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Last Name

Robert Axtell

TitleAssistant Member
InstitutionOklahoma Medical Research Foundation
DepartmentArthritis and Clinical Immunology
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    Collapse Research 
    Collapse research activities and funding
    R56AI118787     (AXTELL, ROBERT C)Sep 1, 2016 - Aug 31, 2017
    Functional Interaction Between T-cell and B-cell Immune Pathways in Neuro- inflammatory Disorders
    Role: Principal Investigator

    R00NS075099     (AXTELL, ROBERT C)Sep 15, 2013 - Aug 31, 2016
    Molecular Stratification of Multiple Sclerosis and Associated Neuro-autoimmune Di
    Role: Principal Investigator

    K99NS075099     (AXTELL, ROBERT C)May 5, 2011 - Apr 30, 2013
    Molecular Stratification of Multiple Sclerosis and Associated Neuro-autoimmune Di
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Quinn JL, Axtell RC. Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 2018 Oct 19; 19(10). PMID: 30347676.
      View in: PubMed
    2. Quinn JL, Kumar G, Agasing A, Ko RM, Axtell RC. Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation. Front Immunol. 2018; 9:382. PMID: 29535739.
      View in: PubMed
    3. Bhat R, Mahapatra S, Axtell RC, Steinman L. Amelioration of ongoing experimental autoimmune encephalomyelitis with fluoxetine. J Neuroimmunol. 2017 12 15; 313:77-81. PMID: 29153612.
      View in: PubMed
    4. Larabee CM, Desai S, Agasing A, Georgescu C, Wren JD, Axtell RC, Plafker SM. Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis. Mol Vis. 2016; 22:1503-1513. PMID: 28050123.
      View in: PubMed
    5. Berkovich R, Bakshi R, Amezcua L, Axtell RC, Cen SY, Tauhid S, Neema M, Steinman L. Adrenocorticotropic hormone versus methylprednisolone added to interferon ß in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial. Ther Adv Neurol Disord. 2017 Jan; 10(1):3-17. PMID: 28450891.
      View in: PubMed
    6. Larabee CM, Hu Y, Desai S, Georgescu C, Wren JD, Axtell RC, Plafker SM. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice. Mol Vis. 2016; 22:332-41. PMID: 27122964.
      View in: PubMed
    7. Hegen H, Adrianto I, Lessard CJ, Millonig A, Bertolotto A, Comabella M, Giovannoni G, Guger M, Hoelzl M, Khalil M, Fazekas F, Killestein J, Lindberg RL, Malucchi S, Mehling M, Montalban X, Rudzki D, Schautzer F, Sellebjerg F, Sorensen PS, Deisenhammer F, Steinman L, Axtell RC. Cytokine profiles show heterogeneity of interferon-ß response in multiple sclerosis patients. Neurol Neuroimmunol Neuroinflamm. 2016 Apr; 3(2):e202. PMID: 26894205; PMCID: PMC4747480.
    8. Schaffert SA, Loh C, Wang S, Arnold CP, Axtell RC, Newell EW, Nolan G, Ansel KM, Davis MM, Steinman L, Chen CZ. mir-181a-1/b-1 Modulates Tolerance through Opposing Activities in Selection and Peripheral T Cell Function. J Immunol. 2015 Aug 15; 195(4):1470-9. PMID: 26163591; PMCID: PMC4763610.
    9. Doyle KP, Quach LN, Solé M, Axtell RC, Nguyen TV, Soler-Llavina GJ, Jurado S, Han J, Steinman L, Longo FM, Schneider JA, Malenka RC, Buckwalter MS. B-lymphocyte-mediated delayed cognitive impairment following stroke. J Neurosci. 2015 Feb 04; 35(5):2133-45. PMID: 25653369; PMCID: PMC4315838.
    10. Schubert RD, Hu Y, Kumar G, Szeto S, Abraham P, Winderl J, Guthridge JM, Pardo G, Dunn J, Steinman L, Axtell RC. IFN-ß treatment requires B cells for efficacy in neuroautoimmunity. J Immunol. 2015 Mar 01; 194(5):2110-6. PMID: 25646307; PMCID: PMC4340715.
    11. Cekanaviciute E, Dietrich HK, Axtell RC, Williams AM, Egusquiza R, Wai KM, Koshy AA, Buckwalter MS. Astrocytic TGF-ß signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J Immunol. 2014 Jul 01; 193(1):139-49. PMID: 24860191; PMCID: PMC4075480.
    12. Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. 2013 Nov; 14(11):1166-72. PMID: 24076635; PMCID: PMC4014310.
    13. Naves R, Singh SP, Cashman KS, Rowse AL, Axtell RC, Steinman L, Mountz JD, Steele C, De Sarno P, Raman C. The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol. 2013 Sep 15; 191(6):2967-77. PMID: 23960239; PMCID: PMC3779698.
    14. Hartung HP, Steinman L, Goodin DS, Comi G, Cook S, Filippi M, O'Connor P, Jeffery DR, Kappos L, Axtell R, Knappertz V, Bogumil T, Schwenke S, Croze E, Sandbrink R, Pohl C. Interleukin 17F level and interferon ß response in patients with multiple sclerosis. JAMA Neurol. 2013 Aug; 70(8):1017-21. PMID: 23732754; PMCID: PMC4290836.
    15. Davidson MG, Alonso MN, Yuan R, Axtell RC, Kenkel JA, Suhoski MM, González JC, Steinman L, Engleman EG. Th17 cells induce Th1-polarizing monocyte-derived dendritic cells. J Immunol. 2013 Aug 01; 191(3):1175-87. PMID: 23794631; PMCID: PMC3954848.
    16. Marabelle A, Kohrt H, Sagiv-Barfi I, Ajami B, Axtell RC, Zhou G, Rajapaksa R, Green MR, Torchia J, Brody J, Luong R, Rosenblum MD, Steinman L, Levitsky HI, Tse V, Levy R. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J Clin Invest. 2013 Jun; 123(6):2447-63. PMID: 23728179; PMCID: PMC3668834.
    17. Axtell RC, Raman C, Steinman L. Type I interferons: beneficial in Th1 and detrimental in Th17 autoimmunity. Clin Rev Allergy Immunol. 2013 Apr; 44(2):114-20. PMID: 22231516.
      View in: PubMed
    18. Steinman L, Axtell RC, Barbieri D, Bhat R, Brownell SE, de Jong BA, Dunn SE, Grant JL, Han MH, Ho PP, Kuipers HF, Kurnellas MP, Ousman SS, Rothbard JB. Piet Mondrian's trees and the evolution in understanding multiple sclerosis, Charcot Prize Lecture 2011. Mult Scler. 2013 Jan; 19(1):5-14. PMID: 23303879.
      View in: PubMed
    19. Sestero CM, McGuire DJ, De Sarno P, Brantley EC, Soldevila G, Axtell RC, Raman C. CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012 Sep 15; 189(6):2918-30. PMID: 22904299; PMCID: PMC3436980.
    20. Grant JL, Ghosn EE, Axtell RC, Herges K, Kuipers HF, Woodling NS, Andreasson K, Herzenberg LA, Herzenberg LA, Steinman L. Reversal of paralysis and reduced inflammation from peripheral administration of ß-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis. Sci Transl Med. 2012 Aug 01; 4(145):145ra105. PMID: 22855462; PMCID: PMC3677069.
    21. Axtell RC, Raman C. Janus-like effects of type I interferon in autoimmune diseases. Immunol Rev. 2012 Jul; 248(1):23-35. PMID: 22725952; PMCID: PMC3383665.
    22. Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med. 2012 Jul 02; 209(7):1325-34. PMID: 22734047; PMCID: PMC3405500.
    23. Herges K, de Jong BA, Kolkowitz I, Dunn C, Mandelbaum G, Ko RM, Maini A, Han MH, Killestein J, Polman C, Goodyear AL, Dunn J, Steinman L, Axtell RC. Protective effect of an elastase inhibitor in a neuromyelitis optica-like disease driven by a peptide of myelin oligodendroglial glycoprotein. Mult Scler. 2012 Apr; 18(4):398-408. PMID: 22343184; PMCID: PMC3319834.
    24. Rothbard JB, Kurnellas MP, Brownell S, Adams CM, Su L, Axtell RC, Chen R, Fathman CG, Robinson WH, Steinman L. Therapeutic effects of systemic administration of chaperone aB-crystallin associated with binding proinflammatory plasma proteins. J Biol Chem. 2012 Mar 23; 287(13):9708-21. PMID: 22308023; PMCID: PMC3322989.
    25. Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model. J Heart Lung Transplant. 2011 Dec; 30(12):1409-17. PMID: 22055099.
      View in: PubMed
    26. Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP. Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion. Circulation. 2011 Sep 13; 124(11 Suppl):S187-96. PMID: 21911812.
      View in: PubMed
    27. Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, Ju S, Mu J, Zhang L, Steinman L, Miller D, Zhang HG. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther. 2011 Oct; 19(10):1769-79. PMID: 21915101; PMCID: PMC3188748.
    28. Lee LF, Axtell R, Tu GH, Logronio K, Dilley J, Yu J, Rickert M, Han B, Evering W, Walker MG, Shi J, de Jong BA, Killestein J, Polman CH, Steinman L, Lin JC. IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-ß in multiple sclerosis. Sci Transl Med. 2011 Jul 27; 3(93):93ra68. PMID: 21795588; PMCID: PMC3739690.
    29. Axtell RC, Raman C, Steinman L. Interferon-ß exacerbates Th17-mediated inflammatory disease. Trends Immunol. 2011 Jun; 32(6):272-7. PMID: 21530402.
      View in: PubMed
    30. Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011 Jan; 43(1):66-71. PMID: 21170044; PMCID: PMC3019286.
    31. Dunn SE, Bhat R, Straus DS, Sobel RA, Axtell R, Johnson A, Nguyen K, Mukundan L, Moshkova M, Dugas JC, Chawla A, Steinman L. Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. J Exp Med. 2010 Aug 02; 207(8):1599-608. PMID: 20624891; PMCID: PMC2916127.
    32. Lanz TV, Ding Z, Ho PP, Luo J, Agrawal AN, Srinagesh H, Axtell R, Zhang H, Platten M, Wyss-Coray T, Steinman L. Angiotensin II sustains brain inflammation in mice via TGF-beta. J Clin Invest. 2010 Aug; 120(8):2782-94. PMID: 20628203; PMCID: PMC2912186.
    33. Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med. 2010 Apr; 16(4):406-12. PMID: 20348925; PMCID: PMC3042885.
    34. Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP. IL-17 contributes to the development of chronic rejection in a murine heart transplant model. J Clin Immunol. 2010 Mar; 30(2):235-40. PMID: 20130970.
      View in: PubMed
    35. Bhat R, Axtell R, Mitra A, Miranda M, Lock C, Tsien RW, Steinman L. Inhibitory role for GABA in autoimmune inflammation. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2580-5. PMID: 20133656; PMCID: PMC2823917.
    36. Axtell RC, Steinman L. Gaining entry to an uninflamed brain. Nat Immunol. 2009 May; 10(5):453-5. PMID: 19381137.
      View in: PubMed
    37. De Sarno P, Axtell RC, Raman C, Roth KA, Alessi DR, Jope RS. Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2008 Jul 01; 181(1):338-45. PMID: 18566399; PMCID: PMC2704026.
    38. Axtell RC, Steinman L. Type 1 interferons cool the inflamed brain. Immunity. 2008 May; 28(5):600-2. PMID: 18482563.
      View in: PubMed
    39. Axtell RC, Xu L, Barnum SR, Raman C. CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system. J Immunol. 2006 Dec 15; 177(12):8542-9. PMID: 17142752; PMCID: PMC2744950.
    40. Bullard DC, Hu X, Schoeb TR, Axtell RC, Raman C, Barnum SR. Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 15; 175(10):6327-33. PMID: 16272284.
      View in: PubMed
    41. Axtell RC, Webb MS, Barnum SR, Raman C. Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice. J Immunol. 2004 Sep 01; 173(5):2928-32. PMID: 15322150.
      View in: PubMed
    42. Lu X, Axtell RC, Collawn JF, Gibson A, Justement LB, Raman C. AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells. J Immunol. 2002 Jun 01; 168(11):5612-20. PMID: 12023358.
      View in: PubMed
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