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Youngjae You

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
Address1110 N Stonewall Ave
Oklahoma City OK 73117-1223
Phone405/271-6593
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    Collapse Biography 
    Collapse education and training
    Chungnam National University, KOREAMS1997Pharmaceutical Chemistry
    Chungname National University, KOREAPhD2001Pharmaceutical Chemistry

    Collapse Overview 
    Collapse overview
    Lab website
    http://www.medichematok.com


    Collapse Research 
    Collapse research activities and funding
    R01GM113940     (YOU, YOUNGJAE)Mar 1, 2015 - Jan 31, 2020
    NIH
    NIR-activatable Prodrugs for Treating Peritoneally Metastasized Ovarian Cancers
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Thapa P, Li M, Karki R, Bio M, Rajaputra P, Nkepang G, Woo S, You Y. Folate-PEG Conjugates of a Far-Red Light-Activatable Paclitaxel Prodrug to Improve Selectivity toward Folate Receptor-Positive Cancer Cells. ACS Omega. 2017 Oct 31; 2(10):6349-6360. PMID: 29104951.
      View in: PubMed
    2. Li M, Thapa P, Rajaputra P, Bio M, Peer CJ, Figg WD, You Y, Woo S. Quantitative modeling of the dynamics and intracellular trafficking of far-red light-activatable prodrugs: implications in stimuli-responsive drug delivery system. J Pharmacokinet Pharmacodyn. 2017 Dec; 44(6):521-536. PMID: 28913666.
      View in: PubMed
    3. Thapa P, Li M, Bio M, Rajaputra P, Nkepang G, Sun Y, Woo S, You Y. Far-Red Light-Activatable Prodrug of Paclitaxel for the Combined Effects of Photodynamic Therapy and Site-Specific Paclitaxel Chemotherapy. J Med Chem. 2016 Apr 14; 59(7):3204-14. PMID: 26974508.
      View in: PubMed
    4. Rajaputra P, Bio M, Nkepang G, Thapa P, Woo S, You Y. Anticancer drug released from near IR-activated prodrug overcomes spatiotemporal limits of singlet oxygen. Bioorg Med Chem. 2016 Apr 01; 24(7):1540-9. PMID: 26928287.
      View in: PubMed
    5. Bio M, Rajaputra P, You Y. Photodynamic therapy via FRET following bioorthogonal click reaction in cancer cells. Bioorg Med Chem Lett. 2016 Jan 01; 26(1):145-8. PMID: 26584884.
      View in: PubMed
    6. Hurst RE, Hauser PJ, You Y, Bailey-Downs LC, Bastian A, Matthews SM, Thorpe J, Earle C, Bourguignon LY, Ihnat MA. Identification of novel drugs to target dormant micrometastases. BMC Cancer. 2015 May 14; 15:404. PMID: 25971923; PMCID: PMC4434572.
    7. Watley RL, Awuah SG, Bio M, Cantu R, Gobeze HB, Nesterov VN, Das SK, D'Souza F, You Y. Dual Functioning Thieno-Pyrrole Fused BODIPY Dyes for NIR Optical Imaging and Photodynamic Therapy: Singlet Oxygen Generation without Heavy Halogen Atom Assistance. Chem Asian J. 2015 Jun; 10(6):1335-43. PMID: 25779683.
      View in: PubMed
    8. Nkepang G, Bio M, Rajaputra P, Awuah SG, You Y. Folate receptor-mediated enhanced and specific delivery of far-red light-activatable prodrugs of combretastatin A-4 to FR-positive tumor. Bioconjug Chem. 2014 Dec 17; 25(12):2175-88. PMID: 25351441.
      View in: PubMed
    9. Muli DK, Rajaputra P, You Y, McGrath DV. Asymmetric ZnPc-rhodamine B conjugates for mitochondrial targeted photodynamic therapy. Bioorg Med Chem Lett. 2014 Sep 15; 24(18):4496-4500. PMID: 25150377.
      View in: PubMed
    10. Bandi V, Das SK, Awuah SG, You Y, D'Souza F. Thieno-pyrrole-fused 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-fullerene dyads: utilization of near-infrared sensitizers for ultrafast charge separation in donor-acceptor systems. J Am Chem Soc. 2014 May 28; 136(21):7571-4. PMID: 24820034.
      View in: PubMed
    11. Bio M, Rajaputra P, Nkepang G, You Y. Far-red light activatable, multifunctional prodrug for fluorescence optical imaging and combinational treatment. J Med Chem. 2014 Apr 24; 57(8):3401-9. PMID: 24694092; PMCID: PMC4002125.
    12. Awuah SG, Das SK, D'Souza F, You Y. Thieno-pyrrole-fused BODIPY intermediate as a platform to multifunctional NIR agents. Chem Asian J. 2013 Dec; 8(12):3123-32. PMID: 24038940.
      View in: PubMed
    13. Bio M, Rajaputra P, Nkepang G, Awuah SG, Hossion AM, You Y. Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry. J Med Chem. 2013 May 23; 56(10):3936-42. PMID: 23631389.
      View in: PubMed
    14. Ngen EJ, Xiao L, Rajaputra P, Yan X, You Y. Enhanced singlet oxygen generation from a porphyrin-rhodamine B dyad by two-photon excitation through resonance energy transfer. Photochem Photobiol. 2013 Jul-Aug; 89(4):841-8. PMID: 23489066.
      View in: PubMed
    15. Rajaputra P, Nkepang G, Watley R, You Y. Synthesis and in vitro biological evaluation of lipophilic cation conjugated photosensitizers for targeting mitochondria. Bioorg Med Chem. 2013 Jan 15; 21(2):379-87. PMID: 23245573.
      View in: PubMed
    16. Hossion AM, Bio M, Nkepang G, Awuah SG, You Y. Visible Light Controlled Release of Anticancer Drug through Double Activation of Prodrug. ACS Med Chem Lett. 2013 Jan 10; 4(1):124-7. PMID: 24900573; PMCID: PMC4027153.
    17. Bio M, Nkepang G, You Y. Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release. Chem Commun (Camb). 2012 Jul 04; 48(52):6517-9. PMID: 22622787.
      View in: PubMed
    18. Nkepang G, Pogula PK, Bio M, You Y. Synthesis and singlet oxygen reactivity of 1,2-diaryloxyethenes and selected sulfur and nitrogen analogs. Photochem Photobiol. 2012 May-Jun; 88(3):753-9. PMID: 22268454.
      View in: PubMed
    19. Paul B, Rajaputra P, You Y. In vitro and in vivo photodynamic activity of core-modified porphyrin IY69 using 690 nm diode laser. Photochem Photobiol. 2011 Nov-Dec; 87(6):1468-73. PMID: 21854396.
      View in: PubMed
    20. Awuah SG, Polreis J, Biradar V, You Y. Singlet oxygen generation by novel NIR BODIPY dyes. Org Lett. 2011 Aug 05; 13(15):3884-7. PMID: 21732590.
      View in: PubMed
    21. Ngen EJ, Rajaputra P, You Y. Evaluation of delocalized lipophilic cationic dyes as delivery vehicles for photosensitizers to mitochondria. Bioorg Med Chem. 2009 Sep 15; 17(18):6631-40. PMID: 19692249.
      View in: PubMed
    22. Minnes R, Weitman H, You Y, Detty MR, Ehrenberg B. Dithiaporphyrin derivatives as photosensitizers in membranes and cells. J Phys Chem B. 2008 Mar 13; 112(10):3268-76. PMID: 18278897.
      View in: PubMed
    23. Ngen EJ, Daniels TS, Murthy RS, Detty MR, You Y. Core-modified porphyrins. Part 6: Effects of lipophilicity and core structures on physicochemical and biological properties in vitro. Bioorg Med Chem. 2008 Mar 15; 16(6):3171-83. PMID: 18164203.
      View in: PubMed
    24. Chintharlapalli S, Papineni S, Liu S, Jutooru I, Chadalapaka G, Cho SD, Murthy RS, You Y, Safe S. 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. Carcinogenesis. 2007 Nov; 28(11):2337-46. PMID: 17724373.
      View in: PubMed
    25. Kim KJ, You YJ, Chung MC, Kang CS, Chung KH, Jeong WJ, Jeong SW, Ahn HG. Effect of nanosized gold particle addition to supported metal oxide catalyst in methanol oxidation. J Nanosci Nanotechnol. 2006 Nov; 6(11):3589-93. PMID: 17252817.
      View in: PubMed
    26. You Y, Gibson SL, Detty MR. Phototoxicity of a core-modified porphyrin and induction of apoptosis. J Photochem Photobiol B. 2006 Dec 01; 85(3):155-62. PMID: 16905327.
      View in: PubMed
    27. Tombline G, Donnelly DJ, Holt JJ, You Y, Ye M, Gannon MK, Nygren CL, Detty MR. Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state. Biochemistry. 2006 Jul 04; 45(26):8034-47. PMID: 16800628.
      View in: PubMed
    28. You Y, Gibson SL, Detty MR. Core-modified porphyrins. Part 5: Electronic effects on photophysical and biological properties in vitro. Bioorg Med Chem. 2005 Nov 01; 13(21):5968-80. PMID: 16084729.
      View in: PubMed
    29. Gibson SL, Holt JJ, Ye M, Donnelly DJ, Ohulchanskyy TY, You Y, Detty MR. Structure-activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells. Bioorg Med Chem. 2005 Dec 01; 13(23):6394-403. PMID: 16084725.
      View in: PubMed
    30. You Y, Gibson SL, Hilf R, Ohulchanskyy TY, Detty MR. Core-modified porphyrins. Part 4: Steric effects on photophysical and biological properties in vitro. Bioorg Med Chem. 2005 Mar 15; 13(6):2235-51. PMID: 15727875.
      View in: PubMed
    31. You Y. Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents. Curr Pharm Des. 2005; 11(13):1695-717. PMID: 15892669.
      View in: PubMed
    32. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. New constituents from Crinum latifolium with inhibitory effects against tube-like formation of human umbilical venous endothelial cells. Nat Prod Res. 2004 Dec; 18(6):485-91. PMID: 15595606.
      View in: PubMed
    33. Nam NH, Hong DH, You YJ, Kim Y, Bang SC, Kim HM, Ahn BZ. Synthesis and cytotoxicity of 2,5-dihydroxychalcones and related compounds. Arch Pharm Res. 2004 Jun; 27(6):581-8. PMID: 15283456.
      View in: PubMed
    34. You YJ, Kim Y, Nam NH, Bang SC, Ahn BZ. Alkyl and carboxylalkyl esters of 4'-demethyl-4-deoxypodophyllotoxin: synthesis, cytotoxic, and antitumor activity. Eur J Med Chem. 2004 Feb; 39(2):189-93. PMID: 14987827.
      View in: PubMed
    35. You YJ, Kim Y, Nam NH, Ahn BZ. Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives. Bioorg Med Chem Lett. 2003 Oct 06; 13(19):3137-40. PMID: 12951080.
      View in: PubMed
    36. You YJ, Kim Y, Nam NH, Ahn BZ. Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin. Bioorg Med Chem Lett. 2003 Aug 18; 13(16):2629-32. PMID: 12873481.
      View in: PubMed
    37. You Y, Gibson SL, Hilf R, Davies SR, Oseroff AR, Roy I, Ohulchanskyy TY, Bergey EJ, Detty MR. Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid-substituted derivatives. J Med Chem. 2003 Aug 14; 46(17):3734-47. PMID: 12904078.
      View in: PubMed
    38. You YJ, Kim Y, Nam NH, Ahn BZ. Inhibitory effect of Adonis amurensis components on tube-like formation of human umbilical venous cells. Phytother Res. 2003 May; 17(5):568-70. PMID: 12749003.
      View in: PubMed
    39. You Y, Ahsan K, Detty MR. Mechanistic studies of the tellurium(II)/tellurium(IV) redox cycle in thiol peroxidase-like reactions of diorganotellurides in methanol. J Am Chem Soc. 2003 Apr 23; 125(16):4918-27. PMID: 12696911.
      View in: PubMed
    40. You YJ, Nam NH, Kim Y, Bae KH, Ahn BZ. Antiangiogenic activity of lupeol from Bombax ceiba. Phytother Res. 2003 Apr; 17(4):341-4. PMID: 12722136.
      View in: PubMed
    41. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Water soluble prodrugs of the antitumor agent 3-[(3-amino-4-methoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)cyclopent-2-ene-1-one. Bioorg Med Chem. 2003 Mar 20; 11(6):1021-9. PMID: 12614888.
      View in: PubMed
    42. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Cytotoxic 2',5'-dihydroxychalcones with unexpected antiangiogenic activity. Eur J Med Chem. 2003 Feb; 38(2):179-87. PMID: 12620662.
      View in: PubMed
    43. Kim Y, You YJ, Nam NH, Ahn BZ. Prodrugs of 4'-demethyl-4-deoxypodophyllotoxin: synthesis and evaluation of the antitumor activity. Bioorg Med Chem Lett. 2002 Dec 02; 12(23):3435-8. PMID: 12419378.
      View in: PubMed
    44. You YJ, Lee IS, Kim Y, Bae KH, Ahn BZ. Antiangiogenic activity of Bupleurum longiradiatum on human umbilical venous endothelial cells. Arch Pharm Res. 2002 Oct; 25(5):640-2. PMID: 12433197.
      View in: PubMed
    45. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Synthesis, cytotoxicity and antitumor activity of 2,3-diarylcyclopent-2-ene-1-ones. Arch Pharm Res. 2002 Oct; 25(5):600-7. PMID: 12433189.
      View in: PubMed
    46. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Synthesis and cytotoxicity of some rigid derivatives of methyl 2,5-dihydroxycinnamate. Arch Pharm Res. 2002 Oct; 25(5):590-9. PMID: 12433188.
      View in: PubMed
    47. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Preliminary structure-antiangiogenic activity relationships of 4-senecioyloxymethyl-6,7-dimethoxycoumarin. Bioorg Med Chem Lett. 2002 Sep 02; 12(17):2345-8. PMID: 12161130.
      View in: PubMed
    48. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Synthesis and anti-tumor activity of novel combretastatins: combretocyclopentenones and related analogues. Bioorg Med Chem Lett. 2002 Aug 05; 12(15):1955-8. PMID: 12113817.
      View in: PubMed
    49. Kim Y, You YJ, Nam NH, Ahn BZ. 2,3-dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity. Arch Pharm Res. 2002 Jun; 25(3):240-9. PMID: 12135092.
      View in: PubMed
    50. Kim Y, Kim SB, You YJ, Ahn BZ. Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from Pulsatilla koreana. Planta Med. 2002 Mar; 68(3):271-4. PMID: 11914969.
      View in: PubMed
    51. Kim Y, Nam NH, You YJ, Ahn BZ. Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones. Bioorg Med Chem Lett. 2002 Feb 25; 12(4):719-22. PMID: 11844709.
      View in: PubMed
    52. Nam NH, Kim Y, You YJ, Hong DH, Kim HM, Ahn BZ. Combretoxazolones: synthesis, cytotoxicity and antitumor activity. Bioorg Med Chem Lett. 2001 Dec 03; 11(23):3073-6. PMID: 11714613.
      View in: PubMed
    53. Kim Y, You YJ, Ahn BZ. Naphthazarin derivatives (VIII): Synthesis, inhibitory effect on DNA topoisomerase-I, and antiproliferative activity of 6-(1-acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinones. Arch Pharm (Weinheim). 2001 Oct; 334(10):318-22. PMID: 11759170.
      View in: PubMed
    54. Jin G, You Y, Ahn B. Esters of 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinones with melphalan as multifunctional anticancer agents. Bioorg Med Chem Lett. 2001 Jun 04; 11(11):1473-6. PMID: 11378380.
      View in: PubMed
    55. Nam NH, You YJ, Kim Y, Hong DH, Kim HM, Ahn BZ. Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity. Bioorg Med Chem Lett. 2001 May 07; 11(9):1173-6. PMID: 11354370.
      View in: PubMed
    56. Jin GZ, You YJ, Kim Y, Nam NH, Ahn BZ. Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents. Eur J Med Chem. 2001 Apr; 36(4):361-6. PMID: 11461761.
      View in: PubMed
    57. Song GY, Kim Y, You YJ, Cho H, Ahn BZ. Naphthazarin derivatives (VII): antitumor action against ICR mice bearing ascitic S-180 cells. Arch Pharm Res. 2001 Feb; 24(1):35-8. PMID: 11235809.
      View in: PubMed
    58. You YJ, Kim Y, Song GY, Ahn BZ. (E) -6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: synthesis, cytotoxic activity and antitumor activity. Bioorg Med Chem Lett. 2000 Oct 16; 10(20):2301-3. PMID: 11055343.
      View in: PubMed
    59. Song GY, Kim Y, You YJ, Cho H, Kim SH, Sok DE, Ahn BZ. Naphthazarin derivatives (VI): synthesis, inhibitory effect on DNA topoisomerase-I and antiproliferative activity of 2- or 6-(1-oxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones. Arch Pharm (Weinheim). 2000 Apr; 333(4):87-92. PMID: 10816900.
      View in: PubMed
    60. Song GY, Kim Y, Zheng XG, You YJ, Cho H, Chung JH, Sok DE, Ahn BZ. Naphthazarin derivatives (IV): synthesis, inhibition of DNA topoisomerase I and cytotoxicity of 2- or 6-acyl-5,8-dimethoxy-1, 4-naphthoquinones. Eur J Med Chem. 2000 Mar; 35(3):291-8. PMID: 10785555.
      View in: PubMed
    61. Song GY, Zheng XG, Kim Y, You YJ, Sok DE, Ahn BZ. Naphthazarin derivatives (II): formation of glutathione conjugate, inhibition of DNA topoisomerase-I and cytotoxicity. Bioorg Med Chem Lett. 1999 Aug 16; 9(16):2407-12. PMID: 10476878.
      View in: PubMed
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