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Yun Zheng Le

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Endocrinology
Address941 Stanton L Young Blvd
Oklahoma City OK 73104-5019
Phone405/271-1087
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    Collapse Research 
    Collapse research activities and funding
    R01EY020900     (LE, YUN ZHENG)Sep 1, 2010 - Aug 31, 2014
    NIH/NEI
    Study of the RPE barrier
    Role: Principal Investigator

    R01EY026970     (LE, YUN ZHENG)Sep 1, 2017 - May 31, 2022
    NIH/NEI
    Müller glia in disease and stress
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hu J, Li T, Du X, Wu Q, Le YZ. G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases. Vision Res. 2017 Jun 23. PMID: 28539261.
      View in: PubMed
    2. Le YZ. VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases. Vision Res. 2017 Jun 21. PMID: 28601428.
      View in: PubMed
    3. Butler MR, Ma H, Yang F, Belcher J, Le YZ, Mikoshiba K, Biel M, Michalakis S, Iuso A, Križaj D, Ding XQ. Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency. J Biol Chem. 2017 Jul 07; 292(27):11189-11205. PMID: 28495882.
      View in: PubMed
    4. Le YZ, Zhu M, Anderson RE. Cre Recombinase: You Can't Live with It, and You Can't Live Without It. Adv Exp Med Biol. 2016; 854:725-30. PMID: 26427481.
      View in: PubMed
    5. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27; 290(48):29035-44. PMID: 26468292; PMCID: PMC4661415 [Available on 11/27/16].
    6. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 06; 290(45):27239-47. PMID: 26391396; PMCID: PMC4646373 [Available on 11/06/16].
    7. Fu S, Dong S, Zhu M, Sherry DM, Wang C, You Z, Haigh JJ, Le YZ. Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes. Diabetes. 2015 Oct; 64(10):3554-63. PMID: 26068541; PMCID: PMC4587642 [Available on 10/01/16].
    8. Wang JJ, Zhu M, Le YZ. Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy. World J Diabetes. 2015 Jun 10; 6(5):726-33. PMID: 26069721; PMCID: PMC4458501.
    9. Ramamurthy V, Jolicoeur C, Koutroumbas D, Mühlhans J, Le YZ, Hauswirth WW, Giessl A, Cayouette M. Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia. J Neurosci. 2014 Oct 15; 34(42):13976-87. PMID: 25319694; PMCID: PMC4577571.
    10. Mao H, Seo SJ, Biswal MR, Li H, Conners M, Nandyala A, Jones K, Le YZ, Lewin AS. Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration. Invest Ophthalmol Vis Sci. 2014 Jul 01; 55(7):4613-27. PMID: 24985474; PMCID: PMC4112607.
    11. Fu S, Zhu M, Wang C, Le YZ. Efficient induction of productive Cre-mediated recombination in retinal pigment epithelium. Mol Vis. 2014; 20:480-7. PMID: 24744608; PMCID: PMC3984040.
    12. Dong S, Liu Y, Zhu M, Xu X, Le YZ. Simplified system to investigate alteration of retinal neurons in diabetes. Adv Exp Med Biol. 2014; 801:139-43. PMID: 24664691.
      View in: PubMed
    13. Fu S, Zhu M, Ash JD, Wang Y, Le YZ. Investigating the role of retinal Müller cells with approaches in genetics and cell biology. Adv Exp Med Biol. 2014; 801:401-5. PMID: 24664724.
      View in: PubMed
    14. He C, Zhu H, Zhang W, Okon I, Wang Q, Li H, Le YZ, Xie Z. 7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B. Am J Pathol. 2013 Aug; 183(2):626-37. PMID: 23770348; PMCID: PMC3730774.
    15. Chen Y, Sawada O, Kohno H, Le YZ, Subauste C, Maeda T, Maeda A. Autophagy protects the retina from light-induced degeneration. J Biol Chem. 2013 Mar 15; 288(11):7506-18. PMID: 23341467; PMCID: PMC3597791.
    16. Lin M, Hu Y, Chen Y, Zhou KK, Jin J, Zhu M, Le YZ, Ge J, Ma JX. Impacts of hypoxia-inducible factor-1 knockout in the retinal pigment epithelium on choroidal neovascularization. Invest Ophthalmol Vis Sci. 2012 Sep 14; 53(10):6197-206. PMID: 22915031; PMCID: PMC4113187.
    17. Zhong Y, Li J, Wang JJ, Chen C, Tran JT, Saadi A, Yu Q, Le YZ, Mandal MN, Anderson RE, Zhang SX. X-box binding protein 1 is essential for the anti-oxidant defense and cell survival in the retinal pigment epithelium. PLoS One. 2012; 7(6):e38616. PMID: 22715395; PMCID: PMC3371004.
    18. Siegert S, Cabuy E, Scherf BG, Kohler H, Panda S, Le YZ, Fehling HJ, Gaidatzis D, Stadler MB, Roska B. Transcriptional code and disease map for adult retinal cell types. Nat Neurosci. 2012 Jan 22; 15(3):487-95, S1-2. PMID: 22267162.
      View in: PubMed
    19. Zhu M, Bai Y, Zheng L, Le YZ. Presence of RPE-produced VEGF in a timely manner is critical to choroidal vascular development. Adv Exp Med Biol. 2012; 723:299-304. PMID: 22183346.
      View in: PubMed
    20. Xu HZ, Song Z, Fu S, Zhu M, Le YZ. RPE barrier breakdown in diabetic retinopathy: seeing is believing. J Ocul Biol Dis Infor. 2011 Jun; 4(1-2):83-92. PMID: 23275801; PMCID: PMC3342408.
    21. Lange C, Heynen SR, Tanimoto N, Thiersch M, Le YZ, Meneau I, Seeliger MW, Samardzija M, Caprara C, Grimm C. Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5872-80. PMID: 21447692.
      View in: PubMed
    22. Kusari J, Padillo E, Zhou SX, Bai Y, Wang J, Song Z, Zhu M, Le YZ, Gil DW. Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats. Invest Ophthalmol Vis Sci. 2011 Jul 20; 52(8):5424-31. PMID: 21482645; PMCID: PMC3176033.
    23. Xu HZ, Le YZ. Significance of outer blood-retina barrier breakdown in diabetes and ischemia. Invest Ophthalmol Vis Sci. 2011 Apr 05; 52(5):2160-4. PMID: 21178141; PMCID: PMC3080181.
    24. Keady BT, Le YZ, Pazour GJ. IFT20 is required for opsin trafficking and photoreceptor outer segment development. Mol Biol Cell. 2011 Apr; 22(7):921-30. PMID: 21307337; PMCID: PMC3069017.
    25. Wang J, Xu X, Elliott MH, Zhu M, Le YZ. Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes. 2010 Sep; 59(9):2297-305. PMID: 20530741; PMCID: PMC2927953.
    26. Le YZ, Bai Y, Zhu M, Zheng L. Temporal requirement of RPE-derived VEGF in the development of choroidal vasculature. J Neurochem. 2010 Mar; 112(6):1584-92. PMID: 20067573; PMCID: PMC2933813.
    27. Zhu M, Zheng L, Ueki Y, Ash JD, Le YZ. Unexpected transcriptional activity of the human VMD2 promoter in retinal development. Adv Exp Med Biol. 2010; 664:211-6. PMID: 20238019.
      View in: PubMed
    28. Le YZ. Computer-assisted semi-quantitative analysis of mouse choroidal density. Adv Exp Med Biol. 2010; 664:349-53. PMID: 20238035.
      View in: PubMed
    29. Ueki Y, Chollangi S, Le YZ, Ash JD. gp130 activation in Müller cells is not essential for photoreceptor protection from light damage. Adv Exp Med Biol. 2010; 664:655-61. PMID: 20238070.
      View in: PubMed
    30. Bai Y, Ma JX, Guo J, Wang J, Zhu M, Chen Y, Le YZ. Müller cell-derived VEGF is a significant contributor to retinal neovascularization. J Pathol. 2009 Dec; 219(4):446-54. PMID: 19768732.
      View in: PubMed
    31. Ueki Y, Le YZ, Chollangi S, Muller W, Ash JD. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21389-94. PMID: 19948961; PMCID: PMC2785722.
    32. Li F, Marchette LD, Brush RS, Elliott MH, Le YZ, Henry KA, Anderson AG, Zhao C, Sun X, Zhang K, Anderson RE. DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Mol Vis. 2009 Jun 13; 15:1185-93. PMID: 19536303; PMCID: PMC2697457.
    33. Thiersch M, Lange C, Joly S, Heynen S, Le YZ, Samardzija M, Grimm C. Retinal neuroprotection by hypoxic preconditioning is independent of hypoxia-inducible factor-1 alpha expression in photoreceptors. Eur J Neurosci. 2009 Jun; 29(12):2291-302. PMID: 19508692.
      View in: PubMed
    34. Haruta M, Bush RA, Kjellstrom S, Vijayasarathy C, Zeng Y, Le YZ, Sieving PA. Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9397-402. PMID: 19470639; PMCID: PMC2685247.
    35. Ueki Y, Ash JD, Zhu M, Zheng L, Le YZ. Expression of Cre recombinase in retinal Müller cells. Vision Res. 2009 Mar; 49(6):615-21. PMID: 19948109; PMCID: PMC2787478.
    36. Le YZ, Zheng W, Rao PC, Zheng L, Anderson RE, Esumi N, Zack DJ, Zhu M. Inducible expression of cre recombinase in the retinal pigmented epithelium. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1248-53. PMID: 18326755; PMCID: PMC2711689.
    37. Le YZ, Zheng L, Le Y, Rucker EB, Anderson RE. Role of BCL-XL in photoreceptor survival. Adv Exp Med Biol. 2008; 613:69-74. PMID: 18188930.
      View in: PubMed
    38. Zheng L, Anderson RE, Agbaga MP, Rucker EB, Le YZ. Loss of BCL-XL in rod photoreceptors: Increased susceptibility to bright light stress. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5583-9. PMID: 17122152.
      View in: PubMed
    39. Le YZ, Zheng L, Zheng W, Ash JD, Agbaga MP, Zhu M, Anderson RE. Mouse opsin promoter-directed Cre recombinase expression in transgenic mice. Mol Vis. 2006 Apr 18; 12:389-98. PMID: 16636658.
      View in: PubMed
    40. Le YZ, Ash JD, Al-Ubaidi MR, Chen Y, Ma JX, Anderson RE. Conditional gene knockout system in cone photoreceptors. Adv Exp Med Biol. 2006; 572:173-8. PMID: 17249572.
      View in: PubMed
    41. Le YZ, Ash JD, Al-Ubaidi MR, Chen Y, Ma JX, Anderson RE. Targeted expression of Cre recombinase to cone photoreceptors in transgenic mice. Mol Vis. 2004 Dec 27; 10:1011-8. PMID: 15635292.
      View in: PubMed
    42. Le Y, Gagneten S, Larson T, Santha E, Dobi A, v Agoston D, Sauer B. Far-upstream elements are dispensable for tissue-specific proenkephalin expression using a Cre-mediated knock-in strategy. J Neurochem. 2003 Feb; 84(4):689-97. PMID: 12562513.
      View in: PubMed
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