10):1726-37. PMID: 15388918.
      View in: PubMed
    26. Sagermann M, Baase WA, Mooers BH, Gay L, Matthews BW. Relocation or duplication of the helix A sequence of T4 lysozyme causes only modest changes in structure but can increase or decrease the rate of folding. Biochemistry. 2004 Feb 10; 43(5):1296-301. PMID: 14756565.
      View in: PubMed
    27. Mooers BH, Datta D, Baase WA, Zollars ES, Mayo SL, Matthews BW. Repacking the Core of T4 lysozyme by automated design. J Mol Biol. 2003 Sep 19; 332(3):741-56. PMID: 12963380.
      View in: PubMed
    28. Gassner NC, Baase WA, Mooers BH, Busam RD, Weaver LH, Lindstrom JD, Quillin ML, Matthews BW. Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability. Biophys Chem. 2003; 100(1-3):325-40. PMID: 12646375.
      View in: PubMed
    29. Eichman BF, Mooers BH, Alberti M, Hearst JE, Ho PS. The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions. J Mol Biol. 2001 Apr 20; 308(1):15-26. PMID: 11302703.
      View in: PubMed
    30. Eichman BF, Vargason JM, Mooers BH, Ho PS. The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):3971-6. PMID: 10760268.
      View in: PubMed
    31. Mooers BH, Eichman BF, Ho PS. The structures and relative stabilities of d(G x G) reverse Hoogsteen, d(G x T) reverse wobble, and d(G x C) reverse Watson-Crick base-pairs in DNA crystals. J Mol Biol. 1997 Jun 27; 269(5):796-810. PMID: 9223642.
      View in: PubMed
    32. Ho PS, Mooers BH. Z-DNA crystallography . Biopolymers. 1997; 14(1):65-90. PMID: 19174848.
      View in: PubMed
    33. Mooers BH, Schroth GP, Baxter WW, Ho PS. Alternating and non-alternating dG-dC hexanucleotides crystallize as canonical A-DNA. J Mol Biol. 1995 Jun 16; 249(4):772-84. PMID: 7602589.
      View in: PubMed
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