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Carol F Webb

TitleProfessor
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentRheumatology/Immunology/Allerg
Address800 Research Parkway
Oklahoma City OK 73104-3611
Phone405/271-4188
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    Collapse Biography 
    Collapse education and training
    Washington University in St. Louis, St. Louis, MOAB05/1979Biology
    University of Alabama at Birmingham, Birmingham, AlabamaPHD05/1985Microbiology and Immunology

    Collapse Overview 
    Collapse overview
    My laboratory studies functions of the transcription factor ARID3a in lupus, immune cells, and stem cells.


    Collapse Research 
    Collapse research activities and funding
    R55GM046462     (WEBB, CAROL F)Sep 30, 1991 - Jul 31, 1992
    NIH/NIGMS
    B CELL REGULATION BY INTERLEUKIN 5 + ANTIGEN
    Role: Principal Investigator

    R29GM046462     (WEBB, CAROL F)Aug 1, 1992 - Apr 30, 1998
    NIH/NIGMS
    B CELL REGULATION BY INTERLEUKIN 5 PLUS ANTIGEN
    Role: Principal Investigator

    R01AI044215     (WEBB, CAROL F)Dec 1, 1998 - Feb 28, 2011
    NIH/NIAID
    Bright Function in the Immune System
    Role: Principal Investigator

    R21AI090343     (WEBB, CAROL F)May 24, 2010 - Apr 30, 2013
    NIH/NIAID
    Role of the transcription factor ARID3a in lupus
    Role: Principal Investigator

    R56AI118836     (WEBB, CAROL F)Aug 1, 2015 - Jul 31, 2016
    NIH/NIAID
    Role of the Transcription Factor ARID3a in Innate Immune Responses
    Role: Principal Investigator

    R03AI123951     (WEBB, CAROL F)Apr 1, 2016 - Mar 31, 2018
    NIH/NIAID
    Identification of Proteins Interacting with ARID3a
    Role: Principal Investigator

    R01AI118836     (WEBB, CAROL F)Nov 15, 2016 - Oct 31, 2020
    NIH/NIAID
    Role of the transcription factor ARID3a in innate immune responses
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ward JM, Ratliff ML, Dozmorov MG, Wiley G, Guthridge JM, Gaffney PM, James JA, Webb CF. Expression and methylation data from SLE patient and healthy control blood samples subdivided with respect to ARID3a levels. Data Brief. 2016 Dec; 9:213-9. PMID: 27656675; PMCID: PMC5021782.
    2. Ward JM, Ratliff ML, Dozmorov MG, Wiley G, Guthridge JM, Gaffney PM, James JA, Webb CF. Human effector B lymphocytes express ARID3a and secrete interferon alpha. J Autoimmun. 2016 Dec; 75:130-140. PMID: 27522115.
      View in: PubMed
    3. Ratliff ML, Mishra M, Frank MB, Guthridge JM, Webb CF. The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors. J Immunol. 2016 Jan 15; 196(2):614-23. PMID: 26685208; PMCID: PMC4858324 [Available on 01/15/17].
    4. Ward JM, James JA, Zhao YD, Webb CF. Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression. Antibodies (Basel). 2015 Dec; 4:354-368. PMID: 28580178.
      View in: PubMed
    5. Webb CF, Ratliff ML, Powell R, Wirsig-Wiechmann CR, Lakiza O, Obara T. A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):1334-1340. PMID: 26111446; PMCID: PMC4526183.
    6. Ratliff ML, Ward JM, Merrill JT, James JA, Webb CF. Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells. J Immunol. 2015 Feb 01; 194(3):940-9. PMID: 25535283; PMCID: PMC4297684.
    7. Ward JM, Rose K, Montgomery C, Adrianto I, James JA, Merrill JT, Webb CF. Disease activity in systemic lupus erythematosus correlates with expression of the transcription factor AT-rich-interactive domain 3A. Arthritis Rheumatol. 2014 Dec; 66(12):3404-12. PMID: 25185498; PMCID: PMC4245462.
    8. Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcón-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet. 2014 Apr 03; 94(4):586-98. PMID: 24702955; PMCID: PMC3980411.
    9. Ratliff ML, Templeton TD, Ward JM, Webb CF. The Bright Side of Hematopoiesis: Regulatory Roles of ARID3a/Bright in Human and Mouse Hematopoiesis. Front Immunol. 2014; 5:113. PMID: 24678314; PMCID: PMC3958700.
    10. Popowski M, Templeton TD, Lee BK, Rhee C, Li H, Miner C, Dekker JD, Orlanski S, Bergman Y, Iyer VR, Webb CF, Tucker H. Bright/Arid3A acts as a barrier to somatic cell reprogramming through direct regulation of Oct4, Sox2, and Nanog. Stem Cell Reports. 2014 Jan 14; 2(1):26-35. PMID: 24511468; PMCID: PMC3916758.
    11. Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The transcription factor encyclopedia. Genome Biol. 2012; 13(3):R24. PMID: 22458515; PMCID: PMC3439975.
    12. Rose K, Long P, Shankar M, Ballard JD, Webb CF. Serum amyloid A protects murine macrophages from lethal toxin-mediated death. Cell Immunol. 2012; 272(2):175-81. PMID: 22082566; PMCID: PMC3244522.
    13. Oldham AL, Miner CA, Wang HC, Webb CF. The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production. Mol Immunol. 2011 Oct; 49(1-2):367-79. PMID: 21963220; PMCID: PMC3205293.
    14. Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011 Mar; 43(3):253-8. PMID: 21336280; PMCID: PMC3103780.
    15. Webb CF, Bryant J, Popowski M, Allred L, Kim D, Harriss J, Schmidt C, Miner CA, Rose K, Cheng HL, Griffin C, Tucker PW. The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development. Mol Cell Biol. 2011 Mar; 31(5):1041-53. PMID: 21199920; PMCID: PMC3067827.
    16. An G, Miner CA, Nixon JC, Kincade PW, Bryant J, Tucker PW, Webb CF. Loss of Bright/ARID3a function promotes developmental plasticity. Stem Cells. 2010 Sep; 28(9):1560-7. PMID: 20680960; PMCID: PMC2977942.
    17. Schmidt C, Kim D, Ippolito GC, Naqvi HR, Probst L, Mathur S, Rosas-Acosta G, Wilson VG, Oldham AL, Poenie M, Webb CF, Tucker PW. Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright. EMBO J. 2009 Mar 18; 28(6):711-24. PMID: 19214191; PMCID: PMC2666038.
    18. Nixon JC, Ferrell S, Miner C, Oldham AL, Hochgeschwender U, Webb CF. Transgenic mice expressing dominant-negative bright exhibit defects in B1 B cells. J Immunol. 2008 Nov 15; 181(10):6913-22. PMID: 18981111; PMCID: PMC2636627.
    19. Chen X, Esplin BL, Garrett KP, Welner RS, Webb CF, Kincade PW. Retinoids accelerate B lineage lymphoid differentiation. J Immunol. 2008 Jan 01; 180(1):138-45. PMID: 18097013; PMCID: PMC2597070.
    20. Shankar M, Nixon JC, Maier S, Workman J, Farris AD, Webb CF. Anti-nuclear antibody production and autoimmunity in transgenic mice that overexpress the transcription factor Bright. J Immunol. 2007 Mar 01; 178(5):2996-3006. PMID: 17312145; PMCID: PMC2705967.
    21. Webb CF, Kincade PW. The divergence of lymphocyte development pathways. J Immunol. 2006 Jun 01; 176(11):6369. PMID: 16709794.
      View in: PubMed
    22. Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol. 2006 Jun; 26(12):4758-68. PMID: 16738337; PMCID: PMC1489113.
    23. Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF. Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol Cell Biol. 2005 Mar; 25(6):2073-84. PMID: 15743806; PMCID: PMC1061591.
    24. Nixon JC, Rajaiya J, Webb CF. Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation. J Biol Chem. 2004 Dec 10; 279(50):52465-72. PMID: 15456761.
      View in: PubMed
    25. Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF. The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. Cell Immunol. 2004 Mar; 228(1):42-53. PMID: 15203319.
      View in: PubMed
    26. Goebel P, Montalbano A, Ayers N, Kompfner E, Dickinson L, Webb CF, Feeney AJ. High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes. J Immunol. 2002 Sep 01; 169(5):2477-87. PMID: 12193717.
      View in: PubMed
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