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Zsolt Jozsef Nagykaldi

TitleAssociate Professor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentFamily Medicine
Address900 NE 10th St
Oklahoma City OK 73104-5420
Phone405/271-8000
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    Collapse Overview 
    Collapse overview
    I am an Associate Professor and the Director of Research in the Department of Family and Preventive Medicine at the University of Oklahoma Health Sciences Center. I am also the Research Director of the Oklahoma Center for Family Medicine Research and the Oklahoma Physicians Resource/Research Network (OKPRN), a nationally acclaimed clinician practice-based research network (PBRN). I hold a BS in pharmacy and a PhD in pharmacology. I also completed a two-year, Masters-level Public Health and Health Services Research curriculum.

    Since 2001, I have been working closely with a large network of community primary care practices throughout Oklahoma (www.okprn.org) to improve the quality and safety of healthcare through translational practice-based health services research, comparative-effectiveness and patient-centered outcomes research. I led or participated in a number of research and care quality improvement studies in various roles (e.g., Practice Facilitator, content expert, co-Investigator and PI), including translation of clinical guidelines into practice, preventive services delivery, chronic disease management, practice facilitation and redesign, patient-centered care, clinical decision-support, and the design and implementation of health information technology in various care settings. A large part of my work focused on the development and advancement of innovative clinical and methodological approaches using Dissemination and Implementation (D&I) Science and multi/mixed-methods research. I authored a seminal systematic review on practice facilitation in the United States (Nagykaldi et al., 2005) and actively contributed to the teaching and shaping of T3 translational research. Partnering with clinicians, community organizations, and patients, I developed and explored over 20 health IT applications that helped improve care delivery locally or nationally. Since 2013, I have been working with various underserved communities (e.g., inner city, rural, tribal, and the uninsured) to develop and study community-based health improvement programs. I have been a PI on a large, community-based project that recently established a novel and sustainable wellness outreach program in rural Oklahoma counties, resulting in significant improvements in preventive screening and return on investment for stakeholders.

    I am a regular reviewer for a number of peer-reviewed journals, member of editorial boards, and sit on study sections related to my field. I have mentored and advised K-awardees and PhD students to help them develop their own line of scientific inquiry. My current work focuses on the continuing development and testing of a novel, shared goal-directed, prospective care delivery approach through computerized health risk assessment, self-management support, health coaching, and system redesign.


    Collapse Research 
    Collapse research activities and funding
    1P30HS021644     (Nagykaldi, Zsolt)Sep 1, 2012 - Aug 31, 2017
    Agency for Healthcare Research and Quality (AHRQ)
    Establishing the Coordinated Consortium of Networks (CoCoNet)
    Role Description: Agency for Healthcare Research and Quality (AHRQ) $532,934 This initiative will create a formal, coordinated coalition of regional practice-based research networks called CoCoNet (the Coordinated Coalition of Networks) that will include a broad spectrum of practices, clinicians, and patients from 4 different parts of the country.
    Role: PI

    1U54RR033563     (James, Judith)Aug 1, 2013 - Jul 31, 2018
    NIH
    Institutional Development Award (IDeA) Program Infrastructure for Clinical and Translational Research
    Role Description: We propose to strengthen productive bidirectional relationships between researchers and communities in Oklahoma with an emphasis on primary care clinicians, pharmacists, and American Indian communities, expand community test sites by enhancing three practice-based research networks and build a system-wide dissemination/implementation/diffusion infrastructure consisting of county health improvement organizations (CHIOs) linked to each other and, through regional coordinating centers, to the academic research partners.
    Role: Co-I

    1R18HS023237     (Nagykaldi, Zsolt)Jul 1, 2014 - Jun 30, 2018
    Agency for Healthcare Research and Quality (AHRQ)
    Disseminating Patient Centered Outcomes Research to Improve Healthcare Delivery
    Role Description: Propose to implement a sustainable, county-based preventive services delivery model that aligns incentives for primary care practices (PCPs), county health departments (CHDs), and hospitals in 3 rural counties. Wellness coordinators will remind patients of recommended primary (immunizations), secondary (screening), and tertiary (chronic disease management) services and direct them to the most appropriate services and resources. Primary care practices will implement systematic screening for tobacco use and physical inactivity and provide brief counseling and referrals. The model will be supported by a comprehensive, web-based Preventive Services Registry and Wellness Portal/Health Risk Assessment tool interfaced to PCPs’ electronic health record systems (EHRs). We expect to reach about 70,000 patients cared for by 59 clinicians in 20 primary care practices (PCPs), increasing delivery of preventive services and average estimated life expectancies, while producing financial and other benefits (e.g. improved health care quality metrics, a better community-level coordination of care, etc) to local hospitals, PCPs, and county health departments (CHDs).
    Role: PI

    ME-1403-11937     (Nagykaldi. Zsolt)Jan 1, 2015 - Dec 31, 2017
    Patient-Centered Outcomes Research Institute (PCORI)
    Development of a Patient-Directed Queries Network to Engage Patients and Prioritize Their Questions to Inform the PCORI Research Agenda
    Role Description: In collaboration with a patient advisory board, a patient advocacy group, a community coalition, and three practice-based research networks, we will address gaps in patient-centered outcomes research (PCOR) methods in the areas of engagement and prioritization, focusing on longitudinal engagement between researchers and existing patient- and community-based organizations and use of value of information calculations. We will learn how these successful groups have achieved engagement and prioritized opportunities. We will then develop recommendations for enhancements.
    Role: PI

    RFA-HS-14-008     (Duffy, Dan)May 1, 2015 - Jan 31, 2018
    Agency for Healthcare Research and Quality (AHRQ)
    Disseminating and Implementing PCOR through the Oklahoma Primary Healthcare Extension System
    Role Description: The goal of this project is to create a Primary Healthcare Improvement Center to support the continuous quality improvement in primary care practices in Oklahoma. This project will accomplish three important tasks: 1) construct an effective and sustainable primary healthcare extension system to disseminate and implement the results of patient-centered outcomes research; 2) to help 300 small to medium-sized primary care practices improve management of four cardiovascular disease risk factors, smoking, blood pressure, cholesterol, and use of low-dose aspirin; and 3) to evaluate the effectiveness of the chosen implementation strategies.
    Role: Co-I

    PA-14-001     (Dwyer, Kathy)Jul 1, 2015 - Jun 30, 2018
    Agency for Healthcare Research and Quality (AHRQ)
    A Community e-Health Promotion Program Addressing Oklahoma’s Urban Disparities
    Role Description: Health disparities persist in spite of widespread public health efforts. Approaches that can influence health culture in communities, beyond the regular clinical environment are needed. We have partnered with the Faithful, Fit and Strong Health Collaborative to conduct the study in African American churches. The proposed study couples an enhanced web-based HRA, used successfully in the primary care setting, with personalized, goal directed health planning, facilitated by health coaching. An evidence-based and strategic community health improvement approach using systematic health risk assessment has great potential to create healthier communities and will facilitate the translation of evidence-based clinical guidelines into practice and create a roadmap for other organizations to engage their communities in prevention and health promotion.
    Role: Co-I

    OSCTR Pilot Research Grant     (Wickersham, Elizabeth)Jul 1, 2016 - Jun 30, 2017
    Oklahoma Shared Clinical and Translational Resource (OSCTR)
    Improving the Adoption of Advance Directives in Ambulatory Care Settings in Oklahoma
    Role Description: We will compare the practice-level adoption rates of the "Five Wishes" Advance Directive (AD) document to those of the current standard Oklahoma AD form in a small, pair-matched, cluster-randomized clinical trial in 6 community primary care practices as our primary outcome measure. We will implement the two ADs in 6 practices (3 practices in each arm) and follow the process of AD adoption and maintenance. We will also determine and compare the experience of patients and clinicians using the two AD forms via semi-structured interviews either over the phone or in person. Clinicians will be similarly interviewed about their experience with AD adoption.
    Role: Co-I and Early Career Faculty Mentor

    1R21AG052849     (Taksler, Glen)Sep 1, 2016 - Aug 31, 2018
    NIH
    Individualizing Disease Prevention for Middle-Aged Adults
    Role Description: Individualizing Disease Prevention for Middle-Aged Adults” will help middle-aged adults to make an informed decision about the handful of health care services that are most likely to promote longevity. We will employ a previously-published analytic model to learn how to communicate the net benefits of all major preventive care services, individualized for a patient’s age and risk factors, and build a web-based portal. We will pilot test the framework with middle-aged adults.
    Role: Co-I

    1R13HS025315     (Nagykaldi, Zsolt)Jul 1, 2017 - Jun 30, 2019
    Agency for Healthcare Research and Quality (AHRQ)
    Promoting the Development and Dissemination of Practice Facilitation in North America
    Role Description: The Steering Committee of the Coordinated Coalition of Primary Care Research Networks (CoCoNet2), working with the North American Primacy Care Research Group (NAPCRG) and other collaborators will develop and organize National Practice Facilitation Conferences to be held in 2017, 2018, and 2019 in conjunction with the PBRN Annual Meetings with an overlapping plenary session relevant to both audiences. The PF conference will: 1) Provide a novel venue for PFs that will be extended and reinforced through an ongoing, national learning community; 2) Support the diffusion and sustainability of practice facilitation by disseminating innovations, knowledge, best practices, and useful resources; and 3) Promote the evolving science of practice facilitation through research presentations, forums, workshops, and continuous professional networking.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nagykaldi ZJ, Dave A, Kristof CJ, Watts TN, Utpala S, Wickersham E. Improving Patient-Clinician Conversations During Annual Wellness Visits. J Am Board Fam Med. 2017 Mar-Apr; 30(2):161-169. PMID: 28379822.
      View in: PubMed
    2. Heu MK, Welborn T, Nagykaldi Z. Clinical Question: In adult patients on warfarin, does-home-self-testing of prothrombin time and/or international normalized ratio provide the same outcomes compared to testing by a home health nurse or in a clinical setting? J Okla State Med Assoc. 2016 Mar; 109(3):99-100. PMID: 27265957; PMCID: PMC4900684.
    3. Campbell-Voytal K, Daly JM, Nagykaldi ZJ, Aspy CB, Dolor RJ, Fagnan LJ, Levy BT, Palac HL, Michaels L, Patterson VB, Kano M, Smith PD, Sussman AL, Williams R, Sterling P, O'Beirne M, Neale AV. Team Science Approach to Developing Consensus on Research Good Practices for Practice-Based Research Networks: A Case Study. Clin Transl Sci. 2015 Dec; 8(6):632-7. PMID: 26602516.
      View in: PubMed
    4. Gadomski AM, Scribani MB, Krupa N, Jenkins P, Nagykaldi Z, Olson AL. Pet Dogs and Children's Health: Opportunities for Chronic Disease Prevention? Prev Chronic Dis. 2015 Nov 25; 12:E205. PMID: 26605705; PMCID: PMC4674442.
    5. Dolor RJ, Campbell-Voytal K, Daly J, Nagykaldi ZJ, O'Beirne M, Sterling P, Fagnan LJ, Levy B, Michaels L, Louks HA, Smith P, Aspy CB, Patterson VB, Kano M, Sussman AL, Williams R, Neale AV. Practice-based Research Network Research Good Practices (PRGPs): Summary of Recommendations. Clin Transl Sci. 2015 Dec; 8(6):638-46. PMID: 26296309.
      View in: PubMed
    6. Voncken-Brewster V, Tange H, de Vries H, Nagykaldi Z, Winkens B, van der Weijden T. A randomized controlled trial evaluating the effectiveness of a web-based, computer-tailored self-management intervention for people with or at risk for COPD. Int J Chron Obstruct Pulmon Dis. 2015; 10:1061-73. PMID: 26089656; PMCID: PMC4467652.
    7. Gadomski AM, Fothergill KE, Larson S, Wissow LS, Winegrad H, Nagykaldi ZJ, Olson AL, Roter DL. Integrating mental health into adolescent annual visits: impact of previsit comprehensive screening on within-visit processes. J Adolesc Health. 2015 Mar; 56(3):267-73. PMID: 25586231; PMCID: PMC4339519.
    8. Nagykaldi ZJ, Jordan M, Quitoriano J, Ciro CA, Mold JW. User-centered design and usability testing of an innovative health-related quality of life module. Appl Clin Inform. 2014; 5(4):958-70. PMID: 25589910; PMCID: PMC4287674.
    9. Nagykaldi Z. Practice-based research networks at the crossroads of research translation. J Am Board Fam Med. 2014 Nov-Dec; 27(6):725-9. PMID: 25381066.
      View in: PubMed
    10. Voncken-Brewster V, Tange H, Moser A, Nagykaldi Z, de Vries H, van der Weijden T. Integrating a tailored e-health self-management application for chronic obstructive pulmonary disease patients into primary care: a pilot study. BMC Fam Pract. 2014 Jan 08; 15:4. PMID: 24400676; PMCID: PMC3907149.
    11. Nagykaldi ZJ, Yeaman B, Jones M, Mold JW, Scheid DC. HIE-i-health information exchange with intelligence. J Ambul Care Manage. 2014 Jan-Mar; 37(1):20-31. PMID: 24309392.
      View in: PubMed
    12. Szarka N, Nagykáldi Z, Végh M, Oberling J. [Patient satisfaction with care in gastrooesophageal reflux disease]. Orv Hetil. 2013 Oct 27; 154(43):1713-8. PMID: 24140511.
      View in: PubMed
    13. Voncken-Brewster V, Tange H, de Vries H, Nagykaldi Z, Winkens B, van der Weijden T. A randomised controlled trial testing a web-based, computer-tailored self-management intervention for people with or at risk for chronic obstructive pulmonary disease: a study protocol. BMC Public Health. 2013 Jun 07; 13:557. PMID: 23742208; PMCID: PMC3691773.
    14. Nagykaldi ZJ, Voncken-Brewster V, Aspy CB, Mold JW. Novel computerized health risk appraisal may improve longitudinal health and wellness in primary care: a pilot study. Appl Clin Inform. 2013; 4(1):75-87. PMID: 23650489; PMCID: PMC3644816.
    15. Voncken-Brewster V, Moser A, van der Weijden T, Nagykaldi Z, de Vries H, Tange H. Usability evaluation of an online, tailored self-management intervention for chronic obstructive pulmonary disease patients incorporating behavior change techniques. JMIR Res Protoc. 2013 Jan 16; 2(1):e3. PMID: 23612363; PMCID: PMC3628158.
    16. Nagykaldi Z, Aspy CB, Chou A, Mold JW. Impact of a Wellness Portal on the delivery of patient-centered preventive care. J Am Board Fam Med. 2012 Mar-Apr; 25(2):158-67. PMID: 22403196.
      View in: PubMed
    17. Nagykaldi ZJ, Chou AF, Aspy CB, Mold JW. Engaging patients and clinicians through a wellness portal to improve the health of Oklahomans. J Okla State Med Assoc. 2010 Oct; 103(10):498-501. PMID: 21189828.
      View in: PubMed
    18. Chou AF, Nagykaldi Z, Aspy CB, Mold JW. Promoting patient-centered preventive care using a wellness portal: preliminary findings. J Prim Care Community Health. 2010 Jul 01; 1(2):88-92. PMID: 23804368.
      View in: PubMed
    19. Nagykaldi Z, Calmbach W, Dealleaume L, Temte J, Mold J, Ryan JG. Facilitating patient self-management through telephony and web technologies in seasonal influenza. Inform Prim Care. 2010; 18(1):9-16. PMID: 20429974.
      View in: PubMed
    20. Smith KD, Merchen E, Turner CD, Vaught C, Nagykaldi Z, Aspy C, Mold J. Patient-physician e-mail communication revisited a decade later: an OKPRN study. J Okla State Med Assoc. 2009 Sep; 102(9):291-3. PMID: 19856821.
      View in: PubMed
    21. Mold JW, Aspy CA, Nagykaldi Z. Implementation of evidence-based preventive services delivery processes in primary care: an Oklahoma Physicians Resource/Research Network (OKPRN) study. J Am Board Fam Med. 2008 Jul-Aug; 21(4):334-44. PMID: 18612060.
      View in: PubMed
    22. Nagykaldi Z, Fox C, Gallo S, Stone J, Fontaine P, Peterson K, Arvanitis T. Improving collaboration between Primary Care Research Networks using Access Grid technology. Inform Prim Care. 2008; 16(1):51-8; discussion 59-60. PMID: 18534077.
      View in: PubMed
    23. Nagykaldi Z, Mold JW. The role of health information technology in the translation of research into practice: an Oklahoma Physicians Resource/Research Network (OKPRN) study. J Am Board Fam Med. 2007 Mar-Apr; 20(2):188-95. PMID: 17341756.
      View in: PubMed
    24. Nagykaldi Z, Mold JW, Robinson A, Niebauer L, Ford A. Practice facilitators and practice-based research networks. J Am Board Fam Med. 2006 Sep-Oct; 19(5):506-10. PMID: 16951300.
      View in: PubMed
    25. Mold JW, Woolley JH, Nagykaldi Z. Associations between night sweats and other sleep disturbances: An OKPRN study. Ann Fam Med. 2006 Sep-Oct; 4(5):423-6. PMID: 17003142; PMCID: PMC1578640.
    26. Nagykaldi Z, Mold JW, Bradley KK, Bos JE. Bridging the gap between public and private healthcare: Influenza-like illness surveillance in a practice-based research network. J Public Health Manag Pract. 2006 Jul-Aug; 12(4):356-64. PMID: 16775533.
      View in: PubMed
    27. Nagykaldi Z, Mold JW, Aspy CB. Practice facilitators: a review of the literature. Fam Med. 2005 Sep; 37(8):581-8. PMID: 16145629.
      View in: PubMed
    28. Török TL, Nagykáldi Z, Sáska Z, Kovács T, Nada SA, Zillikens S, Magyar K. [Electrogenic Na+/Ca2+-exchange regulation by alpha2-receptor in peripheral sympathetic nerve]. Acta Pharm Hung. 2005; 75(1):3-16. PMID: 16045199.
      View in: PubMed
    29. Török TL, Nagykáldi Z, Sáska Z, Kovács T, Nada SA, Zilliikens S, Magyar K, Sylvester Vizi E. Presynaptic alpha2-receptors regulate reverse Na+/Ca2+-exchange and transmitter release in Na+-loaded peripheral sympathetic nerves. Neurochem Int. 2004 Oct; 45(5):699-711. PMID: 15234113.
      View in: PubMed
    30. Nagykaldi Z, Mold JW. Diabetes Patient Tracker, a personal digital assistant-based diabetes management system for primary care practices in Oklahoma. Diabetes Technol Ther. 2003; 5(6):997-1001. PMID: 14709203.
      View in: PubMed
    31. Nagykaldi Z, Kem D, Lazzara R, Szabo B. Conditioning of beta(1)-adrenoceptor effect via beta(2)-subtype on L-type Ca(2+) current in canine ventricular myocytes. Am J Physiol Heart Circ Physiol. 2000 Sep; 279(3):H1329-37. PMID: 10993800.
      View in: PubMed
    32. Nagykáldi Z, Kem D, Lazzara R, Szabó B. [The coupling of canine ventricular myocyte beta2-adrenoceptors to L-type calcium current]. Acta Pharm Hung. 1999 Nov; 69(5):247-57. PMID: 10652792.
      View in: PubMed
    33. Nagykaldi Z, Kem D, Lazzara R, Szabo B. Canine ventricular myocyte beta2-adrenoceptors are not functionally coupled to L-type calcium current. J Cardiovasc Electrophysiol. 1999 Sep; 10(9):1240-51. PMID: 10517658.
      View in: PubMed
    34. Rácz D, Zillikens S, Forstreuter P, Nagykáldi Z, Magyar K, Török T. [Pre- and postsynaptic action of the ATP-dependent K+-channel-(K+ATP)-opener pinacidil in rabbit pulmonary artery]. Acta Pharm Hung. 1999 Jun; 69(3):159-70. PMID: 10401160.
      View in: PubMed
    35. Rácz D, Zillikens S, Forstreuter P, Nagykáldi Z, Magyar K, Török TL. Pre-junctional stimulatory and post-junctional inhibitory effects of pinacidil in the isolated main pulmonary artery of the rabbit under different experimental conditions. Pulm Pharmacol Ther. 1997 Aug; 10(4):199-209. PMID: 9695143.
      View in: PubMed
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